BGC0000354: friulimicin A biosynthetic gene cluster from Actinoplanes friuliensis
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Location: 1 - 70,820 nt. (total: 70,820 nt).
This entry is originally from NCBI GenBank AJ488769.3.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000354
Short description friulimicin A biosynthetic gene cluster from Actinoplanes friuliensis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
AJ488769.3
via
Compounds
  • friulimicin A
  • friulimicin B
  • friulimicin C
  • friulimicin D
Species Actinoplanes friuliensis [taxonomy]
References
Chemical products information
friulimicin A Evidence:
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C58H92N14O19
Chemical database entries
PubCHEM
friulimicin B Evidence:
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C59H94N14O19
Chemical database entries
NPAtlas
friulimicin C Evidence:
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C58H92N14O19
Chemical database entries
NPAtlas
friulimicin D Evidence:
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C60H96N14O19
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAM56763.1
 1 - 1411 (-) hypothetical protein
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    • CAM56764.1
    • orfAP
    		 1614 - 2438 (+) putative alkaline phosphatase
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      • CAM56765.1
      • regA
      		 3057 - 3785 (+) regulatory protein A
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        • CAM56766.1
        • expB
        		 3964 - 4917 (+) ExpB
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          • CAM56767.1
          • dabA
          		 4914 - 5987 (+) DabA
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            • CAM56768.1
            • dabB
            		 5984 - 7426 (+) DabB
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              • CAM56769.1
              • dabC
              		 7423 - 8646 (+) DabC
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                • CAD32904.2
                • pstA
                		 8643 - 11831 (+) non-ribosomal peptide synthetase A
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                  • CAD32905.1
                  		 11828 - 12736 (+) hypothetical protein
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                    • CAD32906.1
                    • regB
                    		 12792 - 13697 (-) regulatory protein B
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                      • CAD32907.1
                      • expA
                      		 13714 - 14553 (-) ABC transporter protein
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                        • CAD32908.1
                        • glmB
                        		 14550 - 15797 (-) glutamate mutase subunit B
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                          • CAD32909.1
                          • glmA
                          		 15794 - 16231 (-) glutamate mutase subunit A
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                            • CAD32910.2
                            • lipA
                            		 16501 - 18267 (+) acyl-CoA synthase
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                              • CAJ18234.2
                              • lipB
                              		 18264 - 19802 (+) acyl-CoA dehydrogenase
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                                • CAJ18235.1
                                		 19799 - 20506 (+) hypothetical protein
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                                  • CAJ18236.1
                                  • lipD
                                  		 20524 - 20790 (+) acyl carrier protein
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                                    • CAJ18237.2
                                    • pstB
                                    		 20826 - 30257 (+) non-ribosomal peptide synthetase B
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                                      • CAM56770.1
                                      • pstC
                                      		 30254 - 50239 (+)
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                                        • CAM56771.1
                                        • pstD
                                        		 50239 - 57351 (+)
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                                          • CAM56772.1
                                          		 57381 - 57593 (+) hypothetical protein
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                                            • CAM56773.1
                                            • lipE
                                            		 57669 - 58475 (+) LipE
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                                              • CAM56774.1
                                              • mem
                                              		 58561 - 60852 (-) Mem
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                                                • CAM56775.1
                                                • pip
                                                		 61160 - 62179 (+) lysine cyclodeaminase
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                                                  • CAM56776.1
                                                  • regC
                                                  		 62183 - 62827 (-) regulatory protein C
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                                                    • CAM56777.1
                                                    • regD
                                                    		 62818 - 64197 (-) regulatory protein D
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                                                      • CAM56778.1
                                                      		 64196 - 64807 (+) hypothetical protein
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                                                        • CAM56779.1
                                                        • mem2
                                                        		 64951 - 66540 (+) Mem2
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                                                          • CAM56780.1
                                                          • regE
                                                          		 66581 - 67204 (+) regulatory protein E
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                                                            • CAM56781.1
                                                            		 67201 - 68169 (+) hypothetical protein
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                                                              • CAM56782.1
                                                              		 68230 - 69102 (+) hypothetical protein
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                                                                • CAM56783.1
                                                                		 69316 - 70509 (+) hypothetical protein
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                                                                  • CAM56784.1
                                                                  		 70587 - >70820 (+) hypothetical protein
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                                                                    Biosynthesis information

                                                                    Biosynthetic modules

                                                                    Name
                                                                    Unk01
                                                                    Type
                                                                    nrps-type1
                                                                    Genes
                                                                    pstA
                                                                    Substrates
                                                                    2,4-diaminobutyric acid (evidence: Structure-based inference, Sequence-based prediction)
                                                                    Integrated Monomers
                                                                    Domains
                                                                    adenylation
                                                                    Name
                                                                    Unk02
                                                                    Type
                                                                    nrps-type1
                                                                    Genes
                                                                    pstB
                                                                    Substrates
                                                                    asparagine, aspartic acid (evidence: Structure-based inference, Sequence-based prediction)
                                                                    Integrated Monomers
                                                                    Domains
                                                                    adenylation
                                                                    Name
                                                                    Unk03
                                                                    Type
                                                                    nrps-type1
                                                                    Genes
                                                                    pstB
                                                                    Substrates
                                                                    pipecolic acid (evidence: Structure-based inference, Sequence-based prediction)
                                                                    Integrated Monomers
                                                                    Domains
                                                                    adenylation
                                                                    Name
                                                                    Unk04
                                                                    Type
                                                                    nrps-type1
                                                                    Genes
                                                                    pstC
                                                                    Substrates
                                                                    3S-methylaspartic acid (evidence: Structure-based inference, Sequence-based prediction)
                                                                    Integrated Monomers
                                                                    Domains
                                                                    adenylation
                                                                    Name
                                                                    Unk05
                                                                    Type
                                                                    nrps-type1
                                                                    Genes
                                                                    pstC
                                                                    Substrates
                                                                    aspartic acid (evidence: Structure-based inference, Sequence-based prediction)
                                                                    Integrated Monomers
                                                                    Domains
                                                                    adenylation
                                                                    Name
                                                                    Unk06
                                                                    Type
                                                                    nrps-type1
                                                                    Genes
                                                                    pstC
                                                                    Substrates
                                                                    glycine (evidence: Structure-based inference, Sequence-based prediction)
                                                                    Integrated Monomers
                                                                    Domains
                                                                    adenylation
                                                                    Name
                                                                    Unk07
                                                                    Type
                                                                    nrps-type1
                                                                    Genes
                                                                    pstC
                                                                    Substrates
                                                                    aspartic acid (evidence: Structure-based inference, Sequence-based prediction)
                                                                    Integrated Monomers
                                                                    Domains
                                                                    adenylation
                                                                    Name
                                                                    Unk08
                                                                    Type
                                                                    nrps-type1
                                                                    Genes
                                                                    pstC
                                                                    Substrates
                                                                    glycine (evidence: Structure-based inference, Sequence-based prediction)
                                                                    Integrated Monomers
                                                                    Domains
                                                                    adenylation
                                                                    Name
                                                                    Unk09
                                                                    Type
                                                                    nrps-type1
                                                                    Genes
                                                                    pstC
                                                                    Substrates
                                                                    2,4-diaminobutyric acid (evidence: Structure-based inference, Sequence-based prediction)
                                                                    Integrated Monomers
                                                                    Domains
                                                                    adenylation
                                                                    Name
                                                                    Unk10
                                                                    Type
                                                                    nrps-type1
                                                                    Genes
                                                                    pstD
                                                                    Substrates
                                                                    valine (evidence: Structure-based inference, Sequence-based prediction)
                                                                    Integrated Monomers
                                                                    Domains
                                                                    adenylation
                                                                    Name
                                                                    Unk11
                                                                    Type
                                                                    nrps-type1
                                                                    Genes
                                                                    pstD
                                                                    Substrates
                                                                    proline (evidence: Structure-based inference, Sequence-based prediction)
                                                                    Integrated Monomers
                                                                    Domains
                                                                    adenylation
                                                                    Annotation changelog

                                                                    Entry version: 4

                                                                    Date
                                                                    Changes
                                                                    Submitters
                                                                    Reviewers
                                                                    2022-10-07
                                                                    Update chemical activity to schema version 2.11
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                    Entry version: 3

                                                                    Date
                                                                    Changes
                                                                    Submitters
                                                                    Reviewers
                                                                    2022-09-15
                                                                    Updated bioactivity data
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                    2022-09-15
                                                                    Added NRP substrate specificities
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                    Entry version: 2

                                                                    Date
                                                                    Changes
                                                                    Submitters
                                                                    Reviewers
                                                                    2019-10-16
                                                                    Migrated from v1.4
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                    2019-10-16
                                                                    Updated compound(s) information (NPAtlas curation)
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                    Entry version: 1

                                                                    Date
                                                                    Changes
                                                                    Submitters
                                                                    Reviewers
                                                                    2015-06-12
                                                                    Submitted
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                    Detailed domain annotation
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