BGC0000380: leupyrrin biosynthetic gene cluster from Sorangium cellulosum
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Location: 1 - 80,175 nt. (total: 80,175 nt).
This entry is originally from NCBI GenBank HM639990.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000380
Short description leupyrrin biosynthetic gene cluster from Sorangium cellulosum
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Other)
Loci NCBI GenBank: HM639990.1
Compounds
  • leupyrrin
Species Sorangium cellulosum [taxonomy]
References
Chemical products information
leupyrrin
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C40H55N2O9
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ADZ24981.1
 469 - 2577 (+) hypothetical protein
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  • ADZ24982.1
 3294 - 4130 (+) phospholipid/glycerol acyl transferase
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  • ADZ24983.1
 4221 - 4742 (+) hypothetical protein
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  • ADZ24984.1
 4739 - 6160 (+) protein kinase-like protein
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  • ADZ24985.1
  • leu1
 6346 - 7125 (+) type II thioesterase
  • Unknown
Sequence-based prediction
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  • ADZ24986.1
  • leu2
 7128 - 9428 (+) formate dehydrogenase
  • Tailoring (Reduction)
Sequence-based prediction
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  • ADZ24987.1
  • leu3
 9476 - 10780 (+) hydroxycinnamoyl-CoA shikimate/quinate hydroxycinnamoyltransferase-like protein
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  • ADZ24988.1
  • leu4
 10927 - 12363 (+) acyltransferase
  • Tailoring (Unknown)
Sequence-based prediction
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  • ADZ24989.1
  • leu5
 12385 - 13953 (-) prolin adenylation protein
  • Precursor biosynthesis
Heterologous expression
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  • ADZ24990.1
  • leu6
 14047 - 15186 (-) prolyl-ACP dehydrogenase
  • Precursor biosynthesis
Heterologous expression
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  • ADZ24991.1
  • leu7
 15471 - 15749 (+) acyl carrier protein
  • Precursor biosynthesis
Heterologous expression
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  • ADZ24992.1
  • leu8
 15927 - 16688 (-) dehydrogenase
  • Tailoring (Oxidation)
Sequence-based prediction
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  • ADZ24993.1
  • leu9
 17478 - 19277 (+) C and PCP domain protein
  • Scaffold biosynthesis
Sequence-based prediction
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  • ADZ24994.1
  • leu10
 19342 - 20541 (+) carboxylase/reductase
  • Precursor biosynthesis
Sequence-based prediction
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  • ADZ24995.1
  • leuA
 20648 - 29653 (+) non-ribosomal peptide synthase/polyketide synthase
  • Scaffold biosynthesis
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  • ADZ24996.1
  • leuB
 29666 - 36448 (+) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ADZ24997.1
  • leuC
 36457 - 42057 (+) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ADZ24998.1
  • leuD
 42069 - 48761 (+) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ADZ24999.1
  • leuE
 48758 - 53011 (+) non-ribosomal peptide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ADZ25000.1
  • leu11
 53008 - 54138 (+) phospholipase
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  • ADZ25001.1
  • leu12
 54135 - 55337 (+) geranyl-geranyl reductase
  • Unknown
Sequence-based prediction
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  • ADZ25002.1
  • leu13
 55402 - 56826 (+) Cytochrome P450 enzyme
  • Tailoring (Oxidation)
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  • ADZ25003.1
  • leu14
 57214 - 58128 (+) O-methyltransferase
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  • ADZ25004.1
  • leu15
 58157 - 59170 (+) Rieske (2Fe-2S) domain-containing protein
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  • ADZ25005.1
  • leu16
 59322 - 60062 (+) TetR family transcriptional regulator
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  • ADZ25006.1
  • leu17
 60188 - 61993 (-) long-chain acyl CoA synthetase
  • Activation / processing
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  • ADZ25007.1
  • leu18
 62201 - 63649 (+) carotenoid oxygenase
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  • ADZ25008.1
  • leu19
 63733 - 64854 (-) HpcH/HpaI aldolase
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  • ADZ25009.1
  • leu20
 65302 - 66198 (+) HpcH/HpaI aldolase
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  • ADZ25010.1
  • leu21
 66306 - 66833 (+) dehydratase
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  • ADZ25011.1
  • leu22
 66918 - 68366 (-) cytochrome P450 hydroxylase
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  • ADZ25012.1
 69262 - 71409 (-) hypothetical protein
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  • ADZ25013.1
 71433 - 72665 (-) hypothetical protein
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  • ADZ25014.1
 72676 - 73602 (-) putative methanol dehydrogenase
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  • ADZ25015.1
 74219 - 75148 (+) hypothetical protein
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Polyketide-specific information
Subclass Other
Cyclic? yes
Release type
  • Hydrolysis
Polyketide-synthases
Genes Properties Modules
leuA
+
leuB
+
leuD 		Synthase subclass: Modular type I
Module 2
Genes: leuA
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 3
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: leuB
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: L-OH
Module 4
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: leuB
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 5
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: leuD
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: L-OH
NRP-specific information
Subclass N/A
Cyclic? no
Release type
  • Hydrolysis
NRP-synthases
Gene Modules
leuA
Module 1
Specificity: cysteine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Heterocyclization
leuE
Module 6
Specificity: proline
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: 7SR74ARK6JXRBGJRGO2LUHE7, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Fixed incorrect gene identifiers and names
  • Remove leading/trailing whitespace in gene identifiers
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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