BGC0000363 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000363 (Mycobacteroides chelonae (Mycobacterium chelonae))

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	39,983	glycopeptidolipid	NRPS:Type I	100%

BGC0000363 - Region 1 - NRPS

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Location: 1 - 39,983 nt. (total: 39,983 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 39,984
Label		BGC0000363

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000363	0.98	NRP	glycopeptidolipid	Mycobacteroides chelonae
BGC0000364	0.66	NRP	glycopeptidolipid	Mycobacteroides abscessus
BGC0000426	0.41	NRP	sevadicin	Paenibacillus larvae
BGC0001133	0.35	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0000365	0.32	NRP	glycopeptidolipid	Mycolicibacterium smegmatis MC2 155
BGC0001627	0.32	NRP	isonitrile lipopeptides	Mycobacterium tuberculosis H37Rv
BGC0002071	0.32	NRP	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0002324	0.31	NRP, Polyketide	myxochelin B, myxochelin N, myxochelin O, myxochelin P, myxochelin Q, myxochelin A	Archangium violaceum
BGC0002492	0.30	NRP	myxochelin B, myxochelin A	Myxococcus xanthus DK 1622
BGC0000351	0.29	NRP	exochelin	Mycolicibacterium smegmatis MC2 155

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000363	1.00	NRP	glycopeptidolipid	Mycobacteroides chelonae
BGC0000364	0.88	NRP	glycopeptidolipid	Mycobacteroides abscessus
BGC0000426	0.73	NRP	sevadicin	Paenibacillus larvae
BGC0001133	0.68	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0000365	0.66	NRP	glycopeptidolipid	Mycolicibacterium smegmatis MC2 155
BGC0001627	0.65	NRP	isonitrile lipopeptides	Mycobacterium tuberculosis H37Rv
BGC0002071	0.65	NRP	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0002324	0.64	NRP, Polyketide	myxochelin B, myxochelin N, myxochelin O, myxochelin P, myxochelin Q, myxochelin A	Archangium violaceum
BGC0002492	0.63	NRP	myxochelin B, myxochelin A	Myxococcus xanthus DK 1622
BGC0000351	0.62	NRP	exochelin	Mycolicibacterium smegmatis MC2 155

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 909 - 39983:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-Phe - D-Thr) + (D-Ala - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

mps1

Search NORINE for peptide: strict or relaxed

AMP-binding (466..854): Phe

nrpys: Phe

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Unpolar aromatic ring (Phe, Trp)
Single AA prediction:: phe (Phe)

Stachelhaus prediction details:

Stachelhaus sequence:: DVWTAVAMCK
Nearest Stachelhaus code(s):: Phe DVWTAVAMCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1974..2375): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: DYWSVGMVHK
Nearest Stachelhaus code(s):: Thr DYWSVGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

mps2

Search NORINE for peptide: strict or relaxed

AMP-binding (46..434): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: ala (Ala)

Stachelhaus prediction details:

Stachelhaus sequence:: DVWCIAAIYK
Nearest Stachelhaus code(s):: Ala DVWCIAAIYK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1554..1945): X

nrpys: Aol

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: ala (Ala)

Stachelhaus prediction details:

Stachelhaus sequence:: DIWFVAGIYK
Nearest Stachelhaus code(s):: Aol DIWFVAGIYK (100% 8Å match)
Stachelhaus code match:: 100% (strong)