BGC0000352: fimsbactin A biosynthetic gene cluster from Acinetobacter sp. ADP1
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Location: 2,699,483 - 2,725,713 nt. (total: 26,231 nt).
This entry is originally from NCBI GenBank CR543861.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000352
Short description fimsbactin A biosynthetic gene cluster from Acinetobacter sp. ADP1
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
CR543861.1
2699483 - 2725713
via Knock-out studies, Gene expression correlated with compound production
Compounds
  • fimsbactin A
Species Acinetobacter sp. ADP1 [taxonomy]
References
Chemical products information
fimsbactin A Evidence:
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C26H30N4O11
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ACIAD2761
  • CAG69505.1
 2699483 - 2700823 (-) putative multidrug resistance pump
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    • ACIAD2762
    • CAG69506.1
    		 2700863 - 2702014 (-) hypothetical protein; putative siderophore-interacting protein
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      • ACIAD2763
      • CAG69507.1
      		 2702041 - 2703264 (-) putative transport protein (MFS superfamily)
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        • ACIAD2764
        • CAG69508.1
        		 2703300 - 2705447 (-) putative ferric siderophore receptor protein
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          • ACIAD2765
          • CAG69509.1
          		 2705698 - 2706438 (+) putative thioesterase
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            • ACIAD2766
            • CAG69510.1
            • entD
            		 2706463 - 2707290 (+) phosphopantetheinyl transferase component of siderophore synthetase
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              • ACIAD2767
              • CAG69511.1
              		 2707493 - 2708080 (-) putative siderophore biosynthesis protein; putative acetyltransferase
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                • ACIAD2768
                • CAG69512.1
                		 2708185 - 2709345 (-) putative ornithine decarboxylase
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                  • ACIAD2769
                  • CAG69513.1
                  		 2709355 - 2710695 (-) putative siderophore biosynthesis protein; putative Lysine/ornithine N-monooxygenase
                  • Precursor biosynthesis
                  • Knock-out
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                  • ACIAD2770
                  • CAG69514.1
                  • entE
                  		 2710709 - 2712328 (-) 2,3-dihydroxybenzoate-AMP ligase
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                    • ACIAD2771
                    • CAG69515.1
                    		 2712341 - 2715541 (-) putative nonribosomal peptide synthetase with phosphopantetheine-binding domain
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                      • ACIAD2772
                      • CAG69516.1
                      		 2715557 - 2718802 (-) putative non-ribosomal peptide synthetase with condensation, AMP-binding and phosphopantetheine-binding domains
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                        • ACIAD2773
                        • CAG69517.1
                        		 2718805 - 2721297 (-) putative non-ribosomal peptide synthetase with phosphopantetheine binding domain (EntF-like)
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                          • ACIAD2774
                          • CAG69518.1
                          • entA
                          		 2721313 - 2722098 (-) 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
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                            • ACIAD2775
                            • CAG69519.1
                            • entB
                            		 2722126 - 2722755 (-) 2,3-dihydro-2,3-dihydroxybenzoate synthetase, isochorismatase
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                              • ACIAD2776
                              • CAG69520.1
                              • entC
                              		 2722849 - 2724036 (-) isochorismate synthetase
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                                • ACIAD2778
                                • CAG69521.1
                                		 2724769 - 2725713 (-) putative transcriptional regulator (AraC family)
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                                  Biosynthesis information

                                  Biosynthetic modules

                                  Name
                                  1
                                  Type
                                  nrps-type1
                                  Genes
                                  entE ACIAD2773
                                  Substrates
                                  2,3-dihydroxybenzoic acid (evidence: Structure-based inference, Feeding study)
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  3
                                  Type
                                  nrps-type1
                                  Genes
                                  ACIAD2772
                                  Substrates
                                  serine, threonine (evidence: Structure-based inference, Feeding study)
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Annotation changelog

                                  Entry version: 4

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2022-10-07
                                  Update chemical activity to schema version 2.11
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                  Entry version: 3

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2022-09-15
                                  Corrected NRP module activity
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  2022-09-15
                                  Corrected NRP gene names
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  2022-09-15
                                  Fixed substrate specificities
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  2022-09-15
                                  Updated NRP substrate specificities
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                  Entry version: 2

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2019-10-16
                                  Migrated from v1.4
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  2019-10-16
                                  Updated compound(s) information (NPAtlas curation)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                  Entry version: 1

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2015-06-12
                                  Submitted
                                  • (ID: SCFYH7235HZBUM2XBV52IUHT)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  Detailed domain annotation
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