BGC0000376: JBIR-34 biosynthetic gene cluster from Streptomyces sp. Sp080513GE-23
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Location: 1 - 43,673 nt. (total: 43,673 nt).
This entry is originally from NCBI GenBank AB902962.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000376
Short description JBIR-34 biosynthetic gene cluster from Streptomyces sp. Sp080513GE-23
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: AB902962.1
Compounds
  • JBIR-34
  • JBIR-35
Species Streptomyces sp. Sp080513GE-23 [taxonomy]
References
Chemical products information
JBIR-34
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C21H25Cl1N4O7
Chemical database entries
NPAtlas
JBIR-35
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C20H23Cl1N4O7
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAP16682.1
 121 - 1227 (+) metalloprotease
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  • BAP16683.1
  • fmoR1
 2135 - 3004 (+) SARP family transcriptional regulator
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  • BAP16684.1
  • fmoA1
 3001 - 4767 (+) nonribosomal peptide synthetase
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  • BAP16685.1
  • fmoB
 4764 - 5504 (+) thioesterase
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  • BAP16686.1
  • fmoC
 5501 - 6697 (+) cytochrome P450 monooxygenase
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  • BAP16687.1
  • fmoD
 6743 - 8395 (+) tryptophan 6-halogenase
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  • BAP16688.1
  • fmoE
 8392 - 8925 (+) flavin reductase
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  • BAP16689.1
  • fmoA2
 8925 - 13415 (+) nonribosomal peptide synthetase
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  • BAP16690.1
  • fmoF
 13561 - 14217 (+) hypothetical protein
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  • BAP16691.1
  • fmoG
 14427 - 15698 (-) integral membrane ion antiporter
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  • BAP16692.1
  • fmoH
 15784 - 17007 (-) alanine/alpha-methylserine hydroxymethyltransferase
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  • BAP16693.1
  • fmoA3
 17168 - 20551 (-) nonribosomal peptide synthetase
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  • BAP16694.1
  • fmoI
 20689 - 22161 (+) aldehyde dehydrogenase
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  • BAP16695.1
  • fmoJ
 22191 - 22931 (-) esterase
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  • BAP16696.1
  • fmoR2
 23029 - 24000 (+) transcriptional regulator
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  • BAP16697.1
  • fmoA4
 24017 - 28396 (-) nonribosomal peptide synthetase
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  • BAP16698.1
  • fmoK
 28531 - 29994 (-) transmembrane transporter
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  • BAP16699.1
  • fmoA5
 30071 - 35677 (-) nonribosomal peptide synthetase
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  • BAP16700.1
  • fmoL
 35738 - 36910 (-) hypothetical protein
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  • BAP16701.1
  • fmoM
 36947 - 38041 (-) L-Threonine aldolase
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  • BAP16702.1
  • fmoR3
 38038 - 38958 (-) LysR family transcriptional regulator
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  • BAP16703.1
 39935 - 40381 (-) hypothetical protein
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  • BAP16704.1
 40533 - 40955 (-) endoribonuclease L-PSP family protein
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  • BAP16705.1
 40952 - 42112 (-) Acyl-CoA dehydrogenase
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
fmoA1
Module ?
Specificity: tryptophan / 6-chlorotryptophan
Evidence for specificity:
  • ATP-PPi exchange assay
fmoA2
Module ?
Specificity: 4-hydroxyindole-3-carboxylic acid
Evidence for specificity:
fmoA3
Module ?
Specificity: 2-methylserine
Evidence for specificity:
fmoA4
Module ?
Specificity: D-alanine
Evidence for specificity:
fmoA5
Module ?
Specificity: serine
Evidence for specificity:
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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