BGC0000360: GE81112 biosynthetic gene cluster from Streptomyces sp. L-49973
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Location: 1 - 55,651 nt. (total: 55,651 nt).
This entry is originally from NCBI GenBank FN821996.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000360
Short description GE81112 biosynthetic gene cluster from Streptomyces sp. L-49973
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
FN821996.1
via
Compounds
  • GE81112
Species Streptomyces sp. L-49973 [taxonomy]
References
Chemical products information
GE81112 Evidence:
Copy SMILES
C24H35Cl1N10O10
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CBL93707.1
 1 - 1005 (-) partitioning binding protein
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    • CBL93708.1
    		 1463 - 2968 (-) hypothetical protein
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      • CBL93709.1
      		 3503 - 4930 (-) hypothetical protein
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        • CBL93710.1
        		 4960 - 8568 (-) hypothetical protein
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          • CBL93711.1
          		 9229 - 12942 (-) Serine/threonine kinase
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            • CBL93712.1
            • getA
            		 13793 - 14644 (+) Thioesterase
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              • CBL93713.1
              • getB
              		 14767 - 16458 (+) ABC multidrug transporter
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                • CBL93714.1
                • getC
                		 16508 - 18295 (+) ABC multidrug transporter
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                  • CBL93715.1
                  • getD
                  		 18201 - 19406 (+) cyclodeaminase
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                    • CBL93716.1
                    • getE
                    		 19457 - 21010 (+) NRPS A-domain
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                      • CBL93717.1
                      • getF
                      		 20986 - 22077 (-) putative pipecolic acid hydroxylase
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                        • CBL93718.1
                        • getH
                        		 22021 - 29232 (+) NRPS didomain PCP-C
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                          • CBL93719.1
                          • getI
                          		 30915 - 31952 (+) putative 2-oxoglutarate/FeII oxygenase
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                            • CBL93720.1
                            • getJ
                            		 32041 - 34500 (-) NRPS didomain PCP-A
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                              • CBL93721.1
                              • getK
                              		 34740 - 36044 (-) putative GTP-binding protein
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                                • CBL93722.1
                                • getL
                                		 36242 - 37996 (-) Halogenase
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                                  • CBL93723.1
                                  • getM
                                  		 37993 - 39843 (-) NRPS didomain A-PCP
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                                    • CBL93724.1
                                    • thioesterase
                                    		 39885 - 40748 (-) GetN
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                                      • CBL93725.1
                                      		 40708 - 41652 (+) 3-oxoacid CoA-transferase
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                                        • CBL93726.1
                                        		 41768 - 42547 (+) Protocatechuate 3,4-dioxygenase alpha subunit
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                                          • CBL93727.1
                                          		 42547 - 43134 (+) Protocatechuate 3,4-dioxygenase beta subunit
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                                            • CBL93728.1
                                            		 43037 - 44500 (+) 3-carboxymuconate cycloisomerase
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                                              • CBL93729.1
                                              		 44497 - 45276 (+) Deoxyribose-phosphate aldolase
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                                                • CBL93730.1
                                                		 45200 - 48781 (-) NRPS
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                                                  • CBL93731.1
                                                  		 48793 - 51246 (-) NRPS
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                                                    • CBL93732.1
                                                    		 51793 - 52647 (-) putative GTPase
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                                                      • CBL93733.1
                                                      		 52763 - 54034 (+) hypothetical protein
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                                                        • CBL93734.1
                                                        		 54194 - 55651 (+) Integrin like protein
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                                                          Biosynthesis information

                                                          Biosynthetic modules

                                                          Name
                                                          Unk01
                                                          Type
                                                          nrps-type1
                                                          Genes
                                                          getE
                                                          Substrates
                                                          3S-hydroxypipecolic acid, pipecolic acid, D-pipecolic acid, proline (evidence: ATP-PPi exchange assay, Structure-based inference)
                                                          Integrated Monomers
                                                          Domains
                                                          adenylation
                                                          Name
                                                          Unk02
                                                          Type
                                                          nrps-type1
                                                          Genes
                                                          getH
                                                          Substrates
                                                          5R-hydroxy-2S-aminopentanoic acid, ornithine (evidence: ATP-PPi exchange assay, Structure-based inference)
                                                          Integrated Monomers
                                                          Domains
                                                          adenylation
                                                          Name
                                                          Unk03
                                                          Type
                                                          nrps-type1
                                                          Genes
                                                          getH
                                                          Substrates
                                                          histidine (evidence: ATP-PPi exchange assay, Structure-based inference)
                                                          Integrated Monomers
                                                          Domains
                                                          adenylation
                                                          Name
                                                          Unk04
                                                          Type
                                                          nrps-type1
                                                          Genes
                                                          getJ
                                                          Substrates
                                                          3S-hydroxy-6-chlorohistidine, histidine (evidence: ATP-PPi exchange assay, Structure-based inference)
                                                          Integrated Monomers
                                                          Domains
                                                          adenylation
                                                          Name
                                                          Unk05
                                                          Type
                                                          nrps-type1
                                                          Genes
                                                          getM
                                                          Substrates
                                                          histidine (evidence: ATP-PPi exchange assay, Structure-based inference)
                                                          Integrated Monomers
                                                          Domains
                                                          adenylation
                                                          Name
                                                          Unk06
                                                          Type
                                                          nrps-type1
                                                          Genes
                                                          CBL93730.1
                                                          Substrates
                                                          histidine (evidence: ATP-PPi exchange assay, Structure-based inference)
                                                          Integrated Monomers
                                                          Domains
                                                          adenylation
                                                          Annotation changelog

                                                          Entry version: 4

                                                          Date
                                                          Changes
                                                          Submitters
                                                          Reviewers
                                                          2022-10-07
                                                          Update chemical activity to schema version 2.11
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                          Entry version: 3

                                                          Date
                                                          Changes
                                                          Submitters
                                                          Reviewers
                                                          2022-09-15
                                                          Updated bioactivity data
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          2022-09-15
                                                          Added NRP substrate specificities
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                          Entry version: 2

                                                          Date
                                                          Changes
                                                          Submitters
                                                          Reviewers
                                                          2019-10-16
                                                          Migrated from v1.4
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          2019-10-16
                                                          Updated compound(s) information (NPAtlas curation)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                          Entry version: 1

                                                          Date
                                                          Changes
                                                          Submitters
                                                          Reviewers
                                                          2015-06-12
                                                          Submitted
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          Detailed domain annotation
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