BGC0000360: GE81112 biosynthetic gene cluster from Streptomyces sp. L-49973
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Location: 1 - 55,651 nt. (total: 55,651 nt).
This entry is originally from NCBI GenBank FN821996.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000360
Short description GE81112 biosynthetic gene cluster from Streptomyces sp. L-49973
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: FN821996.1
Compounds
  • GE81112
Species Streptomyces sp. L-49973 [taxonomy]
References
Chemical products information
GE81112
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C24H35Cl1N10O10
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CBL93707.1
 1 - 1005 (-) partitioning binding protein
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  • CBL93708.1
 1463 - 2968 (-) hypothetical protein
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  • CBL93709.1
 3503 - 4930 (-) hypothetical protein
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  • CBL93710.1
 4960 - 8568 (-) hypothetical protein
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  • CBL93711.1
 9229 - 12942 (-) Serine/threonine kinase
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  • CBL93712.1
  • getA
 13793 - 14644 (+) Thioesterase
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  • CBL93713.1
  • getB
 14767 - 16458 (+) ABC multidrug transporter
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  • CBL93714.1
  • getC
 16508 - 18295 (+) ABC multidrug transporter
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  • CBL93715.1
  • getD
 18201 - 19406 (+) cyclodeaminase
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  • CBL93716.1
  • getE
 19457 - 21010 (+) NRPS A-domain
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  • CBL93717.1
  • getF
 20986 - 22077 (-) putative pipecolic acid hydroxylase
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  • CBL93718.1
  • getH
 22021 - 29232 (+) NRPS didomain PCP-C
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  • CBL93719.1
  • getI
 30915 - 31952 (+) putative 2-oxoglutarate/FeII oxygenase
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  • CBL93720.1
  • getJ
 32041 - 34500 (-) NRPS didomain PCP-A
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  • CBL93721.1
  • getK
 34740 - 36044 (-) putative GTP-binding protein
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  • CBL93722.1
  • getL
 36242 - 37996 (-) Halogenase
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  • CBL93723.1
  • getM
 37993 - 39843 (-) NRPS didomain A-PCP
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  • CBL93724.1
  • thioesterase
 39885 - 40748 (-) GetN
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  • CBL93725.1
 40708 - 41652 (+) 3-oxoacid CoA-transferase
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  • CBL93726.1
 41768 - 42547 (+) Protocatechuate 3,4-dioxygenase alpha subunit
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  • CBL93727.1
 42547 - 43134 (+) Protocatechuate 3,4-dioxygenase beta subunit
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  • CBL93728.1
 43037 - 44500 (+) 3-carboxymuconate cycloisomerase
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  • CBL93729.1
 44497 - 45276 (+) Deoxyribose-phosphate aldolase
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  • CBL93730.1
 45200 - 48781 (-) NRPS
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  • CBL93731.1
 48793 - 51246 (-) NRPS
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  • CBL93732.1
 51793 - 52647 (-) putative GTPase
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  • CBL93733.1
 52763 - 54034 (+) hypothetical protein
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  • CBL93734.1
 54194 - 55651 (+) Integrin like protein
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
getE
Module ?
Specificity: 3S-hydroxypipecolic acid / pipecolic acid / D-pipecolic acid / proline
Evidence for specificity:
  • ATP-PPi exchange assay
  • Structure-based inference
getH
Module ?
Specificity: 5R-hydroxy-2S-aminopentanoic acid / ornithine
Evidence for specificity:
  • ATP-PPi exchange assay
  • Structure-based inference
Module ?
Specificity: histidine
Evidence for specificity:
  • ATP-PPi exchange assay
  • Structure-based inference
getJ
Module ?
Specificity: 3S-hydroxy-6-chlorohistidine / histidine
Evidence for specificity:
  • ATP-PPi exchange assay
  • Structure-based inference
getM
Module ?
Specificity: histidine
Evidence for specificity:
  • ATP-PPi exchange assay
  • Structure-based inference
CBL93730.1
Module ?
Specificity: histidine
Evidence for specificity:
  • ATP-PPi exchange assay
  • Structure-based inference
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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