BGC0000341: enduracidin biosynthetic gene cluster from Streptomyces fungicidicus
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 116,000 nt. (total: 116,000 nt).
This entry is originally from NCBI GenBank DQ403252.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000341
Short description enduracidin biosynthetic gene cluster from Streptomyces fungicidicus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: DQ403252.1
Compounds
  • enduracidin
Species Streptomyces fungicidicus [taxonomy]
References
Chemical products information
enduracidin
Copy SMILES
C53H80O24
Chemical database entries
PubCHEM
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ABD65921.1
 1 - 1230 (+) DXP synthase 2
copy AA seq
copy Nt seq
  • ABD65922.1
 1381 - 2877 (+) cationic amino acid transporter
copy AA seq
copy Nt seq
  • ABD65923.1
 2896 - 3297 (-) unknown
copy AA seq
copy Nt seq
  • ABD65924.1
 3461 - 4582 (+) unknown
copy AA seq
copy Nt seq
  • ABD65925.1
 4606 - 5688 (-) transcriptional regulator
copy AA seq
copy Nt seq
  • ABD65926.1
 6053 - 9925 (+) glycosyltransferase
copy AA seq
copy Nt seq
  • ABD65927.1
 10071 - 10988 (-) unknown
copy AA seq
copy Nt seq
  • ABD65928.1
 11118 - 12566 (+) unknown
copy AA seq
copy Nt seq
  • ABD65929.1
 12610 - 14100 (+) unknown
copy AA seq
copy Nt seq
  • ABD65930.1
 14174 - 16303 (-) fatty acid oxidation complex alpha-subunit
copy AA seq
copy Nt seq
  • ABD65931.1
 16300 - 17517 (-) acetyl-CoA acetyltransferase
copy AA seq
copy Nt seq
  • ABD65932.1
 17697 - 18734 (-) transcriptional regulator
copy AA seq
copy Nt seq
  • ABD65933.1
 18731 - 21112 (-) beta-mannosidase
copy AA seq
copy Nt seq
  • ABD65934.1
 21260 - 22582 (+) probable sugar transport system sugar-binding lipoprotein
copy AA seq
copy Nt seq
  • ABD65935.1
 22760 - 23536 (+) sugar transport system permease protein
copy AA seq
copy Nt seq
  • ABD65936.1
 23533 - 24363 (+) sugar transport system permease protein
copy AA seq
copy Nt seq
  • ABD65937.1
 24341 - 25633 (-) ribonuclease D
copy AA seq
copy Nt seq
  • ABD65938.1
 25792 - 26454 (-) two-component response regulator
copy AA seq
copy Nt seq
  • ABD65939.1
 26724 - 27398 (-) unknown
copy AA seq
copy Nt seq
  • ABD65940.1
 27544 - 28638 (+) uroporphyrinogen decarboxylase
copy AA seq
copy Nt seq
  • ABD65941.1
 28752 - 30746 (+) PAS protein phosphatase 2C-like protein
copy AA seq
copy Nt seq
  • ABD65942.1
 31147 - 32133 (+) StrR-like regulatory protein
copy AA seq
copy Nt seq
  • ABD65943.1
 32266 - 33354 (-) prephenate dehydrogenase
copy AA seq
copy Nt seq
  • ABD65944.1
 33630 - 34565 (+) unknown
copy AA seq
copy Nt seq
  • ABD65945.1
 34644 - 35714 (+) 4-hydroxyphenylpyruvate dioxygenase
copy AA seq
copy Nt seq
  • ABD65946.1
  • endR
 35792 - 36631 (-) unknown
copy AA seq
copy Nt seq
  • ABD65948.1
  • endQ
 36628 - 37887 (-) PLP-dependent aminotransferse
copy AA seq
copy Nt seq
  • ABD65947.1
  • endP
 37887 - 38768 (-) PLP-dependent aminotransferase
copy AA seq
copy Nt seq
  • ABD65949.1
 39403 - 41829 (+) hydroxyphenylglycine aminotransferase/hydroxymandelate oxidase fusion protein
copy AA seq
copy Nt seq
  • ABD65950.1
 41890 - 43404 (-) halogenase
copy AA seq
copy Nt seq
  • ABD65951.1
 43579 - 44604 (-) transmembrane transport protein
copy AA seq
copy Nt seq
  • ABD65952.1
 44601 - 45524 (-) ABC transporter
copy AA seq
copy Nt seq
  • ABD65953.1
 45559 - 47514 (-) ABC transporter
copy AA seq
copy Nt seq
  • ABD65954.1
 47597 - 48424 (-) type II thioesterase
copy AA seq
copy Nt seq
  • ABD65955.1
 48747 - 49019 (+) peptidyl carrier protein
copy AA seq
copy Nt seq
  • ABD65956.1
  • endA
 49041 - 55346 (+) nonribosomal peptide synthetase
copy AA seq
copy Nt seq
  • ABD65957.1
  • endB
 55363 - 76194 (+) nonribosomal peptide synthetase
copy AA seq
copy Nt seq
  • ABD65958.1
  • endC
 76191 - 103151 (+) nonribosomal peptide synthetase
copy AA seq
copy Nt seq
  • ABD65959.1
 103160 - 103984 (+) acyl-CoA dehydrogenase/reductase
copy AA seq
copy Nt seq
  • ABD65960.1
  • endD
 104002 - 106581 (+) nonribosomal peptide synthetase
copy AA seq
copy Nt seq
  • ABD65961.1
 106606 - 107277 (-) two-component system response regulator
copy AA seq
copy Nt seq
  • ABD65962.1
 107274 - 108386 (-) two-component system sensor kinase
copy AA seq
copy Nt seq
  • ABD65963.1
 108538 - 109083 (-) two-component system sensor kinase
copy AA seq
copy Nt seq
  • ABD65964.1
 109184 - 111058 (-) acyl-CoA dehydrogenase
copy AA seq
copy Nt seq
  • ABD65965.1
 110866 - 114399 (-) acyl-CoA ligase/dehydrogenase fusion protein
copy AA seq
copy Nt seq
  • ABD65966.1
 114404 - 114619 (-) MbtH-like protein
copy AA seq
copy Nt seq
  • ABD65967.1
 114877 - 115614 (-) integral membrane protein
copy AA seq
copy Nt seq
  • ABD65968.1
 115590 - 115946 (-) integral membrane protein
copy AA seq
copy Nt seq
NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
endA
Module ?
Specificity: aspartic acid
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: threonine
Evidence for specificity:
  • Structure-based inference
endB
Module ?
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: ornithine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: threonine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: citrulline
Evidence for specificity:
  • Structure-based inference
endC
Module ?
Specificity: enduracididine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: serine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: 3,5-dichloro-4-hydroxyphenylglycine / 4-hydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: glycine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: enduracididine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: alanine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
endD
Module ?
Specificity: allo-threonine
Evidence for specificity:
  • Structure-based inference
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.