BGC0000384: lyngbyatoxin biosynthetic gene cluster from Lyngbya majuscula
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 2,740 - 13,999 nt. (total: 11,260 nt).
This entry is originally from NCBI GenBank AY588942.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000384
Short description lyngbyatoxin biosynthetic gene cluster from Lyngbya majuscula
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "Only one condensation domain is present within AAT12283"
Biosynthetic class(es)
  • NRPS (Type I)
Loci
AY588942.1
2740 - 13999
via Enzymatic assays, Heterologous expression
Compounds
  • lyngbyatoxin
Species Lyngbya majuscula [taxonomy]
References
Chemical products information
lyngbyatoxin Evidence:
Copy SMILES
C27H39N3O2
Chemical database entries
PubCHEM
ChEBI
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAT12283.1
 2740 - 10182 (+) LtxA
    copy AA seq
    copy Nt seq
    • AAT12284.1
    		 10185 - 11567 (+) LtxB
      copy AA seq
      copy Nt seq
      • AAT12285.1
      		 11730 - 12902 (+) LtxC
        copy AA seq
        copy Nt seq
        • AAT12286.1
        		 13259 - 13999 (+) LtxD
          copy AA seq
          copy Nt seq
          Biosynthesis information

          Biosynthetic modules

          Name
          2
          Type
          nrps-type1
          Genes
          AAT12283.1
          Substrates
          tryptophan (evidence: Structure-based inference, Homology)
          Integrated Monomers
          Domains
          condensation (LCL), adenylation
          Name
          1
          Type
          nrps-type1
          Genes
          AAT12283.1
          Substrates
          valine (evidence: Structure-based inference)
          Integrated Monomers
          Domains
          condensation, adenylation, methyltransferase
          Annotation changelog

          Entry version: next

          Date
          Changes
          Submitters
          Reviewers
          2023-10-06
          Removed incorrect literature reference PMID:13880125. Specified locus coordinates.
          • (ID: C62OJVVH7XOTOTFZSJT727YU)
          • (ID: 25OPJFS6AQU3ROUADEVDYF5E)

          Entry version: 4

          Date
          Changes
          Submitters
          Reviewers
          2022-10-07
          Update chemical activity to schema version 2.11
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

          Entry version: 3

          Date
          Changes
          Submitters
          Reviewers
          2022-09-15
          Corrected gene identifiers
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          2022-09-15
          Updated NRP substrate specificities
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

          Entry version: 2

          Date
          Changes
          Submitters
          Reviewers
          2019-10-16
          Migrated from v1.4
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

          Entry version: 1

          Date
          Changes
          Submitters
          Reviewers
          2015-06-12
          Submitted
          • (ID: YKUWK3FUALS4CFYG5HJIMS53)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          Detailed domain annotation
          Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
          A domain glossary is available here, and an explanation of the visualisation is available here.
          Selected features only
          Show module domains
          Similar known gene clusters from MIBiG 4.0
          Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
          Click on reference genes to show details of similarities to genes within the current region.
          Click on an accession to open that entry in the MiBIG database.