BGC0000383: luminmycin A biosynthetic gene cluster from Photorhabdus laumondii subsp. laumondii TTO1
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Location: 2,202,808 - 2,257,564 nt. (total: 54,757 nt).
This entry is originally from NCBI GenBank CP024901.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000383
Short description luminmycin A biosynthetic gene cluster from Photorhabdus laumondii subsp. laumondii TTO1
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Other)
Loci NCBI GenBank: CP024901.1
Compounds
  • luminmycin A
  • glidobactin A
  • cepafungin
Species Photorhabdus laumondii subsp. laumondii TTO1 [taxonomy]
References
Chemical products information
luminmycin A
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C27H44N4O5
Chemical database entries
NPAtlas
glidobactin A
(no structure information available)
cepafungin
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • PluTT01m_09560
  • AXG46991.1
 2202808 - 2204442 (+) methyl-accepting chemotaxis protein
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  • PluTT01m_09565
  • AXG46992.1
 2204449 - 2205336 (+) protein-glutamate O-methyltransferase CheR
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  • PluTT01m_09570
  • AXG46993.1
 2205329 - 2206381 (+) chemotaxis response regulator protein-glutamate methylesterase
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  • PluTT01m_09575
  • AXG46994.1
 2206701 - 2207090 (+) chemotaxis protein CheY
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  • PluTT01m_09580
  • AXG46995.1
 2207100 - 2207750 (+) protein phosphatase CheZ
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  • PluTT01m_09585
  • AXG46996.1
 2207830 - 2208258 (-) IS200/IS605 family transposase
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  • PluTT01m_09590
 2208304 - 2209231 (-) IS110 family transposase
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  • PluTT01m_09595
  • AXG46997.1
  • aepX
 2210257 - 2210997 (+) phosphoenolpyruvate mutase
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  • PluTT01m_09600
  • AXG46998.1
 2211179 - 2212510 (+) LLM class flavin-dependent oxidoreductase
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  • PluTT01m_09605
 2212547 - 2213683 (+) hypothetical protein
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  • PluTT01m_09610
  • AXG49818.1
 2213683 - 2214921 (+) 3-isopropylmalate dehydratase large subunit
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  • PluTT01m_09615
  • AXG46999.1
 2214914 - 2215471 (+) hypothetical protein
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  • PluTT01m_09620
  • AXG47000.1
 2215468 - 2216253 (+) class I SAM-dependent methyltransferase
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  • PluTT01m_09625
  • AXG47001.1
 2216253 - 2216714 (+) N-acetyltransferase
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  • PluTT01m_09630
  • AXG47002.1
 2216711 - 2217874 (+) ATP-grasp domain-containing protein
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  • PluTT01m_09635
  • AXG47003.1
 2217877 - 2219010 (+) ATP-grasp domain-containing protein
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  • PluTT01m_09640
  • AXG47004.1
 2219007 - 2220245 (+) MFS transporter
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  • PluTT01m_09645
  • AXG47005.1
 2220310 - 2221230 (+) hypothetical protein
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  • PluTT01m_09650
  • AXG47006.1
 2221618 - 2221980 (-) nuclear transport factor 2 family protein
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  • PluTT01m_09655
  • AXG47007.1
 2222029 - 2225226 (-) non-ribosomal peptide synthetase
  • Scaffold biosynthesis
Heterologous expression
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  • PluTT01m_09660
  • AXG47008.1
 2225255 - 2226520 (-) MFS transporter
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  • PluTT01m_09665
  • AXG49819.1
 2226517 - 2238951 (-) hybrid non-ribosomal peptide synthetase/type I polyketide synthase
  • Scaffold biosynthesis
Heterologous expression
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  • PluTT01m_09670
  • AXG47009.1
 2239135 - 2239953 (-) hypothetical protein
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  • PluTT01m_09675
 2240711 - 2240818 (+) IS982 family transposase
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  • PluTT01m_09680
  • AXG47010.1
 2240986 - 2242392 (-) porin
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  • PluTT01m_09685
  • AXG47011.1
 2244047 - 2246059 (+) branched-chain alpha-keto acid dehydrogenase
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  • PluTT01m_09690
  • AXG47012.1
 2246069 - 2247634 (+) branched-chain alpha-keto acid dehydrogenase subunit E2
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  • PluTT01m_09695
  • AXG47013.1
 2247627 - 2249477 (+) polyketide synthase
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  • PluTT01m_09700
  • AXG47014.1
 2250126 - 2250548 (+) cupin domain-containing protein
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  • PluTT01m_09705
 2251005 - 2251159 (-) IS982 family transposase
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  • PluTT01m_09710
  • AXG47015.1
 2251383 - 2251634 (+) DUF2442 domain-containing protein
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  • PluTT01m_09715
 2251720 - 2251902 (-) pyocin immunity protein
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  • PluTT01m_09720
  • AXG47016.1
 2252259 - 2252444 (-) hypothetical protein
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  • PluTT01m_09725
  • AXG47017.1
 2252542 - 2253009 (-) pyocin immunity protein
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  • PluTT01m_09730
  • AXG47018.1
 2253113 - 2253583 (-) pyocin immunity protein
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  • PluTT01m_09735
 2253580 - 2254077 (-) killer protein of pyocin s3
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  • PluTT01m_09740
  • AXG47019.1
 2254165 - 2254422 (-) bacteriocin immunity protein
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  • PluTT01m_09745
 2254785 - 2256107 (-) killer protein of pyocin s3
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  • PluTT01m_09750
  • AXG47020.1
 2256413 - 2257564 (+) flagellar type III secretion system protein FlhB
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Polyketide-specific information
Subclass Other
Cyclic? no
Release type
  • Macrolactamization
Polyketide-synthases
Genes Properties Modules
PluTT01m_09665 Synthase subclass: Modular type I
Thioesterases:
  • PluTT01m_09665 (Type I)
Module 4
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: PluTT01m_09665
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
NRP-specific information
Subclass N/A
Cyclic? no
Release type
  • Macrolactamization
NRP-synthases
Gene Modules
PluTT01m_09655
Module 1
Specificity: threonine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Starter
PluTT01m_09665
Module 2
Specificity: lysine / 4S-hydroxylysine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 3
Specificity: alanine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: 7SR74ARK6JXRBGJRGO2LUHE7, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Corrected gene identifiers
  • Corrected NRP gene names
  • Updated bioactivity data
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
  • Merge info from duplicate cluster BGC0002714
Detailed domain annotation
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