BGC0000354: friulimicin A biosynthetic gene cluster from Actinoplanes friuliensis
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Location: 1 - 70,820 nt. (total: 70,820 nt).
This entry is originally from NCBI GenBank AJ488769.3.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000354
Short description friulimicin A biosynthetic gene cluster from Actinoplanes friuliensis
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: AJ488769.3
Compounds
  • friulimicin A
  • friulimicin B
  • friulimicin C
  • friulimicin D
Species Actinoplanes friuliensis [taxonomy]
References
Chemical products information
friulimicin A
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C58H92N14O19
Chemical database entries
PubCHEM
friulimicin B
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C59H94N14O19
Chemical database entries
NPAtlas
friulimicin C
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C58H92N14O19
Chemical database entries
NPAtlas
friulimicin D
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C60H96N14O19
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAM56763.1
 1 - 1411 (-) hypothetical protein
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  • CAM56764.1
  • orfAP
 1614 - 2438 (+) putative alkaline phosphatase
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  • CAM56765.1
  • regA
 3057 - 3785 (+) regulatory protein A
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  • CAM56766.1
  • expB
 3964 - 4917 (+) ExpB
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  • CAM56767.1
  • dabA
 4914 - 5987 (+) DabA
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  • CAM56768.1
  • dabB
 5984 - 7426 (+) DabB
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  • CAM56769.1
  • dabC
 7423 - 8646 (+) DabC
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  • CAD32904.2
  • pstA
 8643 - 11831 (+) non-ribosomal peptide synthetase A
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  • CAD32905.1
 11828 - 12736 (+) hypothetical protein
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  • CAD32906.1
  • regB
 12792 - 13697 (-) regulatory protein B
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  • CAD32907.1
  • expA
 13714 - 14553 (-) ABC transporter protein
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  • CAD32908.1
  • glmB
 14550 - 15797 (-) glutamate mutase subunit B
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  • CAD32909.1
  • glmA
 15794 - 16231 (-) glutamate mutase subunit A
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  • CAD32910.2
  • lipA
 16501 - 18267 (+) acyl-CoA synthase
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  • CAJ18234.2
  • lipB
 18264 - 19802 (+) acyl-CoA dehydrogenase
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  • CAJ18235.1
 19799 - 20506 (+) hypothetical protein
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  • CAJ18236.1
  • lipD
 20524 - 20790 (+) acyl carrier protein
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  • CAJ18237.2
  • pstB
 20826 - 30257 (+) non-ribosomal peptide synthetase B
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  • CAM56770.1
  • pstC
 30254 - 50239 (+)
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  • CAM56771.1
  • pstD
 50239 - 57351 (+)
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  • CAM56772.1
 57381 - 57593 (+) hypothetical protein
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  • CAM56773.1
  • lipE
 57669 - 58475 (+) LipE
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  • CAM56774.1
  • mem
 58561 - 60852 (-) Mem
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  • CAM56775.1
  • pip
 61160 - 62179 (+) lysine cyclodeaminase
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  • CAM56776.1
  • regC
 62183 - 62827 (-) regulatory protein C
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  • CAM56777.1
  • regD
 62818 - 64197 (-) regulatory protein D
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  • CAM56778.1
 64196 - 64807 (+) hypothetical protein
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  • CAM56779.1
  • mem2
 64951 - 66540 (+) Mem2
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  • CAM56780.1
  • regE
 66581 - 67204 (+) regulatory protein E
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  • CAM56781.1
 67201 - 68169 (+) hypothetical protein
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  • CAM56782.1
 68230 - 69102 (+) hypothetical protein
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  • CAM56783.1
 69316 - 70509 (+) hypothetical protein
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  • CAM56784.1
 70587 - >70820 (+) hypothetical protein
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
pstA
Module ?
Specificity: 2,4-diaminobutyric acid
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
pstB
Module ?
Specificity: asparagine / aspartic acid
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: pipecolic acid
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
pstC
Module ?
Specificity: 3S-methylaspartic acid
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: aspartic acid
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: glycine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: aspartic acid
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: glycine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: 2,4-diaminobutyric acid
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
pstD
Module ?
Specificity: valine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: proline
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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