BGC0000347 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000347 (Streptococcus equi subsp. equi)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	NRPS	1	43,397	High	equibactin	NRPS:Type I

BGC0000347 - Region 1 - NRPS

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Location: 1 - 43,397 nt. (total: 43,397 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 43,398
Label		BGC0000347

Tailoring functions

Transferases: PPTase

SEQ1244: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: esterase

SEQ1245: thioesterase

smcogs: SMCOG1004: thioesterase

Ligases: ligase

SEQ1240: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

SEQ1242: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

SEQ1243: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000347.5	0.98	NRPS	equibactin	Streptococcus equi subsp. equi
BGC0000412.5	0.51	NRPS	pyochelin	Pseudomonas aeruginosa PAO1
BGC0001843.2	0.51	NRPS	tridecaptin M	Paenibacillus sp. M-152
BGC0002472.2	0.50	NRPS	ulbactin F, ulbactin G	Brevibacillus brevis
BGC0002410.3	0.49	NRPS	frankobactin A1, frankobactin A2, frankobactin A3, frankobactin B1, frankobactin B2, frankobactin B3, frankobactin C1	Frankia sp. CH37
BGC0000343.5	0.48	NRPS	enterobactin	Pseudomonas sp. J465
BGC0000519.4	0.48	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000410.5	0.48	NRPS	pseudomonine	Pseudomonas fluorescens
BGC0001873.3	0.48	NRPS	pyrrolizixenamide A	Xenorhabdus szentirmaii DSM 16338
BGC0002468.2	0.48	NRPS	anguibactin	Vibrio anguillarum 775

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000347.5	0.98	NRPS	equibactin	Streptococcus equi subsp. equi
BGC0000412.5	0.51	NRPS	pyochelin	Pseudomonas aeruginosa PAO1
BGC0001843.2	0.51	NRPS	tridecaptin M	Paenibacillus sp. M-152
BGC0002472.2	0.50	NRPS	ulbactin F, ulbactin G	Brevibacillus brevis
BGC0002410.3	0.49	NRPS	frankobactin A1, frankobactin A2, frankobactin A3, frankobactin B1, frankobactin B2, frankobactin B3, frankobactin C1	Frankia sp. CH37
BGC0000343.5	0.48	NRPS	enterobactin	Pseudomonas sp. J465
BGC0000519.4	0.48	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000410.5	0.48	NRPS	pseudomonine	Pseudomonas fluorescens
BGC0001873.3	0.48	NRPS	pyrrolizixenamide A	Xenorhabdus szentirmaii DSM 16338
BGC0002468.2	0.48	NRPS	anguibactin	Vibrio anguillarum 775

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 43397:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Cys)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

SEQ1243: X

AMP-binding (29..433): X

nrpys: Sal

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: PLPGQGIILK
Nearest Stachelhaus code(s):: Sal PLPGQGIILK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

SEQ1242: Cys

Search NORINE for peptide: strict or relaxed

AMP-binding (554..956): Cys

nrpys: Cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Small clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Single AA prediction:: Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:

Stachelhaus sequence:: DLYDMSMIWK
Nearest Stachelhaus code(s):: Cys DLYDMSMIWK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor