BGC0000356: verruculogen biosynthetic gene cluster from Aspergillus fumigatus
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Location: 1 - 27,708 nt. (total: 27,708 nt).
This entry is originally from NCBI GenBank AB436628.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000356
Short description verruculogen biosynthetic gene cluster from Aspergillus fumigatus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks "ftmI/ftmO do not catalyze any enzymatic reactions, this has been shown by knock-out studies, and are therefore not regarded as part of the cluster.\nA. fumigatus Af293 harbors a point mutation in ftmMT\nN. fischeri NRRL181 produces fumitremorgin A catalyzed by ftmPT3 present outside the genomic context of the cluster homologous to A. fumigatus\n"
Biosynthetic class(es)
  • NRP
  • Alkaloid (Indole/benzopyrrole)
Loci NCBI GenBank: AB436628.1
Compounds
  • verruculogen
  • fumitremorgin B
  • fumitremorgin c
  • tryprostatin A
  • tryprostatin B
  • demethoxyfumitremorgin C
  • brevianamide F
Species Aspergillus fumigatus [taxonomy]
References
Chemical products information
verruculogen
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C27H33N3O7
Chemical database entries
PubCHEM
fumitremorgin B [synonyms: lanosulin]
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C27H33N3O5
Chemical database entries
PubCHEM
fumitremorgin c
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C22H25N3O3
Chemical database entries
PubCHEM
tryprostatin A
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C22H27N3O3
Chemical database entries
NPAtlas
tryprostatin B
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C21H25N3O2
Chemical database entries
NPAtlas
PubCHEM
demethoxyfumitremorgin C
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C21H23N3O2
Chemical database entries
NPAtlas
PubCHEM
brevianamide F
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C16H17N3O2
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAH23995.1
  • ftmA
 321 - 6956 (-) nonribosomal peptide synthetase
  • Scaffold biosynthesis
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  • BAH23996.1
  • ftmC
 8500 - 10454 (-) cytochrome P450
  • Tailoring (Hydroxylation)
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  • BAH23997.1
  • ftmD
 11206 - 12319 (+) O-methyltransferase
  • Tailoring (Methylation)
Other in vivo study
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  • BAH23998.1
  • ftmB_ftmPT1
 13039 - 14502 (+) prenyltransferase
  • Tailoring (Prenylation)
Activity assay
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  • BAH23999.1
  • ftmE
 14683 - 16263 (-) cytochrome P450
  • Tailoring (Heterocyclization)
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  • BAH24000.1
  • ftmF
 17139 - 18014 (-) alpha-ketoglutarate dioxygenase
  • Tailoring (Heterocyclization)
Activity assay
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  • BAH24001.1
  • ftmG
 19109 - 20921 (-) cytochrome P450
  • Tailoring (Hydroxylation)
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  • BAH24002.1
  • ftmH
 21649 - 22997 (+) prenyltransferase
  • Tailoring (Prenylation)
Activity assay
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  • BAH24003.1
  • ftmI
 23314 - 25356 (-) ankyrin repeat protein
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NRP-specific information
Subclass N/A
Cyclic? no
Release type
  • Hydrolysis
NRP-synthases
Gene Modules
ftmA
Module 1
Specificity: tryptophan / proline
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 2
Specificity: tryptophan / proline
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: J4R6BDENZAM7XVDGVEEHZB2Y, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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