BGC0000345: eponemycin biosynthetic gene cluster from Streptomyces hygroscopicus
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Location: 1 - 25,783 nt. (total: 25,783 nt).
This entry is originally from NCBI GenBank KF647220.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000345
Short description eponemycin biosynthetic gene cluster from Streptomyces hygroscopicus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Other)
Loci NCBI GenBank: KF647220.1
Compounds
  • eponemycin
Species Streptomyces hygroscopicus [taxonomy]
References
Chemical products information
eponemycin
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C20H34N2O6
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AHB38502.1
 28 - 249 (+) transposase
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  • AHB38503.1
  • epnA
 857 - 1177 (+) LuxR-like transcriptional regulator
  • Regulation
Sequence-based prediction
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  • AHB38504.1
  • epnB
 1205 - 1984 (+) thioesterase
  • Unknown
Sequence-based prediction
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  • AHB38505.1
  • epnC
 2040 - 2897 (+) proteasome beta-subunit
  • Resistance/immunity
Sequence-based prediction
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  • AHB38506.1
  • epnD
 3273 - 4322 (+) ketosynthase III
  • Unknown
Sequence-based prediction
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  • AHB38507.1
  • epnE
 4341 - 4583 (+) acyl carrier protein
  • Unknown
Sequence-based prediction
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  • AHB38508.1
  • epnF
 5247 - 7046 (+) acyl-CoA dehydrogenase
  • Tailoring (Unknown)
Sequence-based prediction
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  • AHB38515.1
  • epnG
 7043 - 13456 (+) non-ribosomal peptide synthetase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AHB38509.1
  • epnH
 13453 - 19515 (+) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AHB38510.1
  • epnI
 19515 - 20810 (+) cytochrome P450
  • Tailoring (Unknown)
Sequence-based prediction
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  • AHB38511.1
  • epnJ
 20803 - 22779 (+) adenylation-thiolation bidomain
  • Unknown
Sequence-based prediction
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  • AHB38512.1
  • epnK
 22776 - 23981 (+) cytochrome P450
  • Tailoring (Unknown)
Sequence-based prediction
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  • AHB38513.1
  • epnL
 24307 - 24594 (+) EpnL
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  • AHB38514.1
 24953 - 25783 (+) transposase
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Polyketide-specific information
Subclass Other
Cyclic? no
Polyketide-synthases
Genes Properties Modules
epnH Synthase subclass: Modular type I
Module 3
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: epnH
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
epnJ
Module ?
Specificity: leucine
Evidence for specificity:
  • Sequence-based prediction
epnG
Module 1
Specificity: serine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
Module 2
Specificity: leucine
Evidence for specificity:
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: MQCAQSV425YQGLSERITRLP7K, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Updated bioactivity data
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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