Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000383.1:
Cluster 1NRP / Polyketide118349

BGC0000383, luminmycin biosynthetic gene cluster from Photorhabdus luminescens. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Luminmycin
SMILES string: Copy to clipboard
Molecular formula: C27H44O5N4
Exact molecular mass: 505.3385 Da ([M+H]+)
Molecular activity: Cytotoxic
Molecular target: proteasome

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Other (linear)
Thioesterase type:
None
Release / cyclization type:
Macrolactamization

Nonribosomal peptide synthetases:
plu1878
Module 1
A specificity: Threonine
Evidence for specificity: Structure-based inference
C domain subtype: Starter
plu1880
Module 2
A specificity: Lysine
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Module 3
A specificity: Alanine
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Polyketide subclass:
Other (linear)
Polyketide synthase subclass:
Modular type I
Starter unit:
Unknown
Thioesterase type:
Type I
Release / cyclization type:
Macrolactamization

Modular polyketide synthases:
plu1880
Module 4
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: A-group

Gene cluster description

luminmycin (BGC0000383). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank BX470251, positions 2221617-2239965. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Heterologous expression
MIxS-compliance:No
Comments:origin of polyketide tail currently unknown
Contact for this cluster:Daniel Krug (HIPS)

Literature references

1. Bian X et al. (2012) Luminmycins A-C, cryptic natural products from Photorhabdus luminescens identified by heterologous expression in Escherichia coli. J Nat Prod 75(9):1652-5. doi: 10.1021/np300444e. Epub 2012 Aug 21.