BGC0000344: entolysin biosynthetic gene cluster from Pseudomonas entomophila L48
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Location: 3,206,616 - 3,277,103 nt. (total: 70,488 nt).
This entry is originally from NCBI GenBank CT573326.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000344
Short description entolysin biosynthetic gene cluster from Pseudomonas entomophila L48
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
CT573326.1
3206616 - 3277103
via
Compounds
  • entolysin
Species Pseudomonas entomophila L48 [taxonomy]
References
Chemical products information
entolysin Evidence:
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • PSEEN3032
  • CAK15802.1
 3206617 - 3207276 (-) putative DNA-binding response regulator, OmpR family
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    • PSEEN3033
    • CAK15803.1
    		 3207486 - 3207824 (+) conserved hypothetical protein
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      • PSEEN3034
      • CAK15804.1
      		 3207821 - 3208477 (+) conserved hypothetical protein; putative signal peptide
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        • PSEEN3035
        • CAK15805.1
        		 3208639 - 3209640 (+) conserved hypothetical protein; putative membrane protein, TerC family
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          • PSEEN3036
          • CAK15806.1
          		 3209728 - 3210021 (-) conserved hypothetical protein
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            • PSEEN3037
            • CAK15807.1
            • ribB_A-2
            		 3210100 - 3211212 (+) 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
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              • PSEEN3038
              • CAK15808.1
              		 3211816 - 3212841 (+) putative polyamine ABC transporter, periplasmic polyamine-binding protein
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                • PSEEN3039
                • CAK15809.1
                		 3212838 - 3213755 (+) putative polyamine ABC transporter, permease protein
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                  • PSEEN3040
                  • CAK15810.1
                  		 3213762 - 3214571 (+) putative polyamine ABC transporter, permease protein
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                    • PSEEN3041
                    • CAK15811.1
                    		 3214591 - 3215703 (+) putative polyamine ABC transporter, ATP binding protein
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                      • PSEEN3042
                      • CAK15812.1
                      • macB
                      		 3215810 - 3217813 (-) macrolide ABC efflux protein MacB
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                        • PSEEN3043
                        • CAK15813.1
                        • macA
                        		 3217816 - 3218970 (-) macrolide efflux protein MacA
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                          • PSEEN3044
                          • CAK15814.1
                          		 3219057 - 3233567 (-) putative non-ribosomal peptide synthetase, terminal component
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                            • PSEEN3045
                            • CAK15815.1
                            		 3233564 - 3259045 (-) putative non ribosomal peptide synthetase
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                              • PSEEN3046
                              • CAK15816.1
                              		 3259324 - 3260205 (-) putative transcriptional regulator, LysR family
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                                • PSEEN3047
                                • CAK15817.1
                                		 3260362 - 3261618 (+) hypothetical protein
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                                  • PSEEN3048
                                  • CAK15818.1
                                  • pobA
                                  		 3261697 - 3262884 (-) p-hydroxybenzoate hydroxylase (4-hydroxybenzoate 3-monooxygenase)
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                                    • PSEEN3049
                                    • CAK15819.1
                                    • pobR
                                    		 3263042 - 3263917 (+) transcriptional regulator PobR
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                                      • PSEEN3050
                                      • CAK15820.1
                                      		 3264003 - 3265058 (+) conserved hypothetical protein; TPR domain protein
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                                        • PSEEN3051
                                        • CAK15821.1
                                        		 3265081 - 3267060 (-) putative sensory box histidine kinase/response regulator (hybrid)
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                                          • PSEEN3052
                                          • CAK15822.1
                                          • ccd
                                          		 3267128 - 3267553 (-) Cytosine deaminase
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                                            • PSEEN3053
                                            • CAK15823.1
                                            		 3267721 - 3268410 (+) conserved hypothetical protein; ThiJ/PfpI family protein
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                                              • PSEEN3054
                                              • CAK15824.1
                                              • hpd
                                              		 3268500 - 3269573 (-) 4-hydroxyphenylpyruvate dioxygenase (4HPPD) (HPD) (HPPDase)
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                                                • PSEEN3055
                                                • CAK15825.1
                                                		 3269608 - 3269853 (-) conserved hypothetical protein
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                                                  • PSEEN3057
                                                  • CAK15826.1
                                                  		 3269930 - 3271474 (+) putative phosphodiesterase (EAL domain)
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                                                    • PSEEN3058
                                                    • CAK15827.1
                                                    • rarD-2
                                                    		 3271508 - 3272395 (+) chloramphenicol-sensitive protein rarD
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                                                      • PSEEN3059
                                                      • CAK15828.1
                                                      		 3272358 - 3273929 (-) conserved hypothetical protein; putative CBS domain; putative membrane protein, TerC/CorC family
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                                                        • PSEEN3060
                                                        • CAK15829.1
                                                        		 3274319 - 3276322 (+) putative peptidase, U32 family
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                                                          • PSEEN3061
                                                          • CAK15830.1
                                                          • nfxB
                                                          		 3276546 - 3277103 (+) transcriptional regulator NfxB
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                                                            Biosynthesis information

                                                            Biosynthetic modules

                                                            Name
                                                            Unk01
                                                            Type
                                                            nrps-type1
                                                            Genes
                                                            PSEEN3044
                                                            Substrates
                                                            valine (evidence: )
                                                            Integrated Monomers
                                                            Domains
                                                            adenylation
                                                            Name
                                                            Unk02
                                                            Type
                                                            nrps-type1
                                                            Genes
                                                            PSEEN3044
                                                            Substrates
                                                            isoleucine, leucine (evidence: )
                                                            Integrated Monomers
                                                            Domains
                                                            adenylation
                                                            Name
                                                            Unk03
                                                            Type
                                                            nrps-type1
                                                            Genes
                                                            PSEEN3044
                                                            Substrates
                                                            serine (evidence: )
                                                            Integrated Monomers
                                                            Domains
                                                            adenylation
                                                            Name
                                                            Unk04
                                                            Type
                                                            nrps-type1
                                                            Genes
                                                            PSEEN3044
                                                            Substrates
                                                            isoleucine, leucine (evidence: )
                                                            Integrated Monomers
                                                            Domains
                                                            adenylation
                                                            Name
                                                            Unk05
                                                            Type
                                                            nrps-type1
                                                            Genes
                                                            PSEEN3045
                                                            Substrates
                                                            glutamine (evidence: )
                                                            Integrated Monomers
                                                            Domains
                                                            adenylation
                                                            Name
                                                            Unk06
                                                            Type
                                                            nrps-type1
                                                            Genes
                                                            PSEEN3045
                                                            Substrates
                                                            valine (evidence: )
                                                            Integrated Monomers
                                                            Domains
                                                            adenylation
                                                            Name
                                                            Unk07
                                                            Type
                                                            nrps-type1
                                                            Genes
                                                            PSEEN3045
                                                            Substrates
                                                            isoleucine, leucine (evidence: )
                                                            Integrated Monomers
                                                            Domains
                                                            adenylation
                                                            Name
                                                            Unk08
                                                            Type
                                                            nrps-type1
                                                            Genes
                                                            PSEEN3045
                                                            Substrates
                                                            glutamine (evidence: )
                                                            Integrated Monomers
                                                            Domains
                                                            adenylation
                                                            Name
                                                            Unk09
                                                            Type
                                                            nrps-type1
                                                            Genes
                                                            PSEEN3045
                                                            Substrates
                                                            valine (evidence: )
                                                            Integrated Monomers
                                                            Domains
                                                            adenylation
                                                            Name
                                                            Unk10
                                                            Type
                                                            nrps-type1
                                                            Genes
                                                            PSEEN3045
                                                            Substrates
                                                            isoleucine, leucine (evidence: )
                                                            Integrated Monomers
                                                            Domains
                                                            adenylation
                                                            Name
                                                            Unk11
                                                            Type
                                                            nrps-type1
                                                            Genes
                                                            PSEEN3045
                                                            Substrates
                                                            glutamine (evidence: )
                                                            Integrated Monomers
                                                            Domains
                                                            adenylation
                                                            Name
                                                            Unk12
                                                            Type
                                                            nrps-type1
                                                            Genes
                                                            PSEEN3045
                                                            Substrates
                                                            serine (evidence: )
                                                            Integrated Monomers
                                                            Domains
                                                            adenylation
                                                            Annotation changelog

                                                            Entry version: 4

                                                            Date
                                                            Changes
                                                            Submitters
                                                            Reviewers
                                                            2022-10-07
                                                            Update chemical activity to schema version 2.11
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                            Entry version: 3

                                                            Date
                                                            Changes
                                                            Submitters
                                                            Reviewers
                                                            2022-09-15
                                                            Refined reference coordinates
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            2022-09-15
                                                            Updated bioactivity data
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            2022-09-15
                                                            Added NRP substrate specificities
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                            Entry version: 2

                                                            Date
                                                            Changes
                                                            Submitters
                                                            Reviewers
                                                            2019-10-16
                                                            Migrated from v1.4
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                            Entry version: 1

                                                            Date
                                                            Changes
                                                            Submitters
                                                            Reviewers
                                                            2015-06-12
                                                            Submitted
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            Detailed domain annotation
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