LOCUS       BGC0000345             25783 bp    DNA     linear   BCT 09-DEC-2013
DEFINITION  Streptomyces hygroscopicus strain ATCC 53709 transposase gene,
            complete cds; eponemycin biosynthetic gene cluster, complete
            sequence; and transposase gene, complete cds.
ACCESSION   BGC0000345
VERSION     BGC0000345
KEYWORDS    .
SOURCE      Streptomyces hygroscopicus
  ORGANISM  Streptomyces hygroscopicus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces violaceusniger group.
REFERENCE   1  (bases 1 to 25783)
  AUTHORS   Schorn,M., Zettler,J., Noel,J.P., Dorrestein,P.C., Moore,B.S. and
            Kaysser,L.
  TITLE     Genetic Basis for the Biosynthesis of the Pharmaceutically Important
            Class of Epoxyketone Proteasome Inhibitors
  JOURNAL   ACS Chem. Biol. (2013) In press
   PUBMED   24168704
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 25783)
  AUTHORS   Schorn,M., Zettler,J., Noel,J.P., Dorrestein,P.C., Moore,B.S. and
            Kaysser,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-SEP-2013) Pharmaceutical Biology, Pharmaceutical
            Institut, Auf Der Morgenstelle 8, Tuebingen, Baden-Wuerttemberg
            72076, Germany
COMMENT     ##Assembly-Data-START##
            Assembly Method :: CLC Genomics Workbench software version 5.01
            Sequencing Technology :: Ion Torrent semi-conductor sequencing
            ##Assembly-Data-END##
            ##antiSMASH-Data-START##
            Version               :: 8.dev-5707d64f
            Run date              :: 2025-08-15 16:58:40
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..25783
                     /culture_collection="ATCC:53709"
                     /db_xref="taxon:1912"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces hygroscopicus"
                     /strain="ATCC 53709"
     region          1..25783
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /contig_edge="True"
                     /product="NRPS"
                     /product="T1PKS"
                     /product="NRPS-like"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX) and not
                     alpha_am_amid)"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /rules="cds((PP-binding or NAD_binding_4) and (AMP-binding
                     or A-OX) and not alpha_am_amid)"
                     /subregion_numbers="1"
                     /tool="antismash"
     subregion       1..25783
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000345"
                     /subregion_number="1"
                     /tool="antismash"
     cand_cluster    1..25783
                     /SMILES="NC(CO)C(=O)NC(CC(C)C)C(=O)C(C)C(=O)NC(CC(C)C)C(=O)
                     O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX) and not alpha_am_amid)"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /detection_rules="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX) and not alpha_am_amid)"
                     /kind="interleaved"
                     /product="NRPS"
                     /product="T1PKS"
                     /product="NRPS-like"
                     /protoclusters="1"
                     /protoclusters="2"
                     /protoclusters="3"
                     /tool="antismash"
     protocluster    1..25783
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[7042:13456](+)"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      7043..13456
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     protocluster    1..25783
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[13452:19515](+)"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      13453..19515
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="2"
     CDS             28..249
                     /codon_start=1
                     /note="Orf-1"
                     /product="transposase"
                     /protein_id="AHB38502.1"
                     /transl_table=11
                     /translation="MDSLDFLLRDRDSKYTSTFDAVFQADDVRILLSPPRAPKANAICE
                     RAVAPANATDTGSGHAFCGREFTVAHKS"
     cand_cluster    803..25783
                     /SMILES="NC(CO)C(=O)NC(CC(C)C)C(=O)C(C)C(=O)NC(CC(C)C)C(=O)
                     O"
                     /candidate_cluster_number="2"
                     /contig_edge="True"
                     /detection_rules="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX) and not alpha_am_amid)"
                     /kind="single"
                     /product="NRPS-like"
                     /protoclusters="3"
                     /tool="antismash"
     protocluster    803..25783
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[20802:22779](+)"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX) and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="3"
                     /tool="antismash"
     proto_core      20803..22779
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX) and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="3"
     gene            857..1177
                     /gene="epnA"
     CDS             857..1177
                     /codon_start=1
                     /gene="epnA"
                     /note="LuxR-like transcriptional regulator"
                     /product="EpnA"
                     /protein_id="AHB38503.1"
                     /transl_table=11
                     /translation="MGVAVSGFEGGPGLIALWQPDGSLTVGASDKSKKATLSEMGRRIL
                     EGVARGLSTAKLASQLHMSKNGISYHLGELMRQFQADNRTELVSKAYSMGLLKIGTWPP
                     AT"
     misc_feature    857..24594
                     /note="eponemycin biosynthetic gene cluster"
     misc_feature    905..907
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    989..991
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            1205..1984
                     /gene="epnB"
     CDS             1205..1984
                     /NRPS_PKS="Domain: Thioesterase (20-241). E-value: 8.5e-28.
                     Score: 90.3. Matches aSDomain:
                     nrpspksdomains_epnB_Thioesterase.1"
                     /codon_start=1
                     /gene="epnB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thioesterase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1004: thioesterase"
                     /gene_kind="biosynthetic-additional"
                     /note="thioesterase"
                     /product="EpnB"
                     /protein_id="AHB38504.1"
                     /sec_met_domain="Thioesterase (E-value: 1.1e-25, bitscore:
                     81.0, seeds: 16, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 9.7e-14, bitscore:
                     42.4, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHTVPTPVTYHSIPGADAPVRLIAFHHAGGSASSFLPVLKELPDD
                     CGGFLFELGGRFGESESAPAADFHSAYERFLPDFLRLVDRPTVVIGHSLGALFAHNLVA
                     ALPPDRAALVKTLVVSASKGPVVAAGEASMPAAPFLVRSASSVMEDLRTFGGTAPEFLE
                     DPEFAEAAVSQLGHDLHLADTYILPPGPPSRVPYLVWYGLDDFTLAEADRLAWSESCAQ
                     QPDHEGFPGGHFYLFDRPEPAVRLRELTDRLAAEGFR"
     aSDomain        1265..1927
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_epnB_Thioesterase.1"
                     /evalue="8.50E-28"
                     /label="epnB_Thioesterase.1"
                     /locus_tag="epnB"
                     /protein_end="241"
                     /protein_start="20"
                     /score="90.3"
                     /tool="antismash"
                     /translation="RLIAFHHAGGSASSFLPVLKELPDDCGGFLFELGGRFGESESAPA
                     ADFHSAYERFLPDFLRLVDRPTVVIGHSLGALFAHNLVAALPPDRAALVKTLVVSASKG
                     PVVAAGEASMPAAPFLVRSASSVMEDLRTFGGTAPEFLEDPEFAEAAVSQLGHDLHLAD
                     TYILPPGPPSRVPYLVWYGLDDFTLAEADRLAWSESCAQQPDHEGFPGGHFYLFDRPE"
     CDS_motif       1457..1522
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_epnB_0001"
                     /evalue="2.60E-04"
                     /label="NRPS-te1"
                     /locus_tag="epnB"
                     /protein_end="106"
                     /protein_start="84"
                     /score="13.6"
                     /tool="antismash"
                     /translation="RPTVVIGHSLGALFAHNLVAAL"
     gene            2040..2897
                     /gene="epnC"
     CDS             2040..2897
                     /codon_start=1
                     /gene="epnC"
                     /note="proteasome beta-subunit"
                     /product="EpnC"
                     /protein_id="AHB38505.1"
                     /transl_table=11
                     /translation="MTGTTGGQPLTPWLFTTGTSSFMEFIERYDPDLMPGRGKRAAGAP
                     GLTEDQIPHGTTVLALTYADGVMMAGDRRATMGNLIAQRDLEKVYPADEHTAVAFAGTV
                     GLALDMVKLYQVELAHFEKVEGTAMTLDGKANRLATMIRNNLGQAMQGLTVVPMLAGYD
                     LLAPEGKQGRIFSYDVTGGPYEMQDFHTVGSGSPYARGALKKLYRPGLSRREAALAALQ
                     ALYDAADDDTATGGPDISRRIFPIVASITEEGYERMDEANTEELSRLVVEQRSRQPEGP
                     TVAL"
     gene            3273..4322
                     /gene="epnD"
     CDS             3273..4322
                     /codon_start=1
                     /gene="epnD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) fabH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III"
                     /gene_kind="biosynthetic-additional"
                     /note="ketosynthase III"
                     /product="EpnD"
                     /protein_id="AHB38506.1"
                     /sec_met_domain="fabH (E-value: 3.2e-110, bitscore: 358.0,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLDQGGSYMPVRYEERERAVVVAGVGGWVPPDVVTNDDLCARLD
                     TSDEWIRTRTGIRTRHVISPGMATSDLAFEAGRRALGSADDREIGAVVLATTTPDRPCP
                     ATAPDVAARLGLVGVPAFDISAVCAGFLYGLATAAGLIASGTARQVLLIGADAFTTIVD
                     PKDRSTAVIFADGAGAVVLRAGRADEPGAVGPVVLGSDGRFAHLIQVPAGGSRQRSRSR
                     SCGPGEEFFQMEGRDTFRQAVERMSAASRHAVESAGWSLEDVDRFAAHQANARILEAVA
                     DELAIPAGHRLSNISRVGNTGAASIPLLLAQAAEDSSLAEGHRTLLTAFGGGLAWGAAT
                     LTWPKLPTA"
     gene            4341..4583
                     /gene="epnE"
     CDS             4341..4583
                     /NRPS_PKS="Domain: PP-binding (7-73). E-value: 8.9e-15.
                     Score: 47.0. Matches aSDomain:
                     nrpspksdomains_epnE_PP-binding.1"
                     /codon_start=1
                     /gene="epnE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /note="acyl carrier protein"
                     /product="EpnE"
                     /protein_id="AHB38507.1"
                     /sec_met_domain="PP-binding (E-value: 2.1e-15, bitscore:
                     47.0, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGRPMFETLKEVLVGKLKAASEKITPEATVEEAELDSLSIVELSI
                     ILEKDFTITITDDELLAAPTIGDMAKLIEERNAAA"
     aSDomain        4362..4559
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_epnE_PP-binding.1"
                     /evalue="8.90E-15"
                     /label="epnE_PP-binding.1"
                     /locus_tag="epnE"
                     /protein_end="73"
                     /protein_start="7"
                     /score="47.0"
                     /tool="antismash"
                     /translation="TLKEVLVGKLKAASEKITPEATVEEAELDSLSIVELSIILEKDFT
                     ITITDDELLAAPTIGDMAKLI"
     gene            5247..7046
                     /gene="epnF"
     CDS             5247..7046
                     /codon_start=1
                     /gene="epnF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /note="acyl-CoA dehydrogenase"
                     /product="EpnF"
                     /protein_id="AHB38508.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 2.6e-08, bitscore:
                     24.5, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 7.1e-18, bitscore:
                     54.6, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 4e-17, bitscore:
                     52.7, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDSKSVNLFHRHGVPSFLEGIYQGRFEWDMISNFVAQDSADEKA
                     GDAAVERLTDILRNRVNPTAVDATRELPEGLLEELRRTGFLNLQDSPDIGGLGLSSYNT
                     FRVVQAAASWSVPVALVLGIQTAVGSGTYLRALPPGELHSYVEQRLLDGIISGSADTEP
                     AGASNSARRTRAVPTDDGEAFLLTGEKIHIGNGPIADIVTVSAMLDEDGQDRPRLFFVE
                     TSDPGFSIRSRHEFMGVKGFPNAALVLDGVRVPRERMIVEVDPDTEVRITAELTMAVVR
                     GRLHLITAPSLAISKLCLEWSRNFVNRRTIDGRPLGAREEIQHMVSSTMADVFAIQALA
                     EWSLLPADQPDLGLNVAFEQNVTKAISAEICWRAADRTMDLLAGEGFETAPSKARRGAP
                     ALPLERFYRDARNLRISGGVSFLLQFWAARMSQFTYYGPDHAGQSAALSQDGGQQPCTD
                     GLDPLNADHLRFAAAETRRLGAACQKFAADHPAPGLYEHQHRLIAFSRIADEILTMSVV
                     LAKAARLHHEGRTEAQDLAAIYCAHARDRLAALWRQAEPVTAGPDHAAVSDAWLSGDDT
                     YASLITGVITDVPPTADTHPGKR"
     gene            7043..13456
                     /gene="epnG"
     CDS             7043..13456
                     /NRPS_PKS="Domain: Condensation_LCL (27-308). E-value:
                     7.3e-42. Score: 135.3. Matches aSDomain:
                     nrpspksdomains_epnG_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (490-883). E-value:
                     7.2e-107. Score: 349.4. Matches aSDomain:
                     nrpspksdomains_epnG_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (992-1059). E-value: 3.6e-15. Score:
                     47.9. Matches aSDomain: nrpspksdomains_epnG_PCP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (1077-1365). E-value:
                     6.8e-58. Score: 188.0. Matches aSDomain:
                     nrpspksdomains_epnG_Condensation_LCL.2"
                     /NRPS_PKS="Domain: AMP-binding (1536-1920). E-value:
                     2.8e-82. Score: 268.4. Matches aSDomain:
                     nrpspksdomains_epnG_AMP-binding.2"
                     /NRPS_PKS="Domain: PCP (2025-2092). E-value: 7.6e-22.
                     Score: 69.3. Matches aSDomain: nrpspksdomains_epnG_PCP.2"
                     /codon_start=1
                     /gene="epnG"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127: condensation domain-containing protein"
                     /gene_kind="biosynthetic"
                     /note="non-ribosomal peptide synthetase"
                     /product="EpnG"
                     /protein_id="AHB38515.1"
                     /sec_met_domain="AMP-binding (E-value: 5.9e-119, bitscore:
                     387.1, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="Condensation (E-value: 2e-46, bitscore:
                     148.2, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.2e-15, bitscore:
                     47.8, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKEKDRREESLSPGASRTGTATTPGHRLPLSVDQQAVWVHWQVD
                     PDRSSHIIHMPMLVDEGELDLQRVHAAAAALGQRFPMLRGRIVESGDETELRWDDAPAI
                     PVTEVRTDSPWAETVSRHGAARFDLHQGPLARIQVLHGPDYVVLLIDVHHIVFDGRACG
                     PFLAAFRDAYAGKDLGPADNTEAHVEFARRQHELTHGPEGEKHREHWRRTLGEDLPAPL
                     KLPGGPGEPTFHEVALDPALIAAAHETATAARVHPMIPLYAAFCLLIRDRTGQEDLIVP
                     TPYHGRTRELRDRVGYFSNVLPLRHRLPSGISNRQVLRDLHHNLRDAVRHGSLPYPALL
                     RAAGLTGQQARAHVGQVIFQYWPAPPQDEIDLTALRLTGPDSDAVLRLLATEDYADHTL
                     TVMLREDPRGTSVIWKDPTGAVGRDTVEQLAAAYPVALAELIADLEGTVGATAPDSIAA
                     ADRPSPETLLAKELAWNATDADFPDTSLPGLLRTRAAATPDAIAISDGTQRLTYAELTD
                     RAGTLARGLAARGVRPGDLVGLLLPRGIAQVEAVLGTLFAGAVYVPLDVAAPAERHQMI
                     LEDSAAVCLVTDGHHDVAGFTGPVIALDELRDARDGELPDIDPGSPAYVIFTSGTTGRP
                     KGVVITHRNVVRLVVNDRLPYDFGPGDVWTLFHSYAFDVSVWEMFGCFAHGGRLVVVGS
                     DEAQDPQRLLTLLRSENVTVLSQTPSAFAQLNGVHGTGQAPLDSLRYVIFAGEKLDPGH
                     LAGFAARHPRTALVNMYGITEVTVHTTFRKITDRDIETGRSNVGVPLPTTSLFILGPDR
                     EPLAPGETGEIWVGGLGVADGYLNRPELTAQRFLPNPFGEGTLYRSGDLARRLPDGTVE
                     YVGRADQQVKIRGYRIEPGEIETLLLDHPAVEGAVVLPEAGPGSDQQLVAYLVPHGTPP
                     TTAALRGHLAVRLPDYMLPARFLTVESLPLTVNGKIDTKRLREVGTPLETGQDTDPPRT
                     ATARAVAEVWSDLLKVRAPGADQSFFELGGHSLLAARTLREIAKRLDRDVPPLRMFFEH
                     PVLQDFADAFDRLADGPLPAPAPAPTASGEPLPASGFQQRIWFDEQFLEGGGLYQVPMV
                     WRVRGRLDPVVLRTALYRMTERNEILRTAFVQRDGALWQEPGAPWQPEVVHQDLTGIAG
                     HDRDREVTERLRAAAREPVDPGSGMLLRVTLFDLPGEEQLLLLNTHHLVWDGGSAHPFL
                     HELADCYAQSLAPSGPPPALRPQYRDAVGHPVDPAGLDHWAARLDGAPAHPGFEPPLTP
                     GPNGTTPVPLPPQLSDRLAELGKRHGVSPAMVFAAALAAALHGWTGQDDVTFGTPVAGR
                     LHEEYADVIGPLLNTAVLRSTTRQGETVGELLGRLRDTVLDAIDHQEVPFEDVVERLNP
                     PRRPGWSPYVEVMLAVEAEPVTPVPVGPGQVTPYVFEDPEANHLAKFALTVSFREEDGR
                     FTGNIAYRGDRISVEVSRAFAGLLGRTIEALCGPPSQRVDAVPLLGPEEYRRITAFENG
                     APAAPATTLPSLLAERISELPGAPAVESSRGVLSYGELHARALQLSARIRIAVEGREPI
                     VAIVLGRGEDLVTAMLATWYAGCAFCPIDPDYPDERIRLTLEDVAAGAVIRGPGRRPDT
                     GRIPVLDIGDPSAYEGDTAAPEPHTPDPEAPAYVLYTSGTTGRPKGAVLSHHGLAQLAL
                     WHAEAYDVTPQDRASHLSSVGFDATQWEIWPYLAAGACVVAHEKRVVVPELAPWLAERR
                     ITMTYLSTPVAEAVWGTGADLPALRWMLFAAAAQTRRPPAGLGYRVANNYGPTEGSVVA
                     TWQPGPTPEDAPLNIIGRPIAGKSVYVVDPAGRRCPPGVIGELLIGGVGIALEYRGNPE
                     LSRERFLPTGPDGAPGPVYRTGDRARWREDGTLEFLGRMDRQLKVRGHRIEPQEVEAGL
                     LADPLVQRAYVSGDATTLVAHVVPAAQGGRDSRRVLDGLAARMPAHLVPDALMWLDELP
                     TTAHGKVDVARLPRPGRDDLAGARNWVEPSDRLERRIAAVWEAVLDLERVGAADNFFDL
                     GGNSLKLATLHARLLKELDREIPVHRLFEFPTVRQLARFLAPGGDGPDASSPAARDDIA
                     ARAARWRSPAPRQSPAAHGTPRRNRNS"
     aSDomain        7124..7966
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_epnG_Condensation_LCL.1"
                     /domain_subtypes="Condensation_LCL"
                     /evalue="7.30E-42"
                     /label="epnG_Condensation_LCL.1"
                     /locus_tag="epnG"
                     /protein_end="308"
                     /protein_start="27"
                     /score="135.3"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHIVFDG"
                     /tool="antismash"
                     /translation="RLPLSVDQQAVWVHWQVDPDRSSHIIHMPMLVDEGELDLQRVHAA
                     AAALGQRFPMLRGRIVESGDETELRWDDAPAIPVTEVRTDSPWAETVSRHGAARFDLHQ
                     GPLARIQVLHGPDYVVLLIDVHHIVFDGRACGPFLAAFRDAYAGKDLGPADNTEAHVEF
                     ARRQHELTHGPEGEKHREHWRRTLGEDLPAPLKLPGGPGEPTFHEVALDPALIAAAHET
                     ATAARVHPMIPLYAAFCLLIRDRTGQEDLIVPTPYHGRTRELRDRVGYFSNVLPLRHRL
                     "
     aSModule        7124..10219
                     /complete
                     /domains="nrpspksdomains_epnG_Condensation_LCL.1"
                     /domains="nrpspksdomains_epnG_AMP-binding.1"
                     /domains="nrpspksdomains_epnG_PCP.1"
                     /locus_tags="epnG"
                     /monomer_pairings="Ser -> Ser"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       7223..7294
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_epnG_0001"
                     /evalue="5.90E-03"
                     /label="C2_DCL_024-062"
                     /locus_tag="epnG"
                     /protein_end="84"
                     /protein_start="60"
                     /score="8.9"
                     /tool="antismash"
                     /translation="EGELDLQRVHAAAAALGQRFPMLR"
     CDS_motif       7496..7561
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_epnG_0002"
                     /evalue="4.50E-04"
                     /label="C3_LCL_132-143"
                     /locus_tag="epnG"
                     /protein_end="173"
                     /protein_start="151"
                     /score="13.0"
                     /tool="antismash"
                     /translation="VHHIVFDGRACGPFLAAFRDAY"
     CDS_motif       7871..7957
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_epnG_0003"
                     /evalue="2.60E-07"
                     /label="C5_LCL_267-296"
                     /locus_tag="epnG"
                     /protein_end="305"
                     /protein_start="276"
                     /score="23.1"
                     /tool="antismash"
                     /translation="DLIVPTPYHGRTRELRDRVGYFSNVLPLR"
     CDS_motif       8012..8086
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_epnG_0004"
                     /evalue="1.60E+01"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="epnG"
                     /protein_end="348"
                     /protein_start="323"
                     /score="-2.1"
                     /tool="antismash"
                     /translation="NLRDAVRHGSLPYPALLRAAGLTGQ"
     aSDomain        8513..9691
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_epnG_AMP-binding.1"
                     /evalue="7.20E-107"
                     /label="epnG_AMP-binding.1"
                     /locus_tag="epnG"
                     /protein_end="883"
                     /protein_start="490"
                     /score="349.4"
                     /specificity="substrate consensus: Ser"
                     /tool="antismash"
                     /translation="RTRAAATPDAIAISDGTQRLTYAELTDRAGTLARGLAARGVRPGD
                     LVGLLLPRGIAQVEAVLGTLFAGAVYVPLDVAAPAERHQMILEDSAAVCLVTDGHHDVA
                     GFTGPVIALDELRDARDGELPDIDPGSPAYVIFTSGTTGRPKGVVITHRNVVRLVVNDR
                     LPYDFGPGDVWTLFHSYAFDVSVWEMFGCFAHGGRLVVVGSDEAQDPQRLLTLLRSENV
                     TVLSQTPSAFAQLNGVHGTGQAPLDSLRYVIFAGEKLDPGHLAGFAARHPRTALVNMYG
                     ITEVTVHTTFRKITDRDIETGRSNVGVPLPTTSLFILGPDREPLAPGETGEIWVGGLGV
                     ADGYLNRPELTAQRFLPNPFGEGTLYRSGDLARRLPDGTVEYVGRADQQVKIR"
     CDS_motif       8696..8737
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_epnG_0005"
                     /evalue="2.90E-03"
                     /label="NRPS-A_a2"
                     /locus_tag="epnG"
                     /protein_end="565"
                     /protein_start="551"
                     /score="11.3"
                     /tool="antismash"
                     /translation="LGTLFAGAVYVPLD"
     CDS_motif       8909..8968
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_epnG_0006"
                     /evalue="2.00E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="epnG"
                     /protein_end="642"
                     /protein_start="622"
                     /score="32.4"
                     /tool="antismash"
                     /translation="AYVIFTSGTTGRPKGVVITH"
     CDS_motif       9491..9577
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_epnG_0007"
                     /evalue="2.70E-15"
                     /label="NRPS-A_a6"
                     /locus_tag="epnG"
                     /protein_end="845"
                     /protein_start="816"
                     /score="48.4"
                     /tool="antismash"
                     /translation="PGETGEIWVGGLGVADGYLNRPELTAQRF"
     CDS_motif       9656..9721
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_epnG_0008"
                     /evalue="2.60E-12"
                     /label="NRPS-A_a8"
                     /locus_tag="epnG"
                     /protein_end="893"
                     /protein_start="871"
                     /score="38.6"
                     /tool="antismash"
                     /translation="YVGRADQQVKIRGYRIEPGEIE"
     aSDomain        10019..10219
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_epnG_PCP.1"
                     /evalue="3.60E-15"
                     /label="epnG_PCP.1"
                     /locus_tag="epnG"
                     /protein_end="1059"
                     /protein_start="992"
                     /score="47.9"
                     /tool="antismash"
                     /translation="RAVAEVWSDLLKVRAPGADQSFFELGGHSLLAARTLREIAKRLDR
                     DVPPLRMFFEHPVLQDFADAFD"
     aSDomain        10274..11137
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_epnG_Condensation_LCL.2"
                     /domain_subtypes="Condensation_LCL"
                     /evalue="6.80E-58"
                     /label="epnG_Condensation_LCL.2"
                     /locus_tag="epnG"
                     /protein_end="1365"
                     /protein_start="1077"
                     /score="188.0"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHLVWDG"
                     /tool="antismash"
                     /translation="EPLPASGFQQRIWFDEQFLEGGGLYQVPMVWRVRGRLDPVVLRTA
                     LYRMTERNEILRTAFVQRDGALWQEPGAPWQPEVVHQDLTGIAGHDRDREVTERLRAAA
                     REPVDPGSGMLLRVTLFDLPGEEQLLLLNTHHLVWDGGSAHPFLHELADCYAQSLAPSG
                     PPPALRPQYRDAVGHPVDPAGLDHWAARLDGAPAHPGFEPPLTPGPNGTTPVPLPPQLS
                     DRLAELGKRHGVSPAMVFAAALAAALHGWTGQDDVTFGTPVAGRLHEEYADVIGPLLNT
                     AVLRSTT"
     aSModule        10274..13318
                     /complete
                     /domains="nrpspksdomains_epnG_Condensation_LCL.2"
                     /domains="nrpspksdomains_epnG_AMP-binding.2"
                     /domains="nrpspksdomains_epnG_PCP.2"
                     /locus_tags="epnG"
                     /monomer_pairings="Leu -> Leu"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       10340..10459
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_epnG_0009"
                     /evalue="5.20E-13"
                     /label="C2_DCL_024-062"
                     /locus_tag="epnG"
                     /protein_end="1139"
                     /protein_start="1099"
                     /score="41.3"
                     /tool="antismash"
                     /translation="GLYQVPMVWRVRGRLDPVVLRTALYRMTERNEILRTAFVQ"
     CDS_motif       10676..10738
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_epnG_0010"
                     /evalue="1.50E-06"
                     /label="C3_LCL_132-143"
                     /locus_tag="epnG"
                     /protein_end="1232"
                     /protein_start="1211"
                     /score="20.8"
                     /tool="antismash"
                     /translation="HHLVWDGGSAHPFLHELADCY"
     CDS_motif       10970..11029
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_epnG_0011"
                     /evalue="1.10E-02"
                     /label="Cy4"
                     /locus_tag="epnG"
                     /protein_end="1329"
                     /protein_start="1309"
                     /score="9.0"
                     /tool="antismash"
                     /translation="GVSPAMVFAAALAAALHGWT"
     CDS_motif       11039..11128
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_epnG_0012"
                     /evalue="4.60E-10"
                     /label="C5_LCL_267-296"
                     /locus_tag="epnG"
                     /protein_end="1362"
                     /protein_start="1332"
                     /score="31.9"
                     /tool="antismash"
                     /translation="DVTFGTPVAGRLHEEYADVIGPLLNTAVLR"
     CDS_motif       11177..11293
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_epnG_0013"
                     /evalue="2.70E-16"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="epnG"
                     /protein_end="1417"
                     /protein_start="1378"
                     /score="51.9"
                     /tool="antismash"
                     /translation="RDTVLDAIDHQEVPFEDVVERLNPPRRPGWSPYVEVMLA"
     aSDomain        11651..12802
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_epnG_AMP-binding.2"
                     /evalue="2.80E-82"
                     /label="epnG_AMP-binding.2"
                     /locus_tag="epnG"
                     /protein_end="1920"
                     /protein_start="1536"
                     /score="268.4"
                     /specificity="substrate consensus: Leu"
                     /tool="antismash"
                     /translation="ISELPGAPAVESSRGVLSYGELHARALQLSARIRIAVEGREPIVA
                     IVLGRGEDLVTAMLATWYAGCAFCPIDPDYPDERIRLTLEDVAAGAVIRGPGRRPDTGR
                     IPVLDIGDPSAYEGDTAAPEPHTPDPEAPAYVLYTSGTTGRPKGAVLSHHGLAQLALWH
                     AEAYDVTPQDRASHLSSVGFDATQWEIWPYLAAGACVVAHEKRVVVPELAPWLAERRIT
                     MTYLSTPVAEAVWGTGADLPALRWMLFAAAAQTRRPPAGLGYRVANNYGPTEGSVVATW
                     QPGPTPEDAPLNIIGRPIAGKSVYVVDPAGRRCPPGVIGELLIGGVGIALEYRGNPELS
                     RERFLPTGPDGAPGPVYRTGDRARWREDGTLEFLGRMDRQLKVR"
     CDS_motif       11825..11866
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_epnG_0014"
                     /evalue="2.50E-03"
                     /label="NRPS-A_a2"
                     /locus_tag="epnG"
                     /protein_end="1608"
                     /protein_start="1594"
                     /score="11.4"
                     /tool="antismash"
                     /translation="LATWYAGCAFCPID"
     CDS_motif       12050..12109
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_epnG_0015"
                     /evalue="5.30E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="epnG"
                     /protein_end="1689"
                     /protein_start="1669"
                     /score="28.2"
                     /tool="antismash"
                     /translation="AYVLYTSGTTGRPKGAVLSH"
     CDS_motif       12593..12721
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_epnG_0016"
                     /evalue="3.80E-12"
                     /label="NRPS-A_a6"
                     /locus_tag="epnG"
                     /protein_end="1893"
                     /protein_start="1850"
                     /score="38.4"
                     /tool="antismash"
                     /translation="PPGVIGELLIGGVGIALEYRGNPELSRERFLPTGPDGAPGPVY"
     CDS_motif       12767..12832
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_epnG_0017"
                     /evalue="1.60E-10"
                     /label="NRPS-A_a8"
                     /locus_tag="epnG"
                     /protein_end="1930"
                     /protein_start="1908"
                     /score="33.0"
                     /tool="antismash"
                     /translation="FLGRMDRQLKVRGHRIEPQEVE"
     aSDomain        13118..13318
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_epnG_PCP.2"
                     /evalue="7.60E-22"
                     /label="epnG_PCP.2"
                     /locus_tag="epnG"
                     /protein_end="2092"
                     /protein_start="2025"
                     /score="69.3"
                     /tool="antismash"
                     /translation="ERRIAAVWEAVLDLERVGAADNFFDLGGNSLKLATLHARLLKELD
                     REIPVHRLFEFPTVRQLARFLA"
     gene            13453..19515
                     /gene="epnH"
     CDS             13453..19515
                     /NRPS_PKS="Domain: PKS_KS(Hybrid-KS) (6-423). E-value:
                     5.6e-150. Score: 491.9. Matches aSDomain:
                     nrpspksdomains_epnH_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (525-815). E-value: 1.5e-55.
                     Score: 180.6. Matches aSDomain:
                     nrpspksdomains_epnH_PKS_AT.1"
                     /NRPS_PKS="Domain: cMT (1282-1455). E-value: 1.6e-51.
                     Score: 166.6. Matches aSDomain: nrpspksdomains_epnH_cMT.1"
                     /NRPS_PKS="Domain: PCP (1638-1703). E-value: 2.8e-14.
                     Score: 45.1. Matches aSDomain: nrpspksdomains_epnH_PCP.1"
                     /codon_start=1
                     /gene="epnH"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     itr_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     tra_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     mod_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     hyb_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     ene_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thioesterase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022: Beta-ketoacyl synthase"
                     /gene_kind="biosynthetic"
                     /note="polyketide synthase"
                     /product="EpnH"
                     /protein_id="AHB38509.1"
                     /sec_met_domain="ketoacyl-synt (E-value: 1.2e-67, bitscore:
                     218.0, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="mod_KS (E-value: 1e-129, bitscore: 422.9,
                     seeds: 217, tool: rule-based-clusters)"
                     /sec_met_domain="hyb_KS (E-value: 6.5e-150, bitscore:
                     489.5, seeds: 33, tool: rule-based-clusters)"
                     /sec_met_domain="tra_KS (E-value: 6.2e-145, bitscore:
                     473.1, seeds: 44, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_KS (E-value: 1.3e-150, bitscore:
                     491.9, seeds: 2284, tool: rule-based-clusters)"
                     /sec_met_domain="itr_KS (E-value: 1.3e-113, bitscore:
                     369.8, seeds: 96, tool: rule-based-clusters)"
                     /sec_met_domain="ene_KS (E-value: 5.2e-67, bitscore: 216.2,
                     seeds: 19, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 3.5e-56, bitscore: 180.6,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 3.9e-13, bitscore:
                     39.7, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Thioesterase (E-value: 2.3e-23, bitscore:
                     73.4, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSNQQIAVIGMAARMPGSTDIPGFWADLRAGREGLTRFTVEQSL
                     AAGVDPALSRHPDYIPVRGTIDGGDRFDHSFFGYSPAEAATIDPQQRVFLEVASTALDD
                     AGIDPDRLNGWIGVYAGSDITPDHAPGEGELLSRVIGVEKDFVATRVAYKLGLHGPAMA
                     VQTACSTSLVAIHQACSSLLSQDCDVALAGGVSLRLPQWTGYQYSEGHIMSRDGHCRPF
                     DAAGCGTVPSSGAGVVVLRRLEDALTSGDRVLAVIRGWALNNDGGSKVGYTAPSVTGQR
                     DVIRLALGRAGVDPADVGYIEAHGTATKVGDPIEVAALTSAFRESTDRVGTTWLGAVKS
                     NVGHTGAAAGVAGLIKTVLQLRHREIAPTVHYRSPNPDLDLAQSPFRIATEVQPWDTDG
                     PLLAGVSSFGIGGTNAHVVLESAPRSVRPAQTVRPRIFPLSAKSTWALEKLRTSVADAI
                     ATPAPAASVTSSSGDGLGDVAFTLAEGRRRLSHRTAVVAADRDALAAALRTPRDPVRYD
                     GTTPAVSFVFPGHGTLYQAGAAAHRLLPEFRRVFDEAAQIVLERYDIDLAALVTGQPAP
                     VEDITFQQLALFTLGYALGSQLRAWGVRPAAMMGNSVGEYVAAALSEIWSLPDALALVR
                     LRGRAMLSAAPGRMVAVVRQPGKELHVPDGVTLAIDAPHQLVLSGEPEPVTKAYETWVA
                     EGWSCRLLDIDRASHSPMMDGPAEELRAQVATTPTGATDTGDTVVVSTLTGEPVKPGQL
                     TDPGHWAGHLRGTVQLHRAIGSLLDTPCDLVVELGPGQSTLRAVRMHPGWNTATPAVPA
                     LGRAADQETESVLELCATLWEYGVDVDLAGLLDEDEPSITELPAHPYEPKPLPARPTPT
                     AGTAATPAGAGRPGPEPVSPAAGPHPTLTTDAWTSVSRRLSATSAAAVGETLAAELGLP
                     ATDDRFAGLTAPVVVAELPDDDDWNALTGLADRARTAGVHLLLLGRGLFDVLDDSTGPV
                     GIQSAAAEWLSHREAAGDRTTLLDIGHDGRPDWLPAPWPGATRYAWRGSGWWSLLPQSV
                     PVEPVTDTPRVALVTDAPDATVLAADLASAGVRVNALLGGGSLPARPSPGAVAAAQTWR
                     PGAARLSQRPELTAAVDRYCGGLIARFVLDRAGLRPGDRIAGPELRRRLNAGDRLPRFF
                     DFLLRSLVEEDVLRPEPAGSGTDDGYRVVTGPQELLAAGAGLGEVDGLHRLLDSIAAEL
                     PAVFDGEKEPVAVLWPDGDDSMLRSWLPDNRLEIYDGGFCLNALQETVRSLHRTWGDRP
                     LRILEVGGGHGLFTWQLLEGWQDRDNVDYHFTDISTLLVRRAAKYARTKGIGGVRFSTY
                     DMTRDPVEQGLAAGSFDLIIAYNVIHVAPSVHTALGHLRNLLSPAGALSLVEVTKVTRW
                     SHLLWGLAPGWWDFDDDMRSTSIVLDTATWQRALAESGLPEITVVPDGVPSDHTLMIAA
                     PSPTADEDPATPLAPDADLVLSVLRSPDERAALDATARWKSLRSEGPLAATPGVLLSTG
                     PLDGATRALLDSPADADWTHLHADRFGSAVLGALPQALGQPWLPRTVRLRAPEIPDTAP
                     ASATPAMAPTDVPEAPRPARSAPVDTAPAPRAEEAPPTAPAAEAVEPAPADAAPGGTTA
                     ALEELWRHELGVPQARPEDDFFALGGESLAAVHLLARVRDVCGIQVPMSDFTRNPTYGY
                     LAGLVGSAPRPQPGTPQPEQHRPQQRTQPQTAPHRSATAATTLAGTPNLMVLNDTGQGT
                     PLFFSAPAAGSALCYRGLAKHIGDRPFYGLETPGLHDGRAPLNRLQDIADHHVQLIRSI
                     QPDGPYLLGGWSFGMMLSHEIARQIITDGGEVAVLLGVDGYLPNTGGMPMATQPSFLLG
                     GLVYKTQAVFGFGGAQPTVSADSSEPEDRILRIADVTRWRRQRARAGRHEKTAGNFVSV
                     HNRSIDAMLRYVPQPVRCPAVILKAGVNERARLRLRRDLSSLYTAVEVRSIAGDHWTVM
                     DGRNAPDLAGHLNRALRQHDPVSQKENH"
     aSDomain        13471..14721
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_epnH_PKS_KS.1"
                     /domain_subtypes="Hybrid-KS"
                     /evalue="5.60E-150"
                     /label="epnH_PKS_KS.1"
                     /locus_tag="epnH"
                     /protein_end="423"
                     /protein_start="6"
                     /score="491.9"
                     /tool="antismash"
                     /translation="IAVIGMAARMPGSTDIPGFWADLRAGREGLTRFTVEQSLAAGVDP
                     ALSRHPDYIPVRGTIDGGDRFDHSFFGYSPAEAATIDPQQRVFLEVASTALDDAGIDPD
                     RLNGWIGVYAGSDITPDHAPGEGELLSRVIGVEKDFVATRVAYKLGLHGPAMAVQTACS
                     TSLVAIHQACSSLLSQDCDVALAGGVSLRLPQWTGYQYSEGHIMSRDGHCRPFDAAGCG
                     TVPSSGAGVVVLRRLEDALTSGDRVLAVIRGWALNNDGGSKVGYTAPSVTGQRDVIRLA
                     LGRAGVDPADVGYIEAHGTATKVGDPIEVAALTSAFRESTDRVGTTWLGAVKSNVGHTG
                     AAAGVAGLIKTVLQLRHREIAPTVHYRSPNPDLDLAQSPFRIATEVQPWDTDGPLLAGV
                     SSFGIGGTNAHVVLESAP"
     aSModule        13471..18561
                     /complete
                     /domains="nrpspksdomains_epnH_PKS_KS.1"
                     /domains="nrpspksdomains_epnH_PKS_AT.1"
                     /domains="nrpspksdomains_epnH_cMT.1"
                     /domains="nrpspksdomains_epnH_PCP.1"
                     /locus_tags="epnH"
                     /monomer_pairings="mal -> Me-mal"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       13927..13995
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_epnH_0001"
                     /evalue="1.30E-05"
                     /label="PKSI-KS_m3"
                     /locus_tag="epnH"
                     /protein_end="181"
                     /protein_start="158"
                     /score="17.3"
                     /tool="antismash"
                     /translation="GPAMAVQTACSTSLVAIHQACSS"
     CDS_motif       14350..14397
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_epnH_0002"
                     /evalue="4.70E-04"
                     /label="PKSI-KS_m5"
                     /locus_tag="epnH"
                     /protein_end="315"
                     /protein_start="299"
                     /score="12.4"
                     /tool="antismash"
                     /translation="YIEAHGTATKVGDPIE"
     aSDomain        15028..15897
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_epnH_PKS_AT.1"
                     /evalue="1.50E-55"
                     /label="epnH_PKS_AT.1"
                     /locus_tag="epnH"
                     /protein_end="815"
                     /protein_start="525"
                     /score="180.6"
                     /specificity="substrate consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="VFPGHGTLYQAGAAAHRLLPEFRRVFDEAAQIVLERYDIDLAALV
                     TGQPAPVEDITFQQLALFTLGYALGSQLRAWGVRPAAMMGNSVGEYVAAALSEIWSLPD
                     ALALVRLRGRAMLSAAPGRMVAVVRQPGKELHVPDGVTLAIDAPHQLVLSGEPEPVTKA
                     YETWVAEGWSCRLLDIDRASHSPMMDGPAEELRAQVATTPTGATDTGDTVVVSTLTGEP
                     VKPGQLTDPGHWAGHLRGTVQLHRAIGSLLDTPCDLVVELGPGQSTLRAVRMHPGWNTA
                     TPAVPALGR"
     CDS_motif       15256..15375
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_epnH_0003"
                     /evalue="5.30E-17"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="epnH"
                     /protein_end="641"
                     /protein_start="601"
                     /score="53.9"
                     /tool="antismash"
                     /translation="GVRPAAMMGNSVGEYVAAALSEIWSLPDALALVRLRGRAM"
     aSDomain        17299..17817
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_epnH_cMT.1"
                     /domain_subtypes="cMT"
                     /evalue="1.60E-51"
                     /label="epnH_cMT.1"
                     /locus_tag="epnH"
                     /protein_end="1455"
                     /protein_start="1282"
                     /score="166.6"
                     /tool="antismash"
                     /translation="RPLRILEVGGGHGLFTWQLLEGWQDRDNVDYHFTDISTLLVRRAA
                     KYARTKGIGGVRFSTYDMTRDPVEQGLAAGSFDLIIAYNVIHVAPSVHTALGHLRNLLS
                     PAGALSLVEVTKVTRWSHLLWGLAPGWWDFDDDMRSTSIVLDTATWQRALAESGLPEIT
                     VVPDGVPSDH"
     aSDomain        18367..18561
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_epnH_PCP.1"
                     /evalue="2.80E-14"
                     /label="epnH_PCP.1"
                     /locus_tag="epnH"
                     /protein_end="1703"
                     /protein_start="1638"
                     /score="45.1"
                     /tool="antismash"
                     /translation="ALEELWRHELGVPQARPEDDFFALGGESLAAVHLLARVRDVCGIQ
                     VPMSDFTRNPTYGYLAGLVG"
     CDS_motif       18898..18969
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_epnH_0004"
                     /evalue="7.60E-11"
                     /label="NRPS-te1"
                     /locus_tag="epnH"
                     /protein_end="1839"
                     /protein_start="1815"
                     /score="34.4"
                     /tool="antismash"
                     /translation="QPDGPYLLGGWSFGMMLSHEIARQ"
     gene            19515..20810
                     /gene="epnI"
     CDS             19515..20810
                     /codon_start=1
                     /gene="epnI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /note="cytochrome P450"
                     /product="EpnI"
                     /protein_id="AHB38510.1"
                     /sec_met_domain="p450 (E-value: 8.8e-32, bitscore: 100.2,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVTIDPNTFNADPFPLLHRMREEAPVQRAEFLDGLGRPRWLITRY
                     DEALAALNDLRFSSDLFAVMAQGENPQGPETGLVTEAIKRAEAVQGRAMANLDPPDHTR
                     LRKLVVRAFSAKRMEALRPTVQEVTDTLLDAVAGQDEFDLLETLAYPLSIRMVCTLLGV
                     PADGVEVFRGAAAVLAGFMDDDDWARETIRNLEAFDGYVRQLLADKRDDPRDDMLSDLI
                     HSTEEGGRLSEEELVAMAGLMIFAGHETTVQLIINAVLALHLNPQQMAALRADHGLLSS
                     MTDEVMRYDGPINPGINRVALEDIEIGGVTIPKGSSVIIATAAANRDPRAFRDPDRFDI
                     TRSPDTTHLGFGHGIHYCLGARLAKIEAECAIGTLLRRYPRIALATEPENLRWRPGFLR
                     MAEEFRIRVDIPSLSADVPAASPHRAGENVHA"
     gene            20803..22779
                     /gene="epnJ"
     CDS             20803..22779
                     /NRPS_PKS="Domain: AMP-binding (73-469). E-value: 1.9e-94.
                     Score: 308.5. Matches aSDomain:
                     nrpspksdomains_epnJ_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (576-645). E-value: 2.6e-19. Score:
                     61.2. Matches aSDomain: nrpspksdomains_epnJ_PCP.1"
                     /codon_start=1
                     /gene="epnJ"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /note="adenylation domain"
                     /product="EpnJ"
                     /protein_id="AHB38511.1"
                     /sec_met_domain="AMP-binding (E-value: 4.7e-103, bitscore:
                     334.7, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.7e-13, bitscore:
                     40.9, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPDSGSANHSLVENTEGDLSVWPVTRPVPPGWRPTGHQGSHASCL
                     AEADRRGRERLPGALAPPEGNEGTLLELFSRTVKRHPARPAVSDRELTYTYTALNRRSD
                     GLAQALLARGVRPGDHIAYLLPRGVAPFVVLLAVLKTGAAYVPLDPAAPDDRLRLLIDR
                     SGASVVITHPEMTGRLDDLATARVMEYVADDHADPKPGPAAAATPRQAASVLFTSGSTG
                     IPKAVLLEHRNLVQFAENPTLPALTPQDRVGHVSNLAFDAFHWETWCAFAAGAEVVTLP
                     TMPDLISGDMRRELKQRRITAMLVPTLAFNHLAHEQPETFSSLRILATGGDVVSPGSCR
                     DLLAAGFTGQLVNLYGPTEAATACSAHPVTDAEHDGSVPIGRALEGIGLYVLDDNLDEV
                     TPGSVGQLHIGGPGVARGYHGQPGLTAERFLPDPHGTPGGRLYATGDLAVRGEDGLLRY
                     VGRADDQVKIRGYRVEPREVERQLARHHHVRDVAVVVGGEGVDRYLAALVVLYGDSSFA
                     DLREAAASSMPEYMVPSAFISIPEMPSNDRGKRDLGRLREIVTEHQKHRADRVAPSDPV
                     EIRLADFWKDLISVDEVGLNDDFFALGGNSLQAFRLRRRIVKELGVEVSNREILVTSEL
                     SALADLVRSKTGLVLSEKEDDLV"
     aSDomain        21022..22209
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_epnJ_AMP-binding.1"
                     /evalue="1.90E-94"
                     /label="epnJ_AMP-binding.1"
                     /locus_tag="epnJ"
                     /protein_end="469"
                     /protein_start="73"
                     /score="308.5"
                     /specificity="substrate consensus: Leu"
                     /tool="antismash"
                     /translation="FSRTVKRHPARPAVSDRELTYTYTALNRRSDGLAQALLARGVRPG
                     DHIAYLLPRGVAPFVVLLAVLKTGAAYVPLDPAAPDDRLRLLIDRSGASVVITHPEMTG
                     RLDDLATARVMEYVADDHADPKPGPAAAATPRQAASVLFTSGSTGIPKAVLLEHRNLVQ
                     FAENPTLPALTPQDRVGHVSNLAFDAFHWETWCAFAAGAEVVTLPTMPDLISGDMRREL
                     KQRRITAMLVPTLAFNHLAHEQPETFSSLRILATGGDVVSPGSCRDLLAAGFTGQLVNL
                     YGPTEAATACSAHPVTDAEHDGSVPIGRALEGIGLYVLDDNLDEVTPGSVGQLHIGGPG
                     VARGYHGQPGLTAERFLPDPHGTPGGRLYATGDLAVRGEDGLLRYVGRADDQVKIR"
     aSModule        21022..22737
                     /complete
                     /domains="nrpspksdomains_epnJ_AMP-binding.1"
                     /domains="nrpspksdomains_epnJ_PCP.1"
                     /locus_tags="epnJ"
                     /monomer_pairings="Leu -> Leu"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       21208..21249
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_epnJ_0001"
                     /evalue="3.40E-06"
                     /label="NRPS-A_a2"
                     /locus_tag="epnJ"
                     /protein_end="149"
                     /protein_start="135"
                     /score="20.0"
                     /tool="antismash"
                     /translation="LAVLKTGAAYVPLD"
     CDS_motif       21436..21495
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_epnJ_0002"
                     /evalue="2.60E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="epnJ"
                     /protein_end="231"
                     /protein_start="211"
                     /score="23.0"
                     /tool="antismash"
                     /translation="ASVLFTSGSTGIPKAVLLEH"
     CDS_motif       22003..22089
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_epnJ_0003"
                     /evalue="6.80E-16"
                     /label="NRPS-A_a6"
                     /locus_tag="epnJ"
                     /protein_end="429"
                     /protein_start="400"
                     /score="50.3"
                     /tool="antismash"
                     /translation="PGSVGQLHIGGPGVARGYHGQPGLTAERF"
     CDS_motif       22174..22239
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_epnJ_0004"
                     /evalue="7.00E-12"
                     /label="NRPS-A_a8"
                     /locus_tag="epnJ"
                     /protein_end="479"
                     /protein_start="457"
                     /score="37.2"
                     /tool="antismash"
                     /translation="YVGRADDQVKIRGYRVEPREVE"
     aSDomain        22531..22737
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_epnJ_PCP.1"
                     /evalue="2.60E-19"
                     /label="epnJ_PCP.1"
                     /locus_tag="epnJ"
                     /protein_end="645"
                     /protein_start="576"
                     /score="61.2"
                     /tool="antismash"
                     /translation="EIRLADFWKDLISVDEVGLNDDFFALGGNSLQAFRLRRRIVKELG
                     VEVSNREILVTSELSALADLVRSK"
     gene            22776..23981
                     /gene="epnK"
     CDS             22776..23981
                     /codon_start=1
                     /gene="epnK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /note="cytochrome P450"
                     /product="EpnK"
                     /protein_id="AHB38512.1"
                     /sec_met_domain="p450 (E-value: 1.1e-24, bitscore: 76.7,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTPTIDLTDPELFLGEDAPMIFRQLRESDPVHWHPLPDGGGFWA
                     LTRYADIETAYNDHTSLSSEGGPMLGGSFRSAADPSAGRMLVASDLPRQRHIRQQVHRA
                     FSNGMLRRIAHQVTTLVDTAVRRAVADGGCDFATDIATELPAGAIMTMMGVSHTDAHEL
                     IGMTRRMIGFRDPVFVDPGEDERIGLAVVQAEIFEFFAELLSDRRKNPKDDLVSMLLQA
                     RRNGRPWPEEDILFNCLNVAVGGNETSSYTACAGILALHQNPAQKALLQADPELTDSAV
                     NEMLRWSSTNAYVMRQAVREFTIDGRLIQDGDTVTLWNASGNFDETRFPDPDTFDITRT
                     PNRHLSFGVGIHRCIGAMLAQVELGILVRHMTDRRIFFTVSGPVRACGRTSSGAPPAFP
                     SP"
     gene            24307..24594
                     /gene="epnL"
     CDS             24307..24594
                     /codon_start=1
                     /gene="epnL"
                     /note="hypothetical protein"
                     /product="EpnL"
                     /protein_id="AHB38513.1"
                     /transl_table=11
                     /translation="MSTQPEEAVAPPAPTAPAQIYAQLRTDHRADTWAPAFERDWAKAL
                     EDSRHSYSLTPLHNVIRTWQLRVAAASDVDSYMDSDEEEPGFVDLGFLHS"
     CDS             24953..25783
                     /codon_start=1
                     /note="Orf+1"
                     /product="transposase"
                     /protein_id="AHB38514.1"
                     /transl_table=11
                     /translation="MLLRLAYLGVTNAFAMLRLLPMTDRDKDAEILALRHQVTVLERQL
                     GKDRIRFTPSDRAFLAALLHRLPLHVLRKLRLLVRPDTVLRWHRNLVKRRHAASCRPKR
                     LGRPRTVHSIRILVLRLVKENPSWGYRRLHGELLVLGVKVGASTVWEILKEAGIDPAPE
                     RNSSTWTGFLRSQADALLACDFMETVTLSGVRMYVLVVIEHGSRRIRVLGATTHPSASW
                     VAQAAKNLVMDLEDLGCRARFMIRDRTASSPPSSMPYSRTQESTSSSAASRCQG"
     misc_feature    25175..25177
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
ORIGIN
        1 aacctcacga tgacgctggg gtgccggatg gactccctgg acttcctcct ccgtgaccgg
       61 gacagcaagt acaccagcac cttcgacgcg gtcttccagg ccgacgacgt gaggatccta
      121 ctcagcccgc cgcgggcacc aaaggcgaac gcaatctgcg agcgagccgt ggcaccggcc
      181 aacgccaccg acaccgggtc ggggcacgcg ttctgcggcc gggaattcac ggttgcgcat
      241 aagtcatgaa tacaaaggtc acttacccac aaaaacgccc caaaccttcg actatatcgt
      301 gcatatgttc gacgctgata tcaagcccct gggaagtgtt gtgatttcct gggatcgtcc
      361 gtggtgcacg gcgcggcgca gagatcctac gataagttgc gtatagcagg tacttgcgga
      421 ttggcatata cccttgggcc gctcgctgct gtggcacaat ctagcgggcg tcggcgccac
      481 tcgtgctttg ctcttcaagt gctcgctcac tgttcactcg tcgccgtttc tgggcatact
      541 cgatcgaagg ggtagttgtg cctatagccg ttaacgacgt ggaaacattc catagggcgc
      601 tgctcatgca atccggaatc agcatggccg tgattgacac agagggggga attctgtggg
      661 cgagccccag tttccttcat tacttctcgg gagcggggga gaaagtcatc ggggagcatc
      721 tctccggttt cattcatccg ggagcgaagg agcattttgg ttatctaatg gctgaagttc
      781 tggagggtcg gcggatccga ttctccgagg aagtcgccat ggctcggggg aacgggggtt
      841 cgtcgttgga aacctggtgg gtgtggccgt gagcggattc gagggaggcc ctggtctgat
      901 cgctttatgg cagccggacg gtagcttgac ggtgggcgcg agcgataaga gcaaaaaggc
      961 cactctgagc gagatgggcc gcaggatctt agagggtgtg gcgcgtggcc tgtccaccgc
     1021 caaactggca tcccagctcc acatgagcaa gaacggtatc tcgtaccatc ttggcgagtt
     1081 gatgaggcaa ttccaggccg acaaccggac cgagttggtc tccaaggctt attcgatggg
     1141 cctgctcaag atcggaacgt ggccgccggc cacctgacag tacattcctc cgatttgaag
     1201 ggtgatgcat accgtgccca cgcctgtgac ataccacagt attccgggag ccgacgctcc
     1261 ggtccgattg atcgctttcc atcacgccgg gggatcggcc tcctcgtttc tgccggtact
     1321 gaaggagctt ccggacgact gtggtggatt cctctttgag ctcggagggc ggttcggtga
     1381 gtcggaaagt gcgccggccg ccgattttca ttcggcgtat gagcggttcc ttccggactt
     1441 tctccgcctt gtcgaccggc caaccgtggt gatcgggcac agcctcggcg ccctgttcgc
     1501 gcacaatctt gtcgcggcgc ttccgcccga ccgggcggca ctggtcaaga cgcttgtggt
     1561 ctccgcgtcc aaggggccgg tggtggccgc cggggaggct tcgatgcccg ccgctccatt
     1621 ccttgtgcgg tccgcctcca gcgtcatgga ggatctgcgt acgttcggcg gcaccgcccc
     1681 ggagttcctg gaggacccgg agttcgcgga agccgccgtc agccagctcg ggcacgatct
     1741 gcacctggcc gatacctaca tcctgccgcc cggtccacca tccagggtgc cgtacctggt
     1801 ctggtacggg ctggacgact tcaccctggc cgaggcggac cggctggcct ggtcggagtc
     1861 gtgtgctcag cagccggacc acgagggatt ccccggtggc catttctatc tcttcgacag
     1921 gccggaaccg gcggtccggc ttcgggaact gactgacagg ctagccgcgg agggtttccg
     1981 ttgatcggat gtttggtagg ttccgaacac cttcggccca cacagaaagg ggacaccgag
     2041 tgactgggac taccggcggg cagccgctga cgccctggct gttcaccacc ggaacgtcgt
     2101 cgttcatgga gttcatagag aggtacgacc ccgacctgat gcccggtcgc gggaagcgtg
     2161 ccgccggagc cccggggctg acggaggatc agattcccca cggtaccacc gtgctggccc
     2221 tcacatatgc ggacggtgtg atgatggccg gtgaccggcg cgcgacgatg ggaaatctca
     2281 tcgctcagcg tgatctggaa aaggtgtatc ccgcggacga acacacggcg gtggcattcg
     2341 ccggaaccgt aggtctcgcg ctggacatgg tgaagctcta ccaggtcgag ctggcccact
     2401 tcgaaaaggt cgagggtacg gcgatgaccc tggacggcaa ggccaaccgg ctggccacca
     2461 tgatccggaa caacctcggc caggccatgc agggtctcac cgtagtaccc atgctcgccg
     2521 ggtacgacct actcgccccg gagggcaagc agggtcggat cttcagctac gacgtgaccg
     2581 gcggaccgta cgagatgcag gacttccaca ccgtgggatc cggttctccc tatgcccggg
     2641 gagcgttgaa gaaactctac cggccggggc tctcgcgccg ggaagccgcg ctggccgcgc
     2701 ttcaggcgct gtacgacgcg gcggacgacg acacggcgac cggcggcccg gacatctccc
     2761 ggcggatatt cccgatcgtc gcgtcgatca ccgaggaagg ctacgagcgg atggacgagg
     2821 cgaataccga ggaactgagc cgtctggtgg tcgagcagcg gtcacgccag ccggaaggac
     2881 ccactgtcgc cctgtgaacc ggcagcctcc tgccacaccg tcccggaggg gcgggcccga
     2941 atcgggcccg cccctccggc atttccgcgt ccgggtgttc ccgttcatat ccggcggtgg
     3001 ggatctcacc cctgccgtaa cgactcgcca tgcaagatac acctcggttc ccttcctgtc
     3061 ccgccctaaa cgcttggagt gtacataggc ggacacgaaa ttctcggaaa tctccgagta
     3121 gggtcatggg tgattaagat gacggggaat tcccttgcat ggagcaggaa atgggcgaca
     3181 gtaagtcggt gaattgtttc gctggcgagg ctcactggga ttcttggtgg gcatcgacga
     3241 gtgcgtggaa ttctgccgac gcccgggcgg gcatgacact tgaccaggga ggttcgtaca
     3301 tgccggtgag gtacgaggag agggaacggg cggtggtggt ggcgggtgtc ggcggatggg
     3361 tgcctccgga cgttgtcacc aatgacgatc tgtgcgcccg cctcgacacg tcggacgagt
     3421 ggatccgcac ccgtaccggt atcagaaccc ggcacgtgat ctcccccggt atggccacat
     3481 cggatctcgc gttcgaggcg ggccggaggg cgctgggatc cgcggacgat cgggagatag
     3541 gagcagtcgt gctcgccacg accactcccg accggccctg cccggccacc gcgccggacg
     3601 tggcggcccg tctcgggctc gtgggagtgc cggctttcga catttcggcg gtctgcgccg
     3661 gtttcctcta cggtctggcg acagcggcgg ggctcatcgc ctcagggacg gcgcggcagg
     3721 ttctgctgat cggggcggac gccttcacta ccatcgtcga cccgaaggac cgttccacag
     3781 cggtgatctt cgcggatggg gcgggcgccg tggtgctgcg agcgggccgg gccgacgagc
     3841 ccggtgcggt gggtcccgtg gtactcggca gcgacggcag gttcgcacac ctcatccagg
     3901 tgccggccgg tggttcacgc cagcgttccc ggagccggtc ctgcggcccg ggcgaagagt
     3961 ttttccagat ggagggacgt gacacgttcc ggcaggccgt ggagcggatg tcggcggcat
     4021 cccggcacgc cgtcgagtcc gccggctggt ccctggaaga cgtcgaccgg ttcgccgccc
     4081 accaggccaa cgcccggatc ctcgaggccg tcgcggacga gctggccata ccggccgggc
     4141 accggttgtc gaacatttcc cgggtcggta acaccggcgc cgcctccatc ccgctgctgc
     4201 tcgcccaggc cgctgaggac agcagtcttg ccgaagggca ccggaccctg ctcaccgcgt
     4261 tcggcggcgg actcgcctgg ggcgcggcca cgctcacttg gcccaagctg cccactgcct
     4321 gacaccccct acacagagga atgggacgtc ccatgttcga gacgctcaaa gaagtactgg
     4381 tcggcaaact caaggcggcc tcggagaaga tcaccccgga ggccaccgtc gaggaggccg
     4441 aactggattc gctgtccatc gtcgaactct ccatcatcct ggagaaggat ttcacgatca
     4501 cgatcactga cgacgagctg ctggccgccc ccacgatcgg cgacatggcg aagctgatag
     4561 aggaaaggaa cgcggcggcc tgacgtcggc gcggacggga ggacgccccc gtgcacgggc
     4621 gaatcgcgaa gcggcgccgg gcggcccgat gcccggcgcc ggtcgcggcg cgggcgtcga
     4681 tgctccgtac ggtctcatcg ccgtcgcccg atgcgctgtg gttcccggcg tgccggcgtc
     4741 cgtccggaaa cgtgttccca cgcaggaacg cgcggggagg gaacctcacc gtcgactccg
     4801 accgggcagc gggagaatct ccgtgccgtc cgccacgacg agggtgggac tcagggtgat
     4861 cggctccggc cgccgctcgc gtgatcccgc ggcacgttca ccggaaagac gggggccgct
     4921 cacccgctgc cgggccctgc cgaaggcctc tgagcggcag cctgccgacc ggacggacct
     4981 gagcgccgat accggagtcg tcgaatacgc cggaaggcgg cgcggggatg gcgccgttcc
     5041 cccctttccc gctggtatca cccgctcacc ggtggcgttt ggtcgaacgc atggtgaaca
     5101 aaacttacgg aacccccgtt tcccctcctg tctcgttcta aacatccaga gtgtgcataa
     5161 gtggacacga agtgcgcgaa aatctctggc tagagttatg tgtaattgac ctgagggcag
     5221 gaaccatcgt cataggcggg tccggagtga gtgacagcaa atcggttaac ctattccatc
     5281 ggcacggggt tccgagcttc ctggagggga tctaccaggg tcggttcgaa tgggacatga
     5341 taagtaattt cgttgcacag gattccgctg atgaaaaggc gggagacgcg gcagtggaac
     5401 gcctgacaga tatcctcagg aaccgggtga accccaccgc cgtcgacgcc acccgggaac
     5461 tcccggaagg cctgctcgag gagctgcgcc gcaccgggtt cctgaatctc caggactccc
     5521 cggacatagg cggtctgggt ctctcgagct acaacacctt ccgggtcgtc caggcggcgg
     5581 cgagctggtc ggtgccggtc gcgttggtcc tcgggatcca gacagccgtc ggctccggaa
     5641 catacctgcg ggcgctgccg cccggcgaac tgcactccta cgtcgaacag cggctgctgg
     5701 acggcatcat ctccggttcc gccgacaccg agcccgccgg cgcctccaac agcgcccggc
     5761 ggacccgcgc tgtccctacc gacgacggag aagcgttcct cctgaccggc gagaagatcc
     5821 acatcggcaa cggccccatc gcggacatcg tgaccgtctc cgcgatgctc gacgaggacg
     5881 ggcaggaccg gccccggctg ttcttcgtgg agacctccga cccggggttc agcatccgct
     5941 cccgccacga gttcatgggc gtcaaaggct tccccaatgc ggcactggtg ctggacggcg
     6001 ttcgggtgcc ccgcgaacgc atgatcgtcg aggtcgaccc ggacaccgag gtacgcatca
     6061 ccgcggaact caccatggcc gtggtccggg gccgactgca tctgatcacc gccccctcac
     6121 tcgccatctc caaactctgc ctggaatggt ccaggaactt cgtcaaccgg cgcacgatcg
     6181 acggccgccc actgggggcc cgggaagaaa tccagcacat ggtctcttcc accatggccg
     6241 atgtcttcgc gatccaggcg ctcgccgaat ggagtctgct ccccgccgac caacccgatc
     6301 tcgggctcaa cgtggcgttc gaacagaacg tcaccaaagc gatcagtgcg gagatctgct
     6361 ggcgggccgc cgaccgcacc atggacctgc tggccggaga ggggttcgag acagctccca
     6421 gcaaagcgcg gcgcggcgcg ccggcccttc cgctggaacg cttctaccgg gacgccagaa
     6481 acctccggat ctccggggga gtgtcattcc tgctccaatt ctgggccgcc cgcatgagtc
     6541 agttcaccta ttacggaccg gaccatgccg ggcaatcggc cgccctctcg caggacggcg
     6601 gacaacaacc gtgcaccgac ggcctcgacc cgttgaacgc ggaccacctg cgattcgccg
     6661 cggccgagac ccggcgcctc ggcgccgcct gccagaagtt cgccgctgac catcccgcgc
     6721 cgggactgta cgaacaccag caccgcctca tcgcgttcag ccggatcgcc gacgagatcc
     6781 tgaccatgtc cgtggtcctg gccaaggcag cacgcctgca ccacgagggc cgcaccgagg
     6841 cccaggacct cgcggccatc tattgcgcgc acgccaggga ccgcctcgcc gccctgtggc
     6901 ggcaggccga gcccgtgacg gccggccccg atcacgccgc cgtgagcgac gcctggctca
     6961 gtggcgacga cacgtacgcc tccctgatca caggcgtgat cactgatgta ccgcccacag
     7021 ccgacactca cccggggaag cgatgaacaa ggaaaaggac cggcgcgagg agagcctgtc
     7081 gccgggagct tcccggaccg gcacggcgac cacacccggc caccggcttc cgctctccgt
     7141 cgaccagcag gccgtctggg tgcactggca ggtcgacccg gaccggtcca gccacatcat
     7201 ccacatgccc atgctggtgg atgagggcga gctggacctc caacgggtcc acgcggcggc
     7261 ggcggcgctc gggcaacgct tcccgatgct gcgcggcagg atcgtggaga gcggggacga
     7321 gaccgaactg cgctgggacg acgcccccgc catcccggtc accgaggtgc ggacggacag
     7381 cccgtgggct gagacggtga gccgccacgg cgcggcccgc ttcgacctgc accaggggcc
     7441 gctggcccgg atccaggtgc tgcacgggcc cgactacgtg gtcctgctca tcgacgtcca
     7501 ccacatcgtc ttcgacggac gcgcctgcgg cccgttcctg gccgccttcc gggacgccta
     7561 cgccgggaag gacctcggcc ccgccgataa caccgaggcc cacgtcgagt tcgcccgcag
     7621 gcagcacgaa ctgacccacg gcccggaggg cgagaagcac cgggaacact ggcgccggac
     7681 actgggcgag gacctccccg cgccgctgaa gctgccgggc gggcccggcg agcccacgtt
     7741 ccacgaagtc gccctggacc ccgcgctgat cgccgccgcc cacgagacgg ccaccgccgc
     7801 cagggtgcac ccgatgatcc cgctgtacgc cgccttctgc ctgctcatcc gggaccgcac
     7861 cggccaggag gacctgatcg tccccacgcc gtaccacggc aggacccggg aactgcgcga
     7921 ccgcgtcggc tacttctcca acgtactgcc gctgcgccac cggctgccca gcggtatcag
     7981 caaccgtcag gtcctgcggg acctgcacca caatctgcgc gacgccgtcc ggcacggcag
     8041 cctgccctac cccgcgctgc tgcgcgccgc cgggctcacc gggcagcagg cccgcgccca
     8101 cgtcggccag gtcatcttcc agtactggcc cgcccctccg caggacgaga tcgatctgac
     8161 cgcactccgg ctgaccggcc cggacagcga cgcagtgctg cgactgctgg ccacggagga
     8221 ttacgccgac cacacgctga ccgtgatgct gcgggaggac ccccgcggca ccagcgtgat
     8281 ctggaaagac cccacagggg ccgtcggacg cgacaccgtg gaacaactgg ccgccgccta
     8341 cccggtggca ctggccgaac tcatcgccga cctcgagggc acggtcggtg cgaccgcccc
     8401 ggactccatc gccgccgcag accggccgtc acccgagaca ctgctggcga aggaactggc
     8461 atggaacgcc accgacgcgg acttcccgga tacgtccctg cccggactgc tgcggacacg
     8521 cgcggccgcc acgccggacg cgatcgccat ctcggacggc acgcagcgac tgacctacgc
     8581 cgagctgacc gaccgcgccg ggaccctcgc ccgggggctc gccgcccggg gcgtgcgccc
     8641 cggcgatctg gtgggactgc tgctgccacg cggtatcgca caggtggaag cggttctcgg
     8701 caccctgttc gccggagcgg tgtacgtacc gctggacgtg gcggcgcccg cggagcgcca
     8761 tcagatgatc ctcgaggaca gcgcggcggt ctgcctggtc accgacgggc accatgacgt
     8821 cgcaggcttc accggtccgg tgatcgcgct ggacgagctc cgagacgcac gggacgggga
     8881 actgccggat atcgaccccg gctctcccgc gtacgtgatc ttcacctccg gcaccaccgg
     8941 gcgccccaag ggcgtggtga tcactcaccg caatgtggtg cggctggtgg tcaacgaccg
     9001 gctgccctac gacttcggtc ccggcgacgt gtggacgctg ttccactcct acgccttcga
     9061 cgtctcggtc tgggagatgt tcggctgctt cgcgcacggc ggacgactgg tggtggtggg
     9121 cagcgacgag gcccaggacc cgcagcgcct cctcaccctg ctgcgctccg agaacgtcac
     9181 cgtactcagc cagacaccca gcgccttcgc ccagctcaac ggcgtgcacg ggacagggca
     9241 ggcgccgctg gactccctgc gctacgtgat cttcgcaggc gagaaactcg atcccggaca
     9301 cctcgccggc ttcgccgccc gtcacccgcg cacggccctg gtcaacatgt acgggatcac
     9361 cgaggtcacc gtccacacca ccttccgcaa gatcaccgac cgggacatcg agaccggccg
     9421 cagcaatgtc ggcgtaccgc tgccgacgac cagcctcttc atcctcggcc ccgaccggga
     9481 gccgctcgcg cccggcgaga ccggagagat ctgggtgggc ggtctcggcg tcgccgacgg
     9541 atatctcaac cggcccgagc tgaccgcgca gcgcttcctc cccaacccgt tcggcgaggg
     9601 aaccctgtac cgcagcggcg acctggcccg ccgcctgccg gacggcaccg tcgagtacgt
     9661 cggacgggcc gaccagcagg tcaagatacg cggctaccgg atcgaacccg gcgagatcga
     9721 gacgctgttg ctcgaccatc cggcggtcga aggcgccgtc gtcctgcccg aggcaggccc
     9781 cggcagtgac cagcaactcg tcgcgtacct ggtgccgcac ggtactccgc ccaccaccgc
     9841 ggccctccgc ggtcacctcg cggtgcgcct gcccgactac atgctcccgg cccggttcct
     9901 caccgtggag agcctccccc tgacggtcaa cgggaagatc gacacgaagc ggctgcgaga
     9961 ggtcggaacg ccgctggaga ccggccagga caccgacccg ccgcgcaccg cgaccgcccg
    10021 cgcggtggcc gaggtctggt cggacctgct gaaggtccgc gccccgggcg ccgaccagtc
    10081 cttcttcgaa ctcggcggcc actccctgct cgccgcccgg acgctgcggg agatcgccaa
    10141 gcggctcgac agggacgtac cgccgctgcg gatgttcttc gagcacccgg tgctccagga
    10201 tttcgccgac gccttcgacc ggctcgcgga cggaccgctg cccgcgccgg cccccgcgcc
    10261 gaccgcgtcc ggggagccct tgcccgcttc cggcttccaa cagcggatct ggttcgacga
    10321 acagttcctc gaaggcgggg gcctctacca ggtgccgatg gtgtggcggg tccggggacg
    10381 gctggatccg gtcgttctgc gcacagcctt gtaccggatg accgagcgca acgagatcct
    10441 gagaaccgcc ttcgtccagc gtgacggcgc cctgtggcag gaacccggtg ccccctggca
    10501 gccggaggtc gtccaccaag acctgaccgg gatcgccggg cacgaccggg accgcgaggt
    10561 gaccgagcgg ctgcgggccg ccgcccggga acccgtcgac ccgggctccg gcatgctcct
    10621 gcgcgtcacc ctgttcgacc tgccgggtga ggaacagctc ctcctgctca acacccacca
    10681 cctggtctgg gacggcggct ccgcccaccc cttcctgcac gaactcgccg actgctacgc
    10741 ccagtcgctc gccccctccg ggccgccgcc cgcgctgcgg ccgcagtacc gggacgcggt
    10801 cggccacccg gtcgaccccg cggggctcga ccactgggcc gcccgactgg acggtgcccc
    10861 cgcccacccc gggttcgaac cgcccctcac ccccgggccg aacggcacga ctcccgtacc
    10921 cctacccccg caactttcag accgtttggc ggaattgggg aagcgtcacg gtgtgagccc
    10981 ggccatggtc ttcgcggccg cgctcgccgc cgcactgcac ggctggaccg gtcaggacga
    11041 cgtgaccttc ggaacaccgg tcgccgggcg acttcatgag gagtacgccg atgtcatcgg
    11101 gccgctgctg aacaccgccg tactgcggtc cacaacccgg cagggcgaga ccgtcggcga
    11161 actcctcggt cggctgcgtg acaccgtcct cgacgcgatc gaccaccagg aggtcccctt
    11221 cgaggacgtg gtggagcgcc tcaacccgcc gcgccgcccc ggctggagcc cctacgtcga
    11281 ggtcatgctc gcggtggagg cggagccggt gaccccggtg ccggtgggcc ccggccaggt
    11341 gaccccgtat gtcttcgagg acccggaggc gaaccatctc gcgaagttcg cgctgaccgt
    11401 gagcttccgc gaggaagacg gacgcttcac cggaaatatt gcataccggg gcgaccggat
    11461 ttccgtcgag gtctcccggg ccttcgccgg actgctgggc cggacgatag aggcactgtg
    11521 cggcccgccg tcgcaacgcg tcgacgcggt gcctctgctc ggccccgagg agtaccggcg
    11581 gatcaccgcc ttcgagaacg gcgcaccggc cgcgccggcc accacactgc cctcgctgct
    11641 ggccgagcgg atctccgagc tgcccggcgc accggccgtc gaatcctcca ggggcgttct
    11701 cagctacggc gaactgcacg cacgcgccct acagttgtcc gcacgcatcc ggatcgccgt
    11761 cgagggacgc gagccgatcg tggccatcgt cctgggccgt ggcgaggacc tggtgacggc
    11821 catgctcgcc acctggtatg cgggctgcgc attctgcccg atcgacccgg actacccgga
    11881 cgagcgcatc cggctgaccc tcgaggacgt cgcggccggt gccgtcatca ggggaccggg
    11941 ccgacgtccc gacaccgggc gcatcccggt cctggacatc ggcgacccgt ccgcgtacga
    12001 gggggacacc gcggcgcccg agccgcacac ccctgacccc gaagcgcccg cctacgtgct
    12061 ctacacctca gggacgaccg gacggcccaa gggagccgta ctcagccacc acggcctggc
    12121 tcagctcgcc ctgtggcacg ccgaggcgta cgacgtgacg cctcaggacc gggcgagcca
    12181 tctgtccagc gtgggcttcg acgccaccca gtgggagatc tggccctatc tggccgccgg
    12241 agcctgtgtg gtggcccacg agaagcgcgt cgtggtgccc gagttggcac cgtggctcgc
    12301 cgagcggcgc atcaccatga cctatctgtc cactccggtc gcagaggcgg tgtggggaac
    12361 cggagcagac cttcccgcgc tgcgctggat gctgttcgcc gccgcggccc agacccggcg
    12421 cccgcccgcc ggtctcggct accgggtcgc caacaactac gggcccacgg aaggcagtgt
    12481 ggtcgccacc tggcagcccg gcccgacacc cgaggacgcg ccgctgaaca tcatcggccg
    12541 cccgatcgcc ggcaagtcgg tatacgtcgt ggacccggcc gggcgccgct gcccgcccgg
    12601 agtgatcggt gaactgctca tcggcggggt cggcatcgcc ctggagtacc ggggcaaccc
    12661 ggagctgtcc cgggagcggt tcctgccgac cggccccgat ggagccccgg gccccgtcta
    12721 ccggaccggt gaccgggccc gctggcggga ggacgggaca ctggagttcc tcggccgtat
    12781 ggaccgccag ctcaaggtgc gcggtcaccg gatcgaaccc caggaggtcg aggcgggact
    12841 gctcgccgat cccctggtgc agcgcgccta cgtgtcgggg gacgcgacga ccctggtcgc
    12901 ccatgtggtc cccgccgccc agggcggccg ggacagccga cgtgtcctgg acgggctcgc
    12961 ggcccgtatg cccgcgcacc tggtgcccga tgccctgatg tggctcgacg aactgcccac
    13021 gaccgcgcac gggaaggtcg acgtggcccg gctgccccgg cccggccgtg acgacctggc
    13081 gggcgcgcgc aactgggtgg aaccctcgga tcgtctggaa cggcggatcg ccgccgtctg
    13141 ggaagcggtc ctggacctcg aacgggtcgg ggccgcggac aacttcttcg acctgggcgg
    13201 caactccctg aagctggcca ccctgcatgc ccgtctgctg aaggaattgg accgggagat
    13261 ccccgtacac cggctcttcg aattcccgac ggtacgtcag ctcgcccgtt tcctcgcccc
    13321 aggaggcgac ggccccgacg cgtcctcacc ggccgcccgt gacgacatcg ccgcacgggc
    13381 cgcccgctgg cgatcccccg caccgcggca gtcgcccgca gcccatggaa ctccccggag
    13441 gaaccgcaac tcatgacgtc gaatcaacag atcgcggtca tcggcatggc cgcgcgcatg
    13501 cccgggtcca cggacatccc cggtttctgg gcggatctca gggcgggccg ggaaggactg
    13561 acccggttca ccgtggagca gtccctcgcg gccggggtgg atcccgcgct gagccggcac
    13621 cccgactaca tccccgtgcg cggcaccatc gatggcggtg accggttcga ccactccttc
    13681 ttcggctaca gcccggccga ggccgccacc atcgatccgc agcagcgcgt gttcctggaa
    13741 gtggcgtcca ctgccctcga tgacgccggc atcgacccgg accggctgaa cggctggatc
    13801 ggggtctacg ccggaagcga catcaccccg gatcacgcac ccggtgaggg ggagctgctg
    13861 agccgggtga tcggggtgga gaaggacttc gtcgccacca gggtcgccta caagctgggg
    13921 ctgcacggcc ccgcgatggc ggtgcagacc gcctgctcca cctccctggt cgccatccat
    13981 caggcatgca gcagcctcct gtcgcaggac tgcgacgtgg ccctggccgg gggggtctcg
    14041 ctgcggctgc cccagtggac gggctaccag tacagcgagg gccacatcat gtcccgggac
    14101 gggcactgcc gccccttcga cgccgccggc tgcggcaccg tgccgagcag cggggccggg
    14161 gtggtcgtac tgcgccgcct ggaggacgcg ctgacgagcg gggaccgggt cctcgcggtg
    14221 atccgcggct gggcgctcaa caacgacggc gggtccaagg tcggctacac agcgccctcg
    14281 gtcaccgggc agcgggacgt catccggctg gccctgggca gggccggcgt cgaccccgcc
    14341 gatgtcggct acatcgaggc gcacggcacc gcgaccaagg tcggcgaccc gatcgaggtg
    14401 gcggcactca cctcggcctt ccgggaaagc accgaccgtg tgggcaccac ctggctcggc
    14461 gcggtgaaga gcaacgtcgg ccacaccggc gcggccgccg gggtcgccgg actgatcaag
    14521 accgtccttc agctccgcca ccgggagatc gccccgacgg tgcactaccg ctcgcccaac
    14581 ccggacctgg acctggcgca gagccctttc cggatcgcca ccgaggtaca gccgtgggac
    14641 accgacgggc cgttgctcgc cggtgtgagc tccttcggca tcggcggcac caacgcccat
    14701 gtggtcctgg agagcgcgcc acgctccgtc cggcccgccc agaccgtccg gccccggatc
    14761 ttcccgctgt ccgcgaagag cacctgggca ctggagaaac tgcggacatc ggtcgccgac
    14821 gcgatcgcca cgcccgcccc cgccgcgtcc gttaccagct cctccgggga cggcctcggc
    14881 gacgtggcct tcaccctggc cgaaggacga cgcaggctgt cccaccgcac ggcggtcgtc
    14941 gccgccgacc gggacgcact cgccgccgcc ctgcgcacac cccgcgatcc ggtccggtac
    15001 gacggcacca cccccgccgt ctccttcgtc ttccccggcc acggcaccct ttaccaggcc
    15061 ggagccgccg cccaccggct cctgcccgaa ttccgcaggg tgttcgacga ggccgcgcag
    15121 atcgtcctgg aacgctacga catcgacctg gcagccctgg tcaccggcca gcccgccccc
    15181 gtcgaggaca tcaccttcca gcaactcgcc ctgttcaccc tcggatacgc gctgggcagt
    15241 cagctacgcg cctggggagt gcggcccgcg gcgatgatgg gcaacagcgt cggcgagtac
    15301 gtcgccgccg cgctctccga gatctggagc ctcccggacg ccctggccct ggtccgcctg
    15361 cggggccggg cgatgctgtc cgccgccccc ggccggatgg tcgccgtcgt acggcagccg
    15421 ggcaaggagc tccacgtgcc ggacggcgtc accctcgcca tcgacgcccc ccatcagctc
    15481 gtgctgtccg gcgagccgga accggtgacc aaggcgtacg agacctgggt cgccgagggc
    15541 tggtcctgcc ggcttctgga catcgaccgg gcctcgcact cgccgatgat ggacggcccc
    15601 gccgaggaac tccgggccca agtggccacc acccccacgg gcgccacgga caccggggac
    15661 accgtcgtcg tctccaccct caccggcgag ccggtgaaac ccggacagct caccgacccc
    15721 ggccattggg ccggccatct gcgcggtacc gtccagctcc accgcgccat cggctcgctc
    15781 ctggacaccc cctgcgacct cgtcgtcgaa ctcggccccg gacagagcac gttgcgcgcc
    15841 gtacggatgc accccggctg gaacaccgcc acccctgccg tcccggccct gggaagggcc
    15901 gccgaccagg aaaccgaaag cgtcctggaa ctctgcgcca ccctctggga gtacggagtc
    15961 gacgtcgacc tggccgggct gctggacgag gacgagccct ccatcacgga actgcccgcg
    16021 cacccctacg agccgaaacc gctccccgcc cggcccaccc ccacggccgg taccgccgcc
    16081 acccccgccg gggcagggcg ccccggcccc gagcccgtgt cccccgccgc ggggccccac
    16141 ccgacactga ccacggacgc ctggacctcg gtctccaggc gactgtccgc gaccagcgcc
    16201 gcggcggtcg gtgaaacact cgccgccgaa ctgggcctgc cggccacgga cgaccggttc
    16261 gccgggctca ccgcgcccgt cgtcgtcgcc gaactgccgg acgacgacga ctggaacgcg
    16321 ctgaccggcc tcgccgaccg ggcccgtacc gccggagtcc acctgctgct gctgggcagg
    16381 ggactgttcg acgtcctgga cgacagcaca ggaccggtcg gcatccagtc ggcggctgcc
    16441 gaatggctca gccaccggga ggccgccggg gaccggacca cgctcctgga cataggccac
    16501 gacggccgcc cggactggct ccccgcccct tggccgggtg ccacccgtta cgcctggcgc
    16561 ggcagcggct ggtggtccct gctgccccag tcggtccctg tcgagccggt gaccgacacc
    16621 ccccgggtgg cgctggtcac cgacgccccc gacgccaccg tgctcgccgc ggacctcgcc
    16681 tcggcgggcg tcagggtcaa tgccctgctc ggcggtggct ccctgcccgc gcggccgtct
    16741 cccggcgcgg tcgcggccgc ccagacctgg cggcccggcg ccgccaggct ctcccaacgg
    16801 cccgagttga cggccgcggt cgaccgctat tgcggcggcc tcatcgcccg ctttgtcctg
    16861 gaccgcgccg gactgcgccc gggggaccgg atcgccgggc ccgaactgcg ccgccggctc
    16921 aacgccggtg accggctgcc ccgtttcttc gacttcctgc tgcgttctct cgtcgaggaa
    16981 gacgtcctgc ggcccgaacc ggcgggcagc ggcaccgatg acggctaccg ggtcgtcacc
    17041 ggtccgcagg aactgctggc agcgggcgcc ggcctcggcg aggtggacgg cctgcaccgg
    17101 cttctcgaca gcatcgccgc cgaactgccc gcggtcttcg acggcgagaa ggaaccggtc
    17161 gccgtgctct ggccggacgg cgacgacagc atgctgcgct cctggctgcc ggacaaccgg
    17221 ctggagatct acgacggcgg cttctgcctg aacgcccttc aggagacggt ccgttcactc
    17281 caccggacct ggggcgaccg cccgctgcgg atcctggagg tcggcggcgg acacggcctg
    17341 ttcacctggc aactgctcga aggctggcag gaccgggaca atgtcgacta ccacttcacc
    17401 gacatcagta cgctgctggt gcgcagggcc gccaagtacg cacgtaccaa gggcatcggc
    17461 ggggtgcgtt tctccaccta cgacatgacc cgcgacccgg tggaacaggg actcgcggcg
    17521 ggcagcttcg acctgatcat cgcgtacaac gtcatccacg tcgcaccctc ggtgcatacc
    17581 gccctggggc atctgcggaa cctgctgtca ccggccggcg cgctctccct cgtcgaggtc
    17641 accaaggtga cgcgatggag ccatctgctg tggggactgg caccgggctg gtgggacttc
    17701 gacgacgaca tgcggagcac ctcgatcgtc ctggacacgg cgacctggca gcgggccctc
    17761 gcggagtcgg gactgccgga gatcactgtg gtcccggacg gcgtcccctc ggaccatacg
    17821 ctgatgatcg cggcgccgtc ccccacggcg gacgaggacc ccgccacgcc gctcgccccc
    17881 gacgcggatc tcgtgctgtc cgtgctgcgc tcgcccgacg agcgggcggc actcgacgcc
    17941 acggcccgct ggaagtccct acgttccgaa ggaccactcg cggccacccc gggcgtgctg
    18001 ctgagcaccg gcccgctgga cggggccacc cgcgccctgc tggactcccc ggcggacgcg
    18061 gactggacac atctgcacgc cgaccggttc ggctccgcgg tactcggcgc gctgccccag
    18121 gcactgggcc aaccctggct gccgcgcacg gtccggctgc gcgcaccgga gattccggac
    18181 accgccccgg cttccgccac accggccatg gccccgaccg acgtcccaga agccccgcgg
    18241 cccgcgcgtt cggcgccggt cgacaccgcc ccggcccctc gcgcggaaga agccccgccg
    18301 acggcccccg ccgccgaggc ggtggagccg gccccggccg acgccgcccc gggcgggacc
    18361 accgccgccc tggaggagtt gtggcgtcac gaactgggtg tgccgcaggc ccggcccgag
    18421 gacgacttct tcgccctcgg gggcgagtcg ctcgccgcgg tccatctgct ggcccgggta
    18481 cgggacgtgt gcgggataca ggtgccaatg tccgacttca cccgtaaccc gacctacgga
    18541 tacctggcgg gcctggtcgg ctccgcaccg cgcccgcagc ccggcacacc gcagccggaa
    18601 cagcaccggc cacaacaacg gacacagcca cagaccgcac cgcaccggtc ggctacggcc
    18661 gccaccacac tggccggcac accgaacctc atggtgctga acgacaccgg ccagggcacc
    18721 ccgctcttct tctccgcccc agctgcgggc agcgccctgt gctaccgcgg actcgccaaa
    18781 catatcggcg accgaccctt ctacggcctg gagaccccag gtctgcacga cggacgcgcg
    18841 ccgctgaatc ggctgcaaga catcgcggac caccatgtcc agctgatccg gagcatccaa
    18901 ccggacggcc cgtatctgct cggcgggtgg tcgttcggca tgatgctcag ccacgagatc
    18961 gcccgtcaga tcatcaccga cggcggagaa gtcgccgtgc tgctcggggt ggacggatat
    19021 ctcccgaaca ccggcggaat gcccatggcc acccagccca gcttcctcct cggcggcctg
    19081 gtctacaaga cccaggcggt gttcgggttc ggcggcgcgc agccgacggt gagcgcggac
    19141 agctcagagc cggaagaccg gatactccgt atcgcggacg tgacccgctg gcgcaggcag
    19201 cgggccaggg ccggacggca cgagaagacg gccggcaact tcgtctccgt gcacaaccgc
    19261 agcatcgatg cgatgttgcg ctacgtcccc caaccggtcc gctgccccgc cgtcatcctc
    19321 aaggccgggg tgaacgagcg cgcccgcctg cggctgcgcc gcgacctgag cagcctctac
    19381 accgccgtgg aggtgcgatc gattgccggt gaccactgga ccgtgatgga cggccgcaac
    19441 gccccggacc tcgccggaca tctcaaccgg gccctgcggc agcacgaccc cgtatcgcag
    19501 aaagagaatc actgatggtg acgatcgacc cgaatacgtt caacgccgac ccctttccgc
    19561 ttctccaccg tatgcgggag gaagccccgg tccagcgggc cgagttcctt gacggcctgg
    19621 gacggccacg ctggctgatc acccgctacg acgaggcact ggcggcgctc aacgatctcc
    19681 ggttcagcag cgacctcttc gcggtcatgg cccagggcga gaacccccag gggccggaaa
    19741 ccggcctggt caccgaagcg atcaagcggg ccgaagccgt acagggccgg gcgatggcca
    19801 acctcgaccc gcccgaccac acccggctgc gcaagctggt cgtcagggcg ttcagcgcca
    19861 agcgcatgga ggcgttgcgc cccacggtcc aggaagtcac cgacaccctg ctggacgcgg
    19921 tggccgggca ggacgagttc gacctgctgg agacactcgc ctacccgctc tccatccgaa
    19981 tggtgtgcac cctgctgggc gtgccggcgg acggcgtcga ggtgttccgc ggcgcggccg
    20041 cggtgctcgc gggcttcatg gacgacgacg actgggcccg tgagaccatc cggaacctgg
    20101 aggctttcga cggctacgtg cgacagctgc tggccgacaa acgcgacgat ccccgcgacg
    20161 acatgctcag tgatctcatc cactccaccg aggagggcgg tcggctctcc gaggaggaac
    20221 tggtcgcgat ggccggcctg atgatcttcg ccgggcacga gaccacggtg cagttgatca
    20281 tcaacgcggt cctcgccctg cacctgaacc cccagcagat ggccgccctg cgcgccgacc
    20341 acgggctgtt gtcctccatg acggacgagg tgatgcgcta cgacgggccg atcaacccgg
    20401 gcatcaacag ggtcgccctg gaggacatcg agatcggcgg ggtgaccatc cccaagggct
    20461 cgtccgtcat catcgccacc gccgctgcca accgcgaccc acgggcattt cgcgacccgg
    20521 accgcttcga catcacccgg tcgcccgaca ccacccatct gggcttcggc cacggcatcc
    20581 actactgcct cggagccagg ctggccaaga tcgaagcgga gtgcgccatc ggaaccctgc
    20641 tgcgacgtta cccacggata gccctcgcca cggaaccgga aaacctgcgg tggcgcccgg
    20701 gattcctccg tatggcggag gaattccgga tccgggtcga catcccgtcc ctgtcggcgg
    20761 acgtgccggc agcctccccc caccgagcag gagagaacgt ccatgcctga cagcggctcc
    20821 gcgaaccact cgctggtcga gaacaccgag ggcgacctca gcgtctggcc cgtgacccgg
    20881 ccggtcccac cgggctggcg gccgaccggc catcagggca gtcacgcctc ctgcctggca
    20941 gaggccgacc ggcgcggccg tgaacggctc cccggcgccc tcgccccgcc ggaaggcaac
    21001 gagggcaccc tgctggaact cttcagccgt acggtgaaac gccatccggc caggcccgcg
    21061 gtctccgacc gcgagctcac ctacacctac accgcgctca accggcgctc ggacgggctc
    21121 gcccaggcgc tcctcgcacg cggcgtccgc cccggcgacc acatcgccta tctgctgccc
    21181 cgcggggtcg ccccgttcgt cgtcctgctg gccgtcctca agaccggggc cgcgtatgtg
    21241 ccgctggacc cggcggcccc cgacgaccgg ctgcgtctgc tgatcgaccg aagcggcgcc
    21301 tctgtggtga tcacccaccc ggagatgaca ggccggctgg acgatctggc cacggcacgg
    21361 gtcatggagt acgtggcgga cgaccacgcc gatccgaagc ccgggcccgc cgcggcggcc
    21421 acgccccggc aggccgcgag tgtgctgttc acctccggat ccacgggaat accgaaggcg
    21481 gtgctcctgg aacaccgcaa cttggtccag ttcgccgaaa acccaacgct gcccgcgctc
    21541 actccgcaag accgggtcgg ccatgtctcg aacctcgcct tcgacgcctt ccactgggag
    21601 acctggtgcg ctttcgcggc aggtgccgaa gtggtgaccc tgcccaccat gccggacctg
    21661 atcagcggcg acatgcgtcg cgagctgaag cagcgccgga tcaccgccat gctcgtaccg
    21721 acgctggcct tcaaccatct ggcccatgag caaccggaga ccttctcctc actccggatc
    21781 ctcgccaccg gcggcgacgt ggtgtcgccg ggctcctgcc gtgacctgct cgcggcaggc
    21841 ttcaccgggc aactggtcaa cctgtacggc cccactgagg cggccacagc ctgctcggcc
    21901 cacccggtca ccgatgcgga acacgacggc agcgtgccga tcggccgcgc gctggagggg
    21961 atcggcctgt acgtcctgga cgacaatctt gacgaggtga caccgggttc cgtcgggcaa
    22021 ctccacatcg ggggcccggg cgtggcccgt ggttaccacg gccagccagg gctgacagcg
    22081 gagaggtttc ttcccgaccc ccacggcact ccgggcggcc ggctgtacgc caccggggat
    22141 ctggcggtac gcggggagga cggactgctg cgctatgtcg gcagggcgga cgaccaggtc
    22201 aaaatacgcg gctaccgggt cgagccgaga gaggtcgaac gccagctggc ccgtcaccac
    22261 catgtgcgtg atgtggccgt ggtcgtggga ggagagggcg tcgaccgcta tctcgccgca
    22321 ctcgtggtgc tgtacggcga cagttccttc gccgacctgc gggaagcggc cgcgtcgtcg
    22381 atgcccgagt acatggttcc cagcgccttc atcagcatcc cggagatgcc ctccaacgac
    22441 cgcggcaagc gggatctggg acggctccgg gagatcgtga cggaacacca gaagcaccgc
    22501 gccgaccggg tggcaccgag tgacccggtg gagatccggc tcgccgactt ctggaaggac
    22561 ctgatctcgg tggacgaggt cggcctcaat gatgacttct tcgctctggg cggcaactcc
    22621 ctccaggcct tccggctccg acggcggatc gtcaaggaac tgggcgtgga ggtgagcaac
    22681 cgggaaatcc tggtgaccag tgagctgtcg gcacttgccg atctggtccg ctccaaaacc
    22741 ggtctcgtgc tgtccgagaa ggaggacgat ctcgtatgac cacgcccacg atcgacctca
    22801 ccgaccccga actgttcctc ggcgaggacg ccccgatgat cttccggcaa ctgcgggaga
    22861 gcgacccggt gcactggcac ccactccccg acggcggcgg cttctgggcg ctcaccaggt
    22921 acgcggacat cgagacggcg tacaacgatc acacctcgct cagctccgag ggtgggccca
    22981 tgctgggcgg atcgttccgc agcgccgctg atccctccgc cggccggatg ctcgtggcct
    23041 ccgacctccc gcgccagcga cacatccgcc agcaggtgca ccgtgccttc agcaatggga
    23101 tgctgcgacg gatcgctcac caggtgacca ctctggtgga taccgcggtg cgccgcgccg
    23161 tggccgacgg cggctgtgac ttcgccaccg acatcgccac ggagctcccg gccggcgcca
    23221 taatgaccat gatgggcgtc tcccacaccg acgcccatga gctcatcggc atgacccggc
    23281 gcatgatcgg cttccgggac ccggtcttcg tcgaccccgg ggaggacgaa cggatcgggc
    23341 tcgcggtggt ccaagccgaa atcttcgaat tcttcgcgga acttctgtcg gatcgcagga
    23401 agaacccgaa ggacgacctc gtcagcatgc tgctgcaagc ccggcggaac ggacgcccct
    23461 ggccggagga agacatcctc ttcaactgct tgaacgtcgc cgtcggcggg aacgagacct
    23521 cctcgtacac ggcctgcgcc ggcattctcg cgctgcacca gaacccggcg cagaaggcac
    23581 ttctccaggc cgacccggaa ctcacggaca gcgcggtcaa cgagatgctc cgctggagtt
    23641 cgaccaacgc ctacgtcatg cgccaggccg tccgcgaatt caccatcgac ggtcggttga
    23701 tccaggacgg tgacaccgtg accctgtgga acgcctcggg gaacttcgac gagacccgct
    23761 ttcctgatcc ggacaccttc gacatcaccc gtacgccgaa ccggcacctg tcgttcggcg
    23821 ttggtatcca tcgctgcatt ggtgcgatgc tggctcaggt ggaactcggc atcctggtac
    23881 ggcacatgac cgaccgtcga atattcttca cggtctccgg cccggtacgc gcctgcggtc
    23941 gaacttcatc cggggcacca ccagccttcc cctcaccatg acggctgccg actgagccgc
    24001 ttcgcgggag gcgactgccg tgagttctca tcgaagccga ggtataagag tgcctctcgt
    24061 acagatgaga gatgccttcc gtgcggctcg ctggatgctt tgaggcggcg tctgatttct
    24121 catccgaaga acaacgccga acgcgactaa ccggcagtcg ccgacgactg ccggcgccaa
    24181 gaggagggac aggaggagga acccggggat ttcctgaact gagaaagggc gttggagcag
    24241 tgagcacctc ttttccatca tcccgatggc ggctatcgtg tcggtaccac ccgcctggag
    24301 gaaccgatga gcacgcagcc tgaggaagcc gtcgccccgc cggccccgac cgcccccgcg
    24361 cagatatatg cccagctgcg caccgaccac cgtgccgaca cttgggcacc ggccttcgag
    24421 cgggactggg cgaaggccct ggaggactct cgccacagct acagcctcac cccattgcac
    24481 aacgtcatcc gcacctggca gttgcgcgtc gccgcagcct cggacgtcga ctcgtacatg
    24541 gactccgacg aggaggagcc cggcttcgtg gacctcggct tcctccactc ctgacgagaa
    24601 ccgtggggca gcccgccgac accatgatca gcactgcggg tgccggtaca tcatccgcgc
    24661 aggtcggggc ctggtcacaa gtcttcggtt ctcctcgacg ttcaccccag gtgccttcac
    24721 cctgcaggcg ggtacggtac gagtcggcgg accgtctctg gttcgcagcc ctgtcctcgc
    24781 tgatcccccg ccgccgctgg tccaaggtct tcccggtcac accgagcact gcgcttgccg
    24841 aaaatgtcat ccgccctggt cggggcctgc acaggcctca cggtcgtcga tcgcggtcac
    24901 tcaagtcggc gctctcgcgt agtcggtggt gcgcgcgtca tgatgatcga tcgtgctgct
    24961 gcgactggct tacctgggtg tgacaaacgc gttcgcgatg cttcgcttgc tgccgatgac
    25021 cgaccgggac aaggacgctg agattcttgc cctgcgccat caggtcaccg tgctggaacg
    25081 ccaactcggc aaggacagga tccggttcac gccgagcgac cgggcgttcc tggcagcgct
    25141 gttgcaccgg ctgccactgc acgtcctgcg aaaattacgg ctactcgtcc gccccgacac
    25201 ggtactgcgt tggcaccgca acctcgtcaa acgccgccat gccgcctcct gccgccctaa
    25261 acgcctggga cgaccgcgca cagtgcactc gatccgcatc ctggtgctgc gcttggtgaa
    25321 agagaacccg agctggggct accggcgcct gcacggcgag ctgctcgtgc tgggagtgaa
    25381 ggtaggcgca tccaccgtct gggaaatcct gaaggaggca ggcatcgacc cagcgcccga
    25441 gcggaactcc agtacctgga ccggcttcct tcgctcccag gctgatgcgc tgctggcctg
    25501 cgacttcatg gaaacagtaa ccctgtcggg ggtacggatg tacgtgctcg tggtgatcga
    25561 acacggcagc cgccggatcc gcgtcctggg cgcaaccacg cacccgagcg catcctgggt
    25621 agcacaagcg gcgaagaacc tcgtcatgga cctcgaagac ctcggctgcc gggcacgctt
    25681 catgatccgg gaccggacgg caagttcccc accctcttcg atgccgtact caaggacgca
    25741 ggaatcgaca tcgtcctcag cggcatccag atgccaagga tga
//
