BGC0000373: holomycin biosynthetic gene cluster from Streptomyces clavuligerus ATCC 27064
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Location: 6,204,480 - 6,222,797 nt. (total: 18,318 nt).
This entry is originally from NCBI GenBank CM000913.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000373
Short description holomycin biosynthetic gene cluster from Streptomyces clavuligerus ATCC 27064
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
CM000913.1
6204480 - 6222797
via
Compounds
  • holomycin
Species Streptomyces clavuligerus ATCC 27064 [taxonomy]
References
Chemical products information
holomycin Evidence:
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C7H6N2O2S2
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SCLAV_5266
  • EFG10339.1
 6204480 - 6204707 (+) Hypothetical protein
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    • SCLAV_5267
    • EFG10340.1
    		 6205318 - 6206172 (-) Putative acetyltransferase
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      • SCLAV_5268
      • EFG10341.1
      		 6206255 - 6207394 (-) Acyl-CoA dehydrogenase domain protein
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        • SCLAV_5269
        • EFG10342.1
        		 6207391 - 6208194 (-) Gramicidin S biosynthesis protein grsT
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          • SCLAV_5270
          • EFG10343.1
          		 6208191 - 6209864 (-) Glucose-methanol-choline oxidoreductase
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            • SCLAV_5271
            • EFG10344.1
            		 6209861 - 6213151 (-) Non-ribosomal peptide synthetase
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              • SCLAV_5272
              • EFG10345.1
              		 6213315 - 6213920 (+) Lantibiotic biosynthesis protein, flavoprotein
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                • SCLAV_5273
                • EFG10346.1
                		 6213920 - 6214384 (+) Globin
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                  • SCLAV_5274
                  • EFG10347.1
                  		 6214454 - 6215926 (-) Putative transmembrane efflux protein
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                    • SCLAV_5275
                    • EFG10348.1
                    		 6215992 - 6217056 (-) Thioredoxin reductase
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                      • SCLAV_5276
                      • EFG10349.1
                      		 6217621 - 6218391 (-) Thioesterase
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                        • SCLAV_5277
                        • EFG10350.1
                        		 6218391 - 6219857 (-) condensation domain-containing protein
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                          • SCLAV_5278
                          • EFG10351.1
                          		 6220002 - 6222797 (+) AmphRI-like transcriptional regulator
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                            Biosynthesis information
                            Annotation changelog

                            Entry version: 4

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2022-10-07
                            Update chemical activity to schema version 2.11
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 3

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2022-09-15
                            Updated bioactivity data
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 2

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2019-10-16
                            Migrated from v1.4
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            2019-10-16
                            Updated compound(s) information (NPAtlas curation)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 1

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2015-06-12
                            Submitted
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            Detailed domain annotation
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