BGC0000357 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000357 (Penicillium rubens Wisconsin 54-1255)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	18,536	cyclo-(D-Phe-L-Phe-D-Val-L-Val)/cyclo-(D-Tyr-L-Phe-D-Val-L-Val)/cyclo-(D-Tyr-L-Trp-D-Val-L-Val)/cyclo-(D-Phe-L-Trp-D-Val-L-Val)/cyclo-(D-Phe-L-Phe-D-Val-L-Ile)/cyclo-(D-Phe-L-Phe-D-Ile-L-Val)/cyclo-(D-Tyr-L-Trp-D-Val-L-Ile)/cyclo-(D-Tyr-L-Trp-D-Ile-L-Val)/cyclo-(D-Tyr-L-Phe-D-Val-L-Ile)/cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	NRPS:Type I	100%

BGC0000357 - Region 1 - NRPS

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Location: 1 - 18,536 nt. (total: 18,536 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 18,537
Label		BGC0000357

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000357	1.00	NRP	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001240	0.22	NRP	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0001825	0.22	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0001166	0.21	NRP	HC-toxin	Alternaria jesenskae
BGC0000342	0.20	NRP	enniatin	Fusarium equiseti
BGC0001833	0.20	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0002135	0.20	NRP	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001758	0.20	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001844	0.20	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001641	0.20	NRP	kolossin	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000357	1.00	NRP	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001240	0.56	NRP	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0001825	0.55	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0001166	0.54	NRP	HC-toxin	Alternaria jesenskae
BGC0000342	0.53	NRP	enniatin	Fusarium equiseti
BGC0001833	0.53	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0002135	0.53	NRP	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001758	0.53	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001844	0.53	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001641	0.53	NRP	kolossin	Photorhabdus laumondii subsp. laumondii TTO1

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 18536:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-X - D-Val)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

PCH_Pc16g04690

Search NORINE for peptide: strict or relaxed

AMP-binding (251..644): X

nrpys: Phe, Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAACVAGVAK
Nearest Stachelhaus code(s):: Phe or Tyr DAACVAGVAK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1792..2181): X

nrpys: Ile, Val

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAVSAGLAAK
Nearest Stachelhaus code(s):: Ile or Val DAVSAGLAAK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2583..2987): X

nrpys: Phe, Trp

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVLSIGAVVK
Nearest Stachelhaus code(s):: Phe or Trp DVLSIGAVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3688..4088): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAMFVGGVFK
Nearest Stachelhaus code(s):: Val DAMFVGGVFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)