BGC0000346: epoxomicin biosynthetic gene cluster from Goodfellowiella coeruleoviolacea
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Location: 1 - 29,930 nt. (total: 29,930 nt).
This entry is originally from NCBI GenBank KF647219.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000346
Short description epoxomicin biosynthetic gene cluster from Goodfellowiella coeruleoviolacea
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Type I)
Loci
KF647219.1
via Heterologous expression
Compounds
  • epoxomicin
Species Goodfellowiella coeruleoviolacea [taxonomy]
References
Chemical products information
epoxomicin Evidence:
Copy SMILES
C28H50N4O7
Chemical database entries
PubCHEM
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AHB38501.1
 177 - 1778 (-) FAD-dependent oxidoreductase
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    • AHB38494.1
    • epxA
    		 1987 - 2652 (+) TetR-like transcriptional regulator
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      • AHB38495.1
      • epxB
      		 2768 - 4381 (-) FAD-dependent oxidoreductase
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        • AHB38496.1
        • epxC
        		 4862 - 6139 (+) cytochrome P450
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          • AHB38497.1
          • epxD
          		 6250 - 21543 (+) non-ribosomal peptide synthetase
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            • AHB38498.1
            • epxE
            		 21547 - 27549 (+) polyketide synthase
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              • AHB38499.1
              • epxF
              		 27570 - 29261 (+) acyl-CoA dehydrogenase
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                • AHB38500.1
                		 29429 - 29878 (-) MarR-like transcriptional regulator
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                  Biosynthesis information

                  Biosynthetic modules

                  Name
                  1
                  Type
                  nrps-type1
                  Genes
                  epxD
                  Substrates
                  isoleucine (evidence: Sequence-based prediction)
                  Integrated Monomers
                  Domains
                  condensation (Starter), adenylation, methyltransferase
                  Name
                  2
                  Type
                  nrps-type1
                  Genes
                  epxD
                  Substrates
                  isoleucine (evidence: Sequence-based prediction)
                  Integrated Monomers
                  Domains
                  condensation (LCL), adenylation
                  Name
                  3
                  Type
                  nrps-type1
                  Genes
                  epxD
                  Substrates
                  threonine (evidence: Sequence-based prediction)
                  Integrated Monomers
                  Domains
                  condensation (LCL), adenylation
                  Name
                  4
                  Type
                  nrps-type1
                  Genes
                  epxD
                  Substrates
                  leucine (evidence: )
                  Integrated Monomers
                  Domains
                  condensation (LCL), adenylation
                  Name
                  5
                  Type
                  pks-modular
                  Genes
                  epxE
                  Substrates
                  Integrated Monomers
                  Domains
                  acyltransferase, ketosynthase, acyltransferase, methyltransferase, carrier (ACP)
                  Annotation changelog

                  Entry version: 4

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2022-10-07
                  Update chemical activity to schema version 2.11
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                  Entry version: 3

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2022-09-15
                  Corrected NRP module activity
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  2022-09-15
                  Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  2022-09-15
                  Updated NRP substrate specificities
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                  Entry version: 2

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2019-10-16
                  Migrated from v1.4
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  2019-10-16
                  Updated compound(s) information (NPAtlas curation)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                  Entry version: 1

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2015-06-12
                  Submitted
                  • (ID: MQCAQSV425YQGLSERITRLP7K)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  Detailed domain annotation
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