BGC0000357: cyclo-(D-Phe-L-Phe-D-Val-L-Val) biosynthetic gene cluster from Penicillium rubens Wisconsin 54-1255
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Location: 1,080,827 - 1,099,362 nt. (total: 18,536 nt).
This entry is originally from NCBI GenBank AM920431.1, but has been modified (see Modifications tab for details).

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transport-related genes
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Gene details
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General
Compounds
Genes
NRP
History
KnownClusterBlast
NRPS/PKS domains
Modifications
General information about the BGC
MIBiG accession BGC0000357
Short description cyclo-(D-Phe-L-Phe-D-Val-L-Val) biosynthetic gene cluster from Penicillium rubens Wisconsin 54-1255
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP (Cyclic depsipeptide)
Loci NCBI GenBank: AM920431.1
Compounds
  • cyclo-(D-Phe-L-Phe-D-Val-L-Val)
  • cyclo-(D-Tyr-L-Phe-D-Val-L-Val)
  • cyclo-(D-Tyr-L-Trp-D-Val-L-Val)
  • cyclo-(D-Phe-L-Trp-D-Val-L-Val)
  • cyclo-(D-Phe-L-Phe-D-Val-L-Ile)
  • cyclo-(D-Phe-L-Phe-D-Ile-L-Val)
  • cyclo-(D-Tyr-L-Trp-D-Val-L-Ile)
  • cyclo-(D-Tyr-L-Trp-D-Ile-L-Val)
  • cyclo-(D-Tyr-L-Phe-D-Val-L-Ile)
  • cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)
Species Penicillium rubens Wisconsin 54-1255 [taxonomy]
References
Chemical products information
cyclo-(D-Phe-L-Phe-D-Val-L-Val) [synonyms: fungisporin 1]
(no structure information available)
C28H36N4O4
cyclo-(D-Tyr-L-Phe-D-Val-L-Val) [synonyms: fungisporin 2]
(no structure information available)
C28H36N4O5
cyclo-(D-Tyr-L-Trp-D-Val-L-Val) [synonyms: fungisporin 3]
(no structure information available)
C30H37N5O5
cyclo-(D-Phe-L-Trp-D-Val-L-Val) [synonyms: fungisporin 4]
(no structure information available)
C30H37N5O4
cyclo-(D-Phe-L-Phe-D-Val-L-Ile) [synonyms: fungisporin 5]
(no structure information available)
C29H38N4O4
cyclo-(D-Phe-L-Phe-D-Ile-L-Val) [synonyms: fungisporin 6]
(no structure information available)
C29H38N4O4
cyclo-(D-Tyr-L-Trp-D-Val-L-Ile) [synonyms: fungisporin 7]
(no structure information available)
C31H39N5O5
cyclo-(D-Tyr-L-Trp-D-Ile-L-Val) [synonyms: fungisporin 8]
(no structure information available)
C31H39N5O5
cyclo-(D-Tyr-L-Phe-D-Val-L-Ile) [synonyms: fungisporin 9]
(no structure information available)
C29H38N4O5
cyclo-(D-Tyr-L-Phe-D-Ile-L-Val) [synonyms: fungisporin 10]
(no structure information available)
C29H38N4O5
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • PCH_Pc16g04690
  • CAP93139.1
  • Pc16g04690
1080827 - 1099362 (+) cyclic hydrophobic tetrapeptide
  • Scaffold biosynthesis
Knock-out
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NRP-specific information
Subclass Cyclic depsipeptide
Cyclic? yes
NRP-synthases
Gene Modules
CAP93139.1
Module 0
Specificity: Phenylalanine, Tyrosine
Evidence for specificity:
  • Structure-based inference
Module 1
Specificity: (Phenylalanine, Tryptophane),(Valine, Isoleucine)
Evidence for specificity:
  • Structure-based inference
Condensation domain type: DCL
Module 2
Specificity: Valine, isoleucine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: DCL
Module 3
Condensation domain type: DCL
Module 4
Condensation domain type: DCL
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: 53KWSSAVU3NHQPX32A2FHV6D, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
Similar known gene clusters
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Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
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Modifications to original record
  • regenerated translation for PCH_Pc16g02200: translation longer than location allows: 1746 > 1365: PCH_Pc16g02200
  • regenerated translation for PCH_Pc16g03900: translation longer than location allows: 1725 > 1518: PCH_Pc16g03900
  • regenerated translation for PCH_Pc16g04070: translation longer than location allows: 3936 > 941: PCH_Pc16g04070
  • regenerated translation for PCH_Pc16g04420: translation longer than location allows: 1242 > 672: PCH_Pc16g04420
  • regenerated translation for PCH_Pc16g06740: translation longer than location allows: 2247 > 1364: PCH_Pc16g06740
  • regenerated translation for PCH_Pc16g06790: translation longer than location allows: 1404 > 1397: PCH_Pc16g06790
  • regenerated translation for PCH_Pc16g06850: translation longer than location allows: 1986 > 1720: PCH_Pc16g06850
  • regenerated translation for PCH_Pc16g09090: translation longer than location allows: 2088 > 372: PCH_Pc16g09090
  • regenerated translation for PCH_Pc16g09270: translation longer than location allows: 4539 > 1420: PCH_Pc16g09270
  • regenerated translation for PCH_Pc16g09490: translation longer than location allows: 7098 > 1167: PCH_Pc16g09490
  • regenerated translation for PCH_Pc16g10200: translation longer than location allows: 1632 > 627: PCH_Pc16g10200
  • regenerated translation for PCH_Pc16g10580: translation longer than location allows: 825 > 815: PCH_Pc16g10580
  • regenerated translation for PCH_Pc16g11400: translation longer than location allows: 969 > 821: PCH_Pc16g11400
  • regenerated translation for PCH_Pc16g13010: translation longer than location allows: 2718 > 1338: PCH_Pc16g13010
  • regenerated translation for PCH_Pc16g14360: translation longer than location allows: 1710 > 833: PCH_Pc16g14360
  • regenerated translation for PCH_Pc16g14660: translation longer than location allows: 2790 > 1951: PCH_Pc16g14660