BGC0000367: gramicidin biosynthetic gene cluster from Brevibacillus brevis NBRC 100599
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Location: 3,011,718 - 3,073,069 nt. (total: 61,352 nt).
This entry is originally from NCBI GenBank AP008955.1.

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core biosynthetic genes
additional biosynthetic genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000367
Short description gramicidin biosynthetic gene cluster from Brevibacillus brevis NBRC 100599
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
AP008955.1
3011718 - 3073069
via
Compounds
  • gramicidin
Species Brevibacillus brevis NBRC 100599 [taxonomy]
References
Chemical products information
gramicidin Evidence:
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C99H140N20O17
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BBR47_28840
  • BAH43861.1
  • sdpI
 3011718 - 3012341 (+) immunity protein SdpI homolog
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    • BBR47_28850
    • BAH43862.1
    		 3012343 - 3013098 (+) putative membrane-bound metalloprotease
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      • BBR47_28860
      • BAH43863.1
      		 3013336 - 3016455 (+) putative efflux system
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        • BBR47_28870
        • BAH43864.1
        		 3016480 - 3017814 (+) putative efflux system
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          • BBR47_28880
          • BAH43865.1
          • lgrE
          		 3017836 - 3018618 (+) putative type II thioesterase
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            • BBR47_28890
            • BAH43866.1
            		 3018618 - 3020159 (+) conserved hypothetical protein
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              • BBR47_28900
              • BAH43867.1
              		 3020244 - 3021008 (-) hypothetical membrane protein
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                • BBR47_28910
                • BAH43868.1
                		 3021010 - 3021945 (-) probable ABC transporter ATP binding protein
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                  • BBR47_28920
                  • BAH43869.1
                  • lgrA
                  		 3022439 - 3029266 (+) linear pentadecapeptide gramicidin synthetase LgrA
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                    • BBR47_28930
                    • BAH43870.1
                    • lgrB
                    		 3029271 - 3052508 (+) putative linear pentadecapeptide gramicidin synthetase LgrB
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                      • BBR47_28940
                      • BAH43871.1
                      • lgrC
                      		 3052513 - 3071712 (+) truncated linear pentadecapeptide gramicidin synthetase LgrC
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                        • BBR47_28950
                        • BAH43872.1
                        		 3071726 - 3073069 (-) putative integrase
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                          Biosynthesis information
                          Annotation changelog

                          Entry version: 4

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2022-10-07
                          Update chemical activity to schema version 2.11
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                          Entry version: 3

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2022-09-15
                          Updated bioactivity data
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                          Entry version: 2

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2019-10-16
                          Migrated from v1.4
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2019-10-16
                          Updated reference publication(s) (MIBiG Annotathon)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                          Entry version: 1

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2015-06-12
                          Submitted
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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