Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000350.1:
Cluster 1NRP135392

BGC0000350, ET-743 biosynthetic gene cluster from uncultured organism. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: ET-743
SMILES string: Copy to clipboard
Molecular formula: C39H43N3O11S
Exact molecular mass: 761.2618 Da ([M+H]+)
Molecular activity: Cytotoxic

Class-specific details

Biosynthetic class(es):
NRP
Beta-lactam (cyclic)
Thioesterase type:
Unknown
Release / cyclization type:
Reductive release

Nonribosomal peptide synthetases:
etua3 (ADQ55476.1)
Module 0
A specificity: 3-hydroxy-4-O-methyl-5-methyl-tyrosine
Evidence for specificity: Structure-based inference
C domain subtype: N/A
Module is iterated
Evidence for iteration: Unknown
Module 1
A specificity: 3-hydroxy-4-O-methyl-5-methyl-tyrosine
Evidence for specificity: Sequence-based prediction
C domain subtype: Other
Module is iterated
Evidence for iteration: Unknown
etua1 (ADQ55474.1)
Module 2
A specificity: Glycolic acid
Evidence for specificity: Sequence-based prediction
C domain subtype: Other
Module 3
A specificity: Alanine
Evidence for specificity: Sequence-based prediction
C domain subtype: Other

Gene cluster description

ET-743 (BGC0000350). Gene Cluster 1. Biosynthetic class = NRP. GenBank HQ609499, positions 1-35392. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?incomplete
Evidence for cluster-compound connection:Enzymatic assays
MIxS-compliance:Unknown
Contact for this cluster:Fengan Yu (University of Michigan)

Literature references

1. Rath CM et al. (2011) Meta-omic characterization of the marine invertebrate microbial consortium that produces the chemotherapeutic natural product ET-743. ACS Chem Biol 6(11):1244-56. doi: 10.1021/cb200244t. Epub 2011 Sep