BGC0000359: Fuscachelin A biosynthetic gene cluster from Thermobifida fusca YX
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Location: 2,172,724 - 2,196,882 nt. (total: 24,159 nt).
This entry is originally from NCBI GenBank CP000088.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000359
Short description Fuscachelin A biosynthetic gene cluster from Thermobifida fusca YX
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
CP000088.1
2172724 - 2196882
via
Compounds
  • Fuscachelin A
  • Fuscachelin B
  • Fuscachelin C
Species Thermobifida fusca YX [taxonomy]
References
Chemical products information
Fuscachelin A Evidence: NMR [1]
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C42H59N15O16
Chemical database entries
PubCHEM
NPAtlas
Fuscachelin B Evidence: NMR [1]
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C42H61N15O17
Chemical database entries
PubCHEM
NPAtlas
Fuscachelin C Evidence: NMR [1]
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C42H62N16O16
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • Tfu_1865
  • AAZ55898.1
 2172724 - 2176758 (-) amino acid adenylation
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    • Tfu_1866
    • AAZ55899.1
    		 2176783 - 2180007 (-) amino acid adenylation
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      • Tfu_1867
      • AAZ55900.1
      		 2180004 - 2190893 (-) non-ribosomal peptide synthase:Amino acid adenylation
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        • Tfu_1868
        • AAZ55901.1
        		 2190924 - 2191178 (-) isochorismatase
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          • Tfu_1869
          • AAZ55902.1
          		 2191209 - 2192525 (-) putative peptide monooxygenase
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            • Tfu_1870
            • AAZ55903.1
            		 2192529 - 2193194 (-) isochorismatase
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              • Tfu_1871
              • AAZ55904.1
              		 2193191 - 2194822 (-) 2,3-dihydroxybenzoate-AMP ligase
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                • Tfu_1872
                • AAZ55905.1
                		 2194843 - 2196024 (-) isochorismate synthase
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                  • Tfu_1873
                  • AAZ55906.1
                  		 2196100 - 2196882 (-) 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; RBL00455
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                    Biosynthesis information

                    Biosynthetic modules

                    Name
                    Unk01
                    Type
                    nrps-type1
                    Genes
                    Tfu_1865
                    Substrates
                    N5-hydroxyornithine (evidence: Structure-based inference [2])
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk02
                    Type
                    nrps-type1
                    Genes
                    Tfu_1866
                    Substrates
                    serine (evidence: Structure-based inference [2])
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk03
                    Type
                    nrps-type1
                    Genes
                    Tfu_1867
                    Substrates
                    arginine (evidence: Structure-based inference [2])
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk04
                    Type
                    nrps-type1
                    Genes
                    Tfu_1867
                    Substrates
                    glycine (evidence: Structure-based inference [2])
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk05
                    Type
                    nrps-type1
                    Genes
                    Tfu_1867
                    Substrates
                    glycine (evidence: Structure-based inference [2])
                    Integrated Monomers
                    Domains
                    adenylation
                    Name
                    Unk06
                    Type
                    nrps-type1
                    Genes
                    Tfu_1871
                    Substrates
                    2,3-dihydroxybenzoic acid (evidence: Structure-based inference [2])
                    Integrated Monomers
                    Domains
                    adenylation
                    Annotation changelog

                    Entry version: next

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2024-05-14
                    MIBiG v4 annotathon
                    • (ID: IQDGAEIXNOAWG3AVLVJH6HBZ)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                    Entry version: 4

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2022-10-07
                    Update chemical activity to schema version 2.11
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                    Entry version: 3

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2022-09-15
                    Updated bioactivity data
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    2022-09-15
                    Added NRP substrate specificities
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                    Entry version: 2

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2019-10-16
                    Migrated from v1.4
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    2019-10-16
                    Updated reference publication(s) (MIBiG Annotathon)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    2019-10-16
                    Updated compound(s) information (NPAtlas curation)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                    Entry version: 1

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2015-06-12
                    Submitted
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    Detailed domain annotation
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