Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000357.1:
Cluster 1NRP118536

BGC0000357, fungisporin biosynthetic gene cluster from Penicillium rubens. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: cyclo-(D-Phe-L-Phe-D-Val-L-Val)
Molecular formula: C28H36N4O4
Exact molecular mass: 493.2806 Da ([M+H]+)
Molecular activity: Inhibitor
Molecular target: unknown

Class-specific details

Biosynthetic class(es):
NRP
Cyclic depsipeptide (cyclic)
Thioesterase type:
None
Release / cyclization type:
Other

Nonribosomal peptide synthetases:
HcpA (CAP93139.1)
Module 0
A specificity: Phenylalanine, Tyrosine
Evidence for specificity: Structure-based inference
AA is epimerized
C domain subtype: N/A
Module 1
A specificity: (Phenylalanine, Tryptophane),(Valine, Isoleucine)
Evidence for specificity: Structure-based inference
C domain subtype: DCL
Module 2
A specificity: Valine, isoleucine
Evidence for specificity: Structure-based inference
AA is epimerized
C domain subtype: DCL
Module 3
A specificity: Unknown
Evidence for specificity: Unknown
C domain subtype: DCL
Module 4
A specificity: Unknown
Evidence for specificity: Unknown
C domain subtype: DCL

Gene cluster description

fungisporin (BGC0000357). Gene Cluster 1. Biosynthetic class = NRP. GenBank AM920431. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
MIxS-compliance:Unknown
Contact for this cluster:Arnold J.M. Driessen (Molecular Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute and Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 7, 9747 AG Groningen, The Netherlands)

Literature references

1. Studer RO. (1969) Synthesis and structure of fungisporin. Experientia 25(9):899.
2. Ali H et al. (2014 TI) A non-canonical NRPS is involved in the synthesis of fungisporin and related hydrophobic cyclic tetrapeptides in Penicillium chrysogenum. PLoS One 9(6):e98212. doi: 10.1371/journal.pone.0098212. eCollection