BGC0000378: kutzneride 2 biosynthetic gene cluster from Kutzneria sp. 744
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Location: 1 - 56,081 nt. (total: 56,081 nt).
This entry is originally from NCBI GenBank EU074211.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000378
Short description kutzneride 2 biosynthetic gene cluster from Kutzneria sp. 744
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: EU074211.1
Compounds
  • kutzneride 2
Species Kutzneria sp. 744 [taxonomy]
References
Chemical products information
kutzneride 2
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C37H48Cl3N7O12
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ABV56606.1
 1 - 720 (-) regulator
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  • ABV56605.1
 1754 - 2740 (-) ornithine cyclodeaminase
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  • ABV56604.1
 2934 - 4727 (+) adenylation domain protein
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  • ABV56603.1
 4724 - 6631 (+) radical-SAM
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  • ABV56602.1
 6645 - 7802 (+) acyl-CoA-like dehydrogenase
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  • ABV56601.1
 7939 - 8613 (+) thioesterase
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  • ABV56600.1
 8623 - 9264 (+) regulator
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  • ABV56599.1
  • ktzS
 9274 - 9798 (-) KtzS
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  • ABV56598.1
  • ktzR
 9791 - 11308 (-) KtzR
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  • ABV56597.1
  • ktzQ
 11603 - 13204 (+) KtzQ
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  • ABV56596.1
  • ktzP
 13265 - 14269 (+) KtzP
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  • ABV56595.1
  • ktzO
 14301 - 15272 (+) KtzO
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  • ABV56594.1
  • ktzN
 15295 - 16959 (-) KtzN
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  • ABV56593.1
  • ktzM
 16981 - 18171 (+) KtzM
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  • ABV56592.1
  • ktzL
 18213 - 19235 (+) KtzL
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  • ABV56591.1
  • ktzK
 19328 - 19996 (+) KtzK
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  • ABV56590.1
  • ktzJ
 20077 - 20292 (-) KtzJ
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  • ABV56589.1
  • ktzI
 20316 - 21590 (-) KtzI
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  • ABV56588.1
  • ktzH
 21587 - 37369 (-) KtzH
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  • ABV56587.1
  • ktzG
 37496 - 41317 (-) KtzG
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  • ABV56586.1
  • ktzF
 41314 - 42066 (-) KtzF
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  • ABV56585.1
  • ktzE
 42086 - 47017 (-) KtzE
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  • ABV56584.1
  • ktzD
 47284 - 48249 (+) KtzD
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  • ABV56583.1
  • ktzC
 48246 - 48518 (+) KtzC
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  • ABV56582.1
  • ktzB
 48496 - 50091 (+) KtzB
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  • ABV56581.1
  • ktzA
 50088 - 51233 (+) KtzA
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  • ABV56580.1
 51508 - 52542 (+) transporter
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  • ABV56579.1
 52520 - 54865 (-) penicillin acylase
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  • ABV56578.1
 54855 - 56081 (-) permease
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
ktzB
Module ?
Specificity: isoleucine / valine / leucine / allo-isoleucine
Evidence for specificity:
  • Structure-based inference
  • ATP-PPi exchange assay
ktzE
Module ?
Specificity: 2-(1-methylcyclopropyl)-D-glycine
Evidence for specificity:
  • Structure-based inference
ktzG
Module ?
Specificity: 2-ketoisovaleric acid / 2-ketobutyric acid
Evidence for specificity:
  • Structure-based inference
  • ATP-PPi exchange assay
ktzH
Module ?
Specificity: piperazic acid
Evidence for specificity:
  • Structure-based inference
  • Knock-out studies
Module ?
Specificity: serine
Evidence for specificity:
  • Structure-based inference
  • Heterologous expression
Module ?
Specificity: 6,7-dichlorotryptophan
Evidence for specificity:
  • Structure-based inference
  • Heterologous expression
  • Homology
ktzN
Module ?
Specificity: glutamic acid / aspartic acid
Evidence for specificity:
  • ATP-PPi exchange assay
  • Structure-based inference
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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