BGC0000368: griseobactin biosynthetic gene cluster from Streptomyces sp. ATCC 700974
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Location: 3,182 - 24,298 nt. (total: 21,117 nt).
This entry is originally from NCBI GenBank FN545130.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000368
Short description griseobactin biosynthetic gene cluster from Streptomyces sp. ATCC 700974
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
FN545130.1
3182 - 24298
via
Compounds
  • griseobactin
Species Streptomyces sp. ATCC 700974 [taxonomy]
References
Chemical products information
griseobactin Evidence:
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CBA63655.1
  • dhbG
 3183 - 3422 (-) aryl carrier for 2,3-dihydroxybenzoate
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    • CBA63658.1
    • dhbB
    		 3419 - 4051 (-) isochorismatase
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      • CBA63660.1
      • dhbE
      		 4115 - 5752 (-) 2,3-dihydroxybenzoate-AMP ligase
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        • CBA63662.1
        • dhbC
        		 5749 - 6954 (-) isochorismate synthase
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          • CBA63665.1
          • dhbA
          		 7063 - 7893 (-) 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
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            • CBA63668.1
            • griA
            		 8057 - 10396 (+) siderophore uptake membrane transporter
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              • CBA63671.1
              • griB
              		 10502 - 11776 (+) griseobactin esterase
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                • CBA63674.1
                • griC
                		 12012 - 13331 (-) MFS griseobactin exporter
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                  • CBA63677.1
                  • griD
                  		 13328 - 13531 (-) MbtH-like protein
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                    • CBA63680.1
                    • griE
                    		 13537 - 20943 (-) nonribosomal peptide synthetase NRPS
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                      • CBA63682.1
                      • griF
                      		 21080 - 22273 (+) amidohydrolase
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                        • CBA63685.1
                        • griG
                        		 22350 - 23357 (-) griseobactin-binding lipoprotein
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                          • CBA63688.1
                          • griH
                          		 23507 - 24298 (+) ATPase of griseobactin uptake ABC transporter
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                            Biosynthesis information

                            Biosynthetic modules

                            Name
                            Unk01
                            Type
                            nrps-type1
                            Genes
                            dhbE
                            Substrates
                            2,3-dihydroxybenzoic acid (evidence: Structure-based inference [1])
                            Integrated Monomers
                            Domains
                            adenylation
                            Name
                            Unk02
                            Type
                            nrps-type1
                            Genes
                            griE
                            Substrates
                            arginine (evidence: Structure-based inference [1])
                            Integrated Monomers
                            Domains
                            adenylation
                            Name
                            Unk03
                            Type
                            nrps-type1
                            Genes
                            griE
                            Substrates
                            threonine (evidence: Structure-based inference [1])
                            Integrated Monomers
                            Domains
                            adenylation
                            Annotation changelog

                            Entry version: 4

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2022-10-07
                            Update chemical activity to schema version 2.11
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 3

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2022-09-15
                            Refined reference coordinates
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            2022-09-15
                            Changed compound to that used by the reference paper
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            2022-09-15
                            Updated bioactivity data
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            2022-09-15
                            Added NRP substrate specificities
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 2

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2019-10-16
                            Migrated from v1.4
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            2019-10-16
                            Updated compound(s) information (NPAtlas curation)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 1

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2015-06-12
                            Submitted
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            Detailed domain annotation
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