BGC0000372: hexadehydroastechrome biosynthetic gene cluster from Aspergillus fumigatus Af293
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Location: 3,423,866 - 3,446,129 nt. (total: 22,264 nt).
This entry is originally from NCBI GenBank CM000171.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000372
Short description hexadehydroastechrome biosynthetic gene cluster from Aspergillus fumigatus Af293
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: CM000171.1
Compounds
  • hexadehydroastechrome
  • terezine-D
  • astechrome
Species Aspergillus fumigatus Af293 [taxonomy]
References
Chemical products information
hexadehydroastechrome [synonyms: has]
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C60H60Fe1N9O9
terezine-D
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C19H23N3O2
Chemical database entries
NPAtlas
astechrome
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C60H66Fe1N9O9
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AFUA_3G12890
  • EAL92294.1
 3423866 - 3425153 (-) C6 transcription factor
  • Regulation
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  • AFUA_3G12900
  • EAL92293.2
 3426447 - 3427927 (+) MFS transporter, putative
  • Unknown
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  • AFUA_3G12910
  • EAL92292.1
 3428497 - 3429858 (-) O-methyltransferase
  • Tailoring (Methylation)
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  • AFUA_3G12920
  • EAL92291.2
 3430194 - 3436923 (+) nonribosomal peptide synthtease
  • Scaffold biosynthesis
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  • AFUA_3G12930
  • EAL92290.2
 3437617 - 3439088 (+) dimethylallyl tryptophan synthase
  • Tailoring (Prenylation)
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  • AFUA_3G12940
  • EAL92289.2
 3439311 - 3441817 (-) C6 transcription factor
  • Unknown
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  • AFUA_3G12950
  • EAL92288.1
 3442294 - 3443860 (-) FAD binding domain protein
  • Tailoring (Oxidation)
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  • AFUA_3G12960
  • EAL92287.1
 3444204 - 3446129 (-) cytochrome P450 monooxigenase
  • Tailoring (Hydroxylation)
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NRP-specific information
Subclass N/A
Cyclic? yes
NRP-synthases
Gene Modules
AFUA_3G12920
Module 1
Specificity: tryptophan
Evidence for specificity:
  • Structure-based inference
  • Knock-out studies
Condensation domain type: LCL
Module 2
Specificity: alanine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Heterocyclization
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: J4R6BDENZAM7XVDGVEEHZB2Y, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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