Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000369.1:
Cluster 1NRP / Saccharide167299

BGC0000369, hassallidins biosynthetic gene cluster from Anabaena sp. Syke748. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Hassallidin C
Molecular activity: Antifungal

Class-specific details

Biosynthetic class(es):
NRP / Saccharide
Other (cyclic)
Thioesterase type:
None
Release / cyclization type:
Hydrolysis

Nonribosomal peptide synthetases:
hasG (AHZ20766.1)
Module 0
A specificity: Dihydroxy hexadecanoic acid
Evidence for specificity: Sequence-based prediction
C domain subtype: N/A
hasN (AHZ20773.1)
Module 3
A specificity: Threonine
Evidence for specificity: Sequence-based prediction
AA is epimerized
C domain subtype: LCL
Module 4
A specificity: Tyrosine
Evidence for specificity: Sequence-based prediction
AA is epimerized
C domain subtype: DCL
hasO (AHZ20774.1)
Module 5
A specificity: Threonine
Evidence for specificity: Sequence-based prediction
C domain subtype: DCL
Module 6
A specificity: Glutamine
Evidence for specificity: Sequence-based prediction
AA is epimerized
C domain subtype: DCL
Module 7
A specificity: Glycine
Evidence for specificity: Sequence-based prediction
C domain subtype: DCL
hasV (AHZ20781.1)
Module 1
A specificity: Threonine
Evidence for specificity: Sequence-based prediction
C domain subtype: Starter
Module 2
A specificity: Threonine
Evidence for specificity: Sequence-based prediction
C domain subtype: DCL
hasY (AHZ20784.1)
Module 8
A specificity: N-methyl-threonine
Evidence for specificity: Sequence-based prediction
C domain subtype: LCL
Scaffold-modifying domain: Methylation
Module 9
A specificity: Glutamine / Tyrosine
Evidence for specificity: Sequence-based prediction
C domain subtype: LCL

Gene cluster description

hassallidins (BGC0000369). Gene Cluster 1. Biosynthetic class = NRP/Saccharide. GenBank KJ502174. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:David Fewer (University of Helsinki)

Literature references

1. Vestola J et al. (2014) Hassallidins, antifungal glycolipopeptides, are widespread among cyanobacteria and are the end-product of a nonribosomal pathway. Proc Natl Acad Sci U S A 111(18):E1909-17. doi: