BGC0000368: griseobactin biosynthetic gene cluster from Streptomyces sp. ATCC 700974
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Location: 3,182 - 24,298 nt. (total: 21,117 nt).
This entry is originally from NCBI GenBank FN545130.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000368
Short description griseobactin biosynthetic gene cluster from Streptomyces sp. ATCC 700974
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: FN545130.1
Compounds
  • griseobactin
Species Streptomyces sp. ATCC 700974 [taxonomy]
References
Chemical products information
griseobactin
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CBA63655.1
  • dhbG
 3183 - 3422 (-) aryl carrier for 2,3-dihydroxybenzoate
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  • CBA63658.1
  • dhbB
 3419 - 4051 (-) isochorismatase
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  • CBA63660.1
  • dhbE
 4115 - 5752 (-) 2,3-dihydroxybenzoate-AMP ligase
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  • CBA63662.1
  • dhbC
 5749 - 6954 (-) isochorismate synthase
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  • CBA63665.1
  • dhbA
 7063 - 7893 (-) 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
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  • CBA63668.1
  • griA
 8057 - 10396 (+) siderophore uptake membrane transporter
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  • CBA63671.1
  • griB
 10502 - 11776 (+) griseobactin esterase
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  • CBA63674.1
  • griC
 12012 - 13331 (-) MFS griseobactin exporter
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  • CBA63677.1
  • griD
 13328 - 13531 (-) MbtH-like protein
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  • CBA63680.1
  • griE
 13537 - 20943 (-) nonribosomal peptide synthetase NRPS
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  • CBA63682.1
  • griF
 21080 - 22273 (+) amidohydrolase
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  • CBA63685.1
  • griG
 22350 - 23357 (-) griseobactin-binding lipoprotein
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  • CBA63688.1
  • griH
 23507 - 24298 (+) ATPase of griseobactin uptake ABC transporter
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
dhbE
Module ?
Specificity: 2,3-dihydroxybenzoic acid
Evidence for specificity:
  • Structure-based inference
griE
Module ?
Specificity: arginine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: threonine
Evidence for specificity:
  • Structure-based inference
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Refined reference coordinates
  • Changed compound to that used by the reference paper
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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