BGC0000345: eponemycin biosynthetic gene cluster from Streptomyces hygroscopicus
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Location: 1 - 25,783 nt. (total: 25,783 nt).
This entry is originally from NCBI GenBank KF647220.1.

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core biosynthetic genes
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0000345
Short description eponemycin biosynthetic gene cluster from Streptomyces hygroscopicus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Other)
Loci NCBI GenBank: KF647220.1
Compounds
  • eponemycin
Species Streptomyces hygroscopicus [taxonomy]
References
Chemical products information
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eponemycin
Molecular Formula C20HN2O6
Chemical database entries PubCHEM  
List of genes involved in compound(s) production
Identifiers Position Product Functions Extra
  • AHB38502.1
28 249 + transposase
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  • AHB38503.1
  • epnA
857 1177 + LuxR-like transcriptional regulator
  • Regulation (evidence: S)
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  • AHB38504.1
  • epnB
1205 1984 + thioesterase
  • Unknown (evidence: S)
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  • AHB38505.1
  • epnC
2040 2897 + proteasome beta-subunit
  • Resistance/immunity (evidence: S)
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  • AHB38506.1
  • epnD
3273 4322 + ketosynthase III
  • Unknown (evidence: S)
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  • AHB38507.1
  • epnE
4341 4583 + acyl carrier protein
  • Unknown (evidence: S)
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  • AHB38508.1
  • epnF
5247 7046 + acyl-CoA dehydrogenase
  • Tailoring (Unknown) (evidence: S)
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  • AHB38515.1
  • epnG
7043 13456 + non-ribosomal peptide synthetase
  • Scaffold biosynthesis (evidence: S)
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  • AHB38509.1
  • epnH
13453 19515 + polyketide synthase
  • Scaffold biosynthesis (evidence: S)
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  • AHB38510.1
  • epnI
19515 20810 + cytochrome P450
  • Tailoring (Unknown) (evidence: S)
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  • AHB38511.1
  • epnJ
20803 22779 + adenylation-thiolation bidomain
  • Unknown (evidence: S)
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  • AHB38512.1
  • epnK
22776 23981 + cytochrome P450
  • Tailoring (Unknown) (evidence: S)
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  • AHB38513.1
  • epnL
24307 24594 + EpnL
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  • AHB38514.1
24953 25783 + transposase
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Polyketide-specific information
Subclass Other
Cyclic? no
Polyketide-synthases
Genes Properties Modules
AHB38509.1 Synthase subclass: Modular type I
Module 3
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: AHB38509.1
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: Unknown
NRP-specific information
Subclass n/a
Cyclic? no
NRP-synthases
Gene Modules
AHB38511.1
Module ?
Specificity: Leucine
Evidence for specificity:
  • Sequence-based prediction
AHB38515.1
Module 1
Specificity: Serine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
Module 2
Specificity: Leucine
Evidence for specificity:
Condensation domain type: LCL
Annotation changelog
MIBiG version Notes
2.0
  • Migrated from v1.4
Detailed domain annotation
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