BGC0000376: JBIR-34 biosynthetic gene cluster from Streptomyces sp. Sp080513GE-23
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Location: 1 - 43,673 nt. (total: 43,673 nt).
This entry is originally from NCBI GenBank AB902962.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000376
Short description JBIR-34 biosynthetic gene cluster from Streptomyces sp. Sp080513GE-23
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
AB902962.1
via
Compounds
  • JBIR-34
  • JBIR-35
Species Streptomyces sp. Sp080513GE-23 [taxonomy]
References
Chemical products information
JBIR-34 Evidence:
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C21H25Cl1N4O7
Chemical database entries
NPAtlas
JBIR-35 Evidence:
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C20H23Cl1N4O7
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAP16682.1
 121 - 1227 (+) metalloprotease
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    • BAP16683.1
    • fmoR1
    		 2135 - 3004 (+) SARP family transcriptional regulator
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      • BAP16684.1
      • fmoA1
      		 3001 - 4767 (+) nonribosomal peptide synthetase
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        • BAP16685.1
        • fmoB
        		 4764 - 5504 (+) thioesterase
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          • BAP16686.1
          • fmoC
          		 5501 - 6697 (+) cytochrome P450 monooxygenase
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            • BAP16687.1
            • fmoD
            		 6743 - 8395 (+) tryptophan 6-halogenase
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              • BAP16688.1
              • fmoE
              		 8392 - 8925 (+) flavin reductase
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                • BAP16689.1
                • fmoA2
                		 8925 - 13415 (+) nonribosomal peptide synthetase
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                  • BAP16690.1
                  • fmoF
                  		 13561 - 14217 (+) hypothetical protein
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                    • BAP16691.1
                    • fmoG
                    		 14427 - 15698 (-) integral membrane ion antiporter
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                      • BAP16692.1
                      • fmoH
                      		 15784 - 17007 (-) alanine/alpha-methylserine hydroxymethyltransferase
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                        • BAP16693.1
                        • fmoA3
                        		 17168 - 20551 (-) nonribosomal peptide synthetase
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                          • BAP16694.1
                          • fmoI
                          		 20689 - 22161 (+) aldehyde dehydrogenase
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                            • BAP16695.1
                            • fmoJ
                            		 22191 - 22931 (-) esterase
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                              • BAP16696.1
                              • fmoR2
                              		 23029 - 24000 (+) transcriptional regulator
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                                • BAP16697.1
                                • fmoA4
                                		 24017 - 28396 (-) nonribosomal peptide synthetase
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                                  • BAP16698.1
                                  • fmoK
                                  		 28531 - 29994 (-) transmembrane transporter
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                                    • BAP16699.1
                                    • fmoA5
                                    		 30071 - 35677 (-) nonribosomal peptide synthetase
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                                      • BAP16700.1
                                      • fmoL
                                      		 35738 - 36910 (-) hypothetical protein
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                                        • BAP16701.1
                                        • fmoM
                                        		 36947 - 38041 (-) L-Threonine aldolase
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                                          • BAP16702.1
                                          • fmoR3
                                          		 38038 - 38958 (-) LysR family transcriptional regulator
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                                            • BAP16703.1
                                            		 39935 - 40381 (-) hypothetical protein
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                                              • BAP16704.1
                                              		 40533 - 40955 (-) endoribonuclease L-PSP family protein
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                                                • BAP16705.1
                                                		 40952 - 42112 (-) Acyl-CoA dehydrogenase
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                                                  Biosynthesis information

                                                  Biosynthetic modules

                                                  Name
                                                  Unk01
                                                  Type
                                                  nrps-type1
                                                  Genes
                                                  fmoA1
                                                  Substrates
                                                  tryptophan, 6-chlorotryptophan (evidence: ATP-PPi exchange assay [1])
                                                  Integrated Monomers
                                                  Domains
                                                  adenylation
                                                  Name
                                                  Unk02
                                                  Type
                                                  nrps-type1
                                                  Genes
                                                  fmoA2
                                                  Substrates
                                                  4-hydroxyindole-3-carboxylic acid (evidence: )
                                                  Integrated Monomers
                                                  Domains
                                                  adenylation
                                                  Name
                                                  Unk03
                                                  Type
                                                  nrps-type1
                                                  Genes
                                                  fmoA3
                                                  Substrates
                                                  2-methylserine (evidence: )
                                                  Integrated Monomers
                                                  Domains
                                                  adenylation
                                                  Name
                                                  Unk04
                                                  Type
                                                  nrps-type1
                                                  Genes
                                                  fmoA4
                                                  Substrates
                                                  D-alanine (evidence: )
                                                  Integrated Monomers
                                                  Domains
                                                  adenylation
                                                  Name
                                                  Unk05
                                                  Type
                                                  nrps-type1
                                                  Genes
                                                  fmoA5
                                                  Substrates
                                                  serine (evidence: )
                                                  Integrated Monomers
                                                  Domains
                                                  adenylation
                                                  Annotation changelog

                                                  Entry version: 4

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2022-10-07
                                                  Update chemical activity to schema version 2.11
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                  Entry version: 3

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2022-09-15
                                                  Updated bioactivity data
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  2022-09-15
                                                  Added NRP substrate specificities
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                  Entry version: 2

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2019-10-16
                                                  Migrated from v1.4
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  2019-10-16
                                                  Updated compound(s) information (NPAtlas curation)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                  Entry version: 1

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2015-06-12
                                                  Submitted
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  Detailed domain annotation
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