BGC0000378: Kutzneride 1 biosynthetic gene cluster from Kutzneria sp. 744
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Location: 1 - 56,081 nt. (total: 56,081 nt).
This entry is originally from NCBI GenBank EU074211.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000378
Short description Kutzneride 1 biosynthetic gene cluster from Kutzneria sp. 744
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
EU074211.1
via
Compounds
  • Kutzneride 1
  • Kutzneride 2
  • Kutzneride 3
  • Kutzneride 4
  • Kutzneride 5
  • Kutzneride 6
  • Kutzneride 7
  • Kutzneride 8
Species Kutzneria sp. 744 [taxonomy]
References
Chemical products information
Kutzneride 1 Evidence: NMR [2]
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C37H49Cl2N7O12
Chemical database entries
NPAtlas
Kutzneride 2 Evidence: NMR [2]
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C37H48Cl3N7O12
Chemical database entries
NPAtlas
Kutzneride 3 Evidence: NMR [2]
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C37H49Cl2N7O12
Chemical database entries
NPAtlas
Kutzneride 4 Evidence: NMR [2]
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C37H47Cl2N7O12
Chemical database entries
NPAtlas
Kutzneride 5 Evidence: NMR [3]
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C36H47Cl2N7O12
Chemical database entries
NPAtlas
Kutzneride 6 Evidence: NMR [3]
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C37H47Cl2N7O13
Chemical database entries
NPAtlas
Kutzneride 7 Evidence: NMR [3]
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C36H47Cl2N7O12
Chemical database entries
NPAtlas
Kutzneride 8 Evidence: NMR [3]
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C37H48Cl3N7O12
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ABV56606.1
 1 - 720 (-) regulator
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    • ABV56605.1
    		 1754 - 2740 (-) ornithine cyclodeaminase
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      • ABV56604.1
      		 2934 - 4727 (+) adenylation domain protein
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        • ABV56603.1
        		 4724 - 6631 (+) radical-SAM
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          • ABV56602.1
          		 6645 - 7802 (+) acyl-CoA-like dehydrogenase
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            • ABV56601.1
            		 7939 - 8613 (+) thioesterase
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              • ABV56600.1
              		 8623 - 9264 (+) regulator
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                • ABV56599.1
                • ktzS
                		 9274 - 9798 (-) KtzS
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                  • ABV56598.1
                  • ktzR
                  		 9791 - 11308 (-) KtzR
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                    • ABV56597.1
                    • ktzQ
                    		 11603 - 13204 (+) KtzQ
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                      • ABV56596.1
                      • ktzP
                      		 13265 - 14269 (+) alpha-ketoglutarate dependent PCP-bound L-glutamate 3-hydroxylase
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                        • ABV56595.1
                        • ktzO
                        		 14301 - 15272 (+) alpha-ketoglutarate dependent PCP-bound L-glutamate 3-hydroxylase
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                          • ABV56594.1
                          • ktzN
                          		 15295 - 16959 (-) KtzN
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                            • ABV56593.1
                            • ktzM
                            		 16981 - 18171 (+) KtzM
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                              • ABV56592.1
                              • ktzL
                              		 18213 - 19235 (+) KtzL
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                                • ABV56591.1
                                • ktzK
                                		 19328 - 19996 (+) KtzK
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                                  • ABV56590.1
                                  • ktzJ
                                  		 20077 - 20292 (-) KtzJ
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                                    • ABV56589.1
                                    • ktzI
                                    		 20316 - 21590 (-) KtzI
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                                      • ABV56588.1
                                      • ktzH
                                      		 21587 - 37369 (-) KtzH
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                                        • ABV56587.1
                                        • ktzG
                                        		 37496 - 41317 (-) KtzG
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                                          • ABV56586.1
                                          • ktzF
                                          		 41314 - 42066 (-) KtzF
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                                            • ABV56585.1
                                            • ktzE
                                            		 42086 - 47017 (-) KtzE
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                                              • ABV56584.1
                                              • ktzD
                                              		 47284 - 48249 (+) KtzD
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                                                • ABV56583.1
                                                • ktzC
                                                		 48246 - 48518 (+) KtzC
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                                                  • ABV56582.1
                                                  • ktzB
                                                  		 48496 - 50091 (+) KtzB
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                                                    • ABV56581.1
                                                    • ktzA
                                                    		 50088 - 51233 (+) KtzA
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                                                      • ABV56580.1
                                                      		 51508 - 52542 (+) transporter
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                                                        • ABV56579.1
                                                        		 52520 - 54865 (-) penicillin acylase
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                                                          • ABV56578.1
                                                          		 54855 - 56081 (-) permease
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                                                            Biosynthesis information

                                                            Biosynthetic paths

                                                            NRPS-loaded threo-hydroxy-L-glutamate
                                                            Pathway: ktzH+ktzO [1]
                                                            NRPS-loaded erythro-hydroxy-L-glutamate
                                                            Pathway: ktzH+ktzP [1]

                                                            Biosynthetic modules

                                                            Name
                                                            Unk01
                                                            Type
                                                            nrps-type1
                                                            Genes
                                                            ktzB
                                                            Substrates
                                                            isoleucine, valine, leucine, allo-isoleucine (evidence: Structure-based inference, ATP-PPi exchange assay)
                                                            Integrated Monomers
                                                            Domains
                                                            adenylation
                                                            Name
                                                            Unk02
                                                            Type
                                                            nrps-type1
                                                            Genes
                                                            ktzE
                                                            Substrates
                                                            2-(1-methylcyclopropyl)-D-glycine (evidence: Structure-based inference [4])
                                                            Integrated Monomers
                                                            Domains
                                                            adenylation
                                                            Name
                                                            Unk03
                                                            Type
                                                            nrps-type1
                                                            Genes
                                                            ktzG
                                                            Substrates
                                                            2-ketoisovaleric acid, 2-ketobutyric acid (evidence: Structure-based inference, ATP-PPi exchange assay)
                                                            Integrated Monomers
                                                            Domains
                                                            adenylation
                                                            Name
                                                            Unk04
                                                            Type
                                                            nrps-type1
                                                            Genes
                                                            ktzH
                                                            Substrates
                                                            piperazic acid (evidence: Structure-based inference, Knock-out studies)
                                                            Integrated Monomers
                                                            Domains
                                                            adenylation
                                                            Name
                                                            Unk05
                                                            Type
                                                            nrps-type1
                                                            Genes
                                                            ktzH
                                                            Substrates
                                                            serine (evidence: Structure-based inference, Heterologous expression)
                                                            Integrated Monomers
                                                            Domains
                                                            adenylation
                                                            Name
                                                            Unk06
                                                            Type
                                                            nrps-type1
                                                            Genes
                                                            ktzH
                                                            Substrates
                                                            6,7-dichlorotryptophan (evidence: Structure-based inference, Heterologous expression, Homology)
                                                            Integrated Monomers
                                                            Domains
                                                            adenylation
                                                            Name
                                                            Unk07
                                                            Type
                                                            nrps-type1
                                                            Genes
                                                            ktzN
                                                            Substrates
                                                            glutamic acid, aspartic acid (evidence: ATP-PPi exchange assay, Structure-based inference)
                                                            Integrated Monomers
                                                            Domains
                                                            adenylation
                                                            Annotation changelog

                                                            Entry version: next

                                                            Date
                                                            Changes
                                                            Submitters
                                                            Reviewers
                                                            2024-04-23
                                                            MIBiG v4 annotathon
                                                            • (ID: LS4NEH7WEQDTT7KF4SQJKMYG)
                                                            • (ID: NHJ6M55E7ZEHUFNMEG4QIZWY)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                            Entry version: 4

                                                            Date
                                                            Changes
                                                            Submitters
                                                            Reviewers
                                                            2022-10-07
                                                            Update chemical activity to schema version 2.11
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                            Entry version: 3

                                                            Date
                                                            Changes
                                                            Submitters
                                                            Reviewers
                                                            2022-09-15
                                                            Updated bioactivity data
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            2022-09-15
                                                            Added NRP substrate specificities
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                            Entry version: 2

                                                            Date
                                                            Changes
                                                            Submitters
                                                            Reviewers
                                                            2019-10-16
                                                            Migrated from v1.4
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            2019-10-16
                                                            Updated compound(s) information (NPAtlas curation)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                            Entry version: 1

                                                            Date
                                                            Changes
                                                            Submitters
                                                            Reviewers
                                                            2015-06-12
                                                            Submitted
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            Detailed domain annotation
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