BGC0000352: fimsbactin A biosynthetic gene cluster from Acinetobacter sp. ADP1
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Location: 2,699,483 - 2,725,713 nt. (total: 26,231 nt).
This entry is originally from NCBI GenBank CR543861.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000352
Short description fimsbactin A biosynthetic gene cluster from Acinetobacter sp. ADP1
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP (NRP siderophore)
Loci NCBI GenBank: CR543861.1
Compounds
  • fimsbactin A
Species Acinetobacter sp. ADP1 [taxonomy]
References
Chemical products information
fimsbactin A
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C26H30N4O11
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ACIAD2761
  • CAG69505.1
 2699483 - 2700823 (-) putative multidrug resistance pump
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  • ACIAD2762
  • CAG69506.1
 2700863 - 2702014 (-) hypothetical protein; putative siderophore-interacting protein
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  • ACIAD2763
  • CAG69507.1
 2702041 - 2703264 (-) putative transport protein (MFS superfamily)
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  • ACIAD2764
  • CAG69508.1
 2703300 - 2705447 (-) putative ferric siderophore receptor protein
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  • ACIAD2765
  • CAG69509.1
 2705698 - 2706438 (+) putative thioesterase
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  • ACIAD2766
  • CAG69510.1
  • entD
 2706463 - 2707290 (+) phosphopantetheinyl transferase component of siderophore synthetase
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  • ACIAD2767
  • CAG69511.1
 2707493 - 2708080 (-) putative siderophore biosynthesis protein; putative acetyltransferase
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  • ACIAD2768
  • CAG69512.1
 2708185 - 2709345 (-) putative ornithine decarboxylase
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  • ACIAD2769
  • CAG69513.1
 2709355 - 2710695 (-) putative siderophore biosynthesis protein; putative Lysine/ornithine N-monooxygenase
  • Precursor biosynthesis
Knock-out
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  • ACIAD2770
  • CAG69514.1
  • entE
 2710709 - 2712328 (-) 2,3-dihydroxybenzoate-AMP ligase
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  • ACIAD2771
  • CAG69515.1
 2712341 - 2715541 (-) putative nonribosomal peptide synthetase with phosphopantetheine-binding domain
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  • ACIAD2772
  • CAG69516.1
 2715557 - 2718802 (-) putative non-ribosomal peptide synthetase with condensation, AMP-binding and phosphopantetheine-binding domains
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  • ACIAD2773
  • CAG69517.1
 2718805 - 2721297 (-) putative non-ribosomal peptide synthetase with phosphopantetheine binding domain (EntF-like)
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  • ACIAD2774
  • CAG69518.1
  • entA
 2721313 - 2722098 (-) 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
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  • ACIAD2775
  • CAG69519.1
  • entB
 2722126 - 2722755 (-) 2,3-dihydro-2,3-dihydroxybenzoate synthetase, isochorismatase
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  • ACIAD2776
  • CAG69520.1
  • entC
 2722849 - 2724036 (-) isochorismate synthetase
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  • ACIAD2778
  • CAG69521.1
 2724769 - 2725713 (-) putative transcriptional regulator (AraC family)
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NRP-specific information
Subclass NRP siderophore
Cyclic? no
NRP-synthases
Gene Modules
entE
Module 1
Specificity: 2,3-dihydroxybenzoic acid
Evidence for specificity:
  • Structure-based inference
  • Feeding study
ACIAD2773
Module 1
Trans-activates 2,3-dihydroxybenzoic acid

Modification domains: Unknown
Module 2
Trans-activates serine or threonine

Condensation domain type: Heterocyclization
ACIAD2772
Module 3
Specificity: serine / threonine
Evidence for specificity:
  • Structure-based inference
  • Feeding study
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: SCFYH7235HZBUM2XBV52IUHT, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Corrected NRP gene names
  • Fixed substrate specificities
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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