BGC0000357: cyclo-(D-Phe-L-Phe-D-Val-L-Val) biosynthetic gene cluster from Penicillium rubens Wisconsin 54-1255
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Location: 1,080,827 - 1,099,362 nt. (total: 18,536 nt).
This entry is originally from NCBI GenBank AM920431.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000357
Short description cyclo-(D-Phe-L-Phe-D-Val-L-Val) biosynthetic gene cluster from Penicillium rubens Wisconsin 54-1255
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
AM920431.1
1080827 - 1099362
via Knock-out studies
Compounds
  • cyclo-(D-Phe-L-Phe-D-Val-L-Val)
  • cyclo-(D-Tyr-L-Phe-D-Val-L-Val)
  • cyclo-(D-Tyr-L-Trp-D-Val-L-Val)
  • cyclo-(D-Phe-L-Trp-D-Val-L-Val)
  • cyclo-(D-Phe-L-Phe-D-Val-L-Ile)
  • cyclo-(D-Phe-L-Phe-D-Ile-L-Val)
  • cyclo-(D-Tyr-L-Trp-D-Val-L-Ile)
  • cyclo-(D-Tyr-L-Trp-D-Ile-L-Val)
  • cyclo-(D-Tyr-L-Phe-D-Val-L-Ile)
  • cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)
Species Penicillium rubens Wisconsin 54-1255 [taxonomy]
References
Chemical products information
cyclo-(D-Phe-L-Phe-D-Val-L-Val) Evidence:
(no structure information available)
C28H36N4O4
cyclo-(D-Tyr-L-Phe-D-Val-L-Val) Evidence:
(no structure information available)
C28H36N4O5
cyclo-(D-Tyr-L-Trp-D-Val-L-Val) Evidence:
(no structure information available)
C30H37N5O5
cyclo-(D-Phe-L-Trp-D-Val-L-Val) Evidence:
(no structure information available)
C30H37N5O4
cyclo-(D-Phe-L-Phe-D-Val-L-Ile) Evidence:
(no structure information available)
C29H38N4O4
cyclo-(D-Phe-L-Phe-D-Ile-L-Val) Evidence:
(no structure information available)
C29H38N4O4
cyclo-(D-Tyr-L-Trp-D-Val-L-Ile) Evidence:
(no structure information available)
C31H39N5O5
cyclo-(D-Tyr-L-Trp-D-Ile-L-Val) Evidence:
(no structure information available)
C31H39N5O5
cyclo-(D-Tyr-L-Phe-D-Val-L-Ile) Evidence:
(no structure information available)
C29H38N4O5
cyclo-(D-Tyr-L-Phe-D-Ile-L-Val) Evidence:
(no structure information available)
C29H38N4O5
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • PCH_Pc16g04690
  • CAP93139.1
  • Pc16g04690
 1080827 - 1099362 (+) cyclic hydrophobic tetrapeptide
  • Scaffold biosynthesis
  • Knock-out
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Biosynthesis information

Biosynthetic modules

Name
1
Type
nrps-type1
Genes
Pc16g04690
Substrates
phenylalanine, tyrosine (evidence: Structure-based inference)
Integrated Monomers
Domains
adenylation, epimerase
Name
4
Type
nrps-type1
Genes
Pc16g04690 Pc16g04690
Substrates
valine, isoleucine (evidence: Structure-based inference)
Integrated Monomers
Domains
condensation (DCL), adenylation
Name
2
Type
nrps-type1
Genes
Pc16g04690
Substrates
phenylalanine, tryptophan (evidence: Structure-based inference)
Integrated Monomers
Domains
adenylation
Name
3
Type
nrps-type1
Genes
Pc16g04690
Substrates
valine, isoleucine (evidence: Structure-based inference)
Integrated Monomers
Domains
condensation (DCL), adenylation, epimerase
Annotation changelog

Entry version: 4

Date
Changes
Submitters
Reviewers
2022-10-07
Update chemical activity to schema version 2.11
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

Entry version: 3

Date
Changes
Submitters
Reviewers
2022-09-15
Corrected NRP module activity
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
2022-09-15
Corrected NRP modules
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

Entry version: 2

Date
Changes
Submitters
Reviewers
2019-10-16
Migrated from v1.4
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

Entry version: 1

Date
Changes
Submitters
Reviewers
2015-06-12
Submitted
  • (ID: 53KWSSAVU3NHQPX32A2FHV6D)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
Detailed domain annotation
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