BGC0000383: luminmycin A biosynthetic gene cluster from Photorhabdus laumondii subsp. laumondii TTO1
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Location: 2,202,808 - 2,257,564 nt. (total: 54,757 nt).
This entry is originally from NCBI GenBank CP024901.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000383
Short description luminmycin A biosynthetic gene cluster from Photorhabdus laumondii subsp. laumondii TTO1
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Type I)
Loci
CP024901.1
2202808 - 2257564
via Heterologous expression
Compounds
  • luminmycin A
  • glidobactin A
  • cepafungin
Species Photorhabdus laumondii subsp. laumondii TTO1 [taxonomy]
References
Chemical products information
luminmycin A Evidence:
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C27H44N4O5
Chemical database entries
NPAtlas
glidobactin A Evidence:
(no structure information available)
cepafungin Evidence:
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • PluTT01m_09560
  • AXG46991.1
 2202808 - 2204442 (+) methyl-accepting chemotaxis protein
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    • PluTT01m_09565
    • AXG46992.1
    		 2204449 - 2205336 (+) protein-glutamate O-methyltransferase CheR
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      • PluTT01m_09570
      • AXG46993.1
      		 2205329 - 2206381 (+) chemotaxis response regulator protein-glutamate methylesterase
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        • PluTT01m_09575
        • AXG46994.1
        		 2206701 - 2207090 (+) chemotaxis protein CheY
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          • PluTT01m_09580
          • AXG46995.1
          		 2207100 - 2207750 (+) protein phosphatase CheZ
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            • PluTT01m_09585
            • AXG46996.1
            		 2207830 - 2208258 (-) IS200/IS605 family transposase
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              • PluTT01m_09590
              		 2208304 - 2209231 (-) IS110 family transposase
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                • PluTT01m_09595
                • AXG46997.1
                • aepX
                		 2210257 - 2210997 (+) phosphoenolpyruvate mutase
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                  • PluTT01m_09600
                  • AXG46998.1
                  		 2211179 - 2212510 (+) LLM class flavin-dependent oxidoreductase
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                    • PluTT01m_09605
                    		 2212547 - 2213683 (+) hypothetical protein
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                      • PluTT01m_09610
                      • AXG49818.1
                      		 2213683 - 2214921 (+) 3-isopropylmalate dehydratase large subunit
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                        • PluTT01m_09615
                        • AXG46999.1
                        		 2214914 - 2215471 (+) hypothetical protein
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                          • PluTT01m_09620
                          • AXG47000.1
                          		 2215468 - 2216253 (+) class I SAM-dependent methyltransferase
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                            • PluTT01m_09625
                            • AXG47001.1
                            		 2216253 - 2216714 (+) N-acetyltransferase
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                              • PluTT01m_09630
                              • AXG47002.1
                              		 2216711 - 2217874 (+) ATP-grasp domain-containing protein
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                                • PluTT01m_09635
                                • AXG47003.1
                                		 2217877 - 2219010 (+) ATP-grasp domain-containing protein
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                                  • PluTT01m_09640
                                  • AXG47004.1
                                  		 2219007 - 2220245 (+) MFS transporter
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                                    • PluTT01m_09645
                                    • AXG47005.1
                                    		 2220310 - 2221230 (+) hypothetical protein
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                                      • PluTT01m_09650
                                      • AXG47006.1
                                      		 2221618 - 2221980 (-) nuclear transport factor 2 family protein
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                                        • PluTT01m_09655
                                        • AXG47007.1
                                        		 2222029 - 2225226 (-) non-ribosomal peptide synthetase
                                        • Scaffold biosynthesis
                                        • Heterologous expression
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                                        • PluTT01m_09660
                                        • AXG47008.1
                                        		 2225255 - 2226520 (-) MFS transporter
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                                          • PluTT01m_09665
                                          • AXG49819.1
                                          		 2226517 - 2238951 (-) hybrid non-ribosomal peptide synthetase/type I polyketide synthase
                                          • Scaffold biosynthesis
                                          • Heterologous expression
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                                          • PluTT01m_09670
                                          • AXG47009.1
                                          		 2239135 - 2239953 (-) hypothetical protein
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                                            • PluTT01m_09675
                                            		 2240711 - 2240818 (+) IS982 family transposase
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                                              • PluTT01m_09680
                                              • AXG47010.1
                                              		 2240986 - 2242392 (-) porin
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                                                • PluTT01m_09685
                                                • AXG47011.1
                                                		 2244047 - 2246059 (+) branched-chain alpha-keto acid dehydrogenase
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                                                  • PluTT01m_09690
                                                  • AXG47012.1
                                                  		 2246069 - 2247634 (+) branched-chain alpha-keto acid dehydrogenase subunit E2
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                                                    • PluTT01m_09695
                                                    • AXG47013.1
                                                    		 2247627 - 2249477 (+) polyketide synthase
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                                                      • PluTT01m_09700
                                                      • AXG47014.1
                                                      		 2250126 - 2250548 (+) cupin domain-containing protein
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                                                        • PluTT01m_09705
                                                        		 2251005 - 2251159 (-) IS982 family transposase
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                                                          • PluTT01m_09710
                                                          • AXG47015.1
                                                          		 2251383 - 2251634 (+) DUF2442 domain-containing protein
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                                                            • PluTT01m_09715
                                                            		 2251720 - 2251902 (-) pyocin immunity protein
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                                                              • PluTT01m_09720
                                                              • AXG47016.1
                                                              		 2252259 - 2252444 (-) hypothetical protein
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                                                                • PluTT01m_09725
                                                                • AXG47017.1
                                                                		 2252542 - 2253009 (-) pyocin immunity protein
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                                                                  • PluTT01m_09730
                                                                  • AXG47018.1
                                                                  		 2253113 - 2253583 (-) pyocin immunity protein
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                                                                    • PluTT01m_09735
                                                                    		 2253580 - 2254077 (-) killer protein of pyocin s3
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                                                                      • PluTT01m_09740
                                                                      • AXG47019.1
                                                                      		 2254165 - 2254422 (-) bacteriocin immunity protein
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                                                                        • PluTT01m_09745
                                                                        		 2254785 - 2256107 (-) killer protein of pyocin s3
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                                                                          • PluTT01m_09750
                                                                          • AXG47020.1
                                                                          		 2256413 - 2257564 (+) flagellar type III secretion system protein FlhB
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                                                                            Biosynthesis information

                                                                            Biosynthetic modules

                                                                            Name
                                                                            1
                                                                            Type
                                                                            nrps-type1
                                                                            Genes
                                                                            PluTT01m_09655
                                                                            Substrates
                                                                            threonine (evidence: Structure-based inference [2])
                                                                            Integrated Monomers
                                                                            Domains
                                                                            condensation (Starter), adenylation
                                                                            Name
                                                                            2
                                                                            Type
                                                                            nrps-type1
                                                                            Genes
                                                                            PluTT01m_09665
                                                                            Substrates
                                                                            lysine, 4S-hydroxylysine (evidence: Structure-based inference [2])
                                                                            Integrated Monomers
                                                                            Domains
                                                                            condensation (LCL), adenylation
                                                                            Name
                                                                            3
                                                                            Type
                                                                            nrps-type1
                                                                            Genes
                                                                            PluTT01m_09665
                                                                            Substrates
                                                                            alanine (evidence: Structure-based inference [2])
                                                                            Integrated Monomers
                                                                            Domains
                                                                            condensation (LCL), adenylation
                                                                            Name
                                                                            4
                                                                            Type
                                                                            pks-modular
                                                                            Genes
                                                                            PluTT01m_09665
                                                                            Substrates
                                                                            Integrated Monomers
                                                                            Domains
                                                                            acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                                                                            Annotation changelog

                                                                            Entry version: 4

                                                                            Date
                                                                            Changes
                                                                            Submitters
                                                                            Reviewers
                                                                            2022-10-07
                                                                            Update chemical activity to schema version 2.11
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                            2022-10-07
                                                                            Merge info from duplicate cluster BGC0002714
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                            Entry version: 3

                                                                            Date
                                                                            Changes
                                                                            Submitters
                                                                            Reviewers
                                                                            2022-09-15
                                                                            Corrected NRP module activity
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                            2022-09-15
                                                                            Corrected gene identifiers
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                            2022-09-15
                                                                            Corrected NRP gene names
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                            2022-09-15
                                                                            Updated bioactivity data
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                            2022-09-15
                                                                            Updated NRP substrate specificities
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                            Entry version: 2

                                                                            Date
                                                                            Changes
                                                                            Submitters
                                                                            Reviewers
                                                                            2019-10-16
                                                                            Migrated from v1.4
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                            2019-10-16
                                                                            Updated compound(s) information (NPAtlas curation)
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                            Entry version: 1

                                                                            Date
                                                                            Changes
                                                                            Submitters
                                                                            Reviewers
                                                                            2015-06-12
                                                                            Submitted
                                                                            • (ID: 7SR74ARK6JXRBGJRGO2LUHE7)
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                            Detailed domain annotation
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