BGC0000355: fumiquinazoline A biosynthetic gene cluster from Aspergillus fumigatus Af293
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Location: 3,010,494 - 3,035,305 nt. (total: 24,812 nt).
This entry is originally from NCBI GenBank CM000174.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000355
Short description fumiquinazoline A biosynthetic gene cluster from Aspergillus fumigatus Af293
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: CM000174.1
Compounds
  • fumiquinazoline A
  • fumiquinazoline C
  • fumiquinazoline D
Species Aspergillus fumigatus Af293 [taxonomy]
References
Chemical products information
fumiquinazoline A
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C24H23N5O4
Chemical database entries
NPAtlas
PubCHEM
fumiquinazoline C [synonyms: fqc]
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C24H21N5O4
Chemical database entries
NPAtlas
PubCHEM
fumiquinazoline D
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C24H21N5O4
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AFUA_6G12040
  • EAL89045.1
 3010494 - 3012341 (+) MFS transporter, putative
  • Unknown
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  • AFUA_6G12050
  • EAL89046.1
 3013593 - 3017507 (+) nonribosomal peptide synthetase
  • Tailoring (Unknown)
Activity assay
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  • AFUA_6G12060
  • EAL89047.1
 3017908 - 3019274 (-) FAD-dependent monooxygenase
  • Tailoring (Monooxygenation)
Activity assay
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  • AFUA_6G12070
  • EAL89048.1
 3020103 - 3021926 (+) FAD-dependent oxidoreductase
  • Tailoring (Heterocyclization)
Activity assay
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  • AFUA_6G12080
  • EAL89049.1
 3023316 - 3035305 (-) nonribosomal peptide synthetase
  • Scaffold biosynthesis
Activity assay
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NRP-specific information
Subclass N/A
Cyclic? yes
NRP-synthases
Gene Modules
AFUA_6G12080
Module 1
Specificity: anthanillic acid / benzoic acid / 2-chlorobenzoic acid / 4-chlorobenzoic acid / 3-hydroxybenzoic acid / 3-aminobenzoic acid
Evidence for specificity:
  • Structure-based inference
  • ATP-PPi exchange assay
Condensation domain type: LCL
Module 2
Specificity: tryptophan
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 3
Specificity: alanine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Heterocyclization
AFUA_6G12050
Module 1
Specificity: alanine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Heterocyclization
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: J4R6BDENZAM7XVDGVEEHZB2Y, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Cleaned up synonym list
  • Corrected NRP module activity
  • Corrected gene names referencing other accessions
  • Removed thioesterase annotation for unknown gene
  • Removed inconsistent additional gene names
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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