BGC0000366: gobichelin A biosynthetic gene cluster from Streptomyces sp. NRRL F-4415
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Location: 1 - 36,842 nt. (total: 36,842 nt).
This entry is originally from NCBI GenBank KC215181.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000366
Short description gobichelin A biosynthetic gene cluster from Streptomyces sp. NRRL F-4415
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: KC215181.1
Compounds
  • gobichelin A
  • gobichelin B
Species Streptomyces sp. NRRL F-4415 [taxonomy]
References
Chemical products information
gobichelin A
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C30H41N9O9
Chemical database entries
NPAtlas
gobichelin B
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C30H41N9O9
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AGE11883.1
  • gobA
 183 - 806 (+) TetR transcriptional regulator
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  • AGE11884.1
  • gobB
 1044 - 1874 (-) NH3 dependent NAD+ synthase
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  • AGE11885.1
  • gobC
 2103 - 2756 (-) hypothetical protein
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  • AGE11886.1
  • gobD
 2990 - 3457 (-) acetyltransferase
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  • AGE11887.1
  • gobE
 3803 - 4459 (+) isochorismatase
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  • AGE11888.1
  • gobF
 4479 - 4775 (+) hypothetical protein
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  • AGE11889.1
  • gobG
 5111 - 5713 (+) amidinotransferase
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  • AGE11890.1
  • gobH
 5869 - 7338 (-) salicylate synthase
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  • AGE11891.1
  • gobJ
 8437 - 12144 (-) nonribosomal peptide synthetase
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  • AGE11892.1
  • gobK
 12184 - 13917 (+) 2,3-dihydroxybenzoate-AMP ligase
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  • AGE11893.1
  • gobL
 13945 - 14187 (+) MbtH
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  • AGE11894.1
  • gobM
 14251 - 15312 (-) iron siderophore uptake ABC system
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  • AGE11895.1
  • gobN
 15407 - 16243 (-) ABC transporter
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  • AGE11896.1
  • gobO
 16246 - 17331 (-) ABC transporter
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  • AGE11897.1
  • gobP
 17335 - 18396 (+) iron siderophore transporter
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  • AGE11898.1
  • gobR
 20174 - 27922 (+) nonribosomal peptide synthetase
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  • AGE11899.1
  • gobS
 27919 - 34965 (+) nonribosomal peptide synthetase
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  • AGE11900.1
  • gobT
 35036 - 36463 (-) L-ornithine 5-monooxygenase
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
gobJ
Module ?
Specificity: serine
Evidence for specificity:
  • Structure-based inference
  • Radio labelling
gobK
Module ?
Specificity: salicylic acid
Evidence for specificity:
  • Structure-based inference
gobR
Module ?
Specificity: histidine
Evidence for specificity:
  • Structure-based inference
  • Radio labelling
Module ?
Specificity: lysine
Evidence for specificity:
  • Structure-based inference
gobS
Module ?
Specificity: serine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: N5-hydroxyornithine
Evidence for specificity:
  • Structure-based inference
  • Homology
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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