LOCUS       BGC0000340             18739 bp    DNA     linear   BCT 10-SEP-2014
DEFINITION  Streptomyces sp. LZ35 echosides biosynthetic gene cluster, complete
            sequence.
ACCESSION   BGC0000340
VERSION     BGC0000340
KEYWORDS    .
SOURCE      Streptomyces sp. LZ35
  ORGANISM  Streptomyces sp. LZ35
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-07 18:30:07
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 18739
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..18739
                     /db_xref="taxon:1245024"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces sp. LZ35"
                     /strain="LZ35"
     protocluster    1..18739
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[10228:13132]"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10229..13132
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
     cand_cluster    1..18739
                     /SMILES="NC([*])C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /kind="single"
                     /product="NRPS-like"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..18739
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000340"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..18739
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS-like"
                     /region_number="1"
                     /rules="cds((PP-binding or NAD_binding_4) and (AMP-binding
                     or A-OX))"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            201..977
                     /gene="echD"
     CDS             201..977
                     /codon_start=1
                     /gene="echD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 57.1; E-value:
                     3.2e-17)"
                     /gene_kind="biosynthetic-additional"
                     /note="methyltransferase"
                     /product="EchD"
                     /protein_id="AHN91915.1"
                     /transl_table=11
                     /translation="MTDTVAVADWQAWQRSWDRQQEWYLPDREERFRVMLDAVEAVVGP
                     EPRILDLACGTGSISDRALRRFPGATSTGVDLDPALLTIARGHFASEPRVEFVTADLRD
                     PGWTGRLPHTAYDAVLTATALHWLRSDELRVLYGQIAGVVREGGVFLNADHMPDPATPR
                     LNAADHAYQKRRQARARAEGVQDWVEWWQDAARDEALAGPVAERFTIFGNPADGDHADG
                     ETQSVAWHAEALREGGFGEARAVWCSPSDAMVLGLK"
     misc_feature    201..18539
                     /note="echosides biosynthetic gene cluster"
     CDS             complement(1208..1969)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 233.5; E-value:
                     4.2e-71)"
                     /gene_kind="transport"
                     /note="Orf1"
                     /product="ABC transporter"
                     /protein_id="AHN91916.1"
                     /transl_table=11
                     /translation="MTAMVKAEGVHKSFGPVQVLKGIDLEVAPREVFCLIGPSGSGKST
                     FLRCINHLEKINSGRLYVDGDLVGYRQKGDKLYELKDREVAEKRRDIGMVFQRFNLFPH
                     MTALENVIEAPVQVKRETKAVARERALRLLDRVGLGDKAGNYPSQLSGGQQQRVAIARA
                     LAMEPKLMLFDEPTSALDPELVGEVLDVMRGLAEEGMTMIVVTHEMGFAREVGDSVVFM
                     DDGVVVESGQPREVLTNPRHERTKSFLSKVL"
     CDS             complement(1966..2904)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1096:polar amino
                     acid ABC transporter, inner membrane (Score: 244.6;
                     E-value: 1.5e-74)"
                     /gene_kind="transport"
                     /note="Orf2"
                     /product="ABC transporter permease"
                     /protein_id="AHN91917.1"
                     /transl_table=11
                     /translation="MTTKIEKAGPVGTPPPAPENIKAIPVRHYGRWVAAVITIALLALL
                     ISAFARGDVNWGAIPDYFFDGEVLKGVRNTVWITILSMVLGVALGIVLAVMRLSKNPVT
                     ASIAWGYIWFFRGTPVYVQLLVWFNLGLVFDYINIMPIYKDEWSDFMTPFLAALLGLGL
                     NEAAYMAEICRAGIQSVDEGQSEAAQALGMSHAKTLRRVVLPQAMRVIVPPTGNEFINM
                     LKTTSLVIAVQYWDLLQATSEVGQNSGATAEMLFLAAAWYLILTSVLSVGQYYLERYYA
                     RGSSRSLPATPLQRVRANLLSFSNRSGGVGA"
     CDS             complement(2950..3903)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1091:glutamine-binding lipoprotein glnH (Score: 208.5;
                     E-value: 1.5e-63)"
                     /gene_kind="biosynthetic-additional"
                     /note="Orf3"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="AHN91918.1"
                     /transl_table=11
                     /translation="MTASFTPRGATPKSRMASIGAVAVAGALLLTGCGDQTNKATGGSN
                     TNSAPLFNQLPKEIQSAKVIKVGSDINYPPVEFKKNGQVMGIDPDIADALGKQLGVKFE
                     FNNGTFDTLLSGLRSKRYDIAMSAMTDNKGRQEGVDPDTGKKAGEGVDFVDYFTAGVSI
                     YTKKGDTKGIKTWDDLCGKKIVVQRGTVSHDLAKSQSATCLKNKKGKISIEAFGNDTEA
                     QTRLRGGGAVAGSSDFPVAAYAVKTSGGGKDFELVGDQVEAAPYGIAVAKKNTQLRDAL
                     KQALALIIANGEYDKIIAKWGVKDGAVTKAVINGGK"
     CDS             4417..5649
                     /codon_start=1
                     /note="Orf4"
                     /product="malate dehydrogenase"
                     /protein_id="AHN91919.1"
                     /transl_table=11
                     /translation="MAAEMVDPRSDSTTGSGEGAEGVTDGEPFDPAFALHRGGKMAVQA
                     TVPVRDRDDLSLAYTPGVAKVCSAIAEKPELVHDYTWKSQVVAVVTDGSAVLGLGDIGP
                     EASLPVMEGKAILFKQFGGVDAVPIALDCRDVDEIVETVARFAPSFGGVNLEDISAPRC
                     FEIERKLQERVDIPIFHDDQHGTAVVTLAALRNAAKLTDRALGQLRAVISGAGAAGVAI
                     ARILTEAGIGDVAVCDRKGVVSQDREDLTDVKREVAGFTNKAQLTGSLEAALDGADVFI
                     GVSGGTVPEDAVSKMAPGAFIFAMANPNPEIHPDVAHRYAAVVATGRSDFPNQINNVLA
                     FPGIFAGALQVRASRITEGMKLAAAEALAAVVADELSADKVIPSPFDDRVAPAVTAAVA
                     AAARAEGVARR"
     CDS             5670..6758
                     /NRPS_PKS="Domain: PKS_ER (57-360). E-value: 6.5e-32.
                     Score: 102.7. Matches aSDomain:
                     nrpspksdomains_AHN91920.1_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028:crotonyl-CoA reductase / alcohol dehydrogenase
                     (Score: 229.1; E-value: 1.3e-69)"
                     /gene_kind="biosynthetic-additional"
                     /note="Orf5"
                     /product="alcohol dehydrogenase"
                     /protein_id="AHN91920.1"
                     /sec_met_domain="ADH_zinc_N (E-value: 3e-21, bitscore:
                     66.0, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MITGRPSGRRGGPARAGRCPVGERGHIVARFRGVRTRPMVGIMFA
                     AYAARIDRDQPLSGLELGERPEPETRPGWTTVNVRAASLNHHDLWSLRGVGLGEESLPM
                     ILGCDAAGVDEDGNEVVVHSVIGQSGHGVGPKEPRSILTERYQGTFAEKVTVPSWNLLP
                     KPKELSFEEAACLPTAWLTAYRMLFTNAGVRPGDSVLVQGAGGGVATAAIVLGAAAGLR
                     VLATSRDEAKRARAVELGAEGAYAPGERLPRRVDAVIETVGAATWSHSVKSLKPGGTLV
                     ISGATSGPDPKATELNRIFFLELKVVGSTMGGKDELEDLLSFCAARGVRPVIDSVLPLD
                     RAREGFEKMAGGDLFGKVVLTV"
     aSDomain        5841..6749
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AHN91920.1_PKS_ER.1"
                     /evalue="6.50E-32"
                     /label="AHN91920.1_PKS_ER.1"
                     /locus_tag="AHN91920.1"
                     /protein_end="360"
                     /protein_start="57"
                     /score="102.7"
                     /tool="antismash"
                     /translation="SGLELGERPEPETRPGWTTVNVRAASLNHHDLWSLRGVGLGEESL
                     PMILGCDAAGVDEDGNEVVVHSVIGQSGHGVGPKEPRSILTERYQGTFAEKVTVPSWNL
                     LPKPKELSFEEAACLPTAWLTAYRMLFTNAGVRPGDSVLVQGAGGGVATAAIVLGAAAG
                     LRVLATSRDEAKRARAVELGAEGAYAPGERLPRRVDAVIETVGAATWSHSVKSLKPGGT
                     LVISGATSGPDPKATELNRIFFLELKVVGSTMGGKDELEDLLSFCAARGVRPVIDSVLP
                     LDRAREGFEKMAGGDLFGKVVL"
     CDS_motif       6186..6224
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AHN91920.1_0001"
                     /evalue="6.50E-04"
                     /label="PKSI-ER_m4"
                     /locus_tag="AHN91920.1"
                     /protein_end="185"
                     /protein_start="172"
                     /score="13.2"
                     /tool="antismash"
                     /translation="AACLPTAWLTAYR"
     CDS_motif       6255..6308
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AHN91920.1_0002"
                     /evalue="6.90E-05"
                     /label="PKSI-ER_m5"
                     /locus_tag="AHN91920.1"
                     /protein_end="213"
                     /protein_start="195"
                     /score="15.5"
                     /tool="antismash"
                     /translation="GDSVLVQGAGGGVATAAI"
     CDS             complement(6927..7703)
                     /codon_start=1
                     /note="Orf6"
                     /product="antibiotic biosynthesis monooxygenase"
                     /protein_id="AHN91921.1"
                     /transl_table=11
                     /translation="MSALTSSGPLPDLTRPDVGAALFSTWSVGTPERQRAAVDAIAAAW
                     DGRPWPAPELLSYNVYAGTDGDTLMHHSQWADEAAYHAFVRTHRQERNDAIDRAVPGIE
                     RLGLSRYRHYRGFQAPAAQGGAQDPGLIVVVEIDFDEPDPGLRRSWVDLVIEALESEPD
                     QGLLTADFHLIVDGERHLRTDRARVLNYARWTGAEAYEAALAADGPRGGSSAWDRVRDF
                     PGRVGASARSYRFRRSFVRPSEAPPNSANSPEREAR"
     CDS             complement(7887..8981)
                     /codon_start=1
                     /note="Orf7"
                     /product="PadR family transcriptional regulator"
                     /protein_id="AHN91922.1"
                     /transl_table=11
                     /translation="MPPVFAHGRLRLYLLKLLDEAPRHGYEVIRLLEERFQGLYAPSAG
                     TVYPRLAKLEAEGLVTHTTEGGRKVYSITDAGRAELADRGGELADLELEIRESVAELAA
                     EIREDVRGSASDLRREMREAAQRARTSGGAQDKGGAQDKQDKHGPWEGQWGDKETWRQA
                     KEEMRRAREEWKEQARRAKEESRRARQDAQRARKQAKDAQDFAREEVQRIARRVQEQTQ
                     DHIRAGDWQRAVREGLAEVSRGMSRISRQGTSRSDWGWDDVMGGPEVTVERVDMTKPEG
                     GHEERKPAGGSGPAGVREPEWARDFTPSGAPARDLERLLDRLRDDIRDAARDHGVTDAQ
                     LAEAHRQLGATAARITALLRGERG"
     CDS             complement(8981..9838)
                     /codon_start=1
                     /note="Orf8"
                     /product="hypothetical protein"
                     /protein_id="AHN91923.1"
                     /transl_table=11
                     /translation="MSAGSQWSITAPQKLTFDDPVSTLDVRIVGGTVNVVGAAPGPARL
                     EVSEIDGPPLKVSHTDGILSVGYDDLSWKGFRKWLGQWNRTAHVTLTVPAGTSSTIGVV
                     GGSAVVSGLTGRAELRGVSGDFTLLGLTGPVQADTVSGRVEAQAVTGDLRFHSVSGDLT
                     VVEGSGPLVRAESVSGDMVLDLAPAPRCSDIRLTTVSGEIAIRLPHPADAEVEANTASG
                     SVSNGFEDLRVSGQWGAKRITGRLGAGNGSLKATTVSGAIALLRRPPSEEDTDTADGTQ
                     GKVL"
     gene            10229..13132
                     /gene="echA"
     CDS             10229..13132
                     /NRPS_PKS="Domain: AMP-binding (63-469). E-value: 3e-75.
                     Score: 245.2. Matches aSDomain:
                     nrpspksdomains_echA_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (602-673). E-value: 1.8e-12. Score:
                     39.1. Matches aSDomain: nrpspksdomains_echA_PCP.1"
                     /NRPS_PKS="Domain: Thioesterase (695-936). E-value:
                     1.5e-34. Score: 112.2. Matches aSDomain:
                     nrpspksdomains_echA_Thioesterase.1"
                     /codon_start=1
                     /gene="echA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     285.9; E-value: 8e-87)"
                     /gene_kind="biosynthetic"
                     /note="peptide synthetase"
                     /product="EchA"
                     /protein_id="AHN91924.1"
                     /sec_met_domain="AMP-binding (E-value: 7.7e-89, bitscore:
                     288.2, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 2.9e-12, bitscore:
                     37.2, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLLPSWPRNREGRGAVGGMTSQPWKTSVPEEGAEPPSVARLLLR
                     AARDHAHSGVRYLTGPTASESVRQSYPELLESALGLLSALRDRGLRPRDKVALLLDRQP
                     EFLTVLWACLLGGFVPCPMVPITGDPARWAAQLAHVNGLLDGPLLVTTETMRAELPEVP
                     GLAVAAVEELREAGGPSGAERDREPAVHSAAPEDLALLVLTSGSTGNSKAVMLTHGNIL
                     ASMAGKAGKQRLTAADTTFNWISYDHVAALLEAHMLPLYVGAEQLHAEASVILEEPLRF
                     LRIISRHKVTMTFTPNFLLGPLNSSVQEIAEEISAGGEGLDLSALRHIVSGGEANVVAT
                     GEAFLAHYAPYGLREGALWPAFGMTETCAGSIYNRAFPVTDVGEEFANLGTPVEGLRIR
                     VADDDHRALPAGEIGELQLSGPMITTGYYNNAEATEEAFTPDGWFRSGDLGRIDEGRLT
                     LVGRSKDSVIVNGVNYFSHEIEAALEQLDDVVSGYVAAFPTRRPGSDTEQLVIAVSPEP
                     ADDDEAGLYRMITAVRSTVVIHWGFRPFLILPLPRDAFPKTSLGKTLRRRMRRRLESGG
                     YDDVIERVAELTTRRLGGHTPPEGETERVLAEIYAEMFDTVPERISATAGFFDLGGTSL
                     DILRLRRQVHRRLGVADLPVITVLTAPSVRRLAARIAGGGTHHAAEYDPVVPLQTGGEK
                     TPLFCVHPGVGEVLVFVNLAKYFVGDRPFYALRARGFNEGEKPFTSFEEMVECYVEAIR
                     ARQPHGPYAIAGYSYGGAVAFEIAKALEAQGERVDFAGSFNLPPHIKYRMDELDFIETA
                     TNLAFFLDLINKKQSLDLPAELRPLPREEQLAHLLRIAPRGRLDELDLDLGKFTAWAEL
                     AHGLTTLGRDYHPSGTTRSMTVFYAIPLRGTKEDWLANELRRWDEFTTEPNRYLDVPGE
                     HYTLMGPRHVAAFQAVLRRELDRALGDADRARATGRA"
     misc_feature    10238..10240
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        10418..11635
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_echA_AMP-binding.1"
                     /evalue="3.00E-75"
                     /label="echA_AMP-binding.1"
                     /locus_tag="echA"
                     /protein_end="469"
                     /protein_start="63"
                     /score="245.2"
                     /specificity="consensus: X"
                     /tool="antismash"
                     /translation="SESVRQSYPELLESALGLLSALRDRGLRPRDKVALLLDRQPEFLT
                     VLWACLLGGFVPCPMVPITGDPARWAAQLAHVNGLLDGPLLVTTETMRAELPEVPGLAV
                     AAVEELREAGGPSGAERDREPAVHSAAPEDLALLVLTSGSTGNSKAVMLTHGNILASMA
                     GKAGKQRLTAADTTFNWISYDHVAALLEAHMLPLYVGAEQLHAEASVILEEPLRFLRII
                     SRHKVTMTFTPNFLLGPLNSSVQEIAEEISAGGEGLDLSALRHIVSGGEANVVATGEAF
                     LAHYAPYGLREGALWPAFGMTETCAGSIYNRAFPVTDVGEEFANLGTPVEGLRIRVADD
                     DHRALPAGEIGELQLSGPMITTGYYNNAEATEEAFTPDGWFRSGDLGRIDEGRLTLVGR
                     SKDSVIV"
     aSModule        10418..13036
                     /complete
                     /domains="nrpspksdomains_echA_AMP-binding.1"
                     /domains="nrpspksdomains_echA_PCP.1"
                     /domains="nrpspksdomains_echA_Thioesterase.1"
                     /final_module
                     /locus_tags="echA"
                     /monomer_pairings="X -> X"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       10823..10882
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_echA_0001"
                     /evalue="5.80E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="echA"
                     /protein_end="218"
                     /protein_start="198"
                     /score="19.0"
                     /tool="antismash"
                     /translation="ALLVLTSGSTGNSKAVMLTH"
     CDS_motif       11453..11542
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_echA_0002"
                     /evalue="6.90E-10"
                     /label="NRPS-A_a6"
                     /locus_tag="echA"
                     /protein_end="438"
                     /protein_start="408"
                     /score="31.2"
                     /tool="antismash"
                     /translation="PAGEIGELQLSGPMITTGYYNNAEATEEAF"
     aSDomain        12035..12247
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_echA_PCP.1"
                     /evalue="1.80E-12"
                     /label="echA_PCP.1"
                     /locus_tag="echA"
                     /protein_end="673"
                     /protein_start="602"
                     /score="39.1"
                     /tool="antismash"
                     /translation="ERVLAEIYAEMFDTVPERISATAGFFDLGGTSLDILRLRRQVHRR
                     LGVADLPVITVLTAPSVRRLAARIAG"
     CDS_motif       12314..12343
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_echA_0003"
                     /evalue="5.50E-03"
                     /label="NRPS-beforete1"
                     /locus_tag="echA"
                     /protein_end="705"
                     /protein_start="695"
                     /score="9.8"
                     /tool="antismash"
                     /translation="PLFCVHPGVG"
     aSDomain        12314..13036
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_echA_Thioesterase.1"
                     /evalue="1.50E-34"
                     /label="echA_Thioesterase.1"
                     /locus_tag="echA"
                     /protein_end="936"
                     /protein_start="695"
                     /score="112.2"
                     /tool="antismash"
                     /translation="PLFCVHPGVGEVLVFVNLAKYFVGDRPFYALRARGFNEGEKPFTS
                     FEEMVECYVEAIRARQPHGPYAIAGYSYGGAVAFEIAKALEAQGERVDFAGSFNLPPHI
                     KYRMDELDFIETATNLAFFLDLINKKQSLDLPAELRPLPREEQLAHLLRIAPRGRLDEL
                     DLDLGKFTAWAELAHGLTTLGRDYHPSGTTRSMTVFYAIPLRGTKEDWLANELRRWDEF
                     TTEPNRYLDVPGEHYTLMG"
     CDS_motif       12494..12568
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_echA_0004"
                     /evalue="2.10E-12"
                     /label="NRPS-te1"
                     /locus_tag="echA"
                     /protein_end="780"
                     /protein_start="755"
                     /score="39.4"
                     /tool="antismash"
                     /translation="QPHGPYAIAGYSYGGAVAFEIAKAL"
     gene            13217..14140
                     /gene="echB"
     CDS             13217..14140
                     /NRPS_PKS="Domain: NAD_binding_4 (61-177). E-value:
                     3.8e-12. Score: 37.6. Matches aSDomain:
                     nrpspksdomains_echB_NAD_binding_4.1"
                     /codon_start=1
                     /gene="echB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     189.6; E-value: 1.4e-57)"
                     /gene_kind="biosynthetic-additional"
                     /note="NAD-dependent epimerase/dehydratase"
                     /product="EchB"
                     /protein_id="AHN91925.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 9.6e-09, bitscore:
                     24.8, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEGKKILVTGATGQVARPVAEALAGRNEVWCLGRFGTPGVEKELT
                     DQGITTFHWDMNDQGPAAYEGLPDDFTHVFHSAVRRGEDGDVNAAIEVNSVATGRLMTH
                     CRSAEAFLFVSTGALYKRQTLDHAYSEDDPVDGVADWLPAYPVGKIAAEGAVRAFAQVL
                     GLPTTIARLNIAYGPGGYGGVPMLYFKRMLAGEPIPVPMEGQNWCSLLHTDDLIAHVPH
                     LWQAASTPATLVNWGGDEAVGITDCVRHLEELTGVRARLVPSEVTRETYHFDPTRRREI
                     TGPCRVPWREGVRRTLQALHPEHLPS"
     aSDomain        13400..13747
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_echB_NAD_binding_4.1"
                     /evalue="3.80E-12"
                     /label="echB_NAD_binding_4.1"
                     /locus_tag="echB"
                     /protein_end="177"
                     /protein_start="61"
                     /score="37.6"
                     /tool="antismash"
                     /translation="AAYEGLPDDFTHVFHSAVRRGEDGDVNAAIEVNSVATGRLMTHCR
                     SAEAFLFVSTGALYKRQTLDHAYSEDDPVDGVADWLPAYPVGKIAAEGAVRAFAQVLGL
                     PTTIARLNIAYG"
     gene            14165..14575
                     /gene="echC"
     CDS             14165..14575
                     /codon_start=1
                     /gene="echC"
                     /note="limonene-1,2-epoxide hydrolase"
                     /product="EchC"
                     /protein_id="AHN91926.1"
                     /transl_table=11
                     /translation="MANTMASPNIEAIRASYAGFRDRDIEGILSGMHPDVEWVHPEGMA
                     KYGLGGTKLGHAGIKEFLAHVPTVLGGMRLEPKEFIEQGDRIVVFGTREVTSRRGTTVT
                     LDFVHSWTMRDGKAARMEDIFDTVAFHELIES"
     CDS             complement(14670..15290)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00881"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1159:dihydropteridine reductase (Score: 205.4;
                     E-value: 1.2e-62)"
                     /gene_kind="biosynthetic-additional"
                     /note="Orf9"
                     /product="nitroreductase"
                     /protein_id="AHN91927.1"
                     /sec_met_domain="PF00881 (E-value: 3.8e-20, bitscore: 62.8,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAPENSGALSPLTLAPEAQRQLFLEARTANTFTDEPVTEEQVRA
                     IHELVKYAPTSMNQQPLRAVLVRSAEARARLVAHMTGRNQEKTAKAPLVAVLAADLDFH
                     EELPRLVPFMENPQAFFADPDVREGSARFNTALQVGYFILGVRAAGLAAGPMIGFDHAA
                     VSKEFFEDGRHTAVCVVNIGKPGPDAWMGRLPRLEYDEVFRTV"
     CDS             15408..16091
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057:TetR family
                     transcriptional regulator (Score: 102.4; E-value: 6.8e-31)"
                     /gene_kind="regulatory"
                     /note="Orf10"
                     /product="TetR family transcriptional regulator"
                     /protein_id="AHN91928.1"
                     /transl_table=11
                     /translation="MRTDSGPRRSAAGRPAGPQPAKRQAILEAAVAVFLREGYNRASVD
                     VIADEARVSKQTVYNHFGDKERLFIAAVEEERERVAAGFAAGSPYVLGPDGAANAEAYD
                     GGDARAALIAFGHRVLAVLLDERASALRRLVIAEVARHPSLRPACAEGEPQQLVKYLAE
                     MLGRRSSRGELSVPDPAAAAHQFVALVVQQGLYQSMYGTRPLADDEAAAIYESAADLLV
                     RAYRP"
     CDS             16114..16929
                     /codon_start=1
                     /gene_functions="regulatory (smcogs)
                     SMCOG1041:transcriptional regulator, SARP family (Score:
                     301.7; E-value: 2.2e-91)"
                     /gene_kind="regulatory"
                     /note="Orf11"
                     /product="SARP family transcriptional regulator"
                     /protein_id="AHN91929.1"
                     /transl_table=11
                     /translation="MRVSVLGPLTLGLGARSGVPSAMKPRKVLSLLLLNAGRMVPVQSL
                     MAELWGDQPPRTGLTTLQTYILHLRKLLAEMLGIPSATVTRDVLQTRPGGYAMVVEPGE
                     LDVHEYRDLVAEGECALEVGDERTADTSFRRALALWQGPALVDVTPHGRPLQAEVARLE
                     QSRLTVTERGIETRLRLGSHLEVLSDLASLVVEHRFHEGLHGQYMLALHRSGQRTRALT
                     VYQRLRTAMTEELGLEPSAKLQRLQQAVLVSDPRLDHEAGAPGRGPVVA"
     CDS             17357..18088
                     /NRPS_PKS="Domain: PKS_KR (1-157). E-value: 9.6e-11. Score:
                     33.7. Matches aSDomain: nrpspksdomains_AHN91930.1_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     195; E-value: 2.4e-59)"
                     /gene_kind="biosynthetic-additional"
                     /note="Orf12"
                     /product="short-chain dehydrogenase/reductase SDR"
                     /protein_id="AHN91930.1"
                     /sec_met_domain="adh_short (E-value: 6.6e-32, bitscore:
                     101.1, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 6.6e-34, bitscore:
                     108.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVTGGGTGIGRATARTFAEQGAQVLVVGRTADRLAETAAEAPGI
                     QQLATDVSAPGAAELIVNTAREAFGRIDVLVNNAAVVRQTPLGDAEREAAEEMLAVNLL
                     APVHLTRAALPHLSETAGVVINVSTAIGQRGWPFTGGELYAALKAALDTLTRSWAVQFA
                     PSGVRVVGVAPGPIATPIGQHQGLDAQQIEALRTTLIEHVPLRRVGRAEEVAFWIAQLA
                     RAEAGYTTGVVLPVDGGALVG"
     CDS_motif       17360..17437
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AHN91930.1_0001"
                     /evalue="6.70E-07"
                     /label="PKSI-KR_m1"
                     /locus_tag="AHN91930.1"
                     /protein_end="27"
                     /protein_start="1"
                     /score="22.0"
                     /tool="antismash"
                     /translation="IVTGGGTGIGRATARTFAEQGAQVLV"
     aSDomain        17360..17827
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AHN91930.1_PKS_KR.1"
                     /evalue="9.60E-11"
                     /label="AHN91930.1_PKS_KR.1"
                     /locus_tag="AHN91930.1"
                     /protein_end="157"
                     /protein_start="1"
                     /score="33.7"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="IVTGGGTGIGRATARTFAEQGAQVLVVGRTADRLAETAAEAPGIQ
                     QLATDVSAPGAAELIVNTAREAFGRIDVLVNNAAVVRQTPLGDAEREAAEEMLAVNLLA
                     PVHLTRAALPHLSETAGVVINVSTAIGQRGWPFTGGELYAALKAALDTLTRS"
     CDS             18159..18539
                     /codon_start=1
                     /gene_functions="regulatory (smcogs)
                     SMCOG1171:transcriptional regulator, MerR family (Score:
                     100.3; E-value: 2.9e-30)"
                     /gene_kind="regulatory"
                     /note="Orf13"
                     /product="MerR family transcriptional regulator"
                     /protein_id="AHN91931.1"
                     /transl_table=11
                     /translation="MRIGELAKATGATTRALRFYEERGLLSSARAVNGYRIYDERAIRR
                     VVNIRYLLDAGLTLEDVEHFSACLDGDLPNSPPSEAGLNVGRRRLSVLDERIATLARVR
                     DELAERLAVASGDRAAITPSSC"
ORIGIN
        1 cttggctcct cgctgttgac caggcgcacg gcgagatccg agtaataagc cagttccact
       61 tgtggtcctt acgacggtcg gtctagagtc acgtaagagg cgttctgcct acgagggtat
      121 tacgggcggc tgcgcccgat gacgactgac gacgacgcat gtcgacgaca tgtcgacgac
      181 gcatggcttg gaggggcacg atgacggaca ccgtcgccgt ggcggactgg caggcgtggc
      241 agcggagctg ggaccggcag caggagtggt acctccccga tcgtgaggaa cggttccggg
      301 tgatgctcga cgcggtcgag gccgtcgtcg gcccggagcc gaggatcctg gacctcgcgt
      361 gtggcacggg cagtatctcg gaccgggcgc tgcgccggtt ccctggcgcc accagcaccg
      421 gtgtcgacct cgaccccgcg ctgctgacga tcgcccgcgg ccatttcgcg tccgagccgc
      481 gcgtggagtt cgtgaccgcc gatctgcgcg accccggctg gaccgggcgg ctgccgcaca
      541 ccgcgtacga cgccgtcctg accgccacgg ccctccactg gctgcgctcg gacgagctgc
      601 gggtgctgta cgggcagatc gcgggcgtcg tacgggaggg cggggtgttc ctcaacgcgg
      661 accatatgcc cgatccggcc acgccccggc tcaacgccgc cgaccacgcg taccagaagc
      721 ggcggcaggc ccgggccagg gccgagggcg tccaggactg ggtggagtgg tggcaggacg
      781 ccgcacggga cgaggcgctg gcggggccgg tggccgagcg gttcacgatc ttcggcaatc
      841 cggccgacgg cgaccacgcg gacggtgaga cgcagtccgt cgcctggcat gccgaggcgc
      901 tgcgcgaggg cggcttcggc gaggcgcggg ccgtatggtg ctcgccctcg gacgcgatgg
      961 tgctcgggtt gaagtgaccc cggggcggag tgcgcgaggg cggtacgggc cggcgcccgt
     1021 accgccctcg cgcatgtgcc gcgcctcagc ggattgcctc ggcggatcgg cgtaagtcgg
     1081 ccgcggttcg gtggcgcccc gaaggggcgc ggggccgtgt cgaggtgcgg ctccgccgcg
     1141 cgggcgcgac cggccagggc ggtgccgcgg acgatcgacg gcaggtcagg gcacttccag
     1201 cggagcgcta gagcaccttg gacaggaacg acttcgtccg ctcgtgccgc ggattggtca
     1261 gcacctcccg gggctgcccg gactccacca ccacgccgtc gtccatgaag acgaccgagt
     1321 ccccgacctc gcgggcgaag cccatctcat gcgtgacgac gatcatcgtc atgccctcct
     1381 cggcgagccc gcgcatcaca tcgagcacct cgccgaccag ctccgggtcg agcgccgagg
     1441 tgggctcgtc gaagagcatc agcttcggct ccatcgccag cgcccgcgcg atcgccaccc
     1501 gctgctgctg gccgccggag agctgggagg ggtagttgcc cgccttgtcg ccgaggccca
     1561 cccggtccag cagccgcagc gcgcgctcgc gcgccaccgc cttggtctcc cgcttgacct
     1621 gcaccggcgc ctcgatcacg ttctccagcg ccgtcatatg cgggaagagg ttgaagcgct
     1681 ggaagaccat gccgatgtcg cgccgcttct cggcgacctc gcggtccttg agctcgtaga
     1741 gcttgtcgcc cttctggcgg tagccgacca ggtcgccgtc cacgtacagc cgcccggagt
     1801 tgatcttctc caggtggttg atgcagcgca ggaaggtgga cttgccggag ccggacgggc
     1861 cgatcaggca gaacacctcg cgcggggcga cctcgaggtc gatgcccttg aggacctgga
     1921 ccgggccgaa ggacttgtgg acgccttcgg ccttcaccat ggcggtcatg cgccgacacc
     1981 tccggagcgg ttgctgaagg agagcagatt ggcccggacc cgctggagcg gggtggccgg
     2041 gaggctacgg ctcgagccgc gtgcgtagta ccgctccagg tagtactggc ccacgctcag
     2101 gacggaggtg aggatcaggt accaggcggc cgccaggaag agcatctccg ccgtggcgcc
     2161 ggagttctgg ccgacctcgg aggtggcctg gagcagatcc cagtactgca ccgcgatcac
     2221 cagtgaggtg gtcttgagca tgttgatgaa ctcattgccg gtgggcggca cgatcacccg
     2281 catcgcctgc ggcagcacca cccggcgcag cgtcttggcg tggctcatcc cgagtgcctg
     2341 ggcggcctcg gactggccct cgtcgaccga ctggatgccg gcccggcaga tctcggccat
     2401 gtacgcggcc tcgttcaggc ccagacccag cagggcggcc aggaacgggg tcatgaagtc
     2461 cgaccactcg tccttgtaga tcggcatgat gttgatgtag tcgaacacca ggccgagatt
     2521 gaaccagacc agcagctgta cgtagaccgg ggtgccgcgg aagaaccaga tgtagcccca
     2581 ggcgatggag gcggtcaccg ggttcttcga cagccgcatc accgcgagga cgatgccgag
     2641 ggccacgccg agcaccatcg acaggatggt gatccagacg gtgttgcgga cgcccttgag
     2701 gacctcaccg tcgaagaagt agtccggaat ggcaccccag ttgacatcgc cgcgggcgaa
     2761 ggcggagatc aggagggcga gcagggcgat ggtgatgacc gcggcgaccc agcggccgta
     2821 gtgccgcacc gggatggcct tgatgttctc cggcgcgggc ggcggggtgc cgaccgggcc
     2881 cgccttttcg atcttagtgg tcacggatgg tgcctttcag cgcgagcgcg cggacggggg
     2941 agggccggat cacttgccgc cgttgatgac ggccttggtg accgcgccgt ccttgacgcc
     3001 ccacttcgcg atgatcttgt cgtattcgcc gttcgcgatg atcagggcga gtgcctgctt
     3061 gagggcgtcg cgcagctggg tgttcttctt ggcgacggcg atgccgtacg gggccgcctc
     3121 cacctggtcg cccacgagct cgaagtcctt gccgccgccg gaggtcttca ccgcgtacgc
     3181 cgccaccggg aagtcgctgg agccggcgac ggcgccgccg ccgcgcagcc gggtctgggc
     3241 ctcggtgtca ttgccgaacg cctcgatcga gatcttgccc ttcttgttct tcaggcaggt
     3301 cgccgactgg gacttggcca ggtcgtggga gacggtgccg cgctgtacga cgatcttctt
     3361 gccgcacagg tcgtcccacg tcttgatgcc cttggtgtcg cccttcttgg tgtagatcga
     3421 gacacccgcg gtgaagtagt cgacgaagtc gacgccctcg ccggccttct tgccggtgtc
     3481 cgggtcgacg ccctcctggc ggcccttgtt gtcggtcatg gccgacatgg cgatgtcgta
     3541 gcgcttggag cgcaggccgg agagcagggt gtcgaaggtg ccgttgttga actcgaactt
     3601 caccccgagc tgcttgccga gggcgtcggc gatgtccggg tcgatcccca tgacctggcc
     3661 gttcttcttg aactcgaccg gcgggtagtt gatgtccgag cccaccttga tcaccttggc
     3721 gctctggatc tccttgggca gctggttgaa gagcggggcg gagttggtgt tggacccgcc
     3781 ggtggccttg ttggtctggt cgccgcagcc cgtcagcagc aaggcacctg ccaccgctac
     3841 cgcgccgatg gaggccatcc gggacttcgg ggtggcccca cggggcgtga agctggcggt
     3901 catgctggtt cctccggcag ggtgaggggg gtgagatccc gggaacacgt ttgtgggtgt
     3961 cgcgatctcg tgtgattggg gcatcttgcc atcggacggg ctcgtacggg cctctggcca
     4021 tgtcaaaatc ggataacggg cgatccccgt ggtgcactac cggacagcgg caccggccgg
     4081 acagcggcgg ccggaaccgc ggagcgggct catgatcacg cggagaacag cgcgtgacgg
     4141 tgacatggac tttcaccaga gattcgcccg ccttcaggtg taatgcctgg ttttccggcg
     4201 tcatggcacc agaactcgtt cgtccctcga cgcacgcttc gggtagaaca gacggctaca
     4261 cccctcaccc ggggctcagg gcgcgtgtgc gacgcgcccg gcgttcgtac ccacccccat
     4321 gcggtggtct tccgctgaat gggacgacgc ggtgcccgcc cgctccgaac ctggggcgga
     4381 taccctcgat agaaaaacga caaaggggtc aaaacagtgg cagcggagat ggtcgatcct
     4441 cgcagcgaca gcacaaccgg cagcggcgaa ggagccgaag gcgtgaccga cggcgagccc
     4501 ttcgatccgg ccttcgccct gcaccgcggc ggcaaaatgg ccgtccaggc gacggtgccg
     4561 gtgcgcgacc gggacgatct gtccctcgcg tacacgcccg gtgtggccaa ggtgtgcagc
     4621 gctatcgccg agaagcccga gctcgtccat gactacacct ggaagtccca ggtcgtggcc
     4681 gtggtgacgg acggcagcgc ggtgctgggg ctcggggaca tcggtccgga ggcgtccctc
     4741 ccggtcatgg agggcaaggc gatcctcttc aagcagttcg gcggcgtgga cgcggtgccg
     4801 atcgcgctcg actgccggga cgtggacgag atcgtggaga ccgtcgcccg cttcgcgccc
     4861 tcgttcggcg gcgtcaatct ggaggacatc tccgcgcccc gctgcttcga gatcgagcgc
     4921 aagctccagg agcgcgtcga catcccgatc ttccatgacg accagcacgg cacggcggtg
     4981 gtcaccctcg ccgcgctgcg caacgccgcc aagctgacgg accgcgcgct gggtcagctg
     5041 cgcgccgtga tctccggtgc gggcgccgcc ggtgtggcca tcgcccggat cctcaccgag
     5101 gcgggcatcg gcgatgtggc cgtgtgcgac cgcaagggcg tcgtctccca ggaccgcgag
     5161 gacctcaccg acgtcaagcg cgaggtggcc gggttcacca acaaggccca gctcaccgga
     5221 tcgctggagg ccgcgctgga cggcgccgac gtcttcatcg gcgtcagcgg cggcacggtg
     5281 ccggaggacg cggtgtcgaa gatggcgccg ggcgccttca tcttcgcgat ggccaacccc
     5341 aacccggaga tccacccgga cgtcgcccac cgctacgcgg ccgtggtcgc caccgggcgc
     5401 agcgacttcc cgaaccagat caacaacgtc ctcgccttcc ccggcatctt cgcgggcgcc
     5461 ctccaggtcc gggcctcccg gatcaccgag ggcatgaagc tcgcggccgc cgaggcgctg
     5521 gccgcggtgg tggccgatga gctgagcgcg gacaaggtca tcccctcgcc gttcgacgac
     5581 cgggtcgccc ccgccgtgac cgcggccgtc gccgcggccg cccgcgcgga gggcgtcgcc
     5641 cgccgctgac gccccgccag gtcccaggtg tgatcacggg ccgcccctcc ggccggaggg
     5701 gcggcccggc gcgtgccggg cggtgtccgg tgggcgagcg gggtcacatc gtggcgaggt
     5761 tccgcggggt ccgcacgcgg cctatggtcg ggatcatgtt cgctgcctat gccgcacgta
     5821 tcgaccgtga ccagccgctg agcggccttg aactggggga gcgccccgag ccggagacac
     5881 ggcccggctg gaccaccgtg aacgtcaggg ccgcctcgct caaccaccac gatctgtggt
     5941 cgctgcgcgg tgtgggcctc ggtgaggagt cgcttccgat gatcctcggc tgtgacgcgg
     6001 ccggggtcga cgaggacggc aacgaggtcg tcgtccactc cgtcatcggc cagagcggac
     6061 acggtgtcgg tcccaaggag ccccgctcca tcctcaccga gcgttatcag ggcaccttcg
     6121 ccgagaaggt gaccgtcccc agctggaatc tgctgcccaa gcccaaggag ctctccttcg
     6181 aggaggccgc ctgcctgccc acggcctggc tgaccgccta ccggatgctg ttcaccaacg
     6241 cgggggtgcg ccccggcgac agcgtgctgg tccagggcgc cggcggcggt gtggccaccg
     6301 ccgcgatcgt gctgggcgcg gcggccggtc ttcgggtgct ggccaccagc cgtgacgagg
     6361 ccaagcgggc ccgcgccgtc gagctgggcg ccgagggcgc gtacgcaccg ggggagcggc
     6421 tgccgcgccg ggtggacgcc gtgatcgaga cggtgggcgc cgcgacctgg tcgcattcgg
     6481 tgaagtccct caagccgggc ggcaccttgg tgatttcggg cgccaccagc ggccccgacc
     6541 ccaaggccac cgagctcaac cggatcttct tcctggagct gaaggtcgtc ggctccacga
     6601 tgggcgggaa ggacgagctg gaggacctgc tgagcttctg cgccgcacgc ggtgtacggc
     6661 cggtgatcga ctcggtgctg ccgctggacc gggcccggga ggggttcgag aagatggcgg
     6721 gcggcgatct gttcggcaag gtcgtgctga cggtctgaaa tatcccgtcg gtgtccccgg
     6781 ccacaatgcg ggccggggat tcgcgaagga attcgatttc gtcccgtgga tgccgtccgc
     6841 ttacgtcccg cggatgcggt ccccgtcgag gacggagacc gtgtcgggca tatgccgggg
     6901 gcgtagtgcg aaacccgtac ggcgttctac cgggcctcgc gctccggcga attcgcggaa
     6961 ttcggcggtg cctccgacgg ccgtacgaag ctccgccgga agcgatagga gcgggccgac
     7021 gcgcccactc gtccggggaa gtcgcgcacc cggtcccagg cggatgagcc gccgcgcggc
     7081 ccatccgccg ccagggccgc ctcatacgcc tccgcaccgg tccagcgggc gtagttgagc
     7141 acccgggcgc ggtcggtgcg cagatggcgc tcgccgtcga cgatcagatg gaagtcggcg
     7201 gtgagcaggc cctggtcggg ctcgctctcc agcgcctcga tgaccaggtc gacccaggac
     7261 cggcggagcc cgggatcggg ctcgtcgaag tcgatctcga ccacgacgat cagcccgggg
     7321 tcctgggcgc cgccctgggc ggccggtgcc tggaagccgc ggtagtggcg gtagcgggag
     7381 aggccgagcc gctcgatgcc cgggaccgcc ctgtcgatcg cgtcgttgcg ctcctggcgg
     7441 tgggtccgga cgaaggcgtg gtacgccgcc tcgtcggccc actgggagtg gtgcatcagc
     7501 gtatcgccgt ccgtacccgc atagacgttg tacgagagca gctcgggtgc cggccagggg
     7561 cggccgtccc aggcggcggc gatggcgtcg accgcggccc gctgccgttc cggtgtgccc
     7621 acgctccagg tgctgaagag cgcggcgccc acatcgggcc gggtgaggtc gggcagcgga
     7681 ccggagctgg tcagggcgga catggcggtc tcctcgcggt cgggagaatg cggtgcggac
     7741 aaggggatcg gggtcggagg ggcgcccccg tggcgcgccc ctccgacccc gatcctggaa
     7801 cttcaaccgc ggttgaggtc aagcggacga ccgggccggg caccgcggac gatcgacggc
     7861 aggtcggggc acttccagct aagcgcctag ccgcgttcgc cccgcagcag cgcggtgatc
     7921 cgcgctgccg tcgcccccag ctgacggtgc gcctcggcca gctgggcgtc ggtcaccccg
     7981 tggtcgcggg ccgcgtcgcg gatgtcgtcg cggagccggt cgagcagccg ctccagatcg
     8041 cgggcggggg cgcccgaggg ggtgaagtcc ctggcccact cgggctcccg taccccggcc
     8101 gggccgctgc cgccggccgg cttccgctcc tcgtggccgc cctccggctt ggtcatgtcc
     8161 acccgctcga ccgtgacctc cggcccgccc atcacatcgt cccagcccca gtccgagcgc
     8221 gaggtgccct gccgggagat ccggctcata ccgcgcgaca cctcggccag gccctcgcgc
     8281 accgcacgct gccagtcgcc cgcccggatg tgatcctgcg tctgctcctg aacccgccgg
     8341 gctatccgct ggacctcctc gcgtgcgaag tcctgcgcgt ccttggcctg cttacgggcg
     8401 cgctgggcgt cctgccgggc ccgccggctc tcctccttcg cccggcgcgc ctgctccttc
     8461 cactcctccc gcgcgcgccg catctcctcc ttcgcctgcc gccaggtctc cttgtcgccc
     8521 cactgcccct cccacgggcc gtgcttgtcc tgcttgtcct gggcgccgcc cttgtcctgg
     8581 gcgccgccgg aggtacgggc ccgctgtgcc gcctcccgca tctcccgccg cagatcgctc
     8641 gcggagccgc ggacgtcctc gcggatctcg gcggcgagtt cggcgaccga ctcgcggatc
     8701 tccagctcca gatcggccag ttcaccgccg cggtcggcca gttcggcgcg cccggcgtcg
     8761 gtgatggagt agaccttgcg gccgccctcg gtggtgtggg tgaccaggcc ctcggcctcc
     8821 agcttggcca gccgcggata gacggtgccg gccgagggcg cgtacagccc ctggaaccgc
     8881 tcctccagca ggcggatgac ctcgtagccg tggcgcggcg cctcgtcgag cagcttgagc
     8941 agatacagac gcagtcggcc gtgggcgaat acggggggca tcagaggacc tttccctggg
     9001 tgccgtcggc ggtgtccgtg tcctcctcgg acggtggacg gcgcagcagc gcgatggcgc
     9061 ccgagacggt ggtggccttg agactgccat ttcccgcgcc gagccggccg gtgatcctct
     9121 tggctcccca ctgaccgctg acccgcaggt cctcgaagcc gttggagacc gagccgctgg
     9181 ccgtgttggc ctccacctcg gcgtcggcgg ggtgcggcag ccggatggcg atctcgccgg
     9241 agacggtggt gaggcggatg tcggagcacc gcggggcggg ggccaggtcg agcaccatgt
     9301 ccccgctgac cgactcggcc cgtaccaggg gccccgagcc ctcgacgacg gtgaggtcgc
     9361 cggagacgga gtggaaccgc agatcgccgg tgacggcctg tgcctcgacc cggccggaga
     9421 cggtgtcggc ctggaccggc ccggtcagcc cgagcagggt gaagtcgccg gagacaccgc
     9481 gcagttcggc acggccggtc agcccggaga ccacggcgga gcccccgacg acgccgattg
     9541 tggagctggt gccggcgggc acggtgaggg tcacatgggc ggtgcggttc cactgcccga
     9601 gccacttgcg gaagcccttc caggacaggt cgtcgtagcc gacgctcagg atgccgtcgg
     9661 tgtggctgac cttcagcggc gggccgtcga tctccgagac ctcgaggcgg gcggggccgg
     9721 gggccgcgcc gaccacattg accgtgccgc ccacgatgcg tacgtcgaga gtggacaccg
     9781 ggtcgtcgaa ggtgagcttc tgtggcgcgg tgatcgacca ctgtgatccg gctgacatcc
     9841 ctggcctccc ctggctggac ggcgcgcccc tgaccggatg tgcgcgcgcc gcccttgacc
     9901 ggacgtgcgt ccgccatctg gacgcaacat atcgtgtctc ctgctcaaca cgatatatcg
     9961 cggcagcgcg gagtcaagcc cggtccggac cccgggcggg gtgccgggga ccgggatccc
    10021 ggagccgcgg tcggtgctgg atccgcttcc acacccccgc gcacctgcgc acaatcacgt
    10081 gagcgggtgg cggacgcggc gacagatgca tggcacagtc atcgtttccc gacgggtcga
    10141 atcgcccttc ttcaagaaag tgatccaccg tgggaatttc cgctagagct tcgctagagc
    10201 cctggtagag cgtcatggag acatatgttt gaggctgtta ccttcgtggc ctcggaatcg
    10261 ggaaggaaga ggggccgtgg ggggaatgac gtcacaaccc tggaaaacct cggtaccaga
    10321 agaaggcgcg gagccgccct cggttgcccg gttgctcttg cgggccgccc gtgaccacgc
    10381 ccattcgggg gtgcgctatc tgaccgggcc cacggcgagt gaatcggtgc ggcagtccta
    10441 tccggaactt ctggaatcgg ccctcgggct tctctccgca ctccgggacc gcggattgcg
    10501 gccgcgggac aaggtggccc tgctgctgga ccgccagccg gaattcctga cggtcctctg
    10561 ggcctgtctg ctgggcggct tcgtgccctg cccgatggtg ccgatcaccg gcgacccggc
    10621 tcgctgggcg gcccaactcg cccatgtcaa cgggctgttg gacggccccc tgctggtcac
    10681 caccgagacg atgcgggccg agctgccgga ggttcccggg ctcgcggtgg ccgcagtgga
    10741 ggagctgcgg gaggccggag gcccctccgg cgccgagcgc gaccgggaac ccgccgtgca
    10801 ctccgcggcc ccggaggacc tcgccctgct ggtgctgacc tccggctcca ccgggaattc
    10861 caaggcggtc atgctcaccc atggaaatat cctggcgtcc atggcaggaa aggcggggaa
    10921 acagcggctc accgccgccg acaccacctt caattggatt tcctacgacc atgtggccgc
    10981 gcttttggaa gcgcatatgc tgccgctgta cgtgggcgcc gaacaattgc atgcggaagc
    11041 ctcggtcatt cttgaggagc cgctgcggtt cctccgtatc atttcccgtc acaaggtcac
    11101 gatgaccttt acgccgaact tcctcctcgg cccgctgaat tcctccgtgc aggagatcgc
    11161 ggaggagata tcggcgggcg gtgaaggact cgatctcagc gcgctgcgcc atatcgtcag
    11221 cggcggagag gcgaatgtcg tggcgaccgg cgaggcattc ctcgcccatt acgctccgta
    11281 tggtctgcgg gagggcgcgc tctggcccgc cttcgggatg accgagacct gcgcgggcag
    11341 catctacaac cgcgcgttcc cggtcaccga cgtgggcgag gagttcgcca acctcggcac
    11401 ccccgtcgag gggctgcgga tccgggtcgc cgacgacgac caccgggcgc tgcccgcggg
    11461 cgagatcggc gagctccagc tcagcgggcc gatgatcacc accggctact acaacaacgc
    11521 ggaggccacc gaggaagcct tcacccccga cggctggttc cgcagcggcg acctgggccg
    11581 gatcgacgag ggccggctga ccctcgtcgg gcgcagcaag gacagcgtca tcgtcaatgg
    11641 cgtcaactac ttcagccatg agatagaggc cgccctggag cagctggacg acgtcgtgag
    11701 cggctatgtc gcggcgttcc cgacccgccg ccccggcagc gacaccgagc agctggtcat
    11761 cgccgtcagc ccggagcccg cggacgacga cgaggccggg ctgtaccgca tgatcaccgc
    11821 ggtgcgctcg accgtcgtga tccactgggg cttcagaccc ttcctcatcc tgccgctgcc
    11881 cagggacgcc ttccccaaga ccagcctcgg caagacgctg cgccgcagga tgcgccggcg
    11941 cctggagtcc ggcggctacg acgatgtcat cgagcgggtc gcggagctga ccacccgccg
    12001 cctcggcggc cacaccccgc ccgagggcga gaccgagcgg gtcctggcgg agatctacgc
    12061 cgagatgttc gacaccgtcc ccgagcggat cagcgccacc gccggcttct tcgacctcgg
    12121 cggcacctcg ctggacatcc tgcggctgcg gcgccaggtc caccggcgcc tcggggtcgc
    12181 ggacctgccg gtcatcacgg tgctcacggc gccgtcggta cggcggctcg ccgcccggat
    12241 cgcgggcggc ggcacgcacc acgccgccga gtacgacccg gtcgtaccgc tccagaccgg
    12301 cggtgagaag accccgctgt tctgtgtcca ccccggcgtc ggcgaggtcc tggtcttcgt
    12361 caacctcgcc aagtacttcg tcggcgaccg gccgttctac gcgctgcgcg cccgtggctt
    12421 caacgagggc gagaagccct tcaccagctt cgaggagatg gtggagtgct atgtggaggc
    12481 catccgcgcc cgccagccgc acggccccta cgccatcgcc ggatactcct acggcggcgc
    12541 cgtggccttc gagatcgcca aggcgctcga ggcccagggc gagcgggtcg acttcgcggg
    12601 cagcttcaac ctcccgccgc acatcaagta ccgcatggac gagctcgact tcatcgagac
    12661 cgcgaccaac ctcgccttct tcctcgacct gatcaacaag aagcagtcgc tcgacctccc
    12721 cgccgagctg cgcccgctgc cccgcgagga gcagctcgcg catctgctgc ggatcgcccc
    12781 gcggggccgg ctggacgaac tcgacctgga cctcgggaag ttcaccgcct gggcggagct
    12841 ggcccacggg ctgaccacgc tgggccgcga ctaccacccc agcggcacca cccgttccat
    12901 gaccgtcttc tacgcgatcc cgctgcgcgg caccaaggag gactggctgg cgaacgagtt
    12961 gcgcaggtgg gacgagttca ccaccgagcc caaccggtat ctggacgtcc ccggtgagca
    13021 ctacaccctg atgggcccgc gccatgtcgc ggccttccag gcggtgctgc gcagggaact
    13081 cgaccgtgcg ctgggcgacg ccgaccgggc ccgggccacg ggccgggcat aggccgcccg
    13141 gcagggccgg gcacacaggc cccgcgtggg ccgggcacaa ggacccatga tggccaggca
    13201 aagggagaag agcagggtgg aaggcaagaa gatcctggtc accggcgcca ccgggcaggt
    13261 ggcccggccg gtggccgagg cgctcgccgg gcgcaacgag gtgtggtgcc tgggccggtt
    13321 cggcaccccc ggtgtcgaga aggagctgac cgaccagggg atcaccacat tccactggga
    13381 catgaacgac cagggcccgg cggcgtacga ggggctgccg gacgacttca cccatgtctt
    13441 ccactcggcg gtgcgccgcg gcgaggacgg cgacgtcaac gcggccatcg aggtcaactc
    13501 ggtggccacc ggccggctga tgacccactg ccggagtgcc gaggcgttcc tcttcgtctc
    13561 caccggggcg ctctacaagc ggcagaccct cgaccacgcg tactccgagg acgaccccgt
    13621 cgacggagtg gccgactggc tgcccgccta cccggtgggc aagatcgccg cggagggcgc
    13681 ggtacgggcg ttcgcccagg tgctgggcct gccgacgacc atcgcccggc tcaacatcgc
    13741 ctacggcccc ggcggttacg gcggggtgcc gatgctctac ttcaagcgga tgctcgcggg
    13801 cgagccgata ccggtgccca tggagggcca gaactggtgc tcgctcctcc acaccgacga
    13861 tctgatcgcc catgtccccc atctgtggca ggccgcctcg actccggcca cgctggtcaa
    13921 ctggggcggg gacgaggcgg tcgggatcac cgactgcgtg cgccatctgg aggagctcac
    13981 cggggtacgg gcccggctcg tgcccagcga ggtgacccgc gagacctatc acttcgaccc
    14041 cacgaggcgg cgcgagatca ccggcccctg ccgggtgccg tggcgcgagg gcgtacggcg
    14101 cacgctccag gcgctccacc ccgagcacct tccgtcctag ccgcggcaca ccgccgtccg
    14161 aggagtggcg aacaccatgg catcaccgaa catcgaggcc atccgcgcct cctacgcggg
    14221 tttccgtgac cgcgacatcg aggggatcct gtccggtatg caccccgatg tggagtgggt
    14281 gcatccggag gggatggcca agtacgggct cggcggcacc aagctgggcc atgcggggat
    14341 caaggagttc ctggcccatg tgcccaccgt gctgggcggg atgcggctcg agccgaagga
    14401 gttcatcgaa cagggcgacc ggatcgtggt gttcggcacc cgtgaggtga cctcgcgccg
    14461 tgggacgacc gtgaccctgg acttcgtcca ctcgtggacg atgcgcgacg gcaaggcggc
    14521 gaggatggag gacatcttcg acaccgtggc gttccatgag ctgatcgaga gctgagcgag
    14581 ggctgatcga gagcctccat gacggcctgc ccgcttcccg cgcccgagaa gcgcgggaag
    14641 cgggcggaga cgtcttatgg gccgaggtct cagaccgtac ggaagacctc gtcgtactcc
    14701 aggcgcggca gccgccccat ccaggcgtcg gggcccggct tgccgatgtt gaccacacag
    14761 accgccgtgt gccgaccgtc ctcgaagaac tccttggaga ctgccgcgtg gtcgaagccg
    14821 atcatgggcc cggcggcgag ccccgcggcg cgcacgccca ggatgaagta gcccacctgg
    14881 agcgccgtgt tgaaccgcgc cgatccctcc cggacgtccg ggtcggcgaa gaacgcctgc
    14941 gggttctcca tgaacggcac cagccgcggc agctcctcat ggaagtccag gtccgcggcg
    15001 agcaccgcca ccagcggcgc cttggcggtc ttctcctggt tccgccccgt catatgcgcc
    15061 accagccggg cgcgcgcctc cgccgagcgc accaggaccg cccgcagcgg ctgctggttc
    15121 atcgaggtgg gcgcgtactt gaccaactcg tggatcgcgc ggacctgctc ctccgtgacc
    15181 ggctcgtcgg tgaaggtgtt ggccgtccgg gcctccagga acagctgccg ctgcgcctcc
    15241 ggcgccaggg tgagagggct cagggccccg ctgttctccg gtgcgctcat cgagctctcc
    15301 tttgatgaat taaatggact ggacgggcta gtccactgcg gtaaacgaag gctagactca
    15361 caagtccatc gagggcaaga ccggctcgga gcgaggaggt tgggccgttg cggacggaca
    15421 gcggtccccg gcgcagcgcc gcgggacgac ccgcgggccc ccagcccgcc aagcggcagg
    15481 cgatcttgga ggcggccgtg gccgtcttcc tgcgcgaggg atacaaccgg gccagtgtgg
    15541 atgtcatcgc ggacgaggcc cgcgtgtcca agcagaccgt ctacaaccac ttcggcgaca
    15601 aggaacggct gttcatcgcc gccgtcgagg aggagcggga gcgggtggcg gccggtttcg
    15661 ccgccggttc cccgtacgtc ctcggcccgg acggcgccgc gaacgccgag gcgtacgacg
    15721 gcggcgacgc ccgcgccgcg ctgatcgcct tcggccaccg ggtgctcgcc gtgctcctcg
    15781 acgaacgggc ctccgcactg cgccgcctgg tcatcgccga ggtcgcccgc cacccgtcgc
    15841 tgcgccccgc gtgcgcggag ggcgagcccc agcagctggt gaagtatctc gccgagatgc
    15901 tcggccggcg cagcagccgc ggcgagctga gcgtgccgga tccggccgcc gccgcccacc
    15961 agttcgtggc cctggtcgtc cagcagggcc tctaccagtc gatgtacggt acccgcccgc
    16021 tcgccgacga cgaggccgcc gccatctatg agagcgccgc cgacctgctc gtccgcgcgt
    16081 accgcccatg aagcccgaag agaggtgcca cccatgcggg tgagcgtgct cggaccgctg
    16141 acactcggcc tcggcgcccg ctccggggtg cccagcgcga tgaagccgcg caaggtcctg
    16201 tcgctgctgc tgctcaacgc cggccggatg gtgccggtgc agtcgctgat ggccgagctc
    16261 tggggcgatc agccgccgcg caccgggctg accacgcttc agacgtacat cctgcatctg
    16321 cgcaagctgc tcgccgagat gctggggatc ccctcggcca ccgtcacccg ggatgtgctc
    16381 cagacccggc ccgggggcta cgccatggtg gtggagcccg gtgagctcga cgtccatgag
    16441 taccgcgacc tcgtcgccga gggcgaatgc gcgctggagg tcggcgacga gcggacggcc
    16501 gacacctcct tccggcgggc gctggccctc tggcagggcc cggccctggt cgacgtcacc
    16561 ccgcacggcc ggccgctcca ggcggaggtc gcccggctcg agcagtcgcg gctcacggtc
    16621 accgagcgcg gtatcgagac ccggctgcgg ctcggcagcc atctggaggt gctcagcgac
    16681 ctcgcctcgc tggtcgtgga gcaccgcttc cacgagggcc tgcacgggca gtacatgctc
    16741 gccctccacc gctccggtca gcgcacccgt gccctgacgg tctatcagcg gctgcggacg
    16801 gcgatgacgg aggagctggg tctcgagccc tcggcgaagc tccagcggct ccagcaggcg
    16861 gtgctggtgt ccgacccccg gctggaccac gaggcggggg cgccggggcg cggtccggtg
    16921 gtggcctgag gggcggccac cggggccgcg gcgcccggac gtccccgccc ggggactcgc
    16981 gccctcggcc ggggccgccc tcagccgtca gatgtcgtcg tcttcctcgt cgagccgggc
    17041 cagccaggtc gccagccgct ccaccgggac ctcgaagtcc gggttcaggt cgacgaacgt
    17101 ccgcagttgc tgggcgagcc actcgaaggt gaactcctcg tcgccgcgcc gctgctccag
    17161 ttcctcgata ccgcgatcgg tgaagtacaa gggtcgctcc ggagggggtg gtgtggatgt
    17221 gccagcccag gatatgcggc cgtacggccc ggtgagcgac ccgagggccc gccggggttg
    17281 acgttgacgc atacgtcaat gtttacggtt catcggcatg acagacatga cagccgcaca
    17341 cttccatggc aaagcggtga tcgtcaccgg tgggggcacg gggatcgggc gggccaccgc
    17401 gcggaccttc gccgagcagg gcgcccaggt gctggtggtg ggccgtacgg cggacagact
    17461 cgccgagacg gccgccgagg caccgggcat ccagcagctc gcgaccgacg tctcggcccc
    17521 cggcgccgcc gagctgatcg tgaacaccgc gcgggaggcg ttcggccgga tcgatgtgct
    17581 ggtcaacaac gccgccgtgg tccggcagac gccgctcggg gacgccgagc gggaggccgc
    17641 ggaggagatg ctcgccgtca acctgctcgc cccggtccac ctcacccggg ccgcccttcc
    17701 gcatctgagc gagaccgccg gggtcgtgat caacgtcagt acggcgatcg gccagcgcgg
    17761 ctggccgttc accggtggag agctgtacgc ggcgctgaag gccgcgctgg acacgctgac
    17821 gcggagctgg gcggtgcaat tcgccccgag cggggtgcgc gtggtcgggg tggcccccgg
    17881 ccccatcgcc accccgatcg gacagcacca ggggctcgac gcccagcaga tcgaggccct
    17941 gcggacgacg ctgatcgagc atgtgccgct gcggcgggtc ggccgggcgg aggaggtcgc
    18001 cttctggatc gcccagctcg ccagggccga ggcgggctac accaccggtg tcgtgctgcc
    18061 cgtggacggc ggggcgctgg tcggctgagc gctccgccgg aagtgcgctc caccgcgagt
    18121 gcgccgagct tccgtcgatc catgggtagt gtcgccgtat gcggataggg gagttggcga
    18181 aggccaccgg tgccaccacc agggccctgc gcttctacga ggagcgcggg ctgctgagct
    18241 cggcccgcgc ggtcaacggc taccggatct acgacgagcg ggcgatccgg cgcgtggtca
    18301 acatccgcta tctgctggac gccgggctca cgctggagga cgtcgagcac ttcagcgcct
    18361 gcctggacgg cgatctgccg aacagcccgc cctccgaggc cgggctgaac gtcgggcgcc
    18421 gccgcctgag cgtgctggac gagcggatcg ccaccctcgc ccgggtgcgc gacgaactcg
    18481 ccgagcggct cgccgtcgcc tccggtgacc gggccgcgat cactccgtcg tcctgctgag
    18541 cagccaggac accagcgcgc gtacggcgcc ggagagcacg gcggcggtga gggtcaggag
    18601 ggcggggcgg cggcggttcg gcatcgttga cctctttcgt gaaaccggct ttcgtgaaac
    18661 cggcgaaggc gccgggggta cgtttcacga tgtgcgggct ctggggcgtt gcggcagccc
    18721 gcacgcgttg cagggcggc
//
