BGC0000384 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000384 (Lyngbya majuscula)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	indole,NRPS	1	11,260	lyngbyatoxin	NRPS:Type I	100%

BGC0000384 - Region 1 - NRPS,indole

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Location: 1 - 11,260 nt. (total: 11,260 nt) Show pHMM detection rules used

Region on contig edge.

indole: (indsynth or dmat or indole_PTase)
NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 11,261
Label		BGC0000384

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000384	2.00	NRP	lyngbyatoxin	Lyngbya majuscula
BGC0000391	0.51	NRP	methylpendolmycin, pendolmycin	Marinactinospora thermotolerans
BGC0002324	0.47	NRP, Polyketide	myxochelin B, myxochelin N, myxochelin O, myxochelin P, myxochelin Q, myxochelin A	Archangium violaceum
BGC0001758	0.46	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0000444	0.45	NRP	thaxtomin A	Streptomyces turgidiscabies Car8
BGC0001128	0.45	NRP	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135	0.45	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001844	0.45	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001132	0.45	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002492	0.45	NRP	myxochelin B, myxochelin A	Myxococcus xanthus DK 1622

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000384	1.00	NRP	lyngbyatoxin	Lyngbya majuscula
BGC0000391	0.59	NRP	methylpendolmycin, pendolmycin	Marinactinospora thermotolerans
BGC0002324	0.57	NRP, Polyketide	myxochelin B, myxochelin N, myxochelin O, myxochelin P, myxochelin Q, myxochelin A	Archangium violaceum
BGC0001758	0.56	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0000444	0.56	NRP	thaxtomin A	Streptomyces turgidiscabies Car8
BGC0001128	0.56	NRP	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135	0.55	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001844	0.55	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001132	0.55	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002492	0.55	NRP	myxochelin B, myxochelin A	Myxococcus xanthus DK 1622

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 11260:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (NMe-Val - Trp)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

AAT12283.1

Search NORINE for peptide: strict or relaxed

AMP-binding (22..416): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DIYFWGGTYK
Nearest Stachelhaus code(s):: Val DIYFWGGTYK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1491..1896): Trp

nrpys: Trp

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Unpolar aromatic ring (Phe, Trp)
Single AA prediction:: phe (Phe)

Stachelhaus prediction details:

Stachelhaus sequence:: DGWVISGVCK
Nearest Stachelhaus code(s):: Trp DGWVISGVCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)