Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000380.1:
Cluster 1NRP / Polyketide180175

BGC0000380, leupyrrin biosynthetic gene cluster from Sorangium cellulosum. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Leupyrrin
SMILES string: Copy to clipboard
Molecular formula: C41H58N2O10
Exact molecular mass: 739.4164 Da ([M+H]+)
Molecular activity: Antifungal

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Other (linear)
Thioesterase type:
Type I
Release / cyclization type:
Hydrolysis

Nonribosomal peptide synthetases:
leuA (ADZ24995.1)
Module 1
A specificity: Cysteine
Evidence for specificity: Structure-based inference
C domain subtype: Heterocyclization
leuE (ADZ24999.1)
Module 6
A specificity: Proline
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Polyketide subclass:
Other (cyclic)
Polyketide synthase subclass:
Modular type I
Starter unit:
Other
Thioesterase type:
None
Release / cyclization type:
Hydrolysis

Modular polyketide synthases:
leuA (ADZ24995.1)
Module 2
AT specificity: Other
Evidence for specificity: Structure-based inference
KR stereochemistry: B-group

leuB (ADZ24996.1)
Module 3
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: B-group
Scaffold-modifying domain: Methylation

leuB (ADZ24996.1)
Module 4
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: B-group

leuD (ADZ24998.1)
Module 5
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: B-group
Scaffold-modifying domain: Methylation

Gene cluster description

leupyrrin (BGC0000380). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank HM639990, positions 1-80175. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
MIxS-compliance:No
Contact for this cluster:Daniel Krug (HIPS)

Literature references

1. Pistorius D, Muller R. (2012) Discovery of the rhizopodin biosynthetic gene cluster in Stigmatella aurantiaca Sg a15 by genome mining. Chembiochem 13(3):416-26. doi: 10.1002/cbic.201100575. Epub 2012 Jan