BGC0000348 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000348 (Epichloe festucae var. lolii)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	19,379	ergovaline	NRPS:Type I	100%

BGC0000348 - Region 1 - NRPS

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Location: 1 - 19,379 nt. (total: 19,379 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 19,380
Label		BGC0000348

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000348	1.00	NRP	ergovaline	Epichloe festucae var. lolii
BGC0000900	0.33	Other	ferrichrome	Aspergillus oryzae
BGC0001249	0.33	NRP	dimethylcoprogen	Alternaria alternata
BGC0002710	0.28	NRP	metachelin C, metachelin A, metachelin A-CE, metachelin B, dimerumic acid 11-mannoside, dimerumic acid	Metarhizium robertsii ARSEF 23
BGC0001261	0.26	NRP	AM-toxin	Alternaria alternata
BGC0002164	0.25	NRP	peramine	Epichloe festucae
BGC0002157	0.25	NRP, Alkaloid	(-)-ditryptophenaline	Aspergillus flavus
BGC0002166	0.24	NRP	peramine, intermediate 1, intermediate 2	Metarhizium rileyi
BGC0002248	0.24	Terpene, NRP	flavunoidine	Aspergillus flavus NRRL3357
BGC0001517	0.23	NRP	asperphenamate	Aspergillus terreus NIH2624

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000348	1.00	NRP	ergovaline	Epichloe festucae var. lolii
BGC0000900	0.67	Other	ferrichrome	Aspergillus oryzae
BGC0001249	0.67	NRP	dimethylcoprogen	Alternaria alternata
BGC0002710	0.61	NRP	metachelin C, metachelin A, metachelin A-CE, metachelin B, dimerumic acid 11-mannoside, dimerumic acid	Metarhizium robertsii ARSEF 23
BGC0001261	0.59	NRP	AM-toxin	Alternaria alternata
BGC0002164	0.58	NRP	peramine	Epichloe festucae
BGC0002157	0.58	NRP, Alkaloid	(-)-ditryptophenaline	Aspergillus flavus
BGC0002166	0.58	NRP	peramine, intermediate 1, intermediate 2	Metarhizium rileyi
BGC0002248	0.57	Terpene, NRP	flavunoidine	Aspergillus flavus NRRL3357
BGC0001517	0.57	NRP	asperphenamate	Aspergillus terreus NIH2624

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 19379:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

lpsB

AMP-binding (287..684): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVFSVGLIMK
Nearest Stachelhaus code(s):: D-Lya DVFSVGLVMK (79% 8Å match)
Stachelhaus code match:: 90% (moderate)