BGC0000379: glycinocin A biosynthetic gene cluster from Streptomyces viridochromogenes
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Location: 1 - 88,912 nt. (total: 88,912 nt).
This entry is originally from NCBI GenBank HM756254.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0000379
Short description glycinocin A biosynthetic gene cluster from Streptomyces viridochromogenes
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
HM756254.1
via
Compounds
  • glycinocin A
Species Streptomyces viridochromogenes [taxonomy]
References
Chemical products information
glycinocin A Evidence:
Copy SMILES
C57H90N12O19
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AEG64672.1
 36 - 1925 (-) ABC transporter-like protein
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    • AEG64673.1
    		 2193 - 3959 (-) sodium/hydrogen exchanger
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      • AEG64674.1
      		 3976 - 4926 (-) integral membrane protein
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        • AEG64675.1
        		 5088 - 6905 (+) glycosyl hydrolase
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          • AEG64676.1
          		 6910 - 7854 (+) cyclase
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            • AEG64677.1
            		 7936 - 9516 (+) putative choline dehydrogenase
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              • AEG64678.1
              		 9522 - 10562 (-) cytochrome d ubiquinol oxidase subunit II
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                • AEG64679.1
                		 10562 - 12010 (-) cytochrome bd-I oxidase subunit I
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                  • AEG64680.1
                  		 12039 - 13379 (-) NADH dehydrogenase
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                    • AEG64681.1
                    		 13386 - 14228 (-) 2-deoxy-D-gluconate 3-dehydrogenase
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                      • AEG64682.1
                      		 14403 - 15320 (-) LysR-type transcriptional regulator
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                        • AEG64683.1
                        		 15806 - 16465 (+) HAD superfamily (subfamily IIIB) phosphatase
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                          • AEG64684.1
                          		 16883 - 17719 (+) regulatory protein A
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                            • AEG64685.1
                            		 17743 - 18837 (+) Daunorubicin resistance ABC transporter ATPase subunit
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                              • AEG64686.1
                              • dabA
                              		 18942 - 20018 (+) diaminobutyric acid synthase A
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                                • AEG64687.1
                                • dabB
                                		 20102 - 21520 (+) diaminobutyric acid synthase B
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                                  • AEG64688.1
                                  • dabC
                                  		 21517 - 22791 (+) diaminobutyric acid synthase C
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                                    • AEG64689.1
                                    • lpmA
                                    		 22788 - 25616 (+) LpmA
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                                      • AEF16019.1
                                      		 25748 - 26695 (-) regulatory protein B
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                                        • AEF16020.1
                                        		 26737 - 27579 (-) ABC transporter protein
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                                          • AEF16021.1
                                          		 27878 - 29701 (+) acyl-CoA synthase
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                                            • AEG64690.1
                                            		 29698 - 31437 (+) acyl-CoA dehydrogenase
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                                              • AEF16023.1
                                              		 31434 - 32240 (+) hypothetical protein
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                                                • AEF16024.1
                                                		 32261 - 32542 (+) acyl carrier protein
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                                                  • AEG64696.1
                                                  • lpmB
                                                  		 32712 - 42275 (+) LpmB
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                                                    • AEG64697.1
                                                    • lpmC
                                                    		 42386 - 62701 (+) LpmC
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                                                      • AEG64698.1
                                                      • lpmD
                                                      		 62701 - 69918 (+) LpmD
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                                                        • AEG64691.1
                                                        		 69950 - 70174 (+) MbtH-like protein
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                                                          • AEF16028.1
                                                          		 70265 - 71071 (+) LipE-like protein
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                                                            • AEF16029.1
                                                            		 71176 - 73497 (-) putative drug exporter
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                                                              • AEF16030.1
                                                              		 73752 - 74780 (+) lysine cyclodeaminase
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                                                                • AEF16031.1
                                                                		 74978 - 75622 (-) regulatory protein C
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                                                                  • AEF16032.1
                                                                  		 75613 - 76899 (-) regulatory protein D
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                                                                    • AEF16033.1
                                                                    		 76908 - 77711 (-) hypothetical protein
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                                                                      • AEF16034.1
                                                                      		 77739 - 79493 (-) VanW family protein
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                                                                        • AEF16035.1
                                                                        		 79616 - 80737 (-) integral membrane protein
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                                                                          • AEF16036.1
                                                                          		 81132 - 82637 (-) integral membrane protein
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                                                                            • AEF16037.1
                                                                            		 82645 - 83184 (-) integral membrane protein
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                                                                              • AEF16038.1
                                                                              		 83181 - 84137 (-) hypothetical protein
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                                                                                • AEG64692.1
                                                                                		 84295 - 85956 (+) two component system histidine kinase
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                                                                                  • AEG64693.1
                                                                                  		 85953 - 86636 (+) two component system response regulator
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                                                                                    • AEG64694.1
                                                                                    		 86903 - 87937 (+) hypothetical protein
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                                                                                      • AEG64695.1
                                                                                      		 88235 - 88912 (+) response regulator
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                                                                                        Biosynthesis information

                                                                                        Biosynthetic modules

                                                                                        Name
                                                                                        Unk01
                                                                                        Type
                                                                                        nrps-type1
                                                                                        Genes
                                                                                        lpmA
                                                                                        Substrates
                                                                                        aspartic acid (evidence: Structure-based inference, Sequence-based prediction)
                                                                                        Integrated Monomers
                                                                                        Domains
                                                                                        adenylation
                                                                                        Name
                                                                                        Unk02
                                                                                        Type
                                                                                        nrps-type1
                                                                                        Genes
                                                                                        lpmB
                                                                                        Substrates
                                                                                        2,3-diaminopropionic acid (evidence: Structure-based inference [1])
                                                                                        Integrated Monomers
                                                                                        Domains
                                                                                        adenylation
                                                                                        Name
                                                                                        Unk03
                                                                                        Type
                                                                                        nrps-type1
                                                                                        Genes
                                                                                        lpmB
                                                                                        Substrates
                                                                                        pipecolic acid (evidence: Structure-based inference, Sequence-based prediction)
                                                                                        Integrated Monomers
                                                                                        Domains
                                                                                        adenylation
                                                                                        Name
                                                                                        Unk04
                                                                                        Type
                                                                                        nrps-type1
                                                                                        Genes
                                                                                        lpmC
                                                                                        Substrates
                                                                                        glycine (evidence: Structure-based inference, Sequence-based prediction)
                                                                                        Integrated Monomers
                                                                                        Domains
                                                                                        adenylation
                                                                                        Name
                                                                                        Unk05
                                                                                        Type
                                                                                        nrps-type1
                                                                                        Genes
                                                                                        lpmC
                                                                                        Substrates
                                                                                        aspartic acid (evidence: Structure-based inference, Sequence-based prediction)
                                                                                        Integrated Monomers
                                                                                        Domains
                                                                                        adenylation
                                                                                        Name
                                                                                        Unk06
                                                                                        Type
                                                                                        nrps-type1
                                                                                        Genes
                                                                                        lpmC
                                                                                        Substrates
                                                                                        glycine (evidence: Structure-based inference, Sequence-based prediction)
                                                                                        Integrated Monomers
                                                                                        Domains
                                                                                        adenylation
                                                                                        Name
                                                                                        Unk07
                                                                                        Type
                                                                                        nrps-type1
                                                                                        Genes
                                                                                        lpmC
                                                                                        Substrates
                                                                                        aspartic acid (evidence: Structure-based inference, Sequence-based prediction)
                                                                                        Integrated Monomers
                                                                                        Domains
                                                                                        adenylation
                                                                                        Name
                                                                                        Unk08
                                                                                        Type
                                                                                        nrps-type1
                                                                                        Genes
                                                                                        lpmC
                                                                                        Substrates
                                                                                        glycine (evidence: Structure-based inference, Sequence-based prediction)
                                                                                        Integrated Monomers
                                                                                        Domains
                                                                                        adenylation
                                                                                        Name
                                                                                        Unk09
                                                                                        Type
                                                                                        nrps-type1
                                                                                        Genes
                                                                                        lpmC
                                                                                        Substrates
                                                                                        allo-threonine, threonine (evidence: Structure-based inference, Sequence-based prediction)
                                                                                        Integrated Monomers
                                                                                        Domains
                                                                                        adenylation
                                                                                        Name
                                                                                        Unk10
                                                                                        Type
                                                                                        nrps-type1
                                                                                        Genes
                                                                                        lpmD
                                                                                        Substrates
                                                                                        isoleucine (evidence: Structure-based inference, Sequence-based prediction)
                                                                                        Integrated Monomers
                                                                                        Domains
                                                                                        adenylation
                                                                                        Name
                                                                                        Unk11
                                                                                        Type
                                                                                        nrps-type1
                                                                                        Genes
                                                                                        lpmD
                                                                                        Substrates
                                                                                        proline (evidence: Structure-based inference, Sequence-based prediction)
                                                                                        Integrated Monomers
                                                                                        Domains
                                                                                        adenylation
                                                                                        Annotation changelog

                                                                                        Entry version: 4

                                                                                        Date
                                                                                        Changes
                                                                                        Submitters
                                                                                        Reviewers
                                                                                        2022-10-07
                                                                                        Update chemical activity to schema version 2.11
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                        Entry version: 3

                                                                                        Date
                                                                                        Changes
                                                                                        Submitters
                                                                                        Reviewers
                                                                                        2022-09-15
                                                                                        Updated bioactivity data
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                        2022-09-15
                                                                                        Added NRP substrate specificities
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                        Entry version: 2

                                                                                        Date
                                                                                        Changes
                                                                                        Submitters
                                                                                        Reviewers
                                                                                        2019-10-16
                                                                                        Migrated from v1.4
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                        2019-10-16
                                                                                        Updated compound(s) information (NPAtlas curation)
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                        Entry version: 1

                                                                                        Date
                                                                                        Changes
                                                                                        Submitters
                                                                                        Reviewers
                                                                                        2015-06-12
                                                                                        Submitted
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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