BGC0000345: eponemycin biosynthetic gene cluster from Streptomyces hygroscopicus
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Location: 1 - 25,783 nt. (total: 25,783 nt).
This entry is originally from NCBI GenBank KF647220.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0000345
Short description eponemycin biosynthetic gene cluster from Streptomyces hygroscopicus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Type I)
Loci
KF647220.1
via Heterologous expression
Compounds
  • eponemycin
Species Streptomyces hygroscopicus [taxonomy]
References
Chemical products information
eponemycin Evidence:
Copy SMILES
C20H34N2O6
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AHB38502.1
 28 - 249 (+) transposase
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    • AHB38503.1
    • epnA
    		 857 - 1177 (+) LuxR-like transcriptional regulator
    • Regulation
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    • AHB38504.1
    • epnB
    		 1205 - 1984 (+) thioesterase
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      • AHB38505.1
      • epnC
      		 2040 - 2897 (+) proteasome beta-subunit
      • Resistance/immunity
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      • AHB38506.1
      • epnD
      		 3273 - 4322 (+) ketosynthase III
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        • AHB38507.1
        • epnE
        		 4341 - 4583 (+) acyl carrier protein
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          • AHB38508.1
          • epnF
          		 5247 - 7046 (+) acyl-CoA dehydrogenase
          • Tailoring
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          • AHB38515.1
          • epnG
          		 7043 - 13456 (+) non-ribosomal peptide synthetase
          • Scaffold biosynthesis
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          • AHB38509.1
          • epnH
          		 13453 - 19515 (+) polyketide synthase
          • Scaffold biosynthesis
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          • AHB38510.1
          • epnI
          		 19515 - 20810 (+) cytochrome P450
          • Tailoring
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          • AHB38511.1
          • epnJ
          		 20803 - 22779 (+) adenylation-thiolation bidomain
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            • AHB38512.1
            • epnK
            		 22776 - 23981 (+) cytochrome P450
            • Tailoring
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            • AHB38513.1
            • epnL
            		 24307 - 24594 (+) EpnL
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              • AHB38514.1
              		 24953 - 25783 (+) transposase
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                Biosynthesis information

                Biosynthetic modules

                Name
                Unk01
                Type
                nrps-type1
                Genes
                epnJ
                Substrates
                leucine (evidence: Sequence-based prediction)
                Integrated Monomers
                Domains
                adenylation
                Name
                1
                Type
                nrps-type1
                Genes
                epnG
                Substrates
                serine (evidence: Sequence-based prediction)
                Integrated Monomers
                Domains
                condensation (LCL), adenylation
                Name
                2
                Type
                nrps-type1
                Genes
                epnG
                Substrates
                leucine (evidence: )
                Integrated Monomers
                Domains
                condensation (LCL), adenylation
                Name
                3
                Type
                pks-modular
                Genes
                epnH
                Substrates
                Integrated Monomers
                Domains
                acyltransferase, ketosynthase, acyltransferase, methyltransferase, carrier (ACP)
                Annotation changelog

                Entry version: 4

                Date
                Changes
                Submitters
                Reviewers
                2022-10-07
                Update chemical activity to schema version 2.11
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 3

                Date
                Changes
                Submitters
                Reviewers
                2022-09-15
                Corrected NRP module activity
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-09-15
                Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-09-15
                Updated bioactivity data
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-09-15
                Updated NRP substrate specificities
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 2

                Date
                Changes
                Submitters
                Reviewers
                2019-10-16
                Migrated from v1.4
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 1

                Date
                Changes
                Submitters
                Reviewers
                2015-06-12
                Submitted
                • (ID: MQCAQSV425YQGLSERITRLP7K)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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                Detailed domain annotation
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