BGC0000373 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000373 (Streptomyces clavuligerus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	18,318	holomycin	NRPS:Type I	100%

BGC0000373 - Region 1 - NRPS

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Location: 1 - 18,318 nt. (total: 18,318 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 18,319
Label		BGC0000373

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000373	1.00	NRP	holomycin	Streptomyces clavuligerus ATCC 27064
BGC0000131	0.33	Polyketide	pyrrolomycin	Streptomyces sp. UC 11065
BGC0001463	0.27	Other	2,3,4,5-tetrabromopyrrole	Pseudoalteromonas piscicida
BGC0001464	0.27	Other	tetrabromopyrrole	Pseudoalteromonas sp. PS5
BGC0002410	0.26	NRP	frankobactin A1, frankobactin A2, frankobactin A3, frankobactin B1, frankobactin B2, frankobactin B3, frankobactin C1	Frankia sp. CH37
BGC0001778	0.26	Other	showdomycin	Streptomyces showdoensis
BGC0000706	0.24	Saccharide	kanamycin	Streptomyces kanamyceticus
BGC0000347	0.24	NRP	equibactin	Streptococcus equi subsp. equi
BGC0002468	0.24	NRP	anguibactin	Vibrio anguillarum 775
BGC0000410	0.23	NRP	pseudomonine	Pseudomonas fluorescens

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000373	1.00	NRP	holomycin	Streptomyces clavuligerus ATCC 27064
BGC0000131	0.66	Polyketide	pyrrolomycin	Streptomyces sp. UC 11065
BGC0001463	0.61	Other	2,3,4,5-tetrabromopyrrole	Pseudoalteromonas piscicida
BGC0001464	0.60	Other	tetrabromopyrrole	Pseudoalteromonas sp. PS5
BGC0002410	0.60	NRP	frankobactin A1, frankobactin A2, frankobactin A3, frankobactin B1, frankobactin B2, frankobactin B3, frankobactin C1	Frankia sp. CH37
BGC0001778	0.59	Other	showdomycin	Streptomyces showdoensis
BGC0000706	0.58	Saccharide	kanamycin	Streptomyces kanamyceticus
BGC0000347	0.58	NRP	equibactin	Streptococcus equi subsp. equi
BGC0002468	0.57	NRP	anguibactin	Vibrio anguillarum 775
BGC0000410	0.57	NRP	pseudomonine	Pseudomonas fluorescens

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 18318:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Cys)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

SCLAV_5271

Search NORINE for peptide: strict or relaxed

AMP-binding (503..907): Cys

nrpys: Cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Small clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Single AA prediction:: Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:

Stachelhaus sequence:: DLYNLSLIWK
Nearest Stachelhaus code(s):: Cys DLYNLSLIWK (94% 8Å match)
Stachelhaus code match:: 100% (strong)