LOCUS       BGC0000342             10934 bp    DNA     linear   PLN 26-JUN-2019
DEFINITION  Fusarium scirpi esyn1 gene for enniatin synthetase.
ACCESSION   BGC0000342
VERSION     BGC0000342
KEYWORDS    .
SOURCE      Fusarium scirpi
  ORGANISM  Fusarium scirpi
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Sordariomycetes; Hypocreomycetidae; Hypocreales; Nectriaceae;
            Fusarium; Fusarium incarnatum-equiseti species complex.
COMMENT     On Sep 12, 2001 this sequence version replaced Z18755.2.
            ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 13:25:53
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10934
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..10934
                     /clone="lambda DASH ES1"
                     /clone_lib="lambda DASH"
                     /db_xref="taxon:2211609"
                     /isolate="ETH 1536/J5"
                     /mol_type="genomic DNA"
                     /organism="Fusarium scirpi"
                     /strain="Lambotte et Fautrey"
     protocluster    1..10934
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[1020:10416]"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1021..10416
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     cand_cluster    1..10934
                     /SMILES="OC(C(C)C)C(=O)NC(C(C)C)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..10934
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000342"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..10934
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX))"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            1021..10416
                     /gene="esyn1"
     CDS             1021..10416
                     /NRPS_PKS="Domain: Condensation_DCL (36-301). E-value:
                     1.3e-16. Score: 52.4. Matches aSDomain:
                     nrpspksdomains_esyn1_Condensation_DCL.1"
                     /NRPS_PKS="Domain: AMP-binding (493-887). E-value: 8.7e-74.
                     Score: 240.3. Matches aSDomain:
                     nrpspksdomains_esyn1_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (1017-1082). E-value: 2.9e-12.
                     Score: 38.5. Matches aSDomain: nrpspksdomains_esyn1_PCP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (1103-1397). E-value:
                     1.6e-93. Score: 304.9. Matches aSDomain:
                     nrpspksdomains_esyn1_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (1562-1960). E-value:
                     8.6e-84. Score: 273.3. Matches aSDomain:
                     nrpspksdomains_esyn1_AMP-binding.2"
                     /NRPS_PKS="Domain: nMT (2056-2282). E-value: 4.2e-134.
                     Score: 439.1. Matches aSDomain: nrpspksdomains_esyn1_nMT.1"
                     /NRPS_PKS="Domain: PCP (2509-2576). E-value: 2e-26. Score:
                     83.9. Matches aSDomain: nrpspksdomains_esyn1_PCP.2"
                     /NRPS_PKS="Domain: PCP (2603-2648). E-value: 1.7e-15.
                     Score: 48.9. Matches aSDomain: nrpspksdomains_esyn1_PCP.3"
                     /NRPS_PKS="Domain: Condensation_DCL (2717-2999). E-value:
                     1.1e-33. Score: 108.5. Matches aSDomain:
                     nrpspksdomains_esyn1_Condensation_DCL.2"
                     /codon_start=1
                     /db_xref="GOA:Q00869"
                     /db_xref="InterPro:IPR000873"
                     /db_xref="InterPro:IPR001242"
                     /db_xref="InterPro:IPR006162"
                     /db_xref="InterPro:IPR009081"
                     /db_xref="InterPro:IPR010071"
                     /db_xref="InterPro:IPR013216"
                     /db_xref="InterPro:IPR020806"
                     /db_xref="InterPro:IPR020845"
                     /db_xref="InterPro:IPR023213"
                     /db_xref="InterPro:IPR029058"
                     /db_xref="InterPro:IPR029063"
                     /db_xref="InterPro:IPR036736"
                     /db_xref="InterPro:IPR042099"
                     /db_xref="UniProtKB/Swiss-Prot:Q00869"
                     /function="synthesizes enniatin"
                     /gene="esyn1"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     130.4; E-value: 1.8e-39)"
                     /gene_kind="biosynthetic"
                     /product="enniatin synthetase"
                     /protein_id="CAA79245.2"
                     /sec_met_domain="Condensation (E-value: 7.3e-65, bitscore:
                     205.0, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 4.6e-88, bitscore:
                     281.6, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 5.7e-13, bitscore:
                     35.5, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLHTPSDGQQDPALASKTLCEQISRALGLGQDKIENIFPGTPFQ
                     RDVIDCAADDKQRAVGHAVFEIPKDIDAARLAAAWKETVLHTPALRTCTFTSKSGDVLQ
                     VVLRDSFVFSWMSGPSVDLKEAVVQDEAAAALAGPRCNRFVLLEDPDTKERQLIWTFSH
                     ALVDSTFQERILRRVLKAYKDANDEHPRQFETPDSSQATPEEDLQPNPSKMLKIPQAAD
                     MDRAVEFWKDHLSGLKCFCLPAFVLSSVYAHPDAKAEHRISYSSSAQQKMSSATICRTA
                     LAILLSRYTHSPEALFGIVTEQTPLLEEQLMLDGPTRTVVPIRVSCASEQSVSDIMSTI
                     DSYDQTMRQFAHAGLRNIASAGDDESAACGFQTVLLVSDGDAQPASTWEILKKTEEPEG
                     FIPCTNRALLLSCQMTSSGAHLTARYDQSIIDAEQMARLLRQLGHLIQNLQTSTDLPVE
                     KVDMMTQEDWLEIERWNSDSIDAQDTLIHSEMLKWTSQSPNKAAVAAWDGEWTYAELDN
                     VSSRLAQHINSIDLGKEHAIVPIYFEKSKWVVASMLAVLKAGHAFTLIDPSDPPARTAQ
                     VVQQTSATVALTSKLHRETVQSTVGRCIVVDEEFVKSLPQSSELSASVKAHDLAYVIFT
                     SGSTGIPKGIMIEHRSFSSCAIKFGPALGITSDTRALQFGSHAFGACILEIMTTLIHGG
                     CVCIPSDDDRMNNVLEFINRTNVQLGHATPSYMGTFQPEVVPGLKTLVLVGEQMSASVN
                     EVWAPRVQLLNGYGQSESSSICCVAKISPGSSEPNNIGHAVGAHSWIVDPEDPNRLAPI
                     GAVGELVIESAGIARDYIVAPTQDKSPFIKTAPTWYPAKQLPDGFKIYRTGDLACYASD
                     GSIVCLGRMDSQVKIRGQRVELGAVETHLRQQMPDDMTIVVEAVKFSDSSSTTVLTAFL
                     IGAGEKNSHILDQRATREINAKMEQVLPRHSIPAFYISMNNLPQTATGKVDRRKLRIMG
                     SKILSQKTHSTPSQQSQAAISSGTDTYTKLESIWITSLDLEPGSANMSATFFEMGGNSI
                     IAIKMVNMARSNGIELKVSDIYQNPTLAGLKAIVIGTSLPYSLIPKVTRQGPVSEQSYA
                     QNRMWFLDQLSEGASWYLIPFAVRMRGPVDVDALTRALLALEQRHETLRTTFENQDGVG
                     VQIIHDRLSKELQVIDALDGDEGGLKTLYKVETTTFDITSEAGWSSTLIRLGKDDHILS
                     IVMHHIISDGWSIDVLRRELIQLYAAALQGKDPSSALTPLPIQYSDFAVWQKQEAQAAE
                     HERQLQYWKKQLADSSPAKIPTDFPRPDLLSGDAGVVPVAIDGELYQKLRGFCNKHNST
                     AFSILLAAFRAAHYRLTAVDDAVIGIPIANRNRWELENMIGFFVNTQCMRIAVDETDTF
                     ESLVRQVRSTTTAAFAHEDVPFERVVSALQPGHRDLSRTPLAQIMFAVHSQKDLGRFEL
                     EGIQSEPIASKAYTRFDVEFHLFQQADGLKGSCNFATDLFKPETIQNVVSVFFQILRHG
                     LDQPETCISVLPLTDGVEELRRLDLLEIKRTNYPRDSSVVDVFREQAAANPEVIAVTDS
                     SSRLTYAELDNKSELLSRWLRRRNLTPETLVSVLAPRSCETIVAYVGILKANLAYLPLD
                     VRSPVTRMKDILSSVSGNTIVLMGSGVEDPGFDLPQLELVRITDTFDETIEDVQDSPQP
                     SATSLAYVVFTSGSTGKPKGVMIEHRAIVRLVKSDNFPGFPSPARMSNVFNPAFDGAIW
                     EINWMLLNGGTVVCIDYLTTLDGKELAAVFAKERVNAAFFAPAMLKLYLVDAREALKNL
                     DFLIVGGERFDTKEAVEAMPLVRGKIANIYGPTEAGIISTCYNIPKDEAYTNGVPIGGS
                     IYNSGAYVMDPNQQLVGLGVMGELVVTGDGVGRGYTNPELNKNRFIDITIEGKTFKAYR
                     TGDRMRARVGDGLLEFFGRMDNQFKIRGNRIEAGEVESAMLSLKNVLNAAIVVRGGGED
                     EGPLEMVGFIVADDKNDTTEEEETGNQVEGWQDHFESGMYSDISTAVDQSAIGNDFKGW
                     TSMYDGKDIDKGEMQEWLDDAIHTLHNGQIPRDVLEIGTGSGMILFNLNPGLNSYVGLD
                     PSKSAVEFVNRAVESSPKFAGKAKVHVGMATDVNKLGEVHPDLVVFNSVVQYFPTPEYL
                     AEVIDGLIAIPSVKRIFLGDIRSYATNGHFLAARAIHTLGTNNNATKDRVRQKIQELED
                     REEEFLVEPAFFTTLKERRPDVVKHVEIIPKNMKATNELSAYRYTAVVHLRDETDEPVY
                     HIEKDSWVDFEAKQMDKTALLDHLRLSKDAMSVAVSNITYAHTAFERRIVESLDEDSKD
                     DTKGTLDGAAWLSAVRSEAENRASLTVPDILEIAKEAGFRVEVSAARQWSQSGALDAVF
                     HHFPPSSTDRTLIQFPTDNELRSSLTLANRPLQKLQRRRAALQVREKLQTLVPSYMVPP
                     NIVVLDTMPLNTNGKIDRKELTRRARTLPKQQTAAPVPDFPISDIEITLCEEATEVFGM
                     KVEISDHFFQLGGHSLLATKLISRIQHRLHVRVTVKDVFDSPVFADLAVIIRQGLAMQN
                     PVAEGQDKQGWSSRVAPRTEVEKMLCEEFAAGLGVPVGITDNFFDLGGHSLMATKLAVR
                     IGRRLIRHHSQGHLRLPCAFQLAKKLESSHSKSYEESGDDIQMADYTAFQLLDLEDPQD
                     FVQSQIRPQLDSCYGTIQDVYPSTQMQKAFLFDPTTGEPRGLVPFYIDFPSNADAETLT
                     KAIGALVDKLDMFRTVFLEAAGDLYQVVVEHLNLPIETIETEKNVNTATGDYLDVHGKD
                     PVRLGHPCIQFAILKTASSVRVLLRMSHALYDGLSFEYIVRGLHVLYSGRNLPPPTQFA
                     RYMQYAAHSREEGYPFWREVLQNAPMTVLHDTNNGMSEQEMPASKAVHLSEVVNVPAQA
                     IRNSTNTQATVFNTACALVLAKESGSQDVVFGRIVSGRQGLPVVWQDIIGPCTNAVPVH
                     ARVDDGNPQRIIRDLRDQYLRTLPFESLGFEEIKRNCTDWPEELTNFSVCVTYHNFEYH
                     PESEVDNQKVEMGVLAKYVELSENEPLYDLAIAGEVEADGVNLKVTVVAKARLYNEARI
                     RHVLEEVCKTFNGLNEAL"
     aSDomain        1129..1923
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_esyn1_Condensation_DCL.1"
                     /domain_subtypes="Condensation_DCL"
                     /evalue="1.30E-16"
                     /label="esyn1_Condensation_DCL.1"
                     /locus_tag="esyn1"
                     /protein_end="301"
                     /protein_start="36"
                     /score="52.4"
                     /tool="antismash"
                     /translation="NIFPGTPFQRDVIDCAADDKQRAVGHAVFEIPKDIDAARLAAAWK
                     ETVLHTPALRTCTFTSKSGDVLQVVLRDSFVFSWMSGPSVDLKEAVVQDEAAAALAGPR
                     CNRFVLLEDPDTKERQLIWTFSHALVDSTFQERILRRVLKAYKDANDEHPRQFETPDSS
                     QATPEEDLQPNPSKMLKIPQAADMDRAVEFWKDHLSGLKCFCLPAFVLSSVYAHPDAKA
                     EHRISYSSSAQQKMSSATICRTALAILLSRYTHSPEALFGIVT"
     aSModule        1129..4266
                     /complete
                     /domains="nrpspksdomains_esyn1_Condensation_DCL.1"
                     /domains="nrpspksdomains_esyn1_AMP-binding.1"
                     /domains="nrpspksdomains_esyn1_PCP.1"
                     /locus_tags="esyn1"
                     /monomer_pairings="D-Hiv -> D-Hiv"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       1204..1299
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_esyn1_0001"
                     /evalue="6.60E-04"
                     /label="C2_DCL_024-062"
                     /locus_tag="esyn1"
                     /protein_end="93"
                     /protein_start="61"
                     /score="12.0"
                     /tool="antismash"
                     /translation="HAVFEIPKDIDAARLAAAWKETVLHTPALRTC"
     aSDomain        2500..3681
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_esyn1_AMP-binding.1"
                     /evalue="8.70E-74"
                     /label="esyn1_AMP-binding.1"
                     /locus_tag="esyn1"
                     /protein_end="887"
                     /protein_start="493"
                     /score="240.3"
                     /specificity="substrate consensus: D-Hiv"
                     /tool="antismash"
                     /translation="TSQSPNKAAVAAWDGEWTYAELDNVSSRLAQHINSIDLGKEHAIV
                     PIYFEKSKWVVASMLAVLKAGHAFTLIDPSDPPARTAQVVQQTSATVALTSKLHRETVQ
                     STVGRCIVVDEEFVKSLPQSSELSASVKAHDLAYVIFTSGSTGIPKGIMIEHRSFSSCA
                     IKFGPALGITSDTRALQFGSHAFGACILEIMTTLIHGGCVCIPSDDDRMNNVLEFINRT
                     NVQLGHATPSYMGTFQPEVVPGLKTLVLVGEQMSASVNEVWAPRVQLLNGYGQSESSSI
                     CCVAKISPGSSEPNNIGHAVGAHSWIVDPEDPNRLAPIGAVGELVIESAGIARDYIVAP
                     TQDKSPFIKTAPTWYPAKQLPDGFKIYRTGDLACYASDGSIVCLGRMDSQVKIR"
     CDS_motif       2677..2718
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_esyn1_0002"
                     /evalue="5.30E-02"
                     /label="NRPS-A_a2"
                     /locus_tag="esyn1"
                     /protein_end="566"
                     /protein_start="552"
                     /score="7.5"
                     /tool="antismash"
                     /translation="LAVLKAGHAFTLID"
     CDS_motif       2908..2967
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_esyn1_0003"
                     /evalue="1.20E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="esyn1"
                     /protein_end="649"
                     /protein_start="629"
                     /score="30.1"
                     /tool="antismash"
                     /translation="AYVIFTSGSTGIPKGIMIEH"
     CDS_motif       3451..3519
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_esyn1_0004"
                     /evalue="1.00E-06"
                     /label="NRPS-A_a6"
                     /locus_tag="esyn1"
                     /protein_end="833"
                     /protein_start="810"
                     /score="21.1"
                     /tool="antismash"
                     /translation="PIGAVGELVIESAGIARDYIVAP"
     CDS_motif       3646..3711
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_esyn1_0005"
                     /evalue="2.50E-10"
                     /label="NRPS-A_a8"
                     /locus_tag="esyn1"
                     /protein_end="897"
                     /protein_start="875"
                     /score="32.4"
                     /tool="antismash"
                     /translation="CLGRMDSQVKIRGQRVELGAVE"
     aSDomain        4072..4266
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_esyn1_PCP.1"
                     /evalue="2.90E-12"
                     /label="esyn1_PCP.1"
                     /locus_tag="esyn1"
                     /protein_end="1082"
                     /protein_start="1017"
                     /score="38.5"
                     /tool="antismash"
                     /translation="KLESIWITSLDLEPGSANMSATFFEMGGNSIIAIKMVNMARSNGI
                     ELKVSDIYQNPTLAGLKAIV"
     aSDomain        4330..5211
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_esyn1_Condensation_LCL.1"
                     /domain_subtypes="Condensation_LCL"
                     /evalue="1.60E-93"
                     /label="esyn1_Condensation_LCL.1"
                     /locus_tag="esyn1"
                     /protein_end="1397"
                     /protein_start="1103"
                     /score="304.9"
                     /tool="antismash"
                     /translation="QSYAQNRMWFLDQLSEGASWYLIPFAVRMRGPVDVDALTRALLAL
                     EQRHETLRTTFENQDGVGVQIIHDRLSKELQVIDALDGDEGGLKTLYKVETTTFDITSE
                     AGWSSTLIRLGKDDHILSIVMHHIISDGWSIDVLRRELIQLYAAALQGKDPSSALTPLP
                     IQYSDFAVWQKQEAQAAEHERQLQYWKKQLADSSPAKIPTDFPRPDLLSGDAGVVPVAI
                     DGELYQKLRGFCNKHNSTAFSILLAAFRAAHYRLTAVDDAVIGIPIANRNRWELENMIG
                     FFVNTQCMRIAVD"
     aSModule        4330..8748
                     /complete
                     /domains="nrpspksdomains_esyn1_Condensation_LCL.1"
                     /domains="nrpspksdomains_esyn1_AMP-binding.2"
                     /domains="nrpspksdomains_esyn1_nMT.1"
                     /domains="nrpspksdomains_esyn1_PCP.2"
                     /locus_tags="esyn1"
                     /monomer_pairings="Val -> NMe-Val"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       4390..4497
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_esyn1_0006"
                     /evalue="1.30E-14"
                     /label="C2_LCL_024-062"
                     /locus_tag="esyn1"
                     /protein_end="1159"
                     /protein_start="1123"
                     /score="46.5"
                     /tool="antismash"
                     /translation="YLIPFAVRMRGPVDVDALTRALLALEQRHETLRTTF"
     CDS_motif       4702..4767
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_esyn1_0007"
                     /evalue="6.80E-11"
                     /label="C3_LCL_132-143"
                     /locus_tag="esyn1"
                     /protein_end="1249"
                     /protein_start="1227"
                     /score="34.6"
                     /tool="antismash"
                     /translation="MHHIISDGWSIDVLRRELIQLY"
     CDS_motif       4822..4854
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_esyn1_0008"
                     /evalue="2.60E-04"
                     /label="C4_LCL_164-176"
                     /locus_tag="esyn1"
                     /protein_end="1278"
                     /protein_start="1267"
                     /score="13.6"
                     /tool="antismash"
                     /translation="QYSDFAVWQKQ"
     CDS_motif       5110..5199
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_esyn1_0009"
                     /evalue="5.30E-14"
                     /label="C5_LCL_267-296"
                     /locus_tag="esyn1"
                     /protein_end="1393"
                     /protein_start="1363"
                     /score="44.5"
                     /tool="antismash"
                     /translation="DAVIGIPIANRNRWELENMIGFFVNTQCMR"
     CDS_motif       5248..5367
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_esyn1_0010"
                     /evalue="9.90E-17"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="esyn1"
                     /protein_end="1449"
                     /protein_start="1409"
                     /score="53.3"
                     /tool="antismash"
                     /translation="RSTTTAAFAHEDVPFERVVSALQPGHRDLSRTPLAQIMFA"
     aSDomain        5707..6900
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_esyn1_AMP-binding.2"
                     /evalue="8.60E-84"
                     /label="esyn1_AMP-binding.2"
                     /locus_tag="esyn1"
                     /protein_end="1960"
                     /protein_start="1562"
                     /score="273.3"
                     /specificity="substrate consensus: Val"
                     /tool="antismash"
                     /translation="FREQAAANPEVIAVTDSSSRLTYAELDNKSELLSRWLRRRNLTPE
                     TLVSVLAPRSCETIVAYVGILKANLAYLPLDVRSPVTRMKDILSSVSGNTIVLMGSGVE
                     DPGFDLPQLELVRITDTFDETIEDVQDSPQPSATSLAYVVFTSGSTGKPKGVMIEHRAI
                     VRLVKSDNFPGFPSPARMSNVFNPAFDGAIWEINWMLLNGGTVVCIDYLTTLDGKELAA
                     VFAKERVNAAFFAPAMLKLYLVDAREALKNLDFLIVGGERFDTKEAVEAMPLVRGKIAN
                     IYGPTEAGIISTCYNIPKDEAYTNGVPIGGSIYNSGAYVMDPNQQLVGLGVMGELVVTG
                     DGVGRGYTNPELNKNRFIDITIEGKTFKAYRTGDRMRARVGDGLLEFFGRMDNQFKIR"
     CDS_motif       5896..5934
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_esyn1_0011"
                     /evalue="6.10E-03"
                     /label="NRPS-A_a2"
                     /locus_tag="esyn1"
                     /protein_end="1638"
                     /protein_start="1625"
                     /score="10.3"
                     /tool="antismash"
                     /translation="GILKANLAYLPLD"
     CDS_motif       6127..6186
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_esyn1_0012"
                     /evalue="1.00E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="esyn1"
                     /protein_end="1722"
                     /protein_start="1702"
                     /score="33.4"
                     /tool="antismash"
                     /translation="AYVVFTSGSTGKPKGVMIEH"
     CDS_motif       6694..6777
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_esyn1_0013"
                     /evalue="4.10E-09"
                     /label="NRPS-A_a6"
                     /locus_tag="esyn1"
                     /protein_end="1919"
                     /protein_start="1891"
                     /score="28.7"
                     /tool="antismash"
                     /translation="LGVMGELVVTGDGVGRGYTNPELNKNRF"
     CDS_motif       6865..6930
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_esyn1_0014"
                     /evalue="2.50E-08"
                     /label="NRPS-A_a8"
                     /locus_tag="esyn1"
                     /protein_end="1970"
                     /protein_start="1948"
                     /score="26.2"
                     /tool="antismash"
                     /translation="FFGRMDNQFKIRGNRIEAGEVE"
     aSDomain        7189..7866
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_esyn1_nMT.1"
                     /domain_subtypes="nMT"
                     /evalue="4.20E-134"
                     /label="esyn1_nMT.1"
                     /locus_tag="esyn1"
                     /protein_end="2282"
                     /protein_start="2056"
                     /score="439.1"
                     /tool="antismash"
                     /translation="GKDIDKGEMQEWLDDAIHTLHNGQIPRDVLEIGTGSGMILFNLNP
                     GLNSYVGLDPSKSAVEFVNRAVESSPKFAGKAKVHVGMATDVNKLGEVHPDLVVFNSVV
                     QYFPTPEYLAEVIDGLIAIPSVKRIFLGDIRSYATNGHFLAARAIHTLGTNNNATKDRV
                     RQKIQELEDREEEFLVEPAFFTTLKERRPDVVKHVEIIPKNMKATNELSAYRYTAVVHL
                     RDET"
     aSDomain        8548..8748
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_esyn1_PCP.2"
                     /evalue="2.00E-26"
                     /label="esyn1_PCP.2"
                     /locus_tag="esyn1"
                     /protein_end="2576"
                     /protein_start="2509"
                     /score="83.9"
                     /tool="antismash"
                     /translation="EITLCEEATEVFGMKVEISDHFFQLGGHSLLATKLISRIQHRLHV
                     RVTVKDVFDSPVFADLAVIIRQ"
     aSDomain        8830..8964
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_esyn1_PCP.3"
                     /evalue="1.70E-15"
                     /label="esyn1_PCP.3"
                     /locus_tag="esyn1"
                     /protein_end="2648"
                     /protein_start="2603"
                     /score="48.9"
                     /tool="antismash"
                     /translation="EKMLCEEFAAGLGVPVGITDNFFDLGGHSLMATKLAVRIGRRLIR
                     "
     aSDomain        9172..10017
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_esyn1_Condensation_DCL.2"
                     /domain_subtypes="Condensation_DCL"
                     /evalue="1.10E-33"
                     /label="esyn1_Condensation_DCL.2"
                     /locus_tag="esyn1"
                     /protein_end="2999"
                     /protein_start="2717"
                     /score="108.5"
                     /tool="antismash"
                     /translation="QDVYPSTQMQKAFLFDPTTGEPRGLVPFYIDFPSNADAETLTKAI
                     GALVDKLDMFRTVFLEAAGDLYQVVVEHLNLPIETIETEKNVNTATGDYLDVHGKDPVR
                     LGHPCIQFAILKTASSVRVLLRMSHALYDGLSFEYIVRGLHVLYSGRNLPPPTQFARYM
                     QYAAHSREEGYPFWREVLQNAPMTVLHDTNNGMSEQEMPASKAVHLSEVVNVPAQAIRN
                     STNTQATVFNTACALVLAKESGSQDVVFGRIVSGRQGLPVVWQDIIGPCTNAVPVHARV
                     D"
     CDS_motif       9280..9351
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_esyn1_0015"
                     /evalue="2.50E-03"
                     /label="C2_DCL_024-062"
                     /locus_tag="esyn1"
                     /protein_end="2777"
                     /protein_start="2753"
                     /score="10.1"
                     /tool="antismash"
                     /translation="DAETLTKAIGALVDKLDMFRTVFL"
     CDS_motif       9556..9603
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_esyn1_0016"
                     /evalue="2.60E+00"
                     /label="C3_DCL_135-156"
                     /locus_tag="esyn1"
                     /protein_end="2861"
                     /protein_start="2845"
                     /score="1.0"
                     /tool="antismash"
                     /translation="HALYDGLSFEYIVRGL"
     CDS_motif       9910..10002
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_esyn1_0017"
                     /evalue="2.90E-05"
                     /label="C5_DCL_263-294"
                     /locus_tag="esyn1"
                     /protein_end="2994"
                     /protein_start="2963"
                     /score="16.6"
                     /tool="antismash"
                     /translation="DVVFGRIVSGRQGLPVVWQDIIGPCTNAVPV"
ORIGIN
        1 cctgctgaga caccgaatac aacatcgcac gcttagatca aaacccgctt acgacgagcc
       61 gaaatgggca gttcgtccgc ctacggaggt gttagataga acgtagcatt gcatagacct
      121 tttcgtttgg gacgtgcttt ggcttggctt tgaaataaac ttcgctgatc tcgtacccga
      181 cgtcaggatc gcgacggaaa cgcgtggacc atgctatcga catgtcacgt cgcttagcgt
      241 aaggagaagg tgcctagaga gtttacaagg ctgaggcagc ggtcagttac ccacggtctg
      301 tctacatggt gatatctgag ctagatgtca tgtttctatt ggtcaactga gggatttcca
      361 tgtctgcact tgcatatagg attccgggga aatggattat cgcttggcgt atagacgtgg
      421 aaaacctgct cattcgacaa cattagccgg tttgttatcc tactcggcca cccagacgcg
      481 gggtccttgt cgtaagaaag aaatgttact gatgagatgt tcttttctta ccgggccgga
      541 gcaaagtaag ctttccaaag caaggcggtg gccagcgaag aatgatagta ctcaaaggag
      601 aaacatgctc gtgagagccg tgcacggcag agaaccaggg taatgtttcg tctccacgtg
      661 gacccgaaaa gatacgaatc cttcaatgag gatccgagat ggctaatcag atggctcgtt
      721 gagaaacatc cccagagcag tggctatggt ggctgctgta cgatgtggtg aggtggtgat
      781 acagatgtat aaagatgcaa catggccggt gatgagcaaa gtcttagtgt ttagcagcaa
      841 agagtcatcc agattctcca tttatatata tctaacagct tagaagagct gtcggaacta
      901 gcgacttctt tcaaagttca cttatatctt atagcacttc cctccacggc tacgacagca
      961 tatcaactgt cacctcgcaa ttcccagtct tcaatatcat atcttattca tacgttagcc
     1021 atgtcactcc acaccccaag tgacggtcaa caagacccag cgttagcctc caaaaccctc
     1081 tgtgagcaaa tctcgcgagc cctcggcctc ggccaggaca agattgagaa tatcttccca
     1141 gggacaccct tccagcggga cgtcatagac tgcgccgcag acgacaagca gcgcgccgtg
     1201 ggccacgctg tctttgaaat tcccaaagat atagacgcgg cccgcctggc ggctgcgtgg
     1261 aaggagaccg tgcttcacac ccctgctctg cggacctgca cgtttacgtc caaatctggg
     1321 gatgtgcttc aggtggtcct gagagatagc tttgtctttt cgtggatgtc tgggccgtct
     1381 gtggatctta aggaggcggt tgtgcaagac gaggctgctg ctgctttggc tggcccgcgc
     1441 tgtaaccgct tcgtccttct tgaggaccct gatacaaagg aacgtcagct catctggacg
     1501 ttcagccatg ctctcgttga tagtaccttc caggaacgta tccttcgacg agtcctcaaa
     1561 gcttacaagg atgccaatga cgaacatcct cgccagttcg agacaccaga ttcttcccag
     1621 gccacgcccg aggaggattt acagcccaat ccatccaaga tgctcaagat ccctcaagcc
     1681 gcagatatgg accgtgctgt tgagttttgg aaggatcatc taagtggcct gaaatgcttc
     1741 tgccttcccg catttgtcct ctcatctgtc tatgcacatc cagatgccaa ggcagagcat
     1801 agaatctcct actcgtcttc agcacagcaa aaaatgtcca gtgctactat ttgccgaact
     1861 gccctggcaa ttctgttatc tcgttatacg cactctcctg aagcactctt tggcattgta
     1921 actgagcaaa ctcctctact ggaggagcaa ctcatgcttg atggcccaac acgtacagtc
     1981 gtaccaatcc gcgtatcctg tgcttctgaa cagtcagtgt cagatatcat gagcacgatt
     2041 gactcctacg atcagaccat gcggcagttt gcccacgctg gtcttcgcaa catcgccagt
     2101 gctggagacg atgaatctgc cgcctgcggg ttccagaccg ttctcttggt ctcagatgga
     2161 gacgcccagc cagcatctac ttgggaaatt ctcaagaaaa ctgaagagcc tgagggtttc
     2221 atcccctgta cgaaccgtgc tctgcttcta agttgccaga tgaccagctc tggagcacac
     2281 ctaaccgcca gatacgacca gagtatcatc gacgctgagc aaatggcccg actcctgcga
     2341 caactaggcc atctgatcca aaatcttcaa acctccacag atctacccgt ggaaaaggtg
     2401 gacatgatga cgcaagaaga ctggttagag attgagaggt ggaactcaga ctccatcgac
     2461 gcacaagaca cgcttatcca cagcgagatg ttgaagtgga cttctcagtc gcctaacaaa
     2521 gctgccgtcg ccgcgtggga tggagagtgg acgtatgctg agctggacaa tgtatcttcg
     2581 cgcctggctc agcatatcaa ctctattgac ctgggcaagg agcacgcgat agtacccatc
     2641 tactttgaga aatcgaaatg ggtcgttgct tcgatgctgg ctgtgctcaa ggctggccat
     2701 gcgtttactc tcattgaccc cagtgatcca ccagctcgaa cagcacaggt cgtgcagcaa
     2761 acctctgcga cagttgctct tacttccaag ctccatcgcg agactgttca atcaactgtc
     2821 gggcgctgca ttgttgtcga cgaagagttt gtcaaatccc tcccccagtc cagtgaactc
     2881 tcagcgtctg taaaggcaca tgacctggca tatgtcatct tcacctcggg cagcacaggc
     2941 attccaaagg gaatcatgat tgagcaccgc tcattttcat cctgcgccat caaattcggt
     3001 cccgcgcttg gaataacctc cgacacacgc gctcttcagt ttggatctca tgcctttggc
     3061 gcgtgtatcc tcgagatcat gacgacgctc atccacggag gctgtgtctg tatcccctct
     3121 gacgatgacc gcatgaacaa cgtccttgag ttcatcaacc ggactaacgt tcaactgggt
     3181 catgcaacgc cttcgtacat ggggacattc cagccagagg ttgttcctgg tttgaagacc
     3241 ttggtattgg taggtgagca gatgtctgct tctgtgaatg aggtctgggc tcctcgtgtt
     3301 caactcctga acggttacgg acagagcgag agttcttcta tctgctgcgt agccaagatc
     3361 agccctggtt catctgagcc aaacaatatt ggccacgcag taggcgcaca ttcttggatc
     3421 gttgaccctg aggatcccaa tcgcttggct cccatcggtg ccgttggcga gctggtcatc
     3481 gagagtgcag gtatcgcacg cgattacatc gttgcgccaa ctcaggataa gtctcctttc
     3541 attaagactg ctcctacgtg gtatccggcc aagcagctcc cggacggctt caagatctac
     3601 agaacaggcg atcttgcatg ctacgcatct gatggcagta tagtgtgcct tggccgtatg
     3661 gactcccagg tcaagatcag aggacagcgt gttgagctgg gtgcagtgga gactcatctt
     3721 cgacagcaga tgcctgatga tatgaccatc gttgttgaag ctgtcaagtt ctctgattcc
     3781 tccagtacta cagttttgac agccttcttg attggtgcag gggagaagaa cagtcatatc
     3841 ttggaccagc gtgctacaag ggagatcaat gccaagatgg agcaagttct tcctcgccat
     3901 tccatccccg cgttctacat ctctatgaac aacctccccc aaacagccac tggtaaggtc
     3961 gatcgacgaa aacttcgtat catgggtagc aagatactga gccaaaagac gcattccacc
     4021 ccatctcagc agagtcaggc cgccatctca tctggaaccg acacatatac caagctggag
     4081 agcatctgga tcacaagctt ggacctcgag cccggctctg caaacatgtc agctacattc
     4141 ttcgagatgg gcggaaactc catcatcgca atcaagatgg tcaacatggc gcgctccaat
     4201 ggcatagagc ttaaggtctc ggacatttac cagaacccca cgctcgctgg tctcaaggct
     4261 attgtcattg gtacttcgct gccatacagc cttattccca aggttacccg ccaaggccct
     4321 gttagcgagc agtcttatgc gcaaaacaga atgtggttcc tggatcagtt gtctgagggt
     4381 gcttcatggt atctgattcc tttcgctgtg cgcatgcgag gtccggtgga tgttgatgcg
     4441 ttgacgcgtg ctttgctcgc tcttgaacag cgtcatgaga cactacgaac tacatttgag
     4501 aaccaagatg gtgttggagt ccagatcatc catgatagac tctccaaaga gctacaagtc
     4561 atcgatgcct tggatggtga cgagggtggt ctcaagacac tctacaaagt agagaccacc
     4621 acattcgaca tcacatccga agcaggctgg agctcaaccc tcatccgcct cggcaaagac
     4681 gatcacattc tgtctatcgt catgcaccac atcatctccg acggctggtc catcgacgtt
     4741 ctccgccgcg aactcatcca actctacgcc gccgctctgc agggcaagga tccttcctcc
     4801 gcactaaccc ccctacccat ccagtacagc gacttcgccg tgtggcagaa gcaggaggcc
     4861 caagcagctg agcacgagag gcagctccag tactggaaga agcaactcgc agatagttca
     4921 cctgccaaga tccctaccga cttcccccgt ccagatctcc tgtccggtga cgcaggcgtt
     4981 gtgcccgttg ccatcgacgg cgagctgtat cagaaactaa ggggcttctg caacaagcac
     5041 aacagcactg ccttctccat cctgctcgct gctttccgcg cggcgcatta ccgtctcaca
     5101 gccgttgacg acgccgtgat cggcatcccc attgcaaacc gtaaccgctg ggagctggag
     5161 aacatgattg gtttctttgt caacacgcag tgtatgcgca tcgccgttga cgagacggat
     5221 acatttgaga gtctggtgcg ccaggtcaga tctaccacta cagctgcgtt tgcgcacgag
     5281 gatgtcccct tcgagcgtgt cgtttcagcg cttcagcctg gccatagaga tctctcgcga
     5341 acaccgctgg cacagataat gtttgctgtt cactcgcaga aggaccttgg acgtttcgag
     5401 ctggagggta tccagtctga gcctatcgcc agcaaggcct acaccagatt cgatgtcgag
     5461 ttccatctgt tccaacaggc agacggactg aagggcagtt gcaactttgc cacagatctc
     5521 ttcaagcccg aaactatcca gaatgttgtc agcgtgtttt tccagattct acgccatggc
     5581 cttgaccagc ctgagacgtg tatctcggtt cttccactga ctgatggagt cgaggagctt
     5641 cgcaggttgg atctgctgga aatcaagagg actaactacc ctcgcgattc gagcgtggta
     5701 gatgtcttcc gcgaacaagc tgccgccaac ccagaggtta tcgctgttac cgactcatct
     5761 tctcgtctga cttatgcaga gctggacaat aagtctgagc tgctctcacg atggcttcga
     5821 cgacgtaact tgacgccaga gacgctggtc agtgttcttg ctccccggtc ttgcgagact
     5881 atcgttgcct atgttggtat cctcaaggcg aacctggcgt atcttcctct tgacgtgagg
     5941 tccccggtga ctcgtatgaa ggacatcttg tcgagcgtgt ctggaaacac catagttctt
     6001 atgggctctg gggtagagga tcctggcttt gacttaccgc aactagagct cgtacgcatc
     6061 accgacactt tcgatgagac catcgaggac gtgcaagact ctccccaacc gtctgccaca
     6121 agcctcgcct acgtcgtctt cacatccggt tcaactggta aacccaaggg cgtcatgatc
     6181 gagcaccggg ccattgtgcg tctcgtcaag agtgacaact ttcctggctt cccctccccc
     6241 gctcgcatgt caaatgtctt caaccctgcc ttcgacggag ccatctggga gatcaactgg
     6301 atgctcctga acggcggaac agtcgtctgc atcgactacc tgaccaccct ggacggcaaa
     6361 gagctcgctg ctgtgttcgc caaagagcgc gtcaacgccg ccttcttcgc acctgcgatg
     6421 ctcaagcttt acctcgttga tgcgcgcgag gctttgaaga atcttgactt ccttattgtt
     6481 ggaggtgaga ggttcgatac caaggaagcc gtggaggcca tgccgcttgt gagaggcaag
     6541 attgccaata tctatggtcc gactgaggct ggaataatca gcacgtgcta taacatcccc
     6601 aaggatgagg cttacaccaa tggtgttccc attggtggaa gtatctacaa ctctggtgcc
     6661 tacgtcatgg atcctaacca gcaacttgtc ggccttggcg tcatgggaga gcttgttgtt
     6721 accggagacg gtgttggtcg aggctacact aaccccgagc tcaacaagaa ccgcttcatc
     6781 gacatcacca tcgagggcaa gactttcaag gcttaccgta ctggtgaccg gatgcgtgca
     6841 cgagtaggcg acggcctcct tgagttcttc ggccgcatgg acaaccagtt caagatccgc
     6901 ggcaaccgta tcgaagcagg ggaagttgag tctgccatgc tcagcctcaa gaatgtcctt
     6961 aacgccgcca ttgtcgtccg cgggggcgga gaagatgaag ggccactcga gatggtcgga
     7021 ttcatcgtcg cggacgacaa gaatgatacc acggaggagg aagagacagg caaccaagtt
     7081 gagggctggc aggaccattt cgagagtggt atgtactcgg atatcagcac cgccgtggac
     7141 caatctgcca ttggaaacga ctttaagggc tggacttcta tgtacgatgg taaggatatc
     7201 gacaagggcg agatgcagga gtggttggac gacgctattc acaccctgca taacggccag
     7261 atccctcgcg atgtcctcga gatcggtacc ggtagtggta tgatcctgtt caacctcaac
     7321 ccgggcctca acagctacgt tggtcttgat ccatccaagt cagcagtcga gttcgtcaac
     7381 agagccgtcg agtcctctcc caagttcgca ggaaaagcca aggtccacgt cggcatggcc
     7441 acagacgtca acaaactcgg cgaagtacac cccgatctcg tggtcttcaa ctccgttgtt
     7501 caatacttcc ccacacccga gtatctcgcc gaggtcatcg atggcctcat tgccatcccc
     7561 agcgtcaagc gcatcttcct tggcgatatc agatcatatg ctaccaacgg acacttcctc
     7621 gccgcacgcg ccatccacac gctcggcacc aataacaacg ccaccaagga tagggtgcgc
     7681 cagaagatcc aggagctgga ggatcgagag gaagagtttc tcgttgagcc tgccttcttc
     7741 accactctga aggagcgacg tccagatgtt gtcaagcatg ttgagatcat ccccaagaac
     7801 atgaaggcca ccaacgaact cagcgcctat cgctacacgg ctgttgtgca tctgcgggat
     7861 gaaacggacg aacctgtgta tcatattgag aaggatagct gggttgactt tgaggcgaag
     7921 cagatggaca agacggctct tcttgaccac ctgcgcctct ccaaggatgc tatgagtgtg
     7981 gcggttagca acatcaccta cgcccacact gcctttgaac gtcgtatcgt tgagtctctc
     8041 gatgaggata gcaaggatga caccaagggt acactcgatg gtgcagcctg gctttcagca
     8101 gttcgctccg aagccgaaaa ccgcgcctca ctcaccgtcc ccgacatcct ggagatcgcc
     8161 aaagaggctg gtttccgagt tgaagtcagc gctgctcgcc agtggtccca aagtggtgct
     8221 ttagacgcag tcttccacca ctttccaccc tccagcactg accgcactct aatccagttc
     8281 cccacggaca acgagcttcg atcatcactc accctcgcca accgccctct ccagaagctg
     8341 cagcgccgtc gtgccgctct gcaagtccgc gagaagctcc agacgctggt cccgtcttac
     8401 atggttcctc cgaatatcgt ggtgctggac acgatgcctc tcaatactaa cggcaagatc
     8461 gacagaaagg agcttacgcg tagagcacga acactgccga agcagcagac tgcggcgcct
     8521 gtgccggact tccctatctc tgatatcgag atcacgctgt gcgaggaggc aactgaggtc
     8581 tttggaatga aggttgaaat cagcgatcac ttcttccagc tcggcggtca ctctctcctc
     8641 gctacgaaac tcatttctcg catccagcac cgtctccatg tgcgggttac tgtgaaggac
     8701 gtattcgaca gccctgtctt tgccgatctg gcagtcatca tccgtcaagg acttgctatg
     8761 cagaaccctg ttgctgaagg acaggacaag caaggctggt cctcgagagt tgcccctcgt
     8821 acagaagtcg agaagatgct gtgcgaggag ttcgcagctg gtcttggtgt cccggttggt
     8881 atcactgaca acttcttcga tctcggtggt cactcgctca tggctactaa gctagctgtg
     8941 cgaattggcc gtcgcttgat acgccatcac agtcaaggac atcttcgact accctgtgct
     9001 ttccaattgg cgaagaagtt ggagtcttcg cattccaaga gctacgagga gtctggcgac
     9061 gatatccaga tggccgatta cactgcattc cagctcctcg atctggaaga cccccaagac
     9121 tttgttcagt cccagattcg gcctcaactg gactcctgct acggcaccat ccaggatgtc
     9181 tacccgtcta cgcagatgca aaaggccttc ctcttcgatc ccacgaccgg cgagccccga
     9241 ggtcttgtgc ctttctatat cgacttcccc agcaatgcag atgccgagac cctcaccaag
     9301 gctatcggag ctctagttga caagctcgat atgttcagaa ctgtcttcct ggaggccgca
     9361 ggcgatctgt accaagttgt cgttgagcac ctcaacttgc ctattgagac catcgagact
     9421 gagaagaacg tcaacactgc aaccggtgac tacctggatg ttcatggaaa ggaccctgtc
     9481 cgtctaggcc acccgtgcat ccaattcgcc atcctgaaga ctgcctcctc tgtacgtgtt
     9541 ctcctgcgaa tgtcccacgc tctgtatgat ggtttgagtt ttgagtacat cgtccgtggt
     9601 ctccacgttc tctacagcgg tagaaacctc cccccaccaa cacagtttgc gcgatacatg
     9661 cagtatgctg cacacagtcg tgaagaaggt tatcccttct ggcgcgaggt tctgcagaac
     9721 gcgcccatga cagttctaca cgacaccaat aacggtatgt ctgagcaaga gatgccagcc
     9781 tccaaggcgg tacacctgtc agaggtcgtc aacgttccag cgcaagctat tcgaaacagt
     9841 accaacaccc aagcgaccgt cttcaacacc gcctgtgccc ttgtcctagc caaggaatcc
     9901 ggctcacagg atgtcgtctt cggccgtatt gtctctggtc gacaaggtct accagtcgtc
     9961 tggcaggaca tcatcggccc ctgcacaaac gccgtgcccg tccacgcacg cgtcgacgat
    10021 ggaaaccccc aacgcatcat ccgcgaccta cgcgaccaat acctccgcac tctgcccttc
    10081 gaatcgcttg gcttcgagga aatcaagcgt aactgcacgg actggcccga agaattgacc
    10141 aacttctctg tctgcgtgac gtaccacaac ttcgagtacc accccgagag cgaagttgac
    10201 aaccaaaagg ttgagatggg agttttggca aagtatgttg agttgagtga aaacgagccg
    10261 ctgtacgatc ttgctattgc gggagaggtt gaggcggatg gagttaacct gaaggtcact
    10321 gttgttgcaa aggcaaggct ttacaatgag gcgaggatta gacatgtgct tgaggaagtt
    10381 tgcaaaactt tcaatggttt gaacgaggct ttgtaggcgt catgaacgga atggcaggag
    10441 gtgtgattgg tttgagtatg aggtagtttt gtttgtagtg taattcaagg cgttatataa
    10501 aacatctcag acatactatt tcttgattag tcctcataac taatggccct gtgtaaagtt
    10561 ttacacaact taaggcttgt attttatact ccgaaacctc ttcttgaaag tgttttattc
    10621 attatcacgg ataatgcgac tgttaacatg gtaattcaag actatatttc acgttaaggt
    10681 taaagtcagc tacattagta ttgtcggcgt cgctagggat aataagccta agtgagaatg
    10741 taagatatat aattatattg actggaatcc cctgagggat aaatatctgt aagacttatt
    10801 cccattctat actgctacta cactaactgt caataatgtt attatttaaa tagagcccac
    10861 cctataccaa taatattaaa tcggtaataa agtgtgcgat ggcctatcta agattctatt
    10921 atagttaact gcag
//
