LOCUS       BGC0000372             22264 bp    DNA     linear   CON 23-MAR-2015
DEFINITION  Aspergillus fumigatus Af293 chromosome 3, whole genome shotgun
            sequence.
ACCESSION   BGC0000372
VERSION     BGC0000372
KEYWORDS    .
SOURCE      Aspergillus fumigatus Af293
  ORGANISM  Aspergillus fumigatus Af293
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Aspergillus; Aspergillus subgen. Fumigati.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 13:29:31
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..22264
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[6328:13058]"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      6329..13058
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     cand_cluster    1..22264
                     /SMILES="NC(CC1=CNc2c1cccc2)C(=O)NC(C)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /detection_rules="(indsynth or dmat or indole_PTase)"
                     /kind="neighbouring"
                     /product="NRPS"
                     /product="indole"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     subregion       1..22264
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000372"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..22264
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /contig_edge="True"
                     /product="NRPS"
                     /product="indole"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX))"
                     /rules="(indsynth or dmat or indole_PTase)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(<1..>1288)
                     /locus_tag="AFUA_3G12890"
                     /old_locus_tag="Afu3g12890"
     mRNA            complement(join(<1..870,923..>1288))
                     /locus_tag="AFUA_3G12890"
                     /note="transcript AFUA_3G12890A"
                     /old_locus_tag="Afu3g12890"
                     /product="C6 transcription factor GliZ-like, putative"
     CDS             complement(join(1..870,923..1288))
                     /codon_start=1
                     /locus_tag="AFUA_3G12890"
                     /note="encoded by transcript AFUA_3G12890A; similar to
                     GB:AAS92551.1: SirZ [Leptosphaeria maculans] similar to
                     GB:AAM02989.1: AFLR [Aspergillus pseudotamarii];
                     GO_component: GO:0005634 - nucleus; GO_function: GO:0003700
                     - transcription factor activity; GO_process: GO:0045449 -
                     regulation of transcription"
                     /old_locus_tag="Afu3g12890"
                     /product="C6 transcription factor GliZ-like, putative"
                     /protein_id="EAL92294.1"
                     /transl_table=11
                     /translation="MTSTLPYLTSPPATHPSNSDHKKLRSACDSCHQCKVKCSGGSPCF
                     RCTSKGLNCRYGYQNRAGKPKGSKNRKTLEREHQLRMEWLTSQLRDANGGLGNLNIDLS
                     DPTTLLPSPFFQSTRWKQGHMLPQSSVQPTPANQCIKSTEHESECLPTPQGLDTWTMDL
                     GPIAQTPRESTSESLEAFTTPISFTGGGETYLRQLSDPTTPISFGFPSPHARLDGTGDP
                     CACVQTQAVNISTLHQLTCRDRSDRFDLAMKSITSTLETCEKFVVCEACDKSVASILLT
                     LSAIELIFTLFEQLTMNNRRLSPPEEEQRLIPCSLGDYKVTKEESQAIRNVLVKMTLSK
                     GKQALNALQNLVNGSVDFLDESGPCEASQHDSNNANEPMLSGLSVTDRNYMTQCISRKN
                     AALEVLMAAVAV"
     repeat_region   complement(1870..1894)
                     /rpt_type=tandem
                     /rpt_unit_seq="ttccc"
                     /satellite="microsatellite"
     gene            <2582..>4062
                     /locus_tag="AFUA_3G12900"
                     /old_locus_tag="Afu3g12900"
     mRNA            join(<2582..2760,2833..3191,3251..>4062)
                     /locus_tag="AFUA_3G12900"
                     /note="transcript AFUA_3G12900A"
                     /old_locus_tag="Afu3g12900"
                     /product="MFS transporter, putative"
     CDS             join(2582..2760,2833..3191,3251..4062)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1137:Major
                     facilitator superfamily MFS 1 (Score: 416.2; E-value:
                     1.8e-126)"
                     /gene_kind="transport"
                     /locus_tag="AFUA_3G12900"
                     /note="encoded by transcript AFUA_3G12900A; similar to
                     monocarboxylate permease Mch4p (GI:6324453) [Saccharomyces
                     cerevisiae]; GO_component: GO:0000329 - membrane of vacuole
                     with cell cycle-correlated morphology; GO_function:
                     GO:0005215 - transporter activity; GO_function: GO:0008028
                     - monocarboxylic acid transporter activity; GO_process:
                     GO:0006810 - transport"
                     /old_locus_tag="Afu3g12900"
                     /product="MFS transporter, putative"
                     /protein_id="EAL92293.2"
                     /transl_table=11
                     /translation="MSEEAPKHEAPSVISPIENEEKGLAPKPLERVPPNGGAKAWACVA
                     GSFLLQFCSFGYVNACGIFQLYYQETMLKDQTSSALAWITTLQIFLLFMFGPAVGKMID
                     VYGCRRTLPPFSIGAVFSVCMLSLCTKYWQVMLAQGVAFGLAAAGLSLPAMATATQWFS
                     TKKGLAVGIVSAGSSLGGVIYPCMLPRLIEQVGFASAVRWTALMQGILLFIANLLCSSP
                     YPPLGRASKEASAEKDATEPTPRRSGLRGFKSLPWGFFVLGCFFTMWGLFAPLNYLPEM
                     AALHGYQSFARYTLAIANAGSLVGRIVPGWVSDIIGQFNTMCIVTSLSGVLVLAFWLPL
                     EFHTSLAGIIVFALLFGFVSGGFVSLGPPCVVSLAEDRVDEIGVKLGGFCLAIALGALT
                     GLPIEGAIKDREGNKFTGLMCFAGATMILGGVCTGTARVFKGGPRLMKKV"
     protocluster    3752..22264
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[13751:15223]"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      13752..15223
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="2"
     cand_cluster    3752..22264
                     /candidate_cluster_number="2"
                     /contig_edge="True"
                     /detection_rules="(indsynth or dmat or indole_PTase)"
                     /kind="single"
                     /product="indole"
                     /protoclusters="2"
                     /tool="antismash"
     gene            complement(<4632..>5993)
                     /locus_tag="AFUA_3G12910"
                     /old_locus_tag="Afu3g12910"
     mRNA            complement(join(<4632..5710,5771..>5993))
                     /locus_tag="AFUA_3G12910"
                     /note="transcript AFUA_3G12910A"
                     /old_locus_tag="Afu3g12910"
                     /product="O-methyltransferase GliM-like, putative"
     CDS             complement(join(4632..5710,5771..5993))
                     /EC_number="2.-.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 255.3; E-value:
                     1.5e-77)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="AFUA_3G12910"
                     /note="encoded by transcript AFUA_3G12910A; similar to
                     GB:AAS92548.1: SirM [Leptosphaeria maculans] similar to
                     GliM (GI:56609355) [Aspergillus fumigatus] PMID: 15979823;
                     GO_function: GO:0008171 - O-methyltransferase activity;
                     GO_function: GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity"
                     /old_locus_tag="Afu3g12910"
                     /product="O-methyltransferase GliM-like, putative"
                     /protein_id="EAL92292.1"
                     /transl_table=11
                     /translation="MENELEHLNWNIKHALLQLEGPLAQELDSCLEVSPGALSPSNSVY
                     QKILDTVQVLDKLLVTLTPPHMTLVDGVFAFTNSKVLLCASEYALADHVQKLQPCSISQ
                     LAEATGLHEQGLFQIVRYLREMGYFSQDPKTGLLSNNRLSNLLRKDHWATWINWVDFFP
                     REYYDLLSRLPDQLRSDQPKTATELFYNTDKPIYQYLAETGRAAGFHKVTGTGSVVEAP
                     GLLADYPWEEVKSETVVDVGAGVGDFIRSYLEKFPDATAAAFELPSTAEILKQRFPDDD
                     PLTSRIVSITGGDFFQDPIPESSVYLLRWILHNWGDEDCIKLLRRIRETMVIKPGVSRV
                     LIIESVLFDGRLGRGARYADIRMLARCRNKERTLGEYRKLAEEAGWRLNRVVSPRGCLT
                     QIMELRPVGACTGSPRANGNGNSAGGLEWESELM"
     gene            <6329..>13058
                     /locus_tag="AFUA_3G12920"
                     /old_locus_tag="Afu3g12920"
     mRNA            join(<6329..7034,7089..10097,10165..>13058)
                     /locus_tag="AFUA_3G12920"
                     /note="transcript AFUA_3G12920A"
                     /old_locus_tag="Afu3g12920"
                     /product="nonribosomal peptide synthase GliP-like,
                     putative"
     CDS             join(6329..7034,7089..10097,10165..13058)
                     /EC_number="6.3.2.-"
                     /NRPS_PKS="Domain: AMP-binding (29-419). E-value: 5.3e-78.
                     Score: 254.2. Matches aSDomain:
                     nrpspksdomains_AFUA_3G12920_AMP-binding.1"
                     /NRPS_PKS="Domain: PP-binding (525-589). E-value: 7.6e-09.
                     Score: 27.9. Matches aSDomain:
                     nrpspksdomains_AFUA_3G12920_PP-binding.1"
                     /NRPS_PKS="Domain: Condensation_DCL (624-917). E-value:
                     7e-49. Score: 158.4. Matches aSDomain:
                     nrpspksdomains_AFUA_3G12920_Condensation_DCL.1"
                     /NRPS_PKS="Domain: AMP-binding (1086-1465). E-value:
                     7.7e-83. Score: 270.2. Matches aSDomain:
                     nrpspksdomains_AFUA_3G12920_AMP-binding.2"
                     /NRPS_PKS="Domain: PCP (1569-1641). E-value: 5.5e-13.
                     Score: 40.8. Matches aSDomain:
                     nrpspksdomains_AFUA_3G12920_PCP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (1663-1952). E-value:
                     2.8e-44. Score: 143.2. Matches aSDomain:
                     nrpspksdomains_AFUA_3G12920_Condensation_LCL.1"
                     /NRPS_PKS="Domain: PCP (2132-2198). E-value: 2.4e-09.
                     Score: 29.2. Matches aSDomain:
                     nrpspksdomains_AFUA_3G12920_PCP.2"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     265.8; E-value: 1e-80)"
                     /gene_kind="biosynthetic"
                     /locus_tag="AFUA_3G12920"
                     /note="encoded by transcript AFUA_3G12920A; similar to SirP
                     (GI:46403055) [Leptosphaeria maculans] PMID: 15387811
                     similar to GliP (GI:56609357) [Aspergillus fumigatus] PMID:
                     15979823; GO_function: GO:0003824 - catalytic activity;
                     GO_process: GO:0019184 - nonribosomal peptide biosynthetic
                     process; GO_process: GO:0030651 - peptide antibiotic
                     biosynthetic process; GO_process: GO:0043042 - amino acid
                     adenylylation by nonribosomal peptide synthase"
                     /old_locus_tag="Afu3g12920"
                     /product="nonribosomal peptide synthase GliP-like,
                     putative"
                     /protein_id="EAL92291.2"
                     /sec_met_domain="Condensation (E-value: 3.1e-47, bitscore:
                     150.1, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 2e-88, bitscore:
                     285.7, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 4.2e-11, bitscore:
                     32.4, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNLTLTTTSITIQPSATMANRAPTLLDHFHDQLQKHSSSVAIEDG
                     TQSADQGAWERVTYAQLDALSDSWSKRLRQAGVGAGCIVPLLSKRSVAMVAATLAILKL
                     RAAYVSIDIDSWGKDRIDTVLKTVNPQIIVSTSPCPKDHYPYPVVALERNDFDETVTSN
                     GTQWTRNDEDSIDRGNDLAYIIFTSGTTGIPKGVKIGQRSISRYVKEGGDLPFNFNTTH
                     GTRVLLICSIAFDVCAGVMFNTLCNGGTLVLADPSTFETAAKTCHVLPLTPSILVTLDP
                     KAGFDTVEKIFLGGESPSPSLIEAWSSPRRRLYNAYGPTETTCTAFMGELLPGSPITIG
                     YPISYSTVTLLDEDGMESVEGEICIAGLGLALGYFHDPERTNSAFVEWNGVRIYKTGDY
                     GRRTKHGLQFCGRRDSVVKNRGFLINLEADVEPALLSYDKVDSASAFMSQGQLIAFVTP
                     TSAKEGLREYLANTVSSFLVPDTIYSLDEFPRTSNGKVDRRSLMRMHELEQGSDTASLE
                     RGLGAVESVRRGLSHVLRLPESQILPASSFRHLGGHSLAAVMLVSVLRRMGFGISVAEV
                     LLLDTVENIAAAVVELSDIPHALSAQEDLIERLRHDISTTRPLDEGVTIAPMTDMQTRL
                     LGASVATPGLSFIKTSFTLDHPEKEDLTSTLRAAWVRLHQTHEILRTAFVLTASNGTQI
                     ISQEPDFSWKEKFVTESEWESVCRREEHLDVADFPDFDAENRASLSRVVLIIAPRRRTR
                     FVWTVHHSLIDGWSMATLMRDFASCLDGKPIPAPPQFAQVAQAIGQLKAESSDRAVSFW
                     KEYLDGYTPAQRLRVSPPSDVSDYTQAALSRKLTVSVSALEDAARDRFAVTPATLLYAA
                     WGLLLSRYSGTDRAALGAVLSGRSLPIPGVENIIGPLINTLPLAINTQEAQSTYSFVQS
                     VFRRLCDILEFQWSPVALIQEGCGCNPSELFETLFALQYDFPQTPWKSSEVPEPRDIRY
                     EEATQVPLTVLLDNANGQFEVRFIYRRSHFGDATVQRMIGQFGNLLENLIAAQPDTDLS
                     NVTGQMFNNRVYEMSIAKPGQPVSACKVPESLTEAIENSIQAHPDIYAVEGLTGRLTYR
                     EFGRMTEHISQRLLQHIQPGSVACMISDGSLLWLLAMVAIIRAGAIYCPVDEKLPRDRK
                     DYMVRNSRAALILYANSSQEPLCNGVPSLNMESIMQEISSSSGSPIATSRNRPSGDTVA
                     CLVYTSGSTGLPKAVQLQHKGILNVISQPEGRLYSRPGQRNAQMLSLGFDCCIKEVFST
                     ICFGATLVLKDPENPISHLARVDATMATPSLLATLEPTDYPNLKVITVAGEAVSQVLND
                     KWAAGRTLINGYGPAECTLISTTAILHPGNRVSIGKPLPGLSCYLLDSNKRPVPMGVSG
                     EIYISGVQVTPGYLHNEQETSKRFLSDSFNPGQVMYRTGDIGRMLEDGNIEYIGREDNQ
                     IKLRGFRIDLGEVQSTISKLASTASNVALIVSNGNLVAFMTPETIDVRSLAKSLETQLP
                     QYAVPNRIIALATLPTSANNKVDSSALQRYLRDHGKDGAVVEDLETDTQRVLAVIWADM
                     LGRDLNQTPISPSDRFFELGGHSLLQIKVAQAISKRWNIRPLPLKQVIRHHSLQDLSLA
                     IDELVSDPRTVSTMPFLEMTPVARNGQLPLSYLEKEMLLNHLISGGSPAGNMNFVCKIR
                     GDINAETLADAFQRVTADVEVFRTRYSVIEGTLFRQQAPGSVKVPRVVQTGNLSSFVHG
                     RITKSFDLSTEPPVDVSIIIGTPMQAMLVVVMSHVVGDAATMATYLNRVSRTYDLLRSN
                     SQTTNTSTVPDNLTYIDWAHWASTLQPNPRALTFWSSYLSNPPSPLTFGNPSPAPATYI
                     GLTRSWTLPPSMYRKLSDLAAKASVTMHQLILAAVFFSLQCVDRRDDILVAAPFTHRTE
                     PGTESLPGLFLDRLLLRIQRSPHQSSIFDFLSSVRETSQQALAHVIPFHTLRHSLAHKP
                     SLIDPLFKVMVTYHTAADQRPLLDLSGAEVQPIPWRHTGGSKFPLKFEFTEMATQDLEV
                     DMEYDLGCIREDIALRLEFALSFALQLMVLERETDDIIQLVQMSFCPGEGSPVGLTPSH
                     EGSAELTNGTNKTDSTTGQQELENNLTDVVCECLGLEIQDVDADKSFWDLGAQSMDALK
                     LQHLCEKRGVRVRLRDIFVSRSLLELATCAVII"
     aSDomain        join(6416..7034,7089..7639)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AFUA_3G12920_AMP-binding.1"
                     /evalue="5.30E-78"
                     /label="AFUA_3G12920_AMP-binding.1"
                     /locus_tag="AFUA_3G12920"
                     /protein_end="419"
                     /protein_start="29"
                     /score="254.2"
                     /specificity="substrate consensus: Trp"
                     /tool="antismash"
                     /translation="HDQLQKHSSSVAIEDGTQSADQGAWERVTYAQLDALSDSWSKRLR
                     QAGVGAGCIVPLLSKRSVAMVAATLAILKLRAAYVSIDIDSWGKDRIDTVLKTVNPQII
                     VSTSPCPKDHYPYPVVALERNDFDETVTSNGTQWTRNDEDSIDRGNDLAYIIFTSGTTG
                     IPKGVKIGQRSISRYVKEGGDLPFNFNTTHGTRVLLICSIAFDVCAGVMFNTLCNGGTL
                     VLADPSTFETAAKTCHVLPLTPSILVTLDPKAGFDTVEKIFLGGESPSPSLIEAWSSPR
                     RRLYNAYGPTETTCTAFMGELLPGSPITIGYPISYSTVTLLDEDGMESVEGEICIAGLG
                     LALGYFHDPERTNSAFVEWNGVRIYKTGDYGRRTKHGLQFCGRRDSVVKN"
     aSModule        6416..8149
                     /complete
                     /domains="nrpspksdomains_AFUA_3G12920_AMP-binding.1"
                     /domains="nrpspksdomains_AFUA_3G12920_PP-binding.1"
                     /locus_tags="AFUA_3G12920"
                     /monomer_pairings="Trp -> Trp"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       6623..6664
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AFUA_3G12920_0001"
                     /evalue="8.80E-02"
                     /label="NRPS-A_a2"
                     /locus_tag="AFUA_3G12920"
                     /protein_end="112"
                     /protein_start="98"
                     /score="6.8"
                     /tool="antismash"
                     /translation="LAILKLRAAYVSID"
     CDS_motif       6872..6925
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AFUA_3G12920_0002"
                     /evalue="7.20E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="AFUA_3G12920"
                     /protein_end="199"
                     /protein_start="181"
                     /score="21.7"
                     /tool="antismash"
                     /translation="AYIIFTSGTTGIPKGVKI"
     CDS_motif       7331..7357
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AFUA_3G12920_0003"
                     /evalue="1.20E-01"
                     /label="NRPS-A_a5"
                     /locus_tag="AFUA_3G12920"
                     /protein_end="325"
                     /protein_start="316"
                     /score="5.7"
                     /tool="antismash"
                     /translation="YGPTETTCT"
     CDS_motif       7457..7537
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AFUA_3G12920_0004"
                     /evalue="5.40E-10"
                     /label="NRPS-A_a6"
                     /locus_tag="AFUA_3G12920"
                     /protein_end="385"
                     /protein_start="358"
                     /score="31.6"
                     /tool="antismash"
                     /translation="VEGEICIAGLGLALGYFHDPERTNSAF"
     CDS_motif       7607..7660
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AFUA_3G12920_0005"
                     /evalue="2.50E-03"
                     /label="NRPS-A_a8"
                     /locus_tag="AFUA_3G12920"
                     /protein_end="426"
                     /protein_start="408"
                     /score="10.7"
                     /tool="antismash"
                     /translation="FCGRRDSVVKNRGFLINL"
     aSDomain        7958..8149
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AFUA_3G12920_PP-binding.1"
                     /evalue="7.60E-09"
                     /label="AFUA_3G12920_PP-binding.1"
                     /locus_tag="AFUA_3G12920"
                     /protein_end="589"
                     /protein_start="525"
                     /score="27.9"
                     /tool="antismash"
                     /translation="VRRGLSHVLRLPESQILPASSFRHLGGHSLAAVMLVSVLRRMGFG
                     ISVAEVLLLDTVENIAAAV"
     aSDomain        8255..9133
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AFUA_3G12920_Condensation_DCL.1"
                     /domain_subtypes="Condensation_DCL"
                     /evalue="7.00E-49"
                     /label="AFUA_3G12920_Condensation_DCL.1"
                     /locus_tag="AFUA_3G12920"
                     /protein_end="917"
                     /protein_start="624"
                     /score="158.4"
                     /tool="antismash"
                     /translation="IAPMTDMQTRLLGASVATPGLSFIKTSFTLDHPEKEDLTSTLRAA
                     WVRLHQTHEILRTAFVLTASNGTQIISQEPDFSWKEKFVTESEWESVCRREEHLDVADF
                     PDFDAENRASLSRVVLIIAPRRRTRFVWTVHHSLIDGWSMATLMRDFASCLDGKPIPAP
                     PQFAQVAQAIGQLKAESSDRAVSFWKEYLDGYTPAQRLRVSPPSDVSDYTQAALSRKLT
                     VSVSALEDAARDRFAVTPATLLYAAWGLLLSRYSGTDRAALGAVLSGRSLPIPGVENII
                     GPLINTLPLAIN"
     aSModule        8255..11372
                     /complete
                     /domains="nrpspksdomains_AFUA_3G12920_Condensation_DCL.1"
                     /domains="nrpspksdomains_AFUA_3G12920_AMP-binding.2"
                     /domains="nrpspksdomains_AFUA_3G12920_PCP.1"
                     /locus_tags="AFUA_3G12920"
                     /monomer_pairings="Ala -> Ala"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       8375..8437
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AFUA_3G12920_0006"
                     /evalue="5.00E-05"
                     /label="C2_DCL_024-062"
                     /locus_tag="AFUA_3G12920"
                     /protein_end="685"
                     /protein_start="664"
                     /score="15.6"
                     /tool="antismash"
                     /translation="TLRAAWVRLHQTHEILRTAFV"
     CDS_motif       8654..8713
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AFUA_3G12920_0007"
                     /evalue="3.30E-08"
                     /label="C3_DCL_135-156"
                     /locus_tag="AFUA_3G12920"
                     /protein_end="777"
                     /protein_start="757"
                     /score="26.1"
                     /tool="antismash"
                     /translation="VHHSLIDGWSMATLMRDFAS"
     CDS_motif       9041..9124
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AFUA_3G12920_0008"
                     /evalue="2.90E-11"
                     /label="C5_DCL_263-294"
                     /locus_tag="AFUA_3G12920"
                     /protein_end="914"
                     /protein_start="886"
                     /score="35.8"
                     /tool="antismash"
                     /translation="LGAVLSGRSLPIPGVENIIGPLINTLPL"
     aSDomain        join(9641..10097,10165..10844)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AFUA_3G12920_AMP-binding.2"
                     /evalue="7.70E-83"
                     /label="AFUA_3G12920_AMP-binding.2"
                     /locus_tag="AFUA_3G12920"
                     /protein_end="1465"
                     /protein_start="1086"
                     /score="270.2"
                     /specificity="substrate consensus: Ala"
                     /tool="antismash"
                     /translation="SIQAHPDIYAVEGLTGRLTYREFGRMTEHISQRLLQHIQPGSVAC
                     MISDGSLLWLLAMVAIIRAGAIYCPVDEKLPRDRKDYMVRNSRAALILYANSSQEPLCN
                     GVPSLNMESIMQEISSSSGSPIATSRNRPSGDTVACLVYTSGSTGLPKAVQLQHKGILN
                     VISQPEGRLYSRPGQRNAQMLSLGFDCCIKEVFSTICFGATLVLKDPENPISHLARVDA
                     TMATPSLLATLEPTDYPNLKVITVAGEAVSQVLNDKWAAGRTLINGYGPAECTLISTTA
                     ILHPGNRVSIGKPLPGLSCYLLDSNKRPVPMGVSGEIYISGVQVTPGYLHNEQETSKRF
                     LSDSFNPGQVMYRTGDIGRMLEDGNIEYIGREDNQIKLR"
     CDS_motif       9818..9856
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AFUA_3G12920_0009"
                     /evalue="6.80E-03"
                     /label="NRPS-A_a2"
                     /locus_tag="AFUA_3G12920"
                     /protein_end="1158"
                     /protein_start="1145"
                     /score="10.1"
                     /tool="antismash"
                     /translation="AIIRAGAIYCPVD"
     CDS_motif       join(10055..10097,10165..10181)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AFUA_3G12920_0010"
                     /evalue="4.30E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="AFUA_3G12920"
                     /protein_end="1244"
                     /protein_start="1224"
                     /score="22.4"
                     /tool="antismash"
                     /translation="ACLVYTSGSTGLPKAVQLQH"
     CDS_motif       10512..10535
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AFUA_3G12920_0011"
                     /evalue="2.50E-01"
                     /label="NRPS-A_a5"
                     /locus_tag="AFUA_3G12920"
                     /protein_end="1362"
                     /protein_start="1354"
                     /score="4.8"
                     /tool="antismash"
                     /translation="YGPAECTL"
     CDS_motif       10638..10727
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AFUA_3G12920_0012"
                     /evalue="1.90E-10"
                     /label="NRPS-A_a6"
                     /locus_tag="AFUA_3G12920"
                     /protein_end="1426"
                     /protein_start="1396"
                     /score="33.0"
                     /tool="antismash"
                     /translation="PMGVSGEIYISGVQVTPGYLHNEQETSKRF"
     CDS_motif       10809..10871
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AFUA_3G12920_0013"
                     /evalue="1.70E-09"
                     /label="NRPS-A_a8"
                     /locus_tag="AFUA_3G12920"
                     /protein_end="1474"
                     /protein_start="1453"
                     /score="29.9"
                     /tool="antismash"
                     /translation="YIGREDNQIKLRGFRIDLGEV"
     aSDomain        11157..11372
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AFUA_3G12920_PCP.1"
                     /evalue="5.50E-13"
                     /label="AFUA_3G12920_PCP.1"
                     /locus_tag="AFUA_3G12920"
                     /protein_end="1641"
                     /protein_start="1569"
                     /score="40.8"
                     /tool="antismash"
                     /translation="RVLAVIWADMLGRDLNQTPISPSDRFFELGGHSLLQIKVAQAISK
                     RWNIRPLPLKQVIRHHSLQDLSLAIDE"
     aSDomain        11439..12305
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AFUA_3G12920_Condensation_LCL.1"
                     /domain_subtypes="Condensation_LCL"
                     /evalue="2.80E-44"
                     /label="AFUA_3G12920_Condensation_LCL.1"
                     /locus_tag="AFUA_3G12920"
                     /protein_end="1952"
                     /protein_start="1663"
                     /score="143.2"
                     /tool="antismash"
                     /translation="GQLPLSYLEKEMLLNHLISGGSPAGNMNFVCKIRGDINAETLADA
                     FQRVTADVEVFRTRYSVIEGTLFRQQAPGSVKVPRVVQTGNLSSFVHGRITKSFDLSTE
                     PPVDVSIIIGTPMQAMLVVVMSHVVGDAATMATYLNRVSRTYDLLRSNSQTTNTSTVPD
                     NLTYIDWAHWASTLQPNPRALTFWSSYLSNPPSPLTFGNPSPAPATYIGLTRSWTLPPS
                     MYRKLSDLAAKASVTMHQLILAAVFFSLQCVDRRDDILVAAPFTHRTEPGTESLPGLFL
                     DRLLLRIQ"
     aSModule        11439..13043
                     /domains="nrpspksdomains_AFUA_3G12920_Condensation_LCL.1"
                     /domains="nrpspksdomains_AFUA_3G12920_PCP.2"
                     /incomplete
                     /locus_tags="AFUA_3G12920"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       11532..11618
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AFUA_3G12920_0014"
                     /evalue="1.50E-05"
                     /label="C2_starter_024-063"
                     /locus_tag="AFUA_3G12920"
                     /protein_end="1723"
                     /protein_start="1694"
                     /score="17.7"
                     /tool="antismash"
                     /translation="KIRGDINAETLADAFQRVTADVEVFRTRY"
     CDS_motif       11817..11876
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AFUA_3G12920_0015"
                     /evalue="1.60E+00"
                     /label="C3_starter_134-155"
                     /locus_tag="AFUA_3G12920"
                     /protein_end="1809"
                     /protein_start="1789"
                     /score="2.1"
                     /tool="antismash"
                     /translation="HVVGDAATMATYLNRVSRTY"
     CDS_motif       12210..12299
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AFUA_3G12920_0016"
                     /evalue="2.60E-05"
                     /label="C5_LCL_267-296"
                     /locus_tag="AFUA_3G12920"
                     /protein_end="1950"
                     /protein_start="1920"
                     /score="16.7"
                     /tool="antismash"
                     /translation="DILVAAPFTHRTEPGTESLPGLFLDRLLLR"
     aSDomain        12846..13043
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AFUA_3G12920_PCP.2"
                     /evalue="2.40E-09"
                     /label="AFUA_3G12920_PCP.2"
                     /locus_tag="AFUA_3G12920"
                     /protein_end="2198"
                     /protein_start="2132"
                     /score="29.2"
                     /tool="antismash"
                     /translation="ENNLTDVVCECLGLEIQDVDADKSFWDLGAQSMDALKLQHLCEKR
                     GVRVRLRDIFVSRSLLELATC"
     gene            <13752..>15223
                     /locus_tag="AFUA_3G12930"
                     /old_locus_tag="Afu3g12930"
     mRNA            join(<13752..15052,15106..>15223)
                     /locus_tag="AFUA_3G12930"
                     /note="transcript AFUA_3G12930A"
                     /old_locus_tag="Afu3g12930"
                     /product="dimethylallyl tryptophan synthase SirD-like,
                     putative"
     CDS             join(13752..15052,15106..15223)
                     /EC_number="2.5.1.34"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) indole:
                     dmat"
                     /gene_kind="biosynthetic"
                     /locus_tag="AFUA_3G12930"
                     /note="encoded by transcript AFUA_3G12930A; similar to
                     dimethylallyltryptophan synthase DmaW (GI:32402654)
                     [Claviceps purpurea] similar to SirD (GI:46403064)
                     [Leptosphaeria maculans] PMID: 15387811; GO_function:
                     GO:0050364 - tryptophan dimethylallyltransferase activity;
                     GO_process: GO:0009821 - alkaloid biosynthetic process"
                     /old_locus_tag="Afu3g12930"
                     /product="dimethylallyl tryptophan synthase SirD-like,
                     putative"
                     /protein_id="EAL92290.2"
                     /sec_met_domain="dmat (E-value: 3.5e-143, bitscore: 466.6,
                     seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIGAEIDSLVPAPPGLNGTAAGYPAKTQKELSNGDFDAHDGLSL
                     AQLTPYDVLTAALPLPAPASSTGFWWRETGPVMSKLLAKANYPLYTHYKYLMLYHTHIL
                     PLLGPRPPLENSTHPSPSNAPWRSFLTDDFTPLEPSWNVNGNSEAQSTIRLGIEPIGFE
                     AGAAADPFNQAAVTQFMHSYEATEVGATLTLFEHFRNDMFVGPETYAALRAKIPEGEHT
                     TQSFLAFDLDAGRVTTKAYFFPILMSLKTGQSTTKVVSDSILHLALKSEVWGVQTIAAM
                     SVMEAWIGSYGGAAKTEMISVDCVNEADSRIKIYVRMPHTSLRKVKEAYCLGGRLTDEN
                     TKEGLKLLDELWRTVFGIDDEDAELPQNSHRTAGTIFNFELRPGKWFPEPKVYLPVRHY
                     CESDMQIASRLQTFFGRLGWHNMEKDYCKHLEDLFPHHPLSSSTGTHTFLSFSYKKQKG
                     VYMTMYYNLRVYST"
     gene            complement(<15446..>17952)
                     /locus_tag="AFUA_3G12940"
                     /old_locus_tag="Afu3g12940"
     mRNA            complement(join(<15446..15487,15540..16032,16109..16779,
                     16842..17363,17416..>17952))
                     /locus_tag="AFUA_3G12940"
                     /note="transcript AFUA_3G12940A"
                     /old_locus_tag="Afu3g12940"
                     /product="C6 transcription factor, putative"
     CDS             complement(join(15446..15487,15540..16032,16109..16779,
                     16842..17363,17416..17952))
                     /codon_start=1
                     /locus_tag="AFUA_3G12940"
                     /note="encoded by transcript AFUA_3G12940A; similar to
                     transcriptional activator involved in regulation ofproteins
                     of the lysine biosynthesis pathway; requires 2-aminoadipate
                     semialdehyde as co-inducer; Lys14p (GI:6320237)
                     [Saccharomyces cerevisiae]; GO_component: GO:0005634 -
                     nucleus; GO_function: GO:0003700 - transcription factor
                     activity; GO_process: GO:0045449 - regulation of
                     transcription"
                     /old_locus_tag="Afu3g12940"
                     /product="C6 transcription factor, putative"
                     /protein_id="EAL92289.2"
                     /transl_table=11
                     /translation="MDSTTSSSRFSVSSPQSGPSAGIQKGRQRTITACLTCRRRKVKCD
                     HAQPVCTPCQRGGRVCTYVTPQPVSQAPSRVGTGSRVSRTNLRSGQEEIRSRLERLEKL
                     LERAISGGGNMSILPDAKGTSTGSLSDVDQGGNALPNPKCETLSADGYDGALLLEAEGG
                     QSRWVSSLHYALLADEIHDVKMLLGDQSSGAPADSPPSDQPTPPFPFSGSTVESLTPWS
                     PKSAEDCLALLEIFYSNVDPMTRLVHKPTLQRRFTQYINHTYGTRTQSPGVEEAADASR
                     PDHTIHAFEPLALAIFYSAINSLSAEDVMMRFAAEKDALLAQFQRGVELGLGREDFLTT
                     PSIEVLQAFVLLLTCQSREDDMSRTWTLLGLVVRMALSQGLHREPSLFPSSNMDVVQVE
                     TRRRLWHQICHLDFRSAEGRGQEPTIADEDYTTLLPRNINDEDLIEGAHPTAETYSPPG
                     FTDMTGHLIRLHGIHCFRRIVRSTYRLERRIKSSVANGNGNLYPIAELQSLFVEVRTMV
                     DEMVNHLQTQYLQYCDPQIPHQRMALGLAAVIEWRCWSIFWLRTPKQYREAVVSPEIRQ
                     TVLAKSVSLVESLNMMSDDKDAQKFQWHIGGHACFQSIMHIVSELETPEFQAANHRSLR
                     SRALSVLKRTMDTRGHEVTPMWNVINRIISNCLAKNAPSTFPLSPFQAMFPPNAAIPGL
                     GSSTTVPPQTIAQNSSVSGGSAMATPLPDLSEVGSLDMQDPTLAFDWGFWNFDPADPGS
                     Y"
     gene            complement(<18429..>19995)
                     /locus_tag="AFUA_3G12950"
                     /old_locus_tag="Afu3g12950"
     mRNA            complement(join(<18429..19070,19125..19478,19532..19774,
                     19828..>19995))
                     /locus_tag="AFUA_3G12950"
                     /note="transcript AFUA_3G12950A"
                     /old_locus_tag="Afu3g12950"
                     /product="FAD binding domain protein"
     CDS             complement(join(18429..19070,19125..19478,19532..19774,
                     19828..19995))
                     /EC_number="1.5.3.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1138:FAD linked oxidase domain protein (Score: 352.7;
                     E-value: 7.6e-107)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="AFUA_3G12950"
                     /note="encoded by transcript AFUA_3G12950A; similar to
                     OMNI:GMSORF1743: putative oxidoreductase, oxygen dependent,
                     FAD-dependent protein [Mycobacterium smegmatis str. MC2
                     155]"
                     /old_locus_tag="Afu3g12950"
                     /product="FAD binding domain protein"
                     /protein_id="EAL92288.1"
                     /transl_table=11
                     /translation="MASNPKSDLLNCLSGSNVIVDGDEAWPDAIKRWTGYLGKIPAAVV
                     QVTSEEDVIAAVSYAVQNQRPFVVRGGGHSNGFSTVDSPGIIIDLSRMRKVTVDVERQV
                     VVAQGGATMGDGVKAASSVGMAVATGTCNEVGLIGATLGGGIGRLLGHVGYAADTVLSM
                     RVVVVDQSGVARAVEASPDVNSDLFWGLRGSGHLFGVVVEATFRAYPWTHDTWHSCLVF
                     PPSDAGLVAEAVEKVHYQGGMQGRLVFCAPNKQPIVLLQMWYMGSHEEAASKFQPLLEL
                     PSMTDHSLNFVGRRIPYPNLNDSSDRICGYGGRKNLAAFGLKNLSAGACVAALNVYMDF
                     IVQHPEAAQTHVLTEFYSMDVARQLDQDGQETSIPGEFRREVKYWVMPLAWYDDPALDD
                     ACAGLNKAIREAFLTQHDGTRARGVGYVNMPFEDDTTTSVFGEGERLERLRNLKLKWDP
                     LGVVQGIVKL"
     gene            complement(<20339..>22264)
                     /locus_tag="AFUA_3G12960"
                     /old_locus_tag="Afu3g12960"
     mRNA            complement(join(<20339..20557,20614..20819,20851..21070,
                     21130..21760,21837..22021,22073..>22264))
                     /locus_tag="AFUA_3G12960"
                     /note="transcript AFUA_3G12960A"
                     /old_locus_tag="Afu3g12960"
                     /product="cytochrome P450 monooxigenase GliC-like,
                     putative"
     CDS             complement(join(20339..20557,20614..20819,20851..21070,
                     21130..21760,21837..22021,22073..22264))
                     /EC_number="1.14.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 145.4; E-value: 4.4e-44)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="AFUA_3G12960"
                     /note="encoded by transcript AFUA_3G12960A; similar to SirC
                     (GI:46403057) [Leptosphaeria maculans] PMID: 15387811
                     similar to GliC (GI:56609356) [Aspergillus fumigatus];
                     GO_function: GO:0016491 - oxidoreductase activity;
                     GO_process: GO:0008152 - metabolic process; GO_process:
                     GO:0009405 - pathogenesis"
                     /old_locus_tag="Afu3g12960"
                     /product="cytochrome P450 monooxigenase GliC-like,
                     putative"
                     /protein_id="EAL92287.1"
                     /sec_met_domain="p450 (E-value: 2.9e-42, bitscore: 133.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQKGPCGTELGRLSSKQNMDSAQPTKLDFLTVPATPFSIGGLASI
                     VVLVTVVIGPKAVIDTVLNSYLSLVHRIPAADGKKYMSGPAYTFPNGQMVDKFLAARTR
                     SWEWEEKYGKTYRIWAASIPEVVITDPKDVEVLYQQSTDHNKAPQANAGWLLTQLLGSG
                     LGLINGTRWSTLRKTLDPMFSHRAALQYLRDSLDAGAQDYVAGIHQFAKADGQVQTADG
                     KVMVINATQALQRYPFFEVASMFYGKMSEAEHERLWDLGRRYSEVFAAIVSGGIHRSKL
                     TRYLNTKAWNNARDYQKAWRDFNREIYTARKMTAPDTPIVALTEAAERGELTPNEVTDT
                     IAESTFANLDIVTHVISSCIILLADSPEVQNDLLQEMEKNKADRENYITRKDTLLHYCL
                     LESLRLRPVLCLKEYWLTQVKAFTFPENPPREKILGNFVVPKDTTIIVDAFAINIRNPF
                     WGPDNRAYRPSRFAGIKQSQLRYNLATFGYGPRKCLGQHIADKIVKAVVYHLFSKYRVS
                     LMPMQAVEGDFKVDKTSWVALYDVDLKLEPRES"
ORIGIN
        1 ctagacggca accgcggcca tgagaacctc caatgccgca tttttgcggc tgatacattg
       61 ggtcatgtaa tttcgatcgg tgacggacaa gccactcagc attggctcat tggcgttgtt
      121 ggagtcgtgc tgggaagcct cgcatggccc gctttcgtcc agaaagtcta cggatccatt
      181 caccaggttt tgtaatgcat tgagggcttg tttccccttg gagagggtca tcttgaccag
      241 aacattccgg atagcctgac tctcttcctt ggtgactttg tagtccccca gcgagcaggg
      301 gatcaggcgc tgctcttctt ccggaggcga caggcggcgg ttgttcatgg tcagttgctc
      361 aaataatgtg aagatcagct cgattgcgga aagcgttagg aggatggatg caacggattt
      421 gtcgcaggcc tcacagacga cgaatttctc acacgtctcg agggtggatg tgatggattt
      481 catggccaag tcgaatcgat cggacctgtc acgacaggtg agctgatgta gagtggatat
      541 gttgaccgct tgtgtttgaa cgcaggcgca cggatccccc gtcccgtcga gacgcgcatg
      601 aggggacggg aacccaaagg atatcggtgt ggtggggtca ctgagttgcc gcaagtacgt
      661 ctcgccgcca cctgtgaatg agatgggtgt cgtgaaagct tcaaggctct ctgatgtgct
      721 ttccctgggg gtctgagcaa tcgggcctag gtccatggtc cacgtgtcca agccctgcgg
      781 cgtgggaagg cattcgctct catgttcggt cgacttgatg cattggttgg ccggcgtcgg
      841 ctgcacagaa gattggggaa gcatatggcc ctgcgagcat tagagacagt aggtaaccgg
      901 ggtggcagag gcagcgactc acctgtttcc agcgggttga ctggaaaaat ggacttggta
      961 gtagtgtcgt cggatcggag agatcgatgt tcaggtttcc cagccctccg ttggcatccc
     1021 gcaattgact tgtcagccat tccatccgta gctgatgctc tctctctaat gtcttccggt
     1081 ttttgctccc tttgggcttt cctgccctgt tttgataacc gtagcgacag ttcaagccct
     1141 tggacgtgca acggaaacat ggagaccccc ccgagcactt gaccttgcac tgatgacacg
     1201 aatcacaggc cgagcgtagc tttttgtgat cggaattgct cggatgggtt gctggaggac
     1261 tggtcaaata aggaagtgta gaagtcatag tggtgccaag agttctcaac caaggcggtt
     1321 tcttatccgg tgacgatgct tagcatcttc aagaaacgag aaaaacgcta ccggaagggg
     1381 gttcaaatag gagaggcggc gcgatggggc caaaaaaagg ccacactgca gaacttagca
     1441 aaaggatgct cttacgatcg tctcattgcc caaatcgctg acagatggcg gagtccaata
     1501 gcgaagcaac aatcatgctg acacttcctt ggcgtccaat cgctacgatc agcctggcag
     1561 gctggcaggc cggtacacga gtgctaaaaa ttaacagggg atggcagtga aggaagggga
     1621 gtgcatggcc atgatgacag acactcaaaa gagattatgg tcagctttca tctccagacg
     1681 ctgattgatc gaagtagagt ggttccatga cttaccactt ctgctgaatg gaagggtatg
     1741 atgaacgaga tggataagat ggcgcgggtc gcttcgtatt tagtgagaaa taagcgtgca
     1801 gcgtggagag tagcctagct cgaagagtct aatttctgac caagatagaa tgtttcggta
     1861 agtgagacga gggaagggaa gggaagggaa aggacggaaa accggccgat ggtcagctca
     1921 cctcgtaaaa aggtctggaa tcacaatggg ttgaagatta tggaaggcgt gctcggaggg
     1981 agtctgggtt tagaagcatt agaggcttgg agttacgggg cttggcgagg tggccgccga
     2041 gacacaatta gggccgcagt aggctcagta ggcccaggcg gcctacgcta aggtgcggga
     2101 gtacgggagt acagtactga gtatgtacgg taactctcaa gaaggctcgg ccgagctcag
     2161 gcttgtagat cctcggccga gctaaccggg ctgctttagc tcggccgaac aagcgaacga
     2221 actaatcaaa cggatgcgga tcgcgttgac ggtgatcttc cttaactttg ttttgtctgc
     2281 taactaactg cgtactgttc actgttaact acctacggac tagttgacta ggtagctagt
     2341 aatcactgtt atgatgacct attccgcacg aatctccgcc cgttgctttc aggccgaatg
     2401 tctctctgta tattcccccc ttccccgagg accgagctga ttcctccatc ctctccttaa
     2461 aaagactccc acaccatgga cgacgacgtc tgtctccctc atcctccatg catcctactc
     2521 tcgtgtttct gcagctttga ccctctacgg taattgcttc tcaacgcaat attccatcgc
     2581 aatgtcggaa gaagcgccta agcacgaagc tccctcagtg atcagcccaa tagaaaacga
     2641 ggagaaaggc ctggccccca aacccctcga gcgcgtgccg cccaatggtg gtgccaaggc
     2701 gtgggcttgc gttgcaggct cgtttttgct acagttttgt tcattcggct acgtcaatgc
     2761 gtatgtttcg attctcttct cttctctctt cgtctcgttt gagaaacagc tcactgacct
     2821 tcccgagaac agatgtggga tcttccaatt gtactaccag gagaccatgc tcaaggacca
     2881 aacatcatca gccttggcgt ggatcactac ccttcagatc ttcctgcttt ttatgttcgg
     2941 tcccgctgtc ggcaaaatga ttgatgtcta tggatgtcgc cggacgcttc caccattcag
     3001 catcggggct gtgttttccg tatgcatgct gagcttgtgc accaagtact ggcaggtcat
     3061 gctggcgcag ggagtcgcct tcggtctggc tgccgctggg ctctctcttc ccgctatggc
     3121 gacggcgacg cagtggttct cgactaagaa agggttggcc gttggcattg tgtccgcggg
     3181 tagcagtctc ggtaagaatg gcgaacctct tcaaccaaac tcacatcttg atggctaatg
     3241 acggacgcag gtggagtgat ttatccatgt atgctccctc gactgataga acaggtcggc
     3301 ttcgcgtcgg cggttcgttg gactgccctc atgcaaggca tccttttgtt cattgccaac
     3361 cttctctgct cgtctcccta cccgccgctt ggtagagcaa gtaaagaagc ctctgcagag
     3421 aaggatgcta cagaacctac tccccgccgc agtggtcttc gtggattcaa gagtttgccc
     3481 tggggtttct tcgttttggg ttgtttcttc accatgtggg ggctttttgc gcccctgaat
     3541 tacctcccag agatggctgc gctccatgga tatcagagct ttgctcggta caccctggct
     3601 attgccaatg ccggatccct ggttggccgg attgtgcctg gctgggtaag tgacatcatc
     3661 ggacagttca acaccatgtg catcgtgacc agtctctccg gagtcttggt gttggccttc
     3721 tggctgccac tggagtttca tacgtctctg gccgggatta ttgtgtttgc cttgctcttc
     3781 ggttttgtca gcggcggctt cgtgagcctg gggccccctt gtgtcgtctc gcttgcggaa
     3841 gaccgtgtgg atgagatcgg ggtgaagctc ggcggcttct gcttggccat tgcgctggga
     3901 gcactgaccg gccttcctat cgaaggggca atcaaagacc gcgaaggcaa caaattcacg
     3961 ggtctgatgt gctttgctgg agcaacgatg attctcgggg gggtatgcac ggggaccgct
     4021 cgggtgttca agggcggacc gcgactcatg aagaaagttt gatggaaggg gctgcgagtg
     4081 actggttgca attttgctcc ctgtaatgtt agagtaaata atagcttaat cggatgatcc
     4141 actctctcag ttgatttctg tcccgcagga actacaatag ctgaaccaac ccggctccga
     4201 ttctcttgca accttgtgaa cattagcctg cctgctccag aaagggaact cgcataatag
     4261 aatatgatat gttattatag gacctacagt ttataagggg cacctcccca ttaatttcac
     4321 agcagtatac tcggtgtata tatcacctga atagcctgaa ttctataatt tgtggattac
     4381 tcgatcatat ttcagattgg aggatgttat tatatatggt atacgagctg tgcgactcgg
     4441 ctagagtgcg caatatacac gactatctgt tactgtagat agcatgctgc agtcacacac
     4501 ataaatgtcg aggatttagc tctctctcat ttggtattca ggctgtttac agacaagcat
     4561 aacgacactt cccaactttc aaatcacaga atcaagagcc cgtgacattt aatagaccac
     4621 tggtatctac cctacatcaa ctcagactcc cattccaatc ctccggcact attgccatta
     4681 ccattagcac gtggtgaccc cgtgcatgca cccacagggc gcagctccat gatctgagtg
     4741 agacatccac ggggggagac cacccggttc agccgccatc cagcctcctc cgccagcttt
     4801 cgatactccc ccagcgtgcg ctctttgttc ctgcacctgg ccagcatgcg aatatcagcg
     4861 taccgggccc cgcgtcccag acgcccgtca aacaagaccg actcaataat caaaacacgg
     4921 cttactcccg gcttgatgac catggtctcc cggattcgac gaagcagctt gatacaatcc
     4981 tcgtcgcccc agttatgcaa gatccatcgg aggaggtaga cagatgattc tggaattggg
     5041 tcctggaaga agtcccctcc ggtgatcgag acgattcggc tggtcagagg gtcatcgtcg
     5101 gggaaccgct gcttgaggat ctccgcggtc gacggcagct cgaaggcagc ggccgtggca
     5161 tcggggaact tctccaggta agaccggata aagtctccta ctccggcgcc gacgtcgacc
     5221 acagtctccg acttgacttc ctcccatggg tagtcggcca gcagcccagg ggcctcgacg
     5281 acactacccg taccggtgac tttgtggaag ccggcagctc tgccagtttc ggccagatac
     5341 tggtagatgg gcttgtcggt gttgtagaaa agctctgtgg cagtctttgg ctgatcgctt
     5401 cgcaactggt ctggcagacg cgagaggagg tcatagtatt cgcgcgggaa aaagtcaacc
     5461 cagttgatcc aggtcgccca gtggtctttg cggaggaggt tggagagccg gttgttggac
     5521 aggaggccgg tcttaggatc ctgtgaaaag taccccatct cacgcagata gcgaactatc
     5581 tggaataaac cttgttcgtg caatccggtg gcttcggcca gctgcgaaat gctgcaaggc
     5641 tgcagcttct ggacgtggtc cgccagtgcg tattcggacg cacacagcag gaccttgctg
     5701 ttcgtaaaag ctgattgcta aatcagtcgc gtttcgctat aaaaagtgca tgggctgctg
     5761 aaaggcttac caaaaactcc atctaccaac gtcatatggg gcggagtcag ggtgacgaga
     5821 agcttgtcca agacctgcac agtgtctaag atcttctggt agactgaatt cgacggactc
     5881 agcgcccctg gagacacttc aagacaggaa tcaagctcct gcgccaaagg accttcaagc
     5941 tgcaacaacg catgcttgat gttccagttc aaatgctcaa gttcgttttc cattctgaat
     6001 ctctgccggt caggtacaaa cgtttctcgg taaagtttga tccgtcagta aagcgatagc
     6061 aattattttt ctcggcaggt ttctatcgaa ggaagtagtg tttatgatgc tattaatgat
     6121 caagtcagct tacgcctggc agtgctcggt ggatatccca tacgagccga catattaccc
     6181 cccgggcccc cgaggccgtc cgggggcggc gtccggcacc atctcactca gcttgaaggc
     6241 gccagcatta agcggcgtta ggcttcatcc cagaaatggt ttttttgaag tggtacggct
     6301 cgagcatact tgttggaagg ccgctccaat gaacctgact ctcactacta ccagcatcac
     6361 catacagccg tctgcaacaa tggccaaccg agctcctacc cttctggacc acttccacga
     6421 tcaactgcaa aagcactctt catcagttgc gatcgaagat ggaacacagt ctgcagacca
     6481 gggagcctgg gaaagggtca catatgccca gctcgatgct ctgtccgaca gttggagcaa
     6541 acgtcttcgc caggccggcg tgggtgcagg ctgtatagtt ccccttctat cgaagagatc
     6601 agtcgcaatg gtagcagcga cattggcgat cttgaaactc cgcgccgcct atgtgtccat
     6661 cgacatcgac tcgtggggaa aagatcgaat agacactgtt ttgaagactg tcaacccgca
     6721 aatcattgta tcaacatcgc cgtgtccaaa agatcattac ccgtacccag ttgtggcgtt
     6781 ggagcggaac gacttcgatg agactgtaac gagtaacggg actcaatgga cacgaaacga
     6841 tgaggactcg atcgatagag gaaacgatct agcctatatt atcttcacgt ccggtacgac
     6901 agggataccg aaaggagtga agataggcca gagatcaatt tctcgttatg tgaaagaagg
     6961 gggcgatctg ccattcaatt tcaacaccac acatggcaca agggtgttac tcatctgttc
     7021 catcgctttt gacggtgagt tacttgattc ttgattgtgt gagcgtcctc ctaattcaaa
     7081 acacgtagtc tgtgccggag tcatgtttaa caccctctgc aacgggggaa ccttggtcct
     7141 ggccgatccg tcaacctttg aaaccgcggc caaaacatgc catgttttgc cattgactcc
     7201 aagtatcctg gttacactgg accctaaggc gggctttgat acggtggaaa agatcttcct
     7261 cggtggtgaa agcccaagcc cgtccttgat agaggcatgg tcctctcccc gccgacggct
     7321 ctacaacgcc tacggaccta ccgagacgac atgtacagcg tttatgggag aactcttgcc
     7381 tgggtctccg attactattg gatacccaat ctcatacagc actgtcacat tacttgatga
     7441 ggatggtatg gaatccgtcg aaggagaaat ctgcattgct ggcctaggtc tcgcattggg
     7501 ctatttccat gatccagagc gcacaaacag cgcttttgtc gaatggaacg gggtcagaat
     7561 ctacaaaacc ggggactatg gcaggcggac caagcatggg ctacagtttt gcggtcgcag
     7621 ggacagtgtg gtcaagaaca ggggcttcct gatcaacctc gaagcagatg tcgagcctgc
     7681 tctactgtcc tacgacaaag ttgacagtgc atcagcgttc atgtctcagg ggcaactcat
     7741 cgcttttgtc acacctacat ctgccaaaga gggactccgc gaatatcttg cgaatacggt
     7801 atcgtcgttc ctcgtccccg atacgatata ttcgctagac gaatttccca gaacaagcaa
     7861 cggaaaagtc gaccgacgaa gcctaatgcg tatgcatgag ctagagcaag gatcagatac
     7921 ggccagtctt gagagaggcc ttggtgcagt ggaatccgtt cgtcgaggat tatctcatgt
     7981 cctccgcctg ccagaatcgc aaattcttcc ggcttcgtct tttcgccatc taggtggcca
     8041 ttcactagca gcagtcatgt tagtttcggt tctgaggaga atgggcttcg gtatcagtgt
     8101 cgccgaggtg cttttgttgg atacagtcga aaatatagct gccgctgtcg tggagttgag
     8161 cgatatcccg catgcccttt ctgcccagga agatttgata gaacgactaa ggcacgatat
     8221 ctcaacaacc cggccgcttg atgaaggtgt gacaattgca cctatgaccg acatgcaaac
     8281 cagattgctc ggtgctagtg ttgctactcc aggtctttca tttatcaaga catcatttac
     8341 cttggatcat ccagagaaag aagaccttac atctactctc cgtgctgctt gggttcgtct
     8401 tcatcagacg cacgagatcc tgaggactgc atttgtcttg actgcatcaa atgggaccca
     8461 aataatctcc caagaaccgg acttttcgtg gaaggagaaa ttcgtcacag aatcggagtg
     8521 ggagtcagtt tgtcgacgcg aagagcatct ggacgtggcc gacttccccg actttgacgc
     8581 agagaaccga gcttcgttgt caagagttgt cttgattatc gctccgagga gacgaacccg
     8641 gtttgtctgg acggttcatc acagcttgat tgacggatgg tcgatggcaa ctctgatgcg
     8701 agatttcgcc tcttgtctcg atggtaaacc catcccggca ccaccccaat ttgctcaagt
     8761 tgcgcaagca ataggtcagc ttaaggctga gtcctcggat agagccgttt cattttggaa
     8821 agagtactta gacggataca ctcctgctca gagacttcga gtatcaccac cctctgatgt
     8881 cagcgactat acacaagcag ctttatctcg aaaactcact gtcagcgtgt ctgccctgga
     8941 ggatgctgct agggatcgat ttgcagttac accggccaca cttctttacg ccgcttgggg
     9001 acttctcctc tccaggtatt ctggcacaga ccgcgcagcg ctcggagctg ttctatctgg
     9061 aagaagcttg cctatacctg gtgtagaaaa catcatcggg ccattgatca atactttacc
     9121 actagcaata aacactcagg aggcccagtc cacatacagt tttgtacaaa gtgtgtttag
     9181 aaggctgtgt gacatcctag agttccaatg gtctcctgtt gcattgattc aagaaggctg
     9241 tgggtgcaat ccgtcagagc tttttgagac actctttgcc ttgcagtatg actttccaca
     9301 gacaccctgg aagtcaagcg aggtccctga gccaagggat atacgttatg aggaagccac
     9361 tcaggtccca ctcaccgttc tattggataa cgccaatggc caattcgagg ttcgatttat
     9421 ttatcgccgg tcacattttg gtgatgcaac tgttcagaga atgattggcc agtttggtaa
     9481 tctccttgag aacctgattg ctgcgcaacc agacacggac ttgagcaatg tcaccggaca
     9541 aatgttcaac aatcgagtgt atgagatgtc gattgcgaag ccagggcagc cggtcagcgc
     9601 ctgtaaagtg ccagaaagtt taacggaggc tattgaaaac tctatccaag cgcatcctga
     9661 catctatgct gtcgaagggt tgacggggcg cctcacgtat agggagtttg gaaggatgac
     9721 ggagcatatc tcccagcgtc ttttgcagca catccagccc gggagcgtgg cctgtatgat
     9781 tagcgatggc tctcttcttt ggcttctggc catggttgcg ataatcagag ccggtgctat
     9841 ctactgtcca gtagatgaga aactgcctcg cgatagaaaa gactacatgg ttcgaaatag
     9901 cagagcagca ttgatcctct acgccaattc cagtcaggaa ccgttgtgca atggggttcc
     9961 gtctctaaac atggagtcta ttatgcagga aatatcttca tcttccggct caccgattgc
    10021 aaccagtcgc aatcgtccca gcggtgatac tgttgcatgc ttggtctata cttcaggaag
    10081 tacgggcttg cctaaaggta tgcttaactt taaacatgct acgctacata ttaatgttcg
    10141 aacttgttac tgataagctt atagcggtcc agctgcagca caaaggtatt ttaaatgtga
    10201 tttcccagcc agaaggacga ttgtactccc gtccgggcca gcgcaatgcg cagatgctgt
    10261 cccttgggtt tgattgctgc atcaaggaag tcttttccac catatgcttt ggcgccactc
    10321 tggtcctaaa agaccccgag aaccccatat cccatcttgc gagagtcgac gctacgatgg
    10381 caactccgtc cctacttgca accttggaac ccacagacta tcccaacctg aaggtaatca
    10441 ctgttgctgg agaagccgta tcccaagttc tcaacgataa atgggcggcc ggacgaactt
    10501 tgatcaacgg gtacggtcct gccgagtgca ccttgatatc tacaacagcg attctgcacc
    10561 caggaaacag agtgtccatc ggtaaaccac ttccgggctt gtcatgctat cttctcgatt
    10621 ccaataaacg tcccgtgcca atgggagtga gcggagaaat ctatatttcg ggagtgcagg
    10681 tcactccggg gtatcttcac aacgagcaag agacatctaa acgcttcctt agcgactcgt
    10741 tcaaccctgg ccaagtaatg tatcggacag gtgatattgg aagaatgctg gaggatggaa
    10801 acatcgagta tatcggacga gaagacaatc aaatcaaact ccgcgggttt cgcattgacc
    10861 ttggggaggt ccaaagcaca atttccaaac tagcctcaac ggctagcaat gttgcgctca
    10921 ttgtgtctaa tggaaacctt gttgccttta tgacccctga gaccattgat gtcagaagct
    10981 tagccaaaag ccttgagaca cagctcccac agtacgccgt cccaaatcgg atcatcgcgc
    11041 ttgcgacact tcctacctcg gcgaataaca aggtcgactc gtccgcattg cagaggtatc
    11101 tgagggatca tggaaaggat ggtgctgttg ttgaagacct tgagacggat acgcaacgag
    11161 ttctagcggt gatatgggcg gacatgcttg ggcgtgatct gaaccagacg cccatcagtc
    11221 ccagtgaccg gttctttgag ctcggaggac actccttact gcagatcaaa gtcgctcaag
    11281 ccatctccaa acgctggaat atccggccgt tgccactcaa acaagtaatt cgccatcata
    11341 gccttcaaga tctgtctctt gccatcgacg aacttgtaag cgacccgcgt acagtttcaa
    11401 caatgccctt cctggagatg accccggtgg cgcggaacgg ccagctccca ctgtcgtacc
    11461 tcgagaaaga aatgctgctc aaccacctca tatctggcgg ctcgccggcc ggaaacatga
    11521 acttcgtttg caagatccgg ggtgacatca acgccgaaac cctggcagac gcgtttcaga
    11581 gggttacagc agatgttgaa gtgtttcgca ccagatactc cgttattgag ggcacgctct
    11641 tccggcaaca ggccccagga tctgtcaagg tccctcgcgt ggtccaaacc ggcaatctca
    11701 gctcattcgt ccacggcaga attaccaaat cgtttgatct gagcacagaa ccaccagtag
    11761 atgtctcgat tattatagga acccccatgc aagccatgct ggtggtcgtc atgtcccacg
    11821 tcgttggcga cgcagccaca atggcgactt atctcaaccg ggtctccagg acatacgacc
    11881 tcctgaggtc aaactcgcaa acaacaaaca cctccaccgt accagataat ctgacctata
    11941 tcgactgggc acactgggct tcgacgctac aacccaaccc ccgagcgctc accttctggt
    12001 cctcgtacct ctccaacccc ccctcgccac ttacgttcgg caacccatcc ccagcaccag
    12061 caacatacat cggcctcacc cgctcttgga cactcccccc ctcaatgtac cgcaagctgt
    12121 ctgacctcgc cgccaaagct tccgttacca tgcaccagct catcctcgcc gccgtcttct
    12181 tcagcctcca gtgcgtcgac cgccgcgacg acatcctcgt cgctgctccc ttcacgcacc
    12241 gcaccgagcc cggtaccgag tccctcccag gcctcttcct cgaccgcctc ctcctccgca
    12301 tccaacgctc cccacaccaa tcctcgatct tcgacttcct ctcctccgtc cgcgaaacca
    12361 gccaacaagc ccttgcacac gtcatcccct tccacaccct ccgccactcc ctcgcccaca
    12421 aaccaagcct catcgacccc ctcttcaaag tcatggtcac ctaccacaca gccgctgatc
    12481 aacggcccct cctagacctc tccggtgcgg aagtccagcc cattccgtgg cgccatacag
    12541 gaggttccaa gttcccattg aaatttgagt tcactgagat ggcgacacag gacctcgagg
    12601 tcgacatgga gtatgatctg ggatgtatca gggaagatat cgcactgagg ctggaatttg
    12661 cgctttcctt tgcattacag cttatggttc tcgagaggga gacggatgat atcatccagc
    12721 tcgttcagat gtcattttgc cctggcgagg gcagtcccgt agggctaaca ccttcacacg
    12781 agggttcggc cgagttgacc aatgggacca acaagacgga tagtactacg gggcaacagg
    12841 agctcgagaa taacctcacg gatgtagttt gtgaatgttt gggacttgag attcaggatg
    12901 tggacgcgga caagtctttc tgggaccttg gggcccagag catggatgca ctgaaactac
    12961 aacacctatg cgagaaacgg ggggtcaggg ttagactgcg ggatatattt gtttctagga
    13021 gtcttttgga gttggcaacc tgcgctgtca ttatttgacg atgcatagcg agattgttaa
    13081 acgaattgaa tgcattgttt atgtcaatgg tgtttacttg ctactttcgt agcacagtca
    13141 tggtatgttg accgcacggc ataccgaacg ccatagtcca tagttttact ttttactaag
    13201 ctctaagtat gcctgatgta agaagattcc aaggctcggt tcactcaacg caaagcccca
    13261 tttcttctta ccttgggccc ccaagcagac caagaaatgc caagtcggag ccgagccacc
    13321 cccccggagg aagtatacca caaatcggac gccgcaaaag cataacgtag aaagacctta
    13381 ttagctaagc ggctgagtca aatgcccgga ggaagtgtag ggcaaatcgg acgccgcaaa
    13441 agtagacccc cgaaacaatg ggagtaccga gtaccgagta ccgttgcagc ggagggtctg
    13501 tacgcgggat ctgctgaccc ggggctgagg ggccatgcaa ggctcgtgca gctgaacgag
    13561 tcgagtctcg gacagttggc aaaaggcgca gaacacgtgg ctctgacggg ggatcaccac
    13621 attgtcggac cgtatataga taggcctcgc acgagcccaa gccgaagggg agggaagacc
    13681 gagagatcga ctcaggacag cagtgaacaa catactgcaa agaatctagt ctttgtcaca
    13741 catcattcaa catgtccatc ggagccgaga tcgattcgct ggttcctgct ccaccgggcc
    13801 tcaacggcac cgctgcgggc tatccagcca agacgcagaa ggagttaagc aacggagact
    13861 ttgacgcgca cgatggtctt tctcttgcac aactgacacc gtacgatgtc ttgacggctg
    13921 cacttccgct gccggctccg gcttcgagca cagggttctg gtggcgggag acgggccctg
    13981 ttatgagcaa gcttttggcc aaggcgaact accctcttta cactcattac aagtacctta
    14041 tgttatacca tacccatatt ctcccattgt tgggacctcg accgccgctc gagaactcga
    14101 cgcacccgtc gccgagtaac gcgccgtgga ggtccttcct gacagacgac ttcactccgc
    14161 tcgagccgag ctggaacgtg aacgggaact cggaagcaca gagcacaatc cgtcttggta
    14221 ttgaacctat aggctttgaa gccggggctg cagcggaccc attcaaccaa gctgccgtga
    14281 cgcagttcat gcactcatac gaggcaaccg aagtcggtgc cacgctgacg ctgttcgagc
    14341 acttccgcaa cgacatgttt gttggcccag aaacgtacgc tgcgttaaga gcgaagatac
    14401 cagaaggcga gcataccaca cagagtttcc tggcgttcga cctggacgcg ggtcgtgtca
    14461 ccacaaaggc gtactttttc ccgattctca tgtcgttgaa aactggacag agcacaacaa
    14521 aggtggtctc tgattccatt ctgcatctag cgctgaagag tgaggtgtgg ggtgtgcaga
    14581 ccatcgccgc gatgtcggtc atggaggcgt ggataggtag ctacggtggc gcggcaaaga
    14641 cggagatgat cagcgtcgat tgcgtgaacg aggcagactc tcggatcaag atatacgtgc
    14701 ggatgccaca tacatccttg cggaaggtaa aagaggcgta ctgcttaggt gggcggttga
    14761 cagacgagaa cacaaaggag ggcctgaagc tgctggacga gctgtggagg acggtcttcg
    14821 gcatcgacga cgaggacgcg gagctgccac agaatagcca tcgcaccgca ggcacaatat
    14881 tcaatttcga gctgaggcca gggaaatggt tccccgagcc caaggtatac ctgcccgtcc
    14941 gacactactg tgaaagtgat atgcagattg ctagtcggct acaaacgttc tttggaaggc
    15001 tcggatggca caacatggag aaagattatt gcaagcatct ggaagatttg ttgtaagtta
    15061 tccagtctct ttgacatgga tccgtatcag cgctgacttt tatagtcccc atcatccact
    15121 gtcctcgtca acgggcacac acacctttct ctcattttcg tataagaagc agaagggggt
    15181 ctatatgacc atgtattata atctccgggt gtacagcacc taagcactga tggtgttcat
    15241 ttgagaaagt tatgacagtt tttcaaattg ttatcaagtg gtatcatgtc atcttacgag
    15301 tcgttctctt tcacatacta ggaatgagat actagaagcc agttcataag cctttatcac
    15361 aagtgccaac cttcgacaga gcatgaggta gatgtgcaga gaaaacgagt atagctcacg
    15421 aaaaaaaaaa aaaataaagt agttctcaat aggagccagg atctgcggga tcaaagttcc
    15481 aaaaccccta cccaaaacat cagcggagag cgtctcatca aggcgttaga ttcacttacc
    15541 cagtcaaacg ccaaggtggg atcctgcatg tccagacttc ctacctccga cagatcaggc
    15601 aacggggttg ccattgcgga tcctcccgat actgatgaat tttgtgcaat tgtctgaggc
    15661 gggacagtag ttgaggagcc taatccgggg atcgctgcat ttggaggaaa cattgcctga
    15721 aatggtgata aagggaaggt agacggcgca tttttggcaa gacagttcga gatgatacga
    15781 ttgatcacat tccacatagg cgtgacttca tgccctcttg tatccatcgt ccttttcaag
    15841 acgctcaatg cgcgagaccg gagcgaacgg tggttggccg cttggaattc cggtgtttca
    15901 agctccgata cgatgtgcat aatggattgg aaacaggcgt gaccacctat atgccactgg
    15961 aacttctggg catctttgtc atccgacatc atgttcaggc tctccacgag gctgactgac
    16021 tttgccaata ccctaaacac attcattagc tttcgctcca agacacgaaa aaagacgttc
    16081 tctgctccaa tgacagcacc aaacatacgt ttgtcggatc tcaggggaca cgacggcctc
    16141 ccggtattgt ttcggggttc gcagccagaa aatcgaccag catcgccatt caattacggc
    16201 cgcaagacca agggccatgc gctggtgcgg aatttggggg tcgcagtatt gcaagtattg
    16261 agtttggaga tgattgacca tttcatccac catggttcga acctcgacaa acaaagactg
    16321 aagctctgcg attggatata ggttaccatt tccgttggca accgaagact tgattctccg
    16381 ctccagccga taagtgctcc gaacgattct tcggaagcag tggatgccat gcaagcgaat
    16441 caaatggcct gtcatgtcgg taaatccagg aggtgagtat gtttccgcag ttggatgcgc
    16501 tccttcaatg agatcttcgt cgttgatgtt ccgtggtagc agcgtagtgt agtcctcgtc
    16561 tgctattgtg ggctcctggc ccctaccttc tgcggaacgg aagtcgagat gacatatctg
    16621 atgccacagc ctgcgacgag tctcgacctg gacaacatcc atattacttg acgggaacaa
    16681 ggagggttct ctatgaagac cctgggagag agccattcta acaacaaggc caagaagcgt
    16741 ccacgtcctt gacatgtcat cttcccggga ttggcaagtc tagcaggttg gtcagtaaat
    16801 caaacataca ttgaaccgtt agaacgggga cgccttcgta ccagaagcag gacaaaagcc
    16861 tgtagaacct caatacttgg ggtcgttagg aaatcttctc gtcctaaccc aagttccacc
    16921 cctctttgaa actgagccag gagggcatct ttctctgcag caaatcgcat cataacatct
    16981 tccgccgaca aactgttgat agctgagtag aatatagcca gcgccagagg ctcgaaggca
    17041 tggatggtgt gatcaggtcg cgacgcatcg gcggcctctt ctacacccgg actttgagtc
    17101 ctcgtgccgt atgtatggtt aatatattgg gtgaatcgtc gttgcagcgt aggtttgtgt
    17161 accagtctcg tcatcggatc aacattggaa tagaaaattt caagcaatgc caagcaatcc
    17221 tctgccgact tgggagacca aggcgtaagg ctttccacgg tcgaaccaga aaacgggaat
    17281 gggggggttg gctggtctga cggtggacta tcagccggtg caccactaga ttgatctccc
    17341 agcagcattt tgacgtcgtg aatctagcat tatcagcgct ggatacataa aatcacaacg
    17401 gcagaaagat tgtacctcat cagctaagag agcatagtgc agagacgaaa cccagcggga
    17461 ttggcctcct tcggcctcca ggagcaaggc accgtcataa ccatcagctg acaaagtttc
    17521 gcatttcggg ttgggtaatg cattccctcc ctggtcaacg tcagagaggc ttcctgtact
    17581 agttcctttt gcatcaggca atatcgacat gttaccccca ccggagatcg ctcgctccag
    17641 tagtttttcc agccgttcga ggcgactacg gatctcctct tggccagacc gaaggttggt
    17701 ccgcgacact cgactgccgg tccccacacg ggagggtgcc tgtgagacag gctgtggagt
    17761 gacatacgtg caaacacggc cgcctctctg gcatggagta catacaggtt gcgcatgatc
    17821 gcacttgacc ttccgacggc ggcatgtcag gcacgcggta atggtgcgct gccggccctt
    17881 ctgtatgcca gcagaagggc ccgattgagg actgctaacc gagaaccgtg aggatgaagt
    17941 tgtcgagtcc atcagatggg gtgacagcct tggaatgatg aacgtgttcc aggaaggtga
    18001 caagaaaggt ggcacagtga caaagcaggg tgacgagata caacaatagc gaagcaatac
    18061 ggttgggagg cagaaagtct aaccgcttgg ggctagtagg tccctgctta ctaatgatgg
    18121 ctgactctgc aggacgccat tcacagagta tctaaatatt ataacctaaa atgttcgaag
    18181 ataattgcga aggatacgaa gcgtgcaaag ggctttgcga attatatgat gttttacttt
    18241 ccatttcata gtcgtagcgg ggtgacccac ttgatatgct tctatgaccc attatcgatg
    18301 gatgccttag gcagggaatc cgacgatcct gaggcaccgg catcaggcca ttaaatcccc
    18361 gatttccttt ctaccggcct actactgaat aacctacata tcgacttcca accaactcag
    18421 atccatcctc aaagttttac aattccttgc accacaccaa gcgggtccca tttgagcttg
    18481 aggttccgga gcctttccag tcgctcaccc tcgccaaaaa cgctagtggt ggtgtcgtct
    18541 tcaaagggca tgttgacgta gcctactccc cgtgcgcgtg tgccatcgtg ctgtgttaag
    18601 aatgcctctc gaatggcctt gttgagccca gcacatgcat cgtccagtgc agggtcgtca
    18661 taccaagcta gaggcatgac ccaatacttc acttcgcgcc ggaactcacc agggatagag
    18721 gtctcttgcc cgtcctggtc aagctgccgc gcaacgtcca tgctgtaaaa ttcggtcagg
    18781 acgtgagtct gggccgcctc ggggtgttga acaatgaagt ccatgtagac gttgagggcg
    18841 gccacacagg ctcccgctga caagtttttc aagccaaacg cggcgaggtt ctttctaccc
    18901 ccatagccac atatacggtc gctggagtca ttgaggttag ggtacggaat ccggcggcca
    18961 acaaagttta aagaatgatc tgtcatagac gggagctcca atagaggctg gaatttgctg
    19021 gcagcctctt cgtgtgatcc catataccac atttggagaa gaacaatagg ctaattctca
    19081 aagtcagcca gtgggttcca gtaaagggtt ctggacagac ttacctgctt gtttggagcg
    19141 cagaatacca gccgcccctg catacctccc tggtaatgga ccttctccac agcctctgcc
    19201 accaatcctg cgtcactagg cggaaagacc agacagctgt gccatgtgtc atgggtccac
    19261 gggtaagctc ggaatgtagc ctcaaccacc actccgaaca aatgaccgct accgcgaaga
    19321 ccccagaaga gatcggagtt gacgtcgggc gatgcctcga ctgcgcgagc tactccgctc
    19381 tggtccacca caacgacacg catcgagagc acggtgtctg cggcgtatcc aacgtgccca
    19441 agaaggcgcc cgatccctcc tccaagggta gcgccgatct gttcctcatt attaggttgc
    19501 gtggtggaat aggagaagtc atttccctta ccaggcccac ttcgttacag gttccggtag
    19561 cgacagccat tccgactgaa ctggctgcct tcaccccgtc gcccatagta gcgcctccct
    19621 gtgcaacaac aacctgtctc tccacgtcaa cggtgacttt tctcatacgc gagagatcga
    19681 tgatgatccc agggctgtcg actgtcgaga agccattgct gtggccacct cctcgaacca
    19741 caaacggcct ctggttctgc accgcataag aaacctgagg acacatgtca gcctatacag
    19801 attcaaaagg ggatggggga cccttaccgc tgcaatgacg tcttcctcgc tagtaacttg
    19861 aacgactgct gcaggaatct tgcccagata ccctgtccag cgcttgattg catccggcca
    19921 cgcctcatcg ccgtcaacaa tcacattgga gccggaaagg caattcaaca ggtcggattt
    19981 gggattgctc gccattgtta cgctgacaaa ttctacaaag aggggggggg agtgtagttc
    20041 cattctagtc tgtattcttc atctgataaa tgaatggtgt tctagcttcg gcttacttgg
    20101 cttcggcgca gcgcttttgt gcttacactg tttacccgcc gacggcccca acacacgccg
    20161 ggggccgtat ttctaatgaa ccgtgaacct ttgccggact atgtccaaag agaaaagctc
    20221 gctaaatgag gatatggcag taggagttgg tcattggtgc agggtaatga gaattcttcg
    20281 cagctatcaa gcgtccatct agtgcaggta tatgttcact tgttcataca taacattttc
    20341 aagactctct tggctccagt ttcaaatcaa catcatacaa tgcaacccag ctggttttgt
    20401 caaccttgaa gtctccttcg acagcttgca tcggcatgag agaaactcta tacttgctga
    20461 acaggtgata gaccacggct ttgacgatct tatcggcaat atgctgtccg agacactttc
    20521 tcggcccata gccaaaagtt gcgagattat accggagcta caagaccaat gagcttcaaa
    20581 gcagtctcct taggggcagt ttgagattct cacctgactt tgcttaatac ccgcaaaccg
    20641 gctgggccga tatgcgcggt tgtcgggacc ccagaaggga ttacggatgt tgatcgcgaa
    20701 agcatccaca ataatggtcg tatctttagg taccacaaag tttcccagga tcttctccct
    20761 tggcggattc tcagggaacg tgaatgcttt gacctgcgtc agccagtatt ctttcaagcc
    20821 ttgagcggcc tggtagtgac caatacttac atagaaccgg ccgaagacgg agcgattcca
    20881 acaagcagta atggagaagc gtgtcctttc gagtgatata attttctcgg tctgccttat
    20941 ttttctccat ctcctgaagt aggtcatttt ggacctctgg ggaatcggct agaagaataa
    21001 tgcaagacga gataacatgg gtgacgatgt ccaggttcgc gaaggtagat tccgcaatcg
    21061 tgtcagtcac ctagatctac tgttaaaagg ggtcgccata tcgttccagc caaggggcca
    21121 gccacctacc tcatttggcg tcagttcacc cctttcagct gcctctgtga gggccacaat
    21181 tggcgtatca ggggctgtca tcttccttgc cgtgtatatc tccctattga aatctcgcca
    21241 cgccttctgg tagtctctcg cattgttcca agccttggta ttgagatacc tagtcagctt
    21301 agagcgatga atgccgccag acacaatcgc cgcgaagacc tccgaatacc gacgcccgag
    21361 atcccacagc cgctcgtgct ctgcctcact catcttccca tagaacatgg acgcgacctc
    21421 gaagaacgga tatcgctgca gtgcctgcgt ggcattaatg accatcacct tcccatctgc
    21481 ggtctgcacc tgcccgtcgg cttttgcaaa ctggtgtatc cccgccacat agtcctgagc
    21541 accagcgtcg aggctgtcgc gcaaatactg caaggcagcc cggtgcgaga acatcgggtc
    21601 caaagtcttt cgtaaagtcg accatcgagt cccgttaatc agccccaggc ccgacccaag
    21661 cagctgagtc aagagccagc cggcatttgc ctggggcgcc ttgttatggt cggtcgactg
    21721 ctggtatagc acctcgacgt ctttggggtc cgttatcaca ctatgcgtat acacaagccg
    21781 tgttagcaga tctccagact gcggtcatgt ggaggaatgg agacggggat gcgtacacct
    21841 ccgggatact agcagcccaa atgcgatacg ttttgccata tttctcctcc cactcccagc
    21901 tcctcgtccg tgcagccaga aacttgtcca ccatctgtcc attggggaat gtgtacgccg
    21961 gacccgacat gtacttcttc ccatcggcag ctggaatccg atgaacaaga gacaagtagc
    22021 tctatttcag gcatcagaaa tcgcctttca acccactaga cagtgtactc acattaagaa
    22081 ccgtatcgat caccgctttt ggcccgatta caacagtcac caagaccact atcgaggcca
    22141 aacccccaat gctaaacggg gtggccggca cagtcaaaaa gtccaatttg gtaggttgag
    22201 cggaatccat gttttgctta ctcgacaacc taccgagttc agttccacat ggtcccttct
    22261 gcat
//
