BGC0000347 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000347 (Streptococcus equi subsp. equi)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	23,813	equibactin	NRPS:Type I	100%

BGC0000347 - Region 1 - NRPS

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Location: 1 - 23,813 nt. (total: 23,813 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 23,814
Label		BGC0000347

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000347	1.00	NRP	equibactin	Streptococcus equi subsp. equi
BGC0000343	0.33	NRP	enterobactin	Pseudomonas sp. J465
BGC0002476	0.30	NRP	enterobactin	Escherichia coli str. K-12 substr. MG1655
BGC0002493	0.27	NRP	parabactin	Paracoccus denitrificans PD1222
BGC0002495	0.26	NRP	photobactin	Photorhabdus luminescens
BGC0002474	0.26	NRP	agrobactin	Agrobacterium tumefaciens
BGC0002412	0.26	NRP	holomycin	Photobacterium galatheae
BGC0002091	0.26	NRP	holomycin	Yersinia ruckeri ATCC 29473
BGC0001137	0.26	Alkaloid	marinacarboline A, marinacarboline B, marinacarboline C, marinacarboline D	Marinactinospora thermotolerans
BGC0002494	0.25	NRP	vibriobactin	Vibrio cholerae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000347	1.00	NRP	equibactin	Streptococcus equi subsp. equi
BGC0000343	0.67	NRP	enterobactin	Pseudomonas sp. J465
BGC0002476	0.63	NRP	enterobactin	Escherichia coli str. K-12 substr. MG1655
BGC0002493	0.61	NRP	parabactin	Paracoccus denitrificans PD1222
BGC0002495	0.60	NRP	photobactin	Photorhabdus luminescens
BGC0002474	0.60	NRP	agrobactin	Agrobacterium tumefaciens
BGC0002412	0.60	NRP	holomycin	Photobacterium galatheae
BGC0002091	0.59	NRP	holomycin	Yersinia ruckeri ATCC 29473
BGC0001137	0.59	Alkaloid	marinacarboline A, marinacarboline B, marinacarboline C, marinacarboline D	Marinactinospora thermotolerans
BGC0002494	0.58	NRP	vibriobactin	Vibrio cholerae

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 23813:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Cys)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

SEQ1243

AMP-binding (29..433): X

nrpys: Sal

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: PLPGQGIILK
Nearest Stachelhaus code(s):: Sal PLPGQGIILK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

SEQ1242

Search NORINE for peptide: strict or relaxed

AMP-binding (554..956): Cys

nrpys: Cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Small clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Single AA prediction:: Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:

Stachelhaus sequence:: DLYDMSMIWK
Nearest Stachelhaus code(s):: Cys DLYDMSMIWK (100% 8Å match)
Stachelhaus code match:: 100% (strong)