BGC0000353: tacrolimus biosynthetic gene cluster from Streptomyces sp. MA6548
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Location: 1 - 28,732 nt. (total: 28,732 nt).
This entry is originally from NCBI GenBank AF082100.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000353
Short description tacrolimus biosynthetic gene cluster from Streptomyces sp. MA6548
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
AF082100.1
via
Compounds
  • tacrolimus
Species Streptomyces sp. MA6548 [taxonomy]
References
Chemical products information
tacrolimus Evidence:
Copy SMILES
C44H69N1O12
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAC68816.1
  • fkbP
 61 - 4575 (-) FK506 peptide synthetase
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    • AAC68817.1
    • fkbO
    		 4572 - 5570 (-) FK506 oxidase
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      • AAC68815.1
      • fkbB
      		 5798 - 28528 (+) FK506 polyketide synthase
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        Biosynthesis information

        Biosynthetic modules

        Name
        Unk01
        Type
        nrps-type1
        Genes
        fkbP
        Substrates
        pipecolic acid (evidence: )
        Integrated Monomers
        Domains
        adenylation
        Annotation changelog

        Entry version: 4

        Date
        Changes
        Submitters
        Reviewers
        2022-10-07
        Update chemical activity to schema version 2.11
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        2022-10-07
        Fix the chemical target
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

        Entry version: 3

        Date
        Changes
        Submitters
        Reviewers
        2022-09-15
        Updated bioactivity data
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        2022-09-15
        Added NRP substrate specificities
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

        Entry version: 2

        Date
        Changes
        Submitters
        Reviewers
        2019-10-16
        Migrated from v1.4
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        2019-10-16
        Updated compound(s) information (NPAtlas curation)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

        Entry version: 1

        Date
        Changes
        Submitters
        Reviewers
        2015-06-12
        Submitted
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        Detailed domain annotation
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