BGC0000349: erythrochelin biosynthetic gene cluster from Saccharopolyspora erythraea NRRL 2338
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Location: 3,324,848 - 3,348,992 nt. (total: 24,145 nt).
This entry is originally from NCBI GenBank AM420293.1.

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core biosynthetic genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000349
Short description erythrochelin biosynthetic gene cluster from Saccharopolyspora erythraea NRRL 2338
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
AM420293.1
3324848 - 3348992
via
Compounds
  • erythrochelin
Species Saccharopolyspora erythraea NRRL 2338 [taxonomy]
References
Chemical products information
erythrochelin Evidence:
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C24H41N7O11
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SACE_3032
  • CAM02310.1
 3324848 - 3325741 (+) LysR-family transcriptional regulator
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    • SACE_3033
    • CAM02311.1
    		 3326161 - 3327486 (+) putative peptide monooxygenase
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      • SACE_3034
      • CAM02312.1
      		 3327631 - 3328617 (+) possible ABC Fe(3+) transporter binding protein
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        • SACE_3035
        • CAM02313.1
        		 3328675 - 3344964 (+) putative non-ribosomal peptide synthetase
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          • SACE_3036
          • CAM02314.1
          		 3344961 - 3345164 (+) MbtH protein
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            • SACE_3037
            • CAM02315.1
            		 3345586 - 3347343 (-) putative ABC transporter transmembrane
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              • SACE_3038
              • CAM02316.1
              		 3347355 - 3348992 (-) ABC transporter protein, ATP-binding component
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                Biosynthesis information

                Biosynthetic modules

                Name
                Unk01
                Type
                nrps-type1
                Genes
                SACE_3035
                Substrates
                N5-acetyl-N5-hydroxyornithine (evidence: Structure-based inference [2])
                Integrated Monomers
                Domains
                adenylation
                Name
                Unk02
                Type
                nrps-type1
                Genes
                SACE_3035
                Substrates
                serine (evidence: Structure-based inference [2])
                Integrated Monomers
                Domains
                adenylation
                Name
                Unk03
                Type
                nrps-type1
                Genes
                SACE_3035
                Substrates
                N5-hydroxyornithine (evidence: Structure-based inference [2])
                Integrated Monomers
                Domains
                adenylation
                Name
                Unk04
                Type
                nrps-type1
                Genes
                SACE_3035
                Substrates
                N5-acetyl-N5-hydroxyornithine (evidence: Structure-based inference [2])
                Integrated Monomers
                Domains
                adenylation
                Annotation changelog

                Entry version: 4

                Date
                Changes
                Submitters
                Reviewers
                2022-10-07
                Update chemical activity to schema version 2.11
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 3

                Date
                Changes
                Submitters
                Reviewers
                2022-09-15
                Updated bioactivity data
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-09-15
                Added NRP substrate specificities
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 2

                Date
                Changes
                Submitters
                Reviewers
                2019-10-16
                Migrated from v1.4
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2019-10-16
                Updated compound(s) information (NPAtlas curation)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 1

                Date
                Changes
                Submitters
                Reviewers
                2015-06-12
                Submitted
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                Detailed domain annotation
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