BGC0000341: enduracidin A biosynthetic gene cluster from Streptomyces fungicidicus
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Location: 1 - 116,000 nt. (total: 116,000 nt).
This entry is originally from NCBI GenBank DQ403252.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000341
Short description enduracidin A biosynthetic gene cluster from Streptomyces fungicidicus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
DQ403252.1
via
Compounds
  • enduracidin A
  • enduracidin B
Species Streptomyces fungicidicus [taxonomy]
References
Chemical products information
enduracidin A Evidence: Mass spectrometry [1], [2]
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C108H140Cl2N26O31
Chemical database entries
PubCHEM
NPAtlas
enduracidin B Evidence: Mass spectrometry [1], [2]
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C107H138Cl2N26O31
Chemical database entries
PubCHEM
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ABD65921.1
 1 - 1230 (+) DXP synthase 2
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    • ABD65922.1
    		 1381 - 2877 (+) cationic amino acid transporter
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      • ABD65923.1
      		 2896 - 3297 (-) unknown
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        • ABD65924.1
        		 3461 - 4582 (+) unknown
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          • ABD65925.1
          		 4606 - 5688 (-) transcriptional regulator
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            • ABD65926.1
            		 6053 - 9925 (+) glycosyltransferase
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              • ABD65927.1
              		 10071 - 10988 (-) unknown
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                • ABD65928.1
                		 11118 - 12566 (+) unknown
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                  • ABD65929.1
                  		 12610 - 14100 (+) unknown
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                    • ABD65930.1
                    		 14174 - 16303 (-) fatty acid oxidation complex alpha-subunit
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                      • ABD65931.1
                      		 16300 - 17517 (-) acetyl-CoA acetyltransferase
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                        • ABD65932.1
                        		 17697 - 18734 (-) transcriptional regulator
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                          • ABD65933.1
                          		 18731 - 21112 (-) beta-mannosidase
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                            • ABD65934.1
                            		 21260 - 22582 (+) probable sugar transport system sugar-binding lipoprotein
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                              • ABD65935.1
                              		 22760 - 23536 (+) sugar transport system permease protein
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                                • ABD65936.1
                                		 23533 - 24363 (+) sugar transport system permease protein
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                                  • ABD65937.1
                                  		 24341 - 25633 (-) ribonuclease D
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                                    • ABD65938.1
                                    		 25792 - 26454 (-) two-component response regulator
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                                      • ABD65939.1
                                      		 26724 - 27398 (-) unknown
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                                        • ABD65940.1
                                        		 27544 - 28638 (+) uroporphyrinogen decarboxylase
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                                          • ABD65941.1
                                          		 28752 - 30746 (+) PAS protein phosphatase 2C-like protein
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                                            • ABD65942.1
                                            		 31147 - 32133 (+) StrR-like regulatory protein
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                                              • ABD65943.1
                                              		 32266 - 33354 (-) prephenate dehydrogenase
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                                                • ABD65944.1
                                                		 33630 - 34565 (+) unknown
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                                                  • ABD65945.1
                                                  		 34644 - 35714 (+) 4-hydroxyphenylpyruvate dioxygenase
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                                                    • ABD65946.1
                                                    • endR
                                                    		 35792 - 36631 (-) unknown
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                                                      • ABD65948.1
                                                      • endQ
                                                      		 36628 - 37887 (-) PLP-dependent aminotransferse
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                                                        • ABD65947.1
                                                        • endP
                                                        		 37887 - 38768 (-) PLP-dependent aminotransferase
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                                                          • ABD65949.1
                                                          		 39403 - 41829 (+) hydroxyphenylglycine aminotransferase/hydroxymandelate oxidase fusion protein
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                                                            • ABD65950.1
                                                            		 41890 - 43404 (-) halogenase
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                                                              • ABD65951.1
                                                              		 43579 - 44604 (-) transmembrane transport protein
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                                                                • ABD65952.1
                                                                		 44601 - 45524 (-) ABC transporter
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                                                                  • ABD65953.1
                                                                  		 45559 - 47514 (-) ABC transporter
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                                                                    • ABD65954.1
                                                                    		 47597 - 48424 (-) type II thioesterase
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                                                                      • ABD65955.1
                                                                      		 48747 - 49019 (+) peptidyl carrier protein
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                                                                        • ABD65956.1
                                                                        • endA
                                                                        		 49041 - 55346 (+) nonribosomal peptide synthetase
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                                                                          • ABD65957.1
                                                                          • endB
                                                                          		 55363 - 76194 (+) nonribosomal peptide synthetase
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                                                                            • ABD65958.1
                                                                            • endC
                                                                            		 76191 - 103151 (+) nonribosomal peptide synthetase
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                                                                              • ABD65959.1
                                                                              		 103160 - 103984 (+) acyl-CoA dehydrogenase/reductase
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                                                                                • ABD65960.1
                                                                                • endD
                                                                                		 104002 - 106581 (+) nonribosomal peptide synthetase
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                                                                                  • ABD65961.1
                                                                                  		 106606 - 107277 (-) two-component system response regulator
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                                                                                    • ABD65962.1
                                                                                    		 107274 - 108386 (-) two-component system sensor kinase
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                                                                                      • ABD65963.1
                                                                                      		 108538 - 109083 (-) two-component system sensor kinase
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                                                                                        • ABD65964.1
                                                                                        		 109184 - 111058 (-) acyl-CoA dehydrogenase
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                                                                                          • ABD65965.1
                                                                                          		 110866 - 114399 (-) acyl-CoA ligase/dehydrogenase fusion protein
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                                                                                            • ABD65966.1
                                                                                            		 114404 - 114619 (-) MbtH-like protein
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                                                                                              • ABD65967.1
                                                                                              		 114877 - 115614 (-) integral membrane protein
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                                                                                                • ABD65968.1
                                                                                                		 115590 - 115946 (-) integral membrane protein
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                                                                                                  Biosynthesis information

                                                                                                  Biosynthetic modules

                                                                                                  Name
                                                                                                  Unk01
                                                                                                  Type
                                                                                                  nrps-type1
                                                                                                  Genes
                                                                                                  endA
                                                                                                  Substrates
                                                                                                  aspartic acid (evidence: Structure-based inference [3])
                                                                                                  Integrated Monomers
                                                                                                  Domains
                                                                                                  adenylation
                                                                                                  Name
                                                                                                  Unk02
                                                                                                  Type
                                                                                                  nrps-type1
                                                                                                  Genes
                                                                                                  endA
                                                                                                  Substrates
                                                                                                  threonine (evidence: Structure-based inference [3])
                                                                                                  Integrated Monomers
                                                                                                  Domains
                                                                                                  adenylation
                                                                                                  Name
                                                                                                  Unk03
                                                                                                  Type
                                                                                                  nrps-type1
                                                                                                  Genes
                                                                                                  endB
                                                                                                  Substrates
                                                                                                  4-hydroxyphenylglycine (evidence: Structure-based inference [3])
                                                                                                  Integrated Monomers
                                                                                                  Domains
                                                                                                  adenylation
                                                                                                  Name
                                                                                                  Unk04
                                                                                                  Type
                                                                                                  nrps-type1
                                                                                                  Genes
                                                                                                  endB
                                                                                                  Substrates
                                                                                                  ornithine (evidence: Structure-based inference [3])
                                                                                                  Integrated Monomers
                                                                                                  Domains
                                                                                                  adenylation
                                                                                                  Name
                                                                                                  Unk05
                                                                                                  Type
                                                                                                  nrps-type1
                                                                                                  Genes
                                                                                                  endB
                                                                                                  Substrates
                                                                                                  threonine (evidence: Structure-based inference [3])
                                                                                                  Integrated Monomers
                                                                                                  Domains
                                                                                                  adenylation
                                                                                                  Name
                                                                                                  Unk06
                                                                                                  Type
                                                                                                  nrps-type1
                                                                                                  Genes
                                                                                                  endB
                                                                                                  Substrates
                                                                                                  4-hydroxyphenylglycine (evidence: Structure-based inference [3])
                                                                                                  Integrated Monomers
                                                                                                  Domains
                                                                                                  adenylation
                                                                                                  Name
                                                                                                  Unk07
                                                                                                  Type
                                                                                                  nrps-type1
                                                                                                  Genes
                                                                                                  endB
                                                                                                  Substrates
                                                                                                  4-hydroxyphenylglycine (evidence: Structure-based inference [3])
                                                                                                  Integrated Monomers
                                                                                                  Domains
                                                                                                  adenylation
                                                                                                  Name
                                                                                                  Unk08
                                                                                                  Type
                                                                                                  nrps-type1
                                                                                                  Genes
                                                                                                  endB
                                                                                                  Substrates
                                                                                                  citrulline (evidence: Structure-based inference [3])
                                                                                                  Integrated Monomers
                                                                                                  Domains
                                                                                                  adenylation
                                                                                                  Name
                                                                                                  Unk09
                                                                                                  Type
                                                                                                  nrps-type1
                                                                                                  Genes
                                                                                                  endC
                                                                                                  Substrates
                                                                                                  enduracididine (evidence: Structure-based inference [3])
                                                                                                  Integrated Monomers
                                                                                                  Domains
                                                                                                  adenylation
                                                                                                  Name
                                                                                                  Unk10
                                                                                                  Type
                                                                                                  nrps-type1
                                                                                                  Genes
                                                                                                  endC
                                                                                                  Substrates
                                                                                                  4-hydroxyphenylglycine (evidence: Structure-based inference [3])
                                                                                                  Integrated Monomers
                                                                                                  Domains
                                                                                                  adenylation
                                                                                                  Name
                                                                                                  Unk11
                                                                                                  Type
                                                                                                  nrps-type1
                                                                                                  Genes
                                                                                                  endC
                                                                                                  Substrates
                                                                                                  serine (evidence: Structure-based inference [3])
                                                                                                  Integrated Monomers
                                                                                                  Domains
                                                                                                  adenylation
                                                                                                  Name
                                                                                                  Unk12
                                                                                                  Type
                                                                                                  nrps-type1
                                                                                                  Genes
                                                                                                  endC
                                                                                                  Substrates
                                                                                                  3,5-dichloro-4-hydroxyphenylglycine, 4-hydroxyphenylglycine (evidence: Structure-based inference, Sequence-based prediction)
                                                                                                  Integrated Monomers
                                                                                                  Domains
                                                                                                  adenylation
                                                                                                  Name
                                                                                                  Unk13
                                                                                                  Type
                                                                                                  nrps-type1
                                                                                                  Genes
                                                                                                  endC
                                                                                                  Substrates
                                                                                                  glycine (evidence: Structure-based inference [3])
                                                                                                  Integrated Monomers
                                                                                                  Domains
                                                                                                  adenylation
                                                                                                  Name
                                                                                                  Unk14
                                                                                                  Type
                                                                                                  nrps-type1
                                                                                                  Genes
                                                                                                  endC
                                                                                                  Substrates
                                                                                                  enduracididine (evidence: Structure-based inference [3])
                                                                                                  Integrated Monomers
                                                                                                  Domains
                                                                                                  adenylation
                                                                                                  Name
                                                                                                  Unk15
                                                                                                  Type
                                                                                                  nrps-type1
                                                                                                  Genes
                                                                                                  endC
                                                                                                  Substrates
                                                                                                  alanine (evidence: Structure-based inference [3])
                                                                                                  Integrated Monomers
                                                                                                  Domains
                                                                                                  adenylation
                                                                                                  Name
                                                                                                  Unk16
                                                                                                  Type
                                                                                                  nrps-type1
                                                                                                  Genes
                                                                                                  endC
                                                                                                  Substrates
                                                                                                  4-hydroxyphenylglycine (evidence: Structure-based inference [3])
                                                                                                  Integrated Monomers
                                                                                                  Domains
                                                                                                  adenylation
                                                                                                  Name
                                                                                                  Unk17
                                                                                                  Type
                                                                                                  nrps-type1
                                                                                                  Genes
                                                                                                  endD
                                                                                                  Substrates
                                                                                                  allo-threonine (evidence: Structure-based inference [3])
                                                                                                  Integrated Monomers
                                                                                                  Domains
                                                                                                  adenylation
                                                                                                  Annotation changelog

                                                                                                  Entry version: next

                                                                                                  Date
                                                                                                  Changes
                                                                                                  Submitters
                                                                                                  Reviewers
                                                                                                  2024-05-23
                                                                                                  MIBiG v4 annotathon
                                                                                                  • (ID: LEEWIYEZSPCYOCCY6BHNTE54)
                                                                                                  • (ID: NHJ6M55E7ZEHUFNMEG4QIZWY)
                                                                                                  • (ID: I3D2K5SU7JJDS2LEEQM3W3SO)
                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                  Entry version: 4

                                                                                                  Date
                                                                                                  Changes
                                                                                                  Submitters
                                                                                                  Reviewers
                                                                                                  2022-10-07
                                                                                                  Update chemical activity to schema version 2.11
                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                  Entry version: 3

                                                                                                  Date
                                                                                                  Changes
                                                                                                  Submitters
                                                                                                  Reviewers
                                                                                                  2022-09-15
                                                                                                  Updated bioactivity data
                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                  2022-09-15
                                                                                                  Added NRP substrate specificities
                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                  Entry version: 2

                                                                                                  Date
                                                                                                  Changes
                                                                                                  Submitters
                                                                                                  Reviewers
                                                                                                  2019-10-16
                                                                                                  Migrated from v1.4
                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                  Entry version: 1

                                                                                                  Date
                                                                                                  Changes
                                                                                                  Submitters
                                                                                                  Reviewers
                                                                                                  2015-06-12
                                                                                                  Submitted
                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                  Detailed domain annotation
                                                                                                  Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
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