LOCUS       BGC0000375              9457 bp    DNA     linear   BCT 28-MAY-2013
DEFINITION  Streptomyces chromofuscus strain ATCC 49982 transmembrane
            transporter, indigoidine synthase (indC), IndA (indA), putative
            phosphatase (indB), and phosphoribosyl transferase-type I domain
            protein genes, complete cds.
ACCESSION   BGC0000375
VERSION     BGC0000375
KEYWORDS    .
SOURCE      Streptomyces chromofuscus
  ORGANISM  Streptomyces chromofuscus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2024-10-17 13:29:46
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 9457
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..1266
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 96; E-value: 3.1e-29)"
                     /gene_kind="transport"
                     /note="ORF1"
                     /product="transmembrane transporter"
                     /protein_id="AFV27433.1"
                     /transl_table=11
                     /translation="MTTDEVNESTPRSTAGPRRGTPRGMRRVAVVALVLAALNLRPGVT
                     SLGPVLEEVRDSLDMSGSVTGLVTSIPAVCFAVVGSTAPALARRFGASGVIAAACGVLA
                     VGLALRSFTFDPVLFVVLTALSLAGIAVANVLLPMVVKQRFPDRVGAMTGLYSMALNAG
                     ASSAAALTVPLAQAFGGDWRYGLGAWSVLAALAVPPWLALARRRAQPPAGHIGGAVGPP
                     PAVDPPPAAGGRLSRNPTAWALTAYFGLQASSAYIIIGWLPQIFRDAGLSAGTAGLLFS
                     VSSLLGVPLSLALSAVAGRLRHQGGLAAAIGVCGFAGYAGLWLDPALAPWLWAVLLGIA
                     NCSFPLALTMIGMRGRDGAGVARLSGFVQSLGYALSIPGPLVVGVLYDHSDGWRLPLTF
                     VLLLTLVQIAAAVPAGRDRQIG"
     source          1..9457
                     /culture_collection="ATCC:49982"
                     /db_xref="taxon:42881"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces chromofuscus"
                     /strain="ATCC 49982"
     subregion       1..9457
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="NRPS"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..9457
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            1630..5763
                     /gene="indC"
     CDS             1630..5763
                     /NRPS_PKS="Domain: AMP-binding (20-427). E-value: 5.1e-110.
                     Score: 359.7. Matches aSDomain:
                     nrpspksdomains_indC_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (942-1011). E-value: 3.2e-22. Score:
                     70.4. Matches aSDomain: nrpspksdomains_indC_PCP.1"
                     /codon_start=1
                     /gene="indC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1004:thioesterase (Score: 62.2; E-value: 6.3e-19)"
                     /gene_kind="biosynthetic"
                     /product="indigoidine synthase"
                     /protein_id="AFV27434.1"
                     /sec_met_domain="AMP-binding (E-value: 7.3e-117, bitscore:
                     378.7, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 2.9e-19, bitscore:
                     57.9, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVETIPCSRRAALGLPGLLRERARATPDRTAAVHEHQSLTFAQL
                     TEDSSHVGALLRQAGVGRDSRVGVFMEPSLDLLTGVWGILWAGGCYVPLSPEYPEERIA
                     YMLADAGVDIVLTQEFLRSTLQELAPAGVVVLTLDEMLRTAERDGSAFGRPEPEVRPDD
                     LAYVIYTSGSTGKPKGVMVEHRSIVSQMRWLHDECGIDENEIILQKTPMSFDAAQWELL
                     ALACGSTVVMGSSGIYRDPEAIISTVQRHGVTTLQCVPTLLQALLDTEKFPDCGTLRRI
                     FSGGEALSRSLAAQCLDTMPGARLVNLYGPTECTINASSFVVDRAALEDGPLVMPIGTP
                     VHDTSLHVLRPDGAPVSAGEIGELYIGGVQVARGYLGRPDLTGDRFMADPFSDAPGSRL
                     YRTGDLAHVNADGTVQFVGRADNQVKLRGYRVELDEIRQTVETHDWVRAAAVLLRDDAT
                     TGFQNLVAFVELNPKEAALMDQGNHGSHHQSKASRLQVRAQLAHPGCRDDADLAGRAAI
                     DLPGAEATPGQRALAFSRKTYRFYEGSPVTRDDILHLLGPRPRPRPSARTSDIVGRDEL
                     GTILRNFGRHLSDQRLLPKYAYASPGSLYATQLYVEIGGGHDVPAGLYYYHPLHHRLVL
                     VGPASETETSPVRIHFLGKHGAIEPVYRNNVREVLEIEAGHMVGLFEEVLPAHGLRIAA
                     AAYQPAVRHRLDCAPEDHYLGSFDLLPQARGASEDTDTLDIYVQAHSTRIEGLPPGQYR
                     YTGAGLVRIGDDVILKKHVIAINQRVYERSDFGISLVATGSASWRRYLDLGRGLQRLQM
                     NDLHLGFMSSGYSSKSGNDLPSAKRLGRILADGGLPAGPSYFCVGGRVSDAQWRGEDMK
                     EDVVHMQGPAELIKEDLAALLPRYMLPNRIVVLDRLPQTANGKIDLKALQTTQEAQLTV
                     GERAFMAPRTPLERRIRDIWQAVLKRDQVSVTDDFFELGGNSLLAVALVSRLNADFGGA
                     IPLQILFEAPTVERLAAALEATSPRPASRLVPLQPEGRGTPLYCWPGLGGYPMNLRPLA
                     AALGTERPVHGVQAHGINPGEFPYDDVRAMAAADVEAIREIQPHGPYLLCGYSFGARVA
                     FEAARQLEQAGEQVEQLFLVAPGQPRLRPEDAVGATGRADFTDRAFLALLFSVFAGTLS
                     GPRLDQCLRTVTDEDGFVAFVTASFPGLGEELVRAVTGIVRRTYSLTYEFHELRGRRLD
                     APVTLVRATDDNYSFIEHEGGYSARPPAVHQLRSGHYELLREPHVARLAAVLNDRLSAG
                     PSTSPRHSQPAQATVQEVGVPHINIKHFPVSITEEKELELVAAVTTAVRNAFGCTEEVV
                     SIALEPVAQEVWNERVYIPEIVARQELLRKTPNY"
     aSDomain        1690..2910
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_indC_AMP-binding.1"
                     /evalue="5.10E-110"
                     /label="indC_AMP-binding.1"
                     /locus_tag="indC"
                     /protein_end="427"
                     /protein_start="20"
                     /score="359.7"
                     /tool="antismash"
                     /translation="RERARATPDRTAAVHEHQSLTFAQLTEDSSHVGALLRQAGVGRDS
                     RVGVFMEPSLDLLTGVWGILWAGGCYVPLSPEYPEERIAYMLADAGVDIVLTQEFLRST
                     LQELAPAGVVVLTLDEMLRTAERDGSAFGRPEPEVRPDDLAYVIYTSGSTGKPKGVMVE
                     HRSIVSQMRWLHDECGIDENEIILQKTPMSFDAAQWELLALACGSTVVMGSSGIYRDPE
                     AIISTVQRHGVTTLQCVPTLLQALLDTEKFPDCGTLRRIFSGGEALSRSLAAQCLDTMP
                     GARLVNLYGPTECTINASSFVVDRAALEDGPLVMPIGTPVHDTSLHVLRPDGAPVSAGE
                     IGELYIGGVQVARGYLGRPDLTGDRFMADPFSDAPGSRLYRTGDLAHVNADGTVQFVGR
                     ADNQVKLR"
     aSModule        1690..4662
                     /complete
                     /domains="nrpspksdomains_indC_AMP-binding.1"
                     /domains="nrpspksdomains_indC_PCP.1"
                     /locus_tags="indC"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       1873..1911
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_indC_0001"
                     /evalue="7.00E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="indC"
                     /protein_end="94"
                     /protein_start="81"
                     /score="13.1"
                     /tool="antismash"
                     /translation="WGILWAGGCYVPL"
     CDS_motif       2122..2181
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_indC_0002"
                     /evalue="8.40E-12"
                     /label="NRPS-A_a3"
                     /locus_tag="indC"
                     /protein_end="184"
                     /protein_start="164"
                     /score="36.6"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGKPKGVMVEH"
     CDS_motif       2701..2787
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_indC_0003"
                     /evalue="3.40E-15"
                     /label="NRPS-A_a6"
                     /locus_tag="indC"
                     /protein_end="386"
                     /protein_start="357"
                     /score="48.1"
                     /tool="antismash"
                     /translation="AGEIGELYIGGVQVARGYLGRPDLTGDRF"
     CDS_motif       2875..2937
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_indC_0004"
                     /evalue="2.20E-10"
                     /label="NRPS-A_a8"
                     /locus_tag="indC"
                     /protein_end="436"
                     /protein_start="415"
                     /score="32.6"
                     /tool="antismash"
                     /translation="FVGRADNQVKLRGYRVELDEI"
     aSDomain        4456..4662
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_indC_PCP.1"
                     /evalue="3.20E-22"
                     /label="indC_PCP.1"
                     /locus_tag="indC"
                     /protein_end="1011"
                     /protein_start="942"
                     /score="70.4"
                     /tool="antismash"
                     /translation="ERRIRDIWQAVLKRDQVSVTDDFFELGGNSLLAVALVSRLNADFG
                     GAIPLQILFEAPTVERLAAALEAT"
     CDS_motif       4897..4971
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_indC_0005"
                     /evalue="8.20E-13"
                     /label="NRPS-te1"
                     /locus_tag="indC"
                     /protein_end="1114"
                     /protein_start="1089"
                     /score="40.6"
                     /tool="antismash"
                     /translation="QPHGPYLLCGYSFGARVAFEAARQL"
     gene            5798..6751
                     /gene="indA"
     CDS             5798..6751
                     /codon_start=1
                     /gene="indA"
                     /note="Sc-indA"
                     /product="IndA"
                     /protein_id="AFV27435.1"
                     /transl_table=11
                     /translation="MTIPAPRHRSVPLVFTDEVAAALADGDPVVALESNVITHGLPYPD
                     NAATARKVEDAVRAGGAVPATIGIDDGRIMVGMTDGDIERFAATPGIPKVSSRDLAAVL
                     ASGGTGATTVASSLVAAELAGIPFFSSAGIGGVHRGAETTMDISSDLIQFTRSRVAVVC
                     AGAKKILDLGLTLEFLETHCVPVIAHGSDDFPAFYCRSSGLRAPQRLDDETLIARAVET
                     HWALGNPGGVLVTSPTRPEDAIDEQDVEGAIADALRGAEADGVRGGAVTKYVMRAVDRA
                     TEGRSARANTAVLIHTAQIGGRIAAAHARLRREEDQ"
     gene            6835..8679
                     /gene="indB"
     CDS             6835..8679
                     /codon_start=1
                     /gene="indB"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115:HAD-superfamily hydrolase, subfamily IA, variant
                     (Score: 175.4; E-value: 2e-53)"
                     /gene_kind="biosynthetic-additional"
                     /note="Sc-indB"
                     /product="putative phosphatase"
                     /protein_id="AFV27436.1"
                     /transl_table=11
                     /translation="MFDLDGTLVDSPRAIVEAFAAAFWAMGLAPRDPADIRATIGLPLE
                     QAFGKLLGVPQNDPSVADGVARYQEAFRTLILPRAHSLVFPGVPEGLAELRRHGVVVTV
                     ATSKFHASADALLTAAGLRDHVTTLVGADDVTRPKPHPESGLLILGELGARPEHAVMVG
                     DTTHDLKMAAAAGLASVAVTYGVHERAELETASPTHVADTFAQAVEQILAVLPADGGPE
                     DTGTVESLLDDSTYHIEFNGHLTNHIKHAVVALAGLGVDPGRIKAYHDNYIALTPYGCR
                     VEPARPPQRLIDDGNWLEHLGRREDFAAYCAFFDRRERELGMAGLLRQYVPRLLAGWAG
                     ALQHATIHLGWALDAGNRRMAIEGIAYLAFAYVDCHPERAVPSEAPGTDKPGDSLLSIA
                     RHWEENGPRLGAWVEDLVGTTSADIHPELLRSGLQYRIARMLGEGHPLMYGTPSWIAAQ
                     DPDTSWEQLAYLVTVLYLTEPGDFLLLHLVTALHAMRHIADALPAEQQRRAVACYWTGI
                     LGVLFSRGHFVAPSKLTAIDSLFDTALDDLDDPRWAREWDWHIARAVEEEEEHNAKLVY
                     VMRELWRGSGGRSVYRVAAGQFTTTPELPATFEQPPVD"
     CDS             8741..9457
                     /codon_start=1
                     /note="Orf2"
                     /product="phosphoribosyl transferase-type I domain protein"
                     /protein_id="AFV27437.1"
                     /transl_table=11
                     /translation="MSIATQPRTAAAHPTAATSTYHHHLGTSVHLLPQTDQLRALHTVI
                     RDRDARREDFVFYAGRIIRLLTEAALNLLPFEPYDVTTPVGRTYQGLRFAENLVGVPIV
                     RAGESMEAELRAVVPGIRIGKILIQRDKTTKQPRLYYTAFPEDIATRQVLLLDPMLATG
                     GTALAAIEVLRDLGVPEEHIVFVNFITCPEGIAAVGERYPGVRIVTSAIEEGLNENAYM
                     MPGIGDFGDRYFGTDR"
ORIGIN
        1 atgacaacgg atgaggtcaa cgagagcacc cctcgttcca ccgccggccc gcgccgcggc
       61 acgccgcggg ggatgcgccg cgtcgccgtg gtggcgctgg tcctggccgc cctgaatctg
      121 cgccccgggg tcaccagcct cggccccgtc ctggaggaag tccgggacag tctcgacatg
      181 agcggctcgg tgaccgggct cgtgacctcc atccccgcgg tgtgtttcgc ggtggtcggc
      241 tcgacggccc ccgccctggc ccggcgcttc ggtgcgagcg gcgtcatcgc ggccgcctgt
      301 ggggtgctcg ccgtagggct ggcactgcgg tcgttcacct tcgatccggt gctgttcgtc
      361 gtactgacgg cgctgtcgct ggccggaatc gccgtggcca acgtgctgct gccgatggtc
      421 gtcaaacagc gtttccccga ccgggtgggc gcgatgacgg gtctgtactc catggcgctg
      481 aacgccggcg cctcgtccgc ggcggcgctg acggtgccct tggcgcaggc gttcggtggc
      541 gactggcggt acggcctggg ggcctggtcg gtgctggcgg cgctggccgt acctccctgg
      601 ctggccctgg cgcgccgccg ggcgcagcca cccgcgggcc acatcggtgg cgcggtcggc
      661 cccccgcccg cggtcgatcc cccgcccgcg gccggcggcc gactctcccg caaccccacg
      721 gcctgggcgc tcacggcgta cttcggactt caggcgagtt ccgcctacat catcatcggc
      781 tggctgcccc agatcttccg ggacgcgggg ctgtccgccg gcaccgcggg gctgctgttc
      841 tccgtatcct ccctgctggg ggtgcctctg tccctcgcgc tgtcggccgt ggccggcagg
      901 ctgcgccacc agggcgggct cgccgccgcg atcggcgtgt gcggcttcgc cgggtacgcc
      961 gggctgtggc tcgaccccgc tctcgcaccc tggctctggg cggtcctgct gggtatcgcc
     1021 aactgctcct tcccgctggc cctgacgatg atcggcatgc ggggccgcga cggcgccggt
     1081 gtcgcccggc tctccggctt cgtgcagagc ctcggctacg ccctgtccat ccccggtcct
     1141 ctcgtcgtcg gtgtcctcta cgaccactcc gacggctggc ggctgcctct caccttcgtc
     1201 ctgctgctga ccctggtcca gatcgctgcc gccgtgcccg ccggccgcga ccgtcagatc
     1261 ggctaaaacg gaccggctcg gcagaaaaac gctccacaga actgaccatc tcccgcattt
     1321 cgcctttcat ttcccatgcc atccgcaggg aaatgactta gggagatagc atgcggtaaa
     1381 gcacggatgt agcgcgcatc ggttcttcgt ggtaattttc tgacgaacta cgcgacgccc
     1441 gttcagactt ccgtcaggat tctgattcga ttccgcagaa gttccgctcg cattccgcag
     1501 aggtcgccac ccgcactggt cgacgagcaa ttccgagtac cgcaccagga aagaacaccg
     1561 agttcgacgc ggcgtcttgt cttcgaaacg gacaccgccc tcccaagacg cggaaaaagg
     1621 aagcccccca tgagcgtaga gaccatcccc tgctctcgtc gtgccgccct cggcctgccc
     1681 ggcctgttgc gcgaacgagc tcgggccacc cccgaccgga cagccgccgt tcacgagcac
     1741 cagagcctga cattcgccca gttgacggag gacagctccc atgtgggagc gctcctgcgg
     1801 caggccgggg tgggccggga cagccgggtc ggcgtgttca tggagccgtc gctcgacctg
     1861 ctgacgggcg tctggggaat cctgtgggcc ggcggatgct acgtaccgtt gtccccggaa
     1921 tacccggagg agaggatcgc gtacatgctg gcggacgccg gcgtcgacat cgttctcacc
     1981 caggaattcc ttcggtcgac ccttcaggag ctcgctccgg ccggggtcgt tgttctcact
     2041 ctcgacgaga tgttgaggac ggcggagagg gacggcagtg cattcggccg gccggagccc
     2101 gaggtacggc ccgacgatct cgcctatgtc atctacacct ccggcagcac cggaaagcca
     2161 aaaggtgtga tggtcgagca ccggagcatc gtgagtcaaa tgcgatggct gcacgacgag
     2221 tgcggtatcg atgaaaacga aataatactg cagaagaccc cgatgagttt cgatgccgcg
     2281 cagtgggaat tactcgccct cgcctgcggc agcaccgtgg tgatgggatc ctccggtatc
     2341 taccgcgacc ccgaggcgat catctccacc gtccaacggc acggcgtgac caccctccag
     2401 tgcgtgccca ccctgctcca ggcgctcctg gacaccgaga agttccccga ctgcgggacc
     2461 ctgcgccgca tcttcagcgg gggcgaggcg ctctcccgga gtctcgccgc gcagtgcctg
     2521 gacaccatgc cgggggcccg tctggtcaac ctctacggcc ccaccgagtg caccatcaac
     2581 gcctcgtcct tcgtggtgga ccgcgccgcg ctggaggacg ggccgctcgt catgccgatc
     2641 ggcacccccg tgcacgacac ctccctgcac gtcctgagac cggacggtgc gccggtctcc
     2701 gccggggaga tcggcgaact gtacatcggc ggtgtgcagg tggcccgcgg ctacctcggc
     2761 cgcccggacc tgaccggcga ccggttcatg gccgacccct tctccgacgc gcccggctcc
     2821 cgcctctacc ggaccggcga cctcgcccat gtcaacgcgg acggcacggt gcagttcgtc
     2881 ggacgcgccg acaaccaggt caagctgcgc ggctaccggg tcgaactgga cgagatacgc
     2941 cagaccgtcg agacgcacga ctgggtccgc gccgcggccg tcctgctccg cgacgacgcc
     3001 accacgggct tccagaacct cgtcgccttc gtcgagctca accccaagga agccgccctg
     3061 atggaccagg gcaaccacgg ctcccaccac cagtccaagg ccagccggct ccaggtcagg
     3121 gcccaactgg cccaccccgg ctgccgcgac gacgccgatc tggccggccg ggcggccatc
     3181 gacctgcccg gcgccgaggc cacccccggg cagcgggccc tcgccttctc ccgcaagacg
     3241 taccgcttct acgagggctc cccggtgacc cgggacgaca tcctgcacct gctcggcccc
     3301 cgtccccggc cgcggccgtc cgcccgtacc tccgacatcg tcggccgcga cgaactcggt
     3361 acgatcctgc ggaacttcgg ccgtcacctc agcgaccaga ggctgctgcc caagtacgcc
     3421 tacgcctcac ccggctccct gtacgcgacg cagttgtacg tcgagatcgg cggcgggcac
     3481 gacgttcccg cgggcctgta ctactaccac ccgctccacc accggctggt gctcgtcggc
     3541 ccggcctccg agaccgagac ctccccggta cggatccact tcctcggcaa gcacggcgcc
     3601 atcgagccgg tctaccgcaa caacgtccgc gaggtcctgg agatcgaggc gggccacatg
     3661 gtcggcctgt tcgaggaggt gctgccggcc cacggcctgc gcatcgccgc ggccgcgtac
     3721 caaccggccg tcagacaccg tctcgactgc gcgccggagg accactacct gggcagcttc
     3781 gacctccttc cgcaggcgcg gggcgcgtcc gaggacaccg acaccctcga catctacgtc
     3841 caggcccact ccacccggat cgagggcctg ccgccgggtc agtaccggta caccggcgcc
     3901 ggcctcgtcc gtatcggcga cgacgtgatc ctcaagaagc acgtcatcgc catcaaccag
     3961 cgggtctacg agcgttccga cttcggtatc agcctggtcg ccaccggttc cgcctcctgg
     4021 cggcgctatc tcgacctggg tcgcgggctc cagcgcctcc agatgaacga cctgcacctc
     4081 ggcttcatgt cctcgggcta cagctcgaag tccggtaacg acctgccgtc ggccaagcgg
     4141 ctgggccgga tcctcgccga cggcgggttg cccgccggac cgtcgtactt ctgcgtcggc
     4201 gggcgtgtca gcgacgcgca gtggcgcggc gaggacatga aggaggacgt ggtccacatg
     4261 caggggcccg ccgagctgat caaggaggat ctggccgcgc tgctgccccg ctacatgctg
     4321 cccaaccgga tcgtcgtcct ggaccggctg ccccagaccg ccaacggcaa gatcgacctg
     4381 aaggccctgc agaccactca ggaagcccaa ctgaccgtcg gcgaacgcgc tttcatggct
     4441 ccgcgcaccc cgctggagcg gcggatccgc gacatctggc aggcggtgct caagcgggac
     4501 caggtctccg tcaccgacga cttcttcgaa ctgggcggga actccctgct cgccgtggct
     4561 ctggtcagcc gcctgaacgc ggacttcggc ggcgcgatcc ccctgcagat cctgttcgag
     4621 gcccccaccg tggagaggct cgccgcggcc ctggaggcca cgtcaccccg gcccgcctcc
     4681 cgtctggtgc cgctccagcc cgagggcagg ggcaccccgc tgtactgctg gccgggcctc
     4741 ggcggctacc ccatgaacct gcgtccgctg gccgcggccc tgggcacgga gcggcccgtc
     4801 cacggggtcc aggcccacgg catcaacccc ggcgagttcc cctacgacga tgtccgtgcc
     4861 atggccgccg ccgatgtcga ggcgatccgg gagatccagc cccacggccc gtacctgctg
     4921 tgcggatact ccttcggcgc ccgggtcgcc ttcgaggccg cgcgccagtt ggaacaggcg
     4981 ggcgagcagg tggagcagtt gttcctcgtg gctcccggcc agccgcggct gcgccccgag
     5041 gacgccgtcg gcgcgaccgg ccgggcggac ttcacggacc gcgccttcct cgccctgctc
     5101 ttctccgtct tcgccggcac gctcagcggc ccgcgactgg accagtgcct gcgcaccgtc
     5161 accgacgagg acggcttcgt cgcattcgtc accgcgtcct tcccgggact cggcgaggag
     5221 ctggtacggg cggtcaccgg gatcgtacgc cgcacgtact ccctcaccta cgagttccac
     5281 gagctgcgcg gacgccgtct cgacgcgccc gtgaccctgg tcagggccac cgacgacaac
     5341 tactccttca tcgagcacga gggcgggtac tccgcccggc cgcccgccgt ccaccaactg
     5401 cggtccggcc actacgaact gctgcgcgag ccgcatgtcg cccggctcgc cgctgtcctc
     5461 aacgaccggc tgtccgccgg tcccagcacg tccccccgtc acagccagcc ggcgcaagcc
     5521 acggtccagg aggtcggagt gccccacatc aacatcaagc acttcccggt gtcgatcacc
     5581 gaggagaagg agctggagct ggtcgccgcg gtcaccacgg ccgtgcgcaa cgccttcggc
     5641 tgcaccgagg aggtcgtctc catcgccctg gagcccgtcg cccaggaggt gtggaacgag
     5701 cgggtctaca tccccgagat cgtcgcccgg caggagttgc tgcgcaagac gcccaactac
     5761 tgaccgccgc ccgcagccga cgagaaggac ccctcccatg acgatccccg ccccccggca
     5821 ccgttcggtg cccctggtgt tcaccgacga ggtggctgcc gcgctcgccg acggcgaccc
     5881 cgtggtcgcc ctggaatcga acgtcatcac ccacgggctc ccgtaccctg acaacgctgc
     5941 caccgcccgc aaggtggagg acgcggtacg ggccggcggc gccgtgcccg ccaccatcgg
     6001 catcgacgac ggccgcatca tggtcgggat gaccgacggc gacatcgagc gcttcgccgc
     6061 caccccgggc atccccaagg tcagcagcag ggacctggcg gccgtcctcg cctcgggcgg
     6121 caccggcgcc accacggtcg cttcctcgct ggtcgccgcg gaactggccg gcatcccctt
     6181 cttctcctcc gccggtatcg gcggtgtcca ccggggcgcc gagaccacca tggacatctc
     6241 ctccgatctg atccagttca cccgctccag ggtggcggtg gtctgcgccg gcgcaaagaa
     6301 gatcctggac ctcggtctga cgctggagtt cctggagacc cactgcgtgc ccgtcatcgc
     6361 ccacggctcc gacgacttcc ccgccttcta ctgccgctcc agcgggctgc gcgcccctca
     6421 gcgtctggac gacgagaccc tgatcgcccg cgccgtcgag acccactggg cgctgggcaa
     6481 ccccggcggc gtcctcgtca ccagccccac ccggccggag gacgccatcg acgagcagga
     6541 cgtcgagggg gccatcgccg acgccctgcg cggcgccgag gcggacgggg tccggggcgg
     6601 cgccgtcacg aagtacgtca tgcgcgcggt ggaccgcgcc accgaaggac gctccgcacg
     6661 ggccaacacc gccgtactca tccacaccgc acagatcggc ggccgcatcg cggcggccca
     6721 cgcccggctc cgacgagagg aagaccagtg accacgaccc aggtcgagac cgtcccgaca
     6781 acgacctcgc cagtccccgc cgggacggag aagacaggac cgacccgggt cgcgatgttc
     6841 gacctggacg gaaccctcgt cgactcgccc cgggcgatcg tggaggcgtt cgccgccgct
     6901 ttctgggcga tgggcctcgc gccccgggac ccggcggaca tccgggccac catcggcctg
     6961 cccctggagc aggcgttcgg gaaactgctg ggagtaccgc agaacgaccc ctcggtcgcc
     7021 gacggcgtgg cccgctacca ggaggcgttc cgcaccctca tcctcccccg cgcccactcg
     7081 ctggtcttcc ccggcgtccc cgagggcctc gccgaactgc gccgtcacgg tgtcgtggtg
     7141 acggtggcca cgagcaagtt ccatgccagc gccgatgccc tgctcaccgc cgcgggcctg
     7201 cgcgaccacg tcaccacact ggtcggcgcc gacgacgtca cccgtcccaa gccgcacccc
     7261 gagtcggggc tgctgatcct cggagagctc ggcgcccggc ccgagcacgc cgtgatggtc
     7321 ggcgacacca cccacgacct gaagatggcc gcggcggccg gcctggcgtc cgtggcggtc
     7381 acctacgggg tccacgagcg ggcggagctg gagacggcct caccgacaca cgtcgccgac
     7441 acgttcgccc aggccgtgga gcagatcctc gccgtcctgc cggccgacgg cggaccggag
     7501 gacaccggca ccgtcgagag cctcctggac gacagcacgt accacatcga gttcaacggc
     7561 cacctcacca accacatcaa gcacgccgtc gtcgccctcg ccggcctcgg tgtcgacccc
     7621 ggccggatca aggcgtacca cgacaactac atcgccctca cgccgtacgg ctgccgcgtc
     7681 gagccggcca gacctcccca gcgactgatc gacgacggca actggctcga acacctcggc
     7741 cggcgcgagg acttcgccgc gtactgcgcg ttcttcgacc ggcgcgaacg ggaactgggc
     7801 atggcgggtc tgctacggca gtacgtaccg cgcctgctcg cgggctgggc cggtgcgctc
     7861 cagcacgcga ccatccacct gggctgggcc ctggacgccg gcaaccgccg catggccatc
     7921 gagggcatcg cctacctggc cttcgcgtac gtcgactgcc atcccgaacg cgccgtgccc
     7981 tcggaagcgc ccggcaccga caagcccggg gactcgctgc tgagcatcgc ccgccactgg
     8041 gaggagaacg ggccccggct cggcgcctgg gtcgaggacc tggtcggaac cacgagcgcc
     8101 gacatccacc ccgaactcct gcggtccggg ctgcagtacc ggatcgcccg gatgctcggc
     8161 gagggccatc cgctgatgta cgggacaccc tcctggatcg ccgcgcagga ccccgacacc
     8221 agttgggagc agctcgccta cctcgtcacc gttctctacc tgaccgaacc gggagacttc
     8281 ctcctgctgc acctggtcac cgcgctccac gcgatgcgtc acatcgcgga cgccctcccc
     8341 gccgagcagc agcggcgagc ggtcgcgtgc tactggaccg gcatcctcgg tgtgctcttc
     8401 tcccggggcc acttcgtcgc cccttcgaag ctgaccgcga tcgacagcct cttcgacacc
     8461 gccctggacg acctggacga cccgcgctgg gcccgggagt gggactggca catcgcgcgg
     8521 gccgtggagg aggaagagga gcacaacgcc aagctcgtct acgtgatgcg cgagttgtgg
     8581 cgcggctcgg gcggcaggtc cgtgtaccgc gtcgccgccg ggcagttcac caccaccccg
     8641 gagctccccg ccaccttcga gcagcccccg gtcgactgaa ccgtcccgcc ccgtcctccc
     8701 ccgtccctcc ccccgtccct ccccacccga ggagccaccg atgtccatcg ccacacagcc
     8761 caggaccgct gccgcgcacc ccaccgccgc cacgagcacg taccaccacc acctcggcac
     8821 gagcgtccac ctgctcccgc agaccgacca gttgcgcgcc ctgcacaccg tcatccgtga
     8881 ccgcgacgcc cgccgcgagg acttcgtctt ctacgccggc cggatcatcc gcctgctcac
     8941 cgaggcggcg ctgaacctcc tgcccttcga gccctacgac gtcaccacgc ccgtcggccg
     9001 gacctaccag ggcctgcgct tcgccgagaa cctggtcggg gtgccgatcg tacgtgccgg
     9061 ggagagcatg gaggccgagc tgcgcgccgt cgtccccggc atcaggatcg gcaagatcct
     9121 catccagcgc gacaagacga ccaagcagcc gcgcctgtac tacacggcgt tccccgagga
     9181 catcgccaca cgccaggtcc tcctcctcga cccgatgctg gcgaccggcg gcaccgccct
     9241 cgcggccatc gaggtcctgc gcgatctcgg tgttccggag gagcacatcg tcttcgtcaa
     9301 cttcatcacc tgccccgagg gcatcgccgc cgtgggcgag cgctaccccg gggtccggat
     9361 cgtgacctcc gccatcgagg agggactcaa cgagaacgcc tacatgatgc cgggcatcgg
     9421 cgacttcggc gaccgctact tcggaacgga ccgctga
//
