BGC0000355 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000355 (Aspergillus fumigatus Af293)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	24,812	fumiquinazoline A/fumiquinazoline C/fumiquinazoline D	NRPS:Type I	100%

BGC0000355 - Region 1 - NRPS

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Location: 1 - 24,812 nt. (total: 24,812 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 24,813
Label		BGC0000355

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000355	1.00	NRP	fumiquinazoline A, fumiquinazoline C, fumiquinazoline D	Aspergillus fumigatus Af293
BGC0000900	0.32	Other	ferrichrome	Aspergillus oryzae
BGC0001249	0.32	NRP	dimethylcoprogen	Alternaria alternata
BGC0000293	0.32	NRP	acetylaszonalenin	Aspergillus fischeri NRRL 181
BGC0002617	0.31	NRP	psychrophilin D, psychrophilin H, psychrophilin F, psychrophilin C, psychrophilin G, psychrophilin E, psychrophilin A, psychrophilin B, psychrophilin I	Penicillium sp. YT-2016
BGC0002157	0.30	NRP, Alkaloid	(-)-ditryptophenaline	Aspergillus flavus
BGC0001261	0.30	NRP	AM-toxin	Alternaria alternata
BGC0002710	0.30	NRP	metachelin C, metachelin A, metachelin A-CE, metachelin B, dimerumic acid 11-mannoside, dimerumic acid	Metarhizium robertsii ARSEF 23
BGC0000404	0.28	NRP	penicillin	Penicillium chrysogenum
BGC0000313	0.27	NRP	beauvericin	Beauveria bassiana

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000355	1.00	NRP	fumiquinazoline A, fumiquinazoline C, fumiquinazoline D	Aspergillus fumigatus Af293
BGC0000900	0.66	Other	ferrichrome	Aspergillus oryzae
BGC0001249	0.65	NRP	dimethylcoprogen	Alternaria alternata
BGC0000293	0.65	NRP	acetylaszonalenin	Aspergillus fischeri NRRL 181
BGC0002617	0.65	NRP	psychrophilin D, psychrophilin H, psychrophilin F, psychrophilin C, psychrophilin G, psychrophilin E, psychrophilin A, psychrophilin B, psychrophilin I	Penicillium sp. YT-2016
BGC0002157	0.64	NRP, Alkaloid	(-)-ditryptophenaline	Aspergillus flavus
BGC0001261	0.63	NRP	AM-toxin	Alternaria alternata
BGC0002710	0.63	NRP	metachelin C, metachelin A, metachelin A-CE, metachelin B, dimerumic acid 11-mannoside, dimerumic acid	Metarhizium robertsii ARSEF 23
BGC0000404	0.61	NRP	penicillin	Penicillium chrysogenum
BGC0000313	0.61	NRP	beauvericin	Beauveria bassiana

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 24812:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ala) + (X - D-Trp - Ala)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

AFUA_6G12050

Search NORINE for peptide: strict or relaxed

AMP-binding (110..505): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: ala (Ala)

Stachelhaus prediction details:

Stachelhaus sequence:: DLFVLAGCIK
Nearest Stachelhaus code(s):: Ala DLFVLAGCIK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AFUA_6G12080

Search NORINE for peptide: strict or relaxed

AMP-binding (274..668): X

nrpys: 4clBza, 2clBza

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: ala (Ala)

Stachelhaus prediction details:

Stachelhaus sequence:: GVIILAAGIK
Nearest Stachelhaus code(s):: 4clBza or 2clBza GVIILAAGIK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1355..1750): Trp

nrpys: Trp

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DGMHVVGVSK
Nearest Stachelhaus code(s):: Trp DGMHVVGVSK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2886..3283): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: ala (Ala)

Stachelhaus prediction details:

Stachelhaus sequence:: DIVMSAGALK
Nearest Stachelhaus code(s):: Ala DIVMSAGALK (100% 8Å match)
Stachelhaus code match:: 100% (strong)