BGC0000385: lysobactin biosynthetic gene cluster from Lysobacter sp. ATCC 53042
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Location: 79,934 - 129,211 nt. (total: 49,278 nt).
This entry is originally from NCBI GenBank JF412274.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000385
Short description lysobactin biosynthetic gene cluster from Lysobacter sp. ATCC 53042
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
JF412274.1
79934 - 129211
via
Compounds
  • lysobactin
Species Lysobacter sp. ATCC 53042 [taxonomy]
References
Chemical products information
lysobactin Evidence:
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C58H97N15O17
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AEH59096.1
 79934 - 80239 (-) hypothetical protein
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    • AEH59097.1
    		 80299 - 80391 (-) RNA-directed RNA polymerase
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      • AEH59098.1
      		 80447 - 80638 (-) unknown
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        • AEH59099.1
        		 80817 - 92306 (+) amino acid adenylation domain-containing protein/NRPS
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          • AEH59100.1
          		 92306 - 117916 (+) amino acid adenylation domain-containing protein/NRPS
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            • AEH59101.1
            		 117913 - 119505 (+) lactamase B
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              • AEH59102.1
              		 119502 - 121310 (+) ABC transporter/permease/ATP-binding protein
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                • AEH59103.1
                		 121303 - 124524 (+) RND superfamily protein/acriflavin resistance protein
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                  • AEH59104.1
                  		 124702 - 125979 (+) membrane fusion protein precursor
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                    • AEH59105.1
                    		 125987 - 129211 (+) RND superfamily protein/acriflavin resistance protein
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                      Biosynthesis information

                      Biosynthetic modules

                      Name
                      Unk01
                      Type
                      nrps-type1
                      Genes
                      AEH59099.1
                      Substrates
                      leucine, D-leucine, isoleucine, valine, serine, lysine, phenylalanine, alanine (evidence: ATP-PPi exchange assay, Structure-based inference, Sequence-based prediction)
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk02
                      Type
                      nrps-type1
                      Genes
                      AEH59099.1
                      Substrates
                      leucine (evidence: Structure-based inference, Sequence-based prediction)
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk03
                      Type
                      nrps-type1
                      Genes
                      AEH59099.1
                      Substrates
                      phenylalanine, beta-hydroxyphenylalanine (evidence: Structure-based inference, Sequence-based prediction)
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk04
                      Type
                      nrps-type1
                      Genes
                      AEH59099.1
                      Substrates
                      leucine, 3R-hydroxyleucine (evidence: Structure-based inference, Sequence-based prediction)
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk05
                      Type
                      nrps-type1
                      Genes
                      AEH59100.1
                      Substrates
                      leucine (evidence: Structure-based inference, Sequence-based prediction)
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk06
                      Type
                      nrps-type1
                      Genes
                      AEH59100.1
                      Substrates
                      arginine, D-arginine (evidence: ATP-PPi exchange assay, Structure-based inference, Sequence-based prediction)
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk07
                      Type
                      nrps-type1
                      Genes
                      AEH59100.1
                      Substrates
                      isoleucine (evidence: Structure-based inference, Sequence-based prediction)
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk08
                      Type
                      nrps-type1
                      Genes
                      AEH59100.1
                      Substrates
                      threonine, allo-threonine (evidence: Structure-based inference, Sequence-based prediction)
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk09
                      Type
                      nrps-type1
                      Genes
                      AEH59100.1
                      Substrates
                      glycine (evidence: ATP-PPi exchange assay, Structure-based inference, Sequence-based prediction)
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk10
                      Type
                      nrps-type1
                      Genes
                      AEH59100.1
                      Substrates
                      asparagine, 3S-hydroxyasparagine (evidence: Structure-based inference, Sequence-based prediction)
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk11
                      Type
                      nrps-type1
                      Genes
                      AEH59100.1
                      Substrates
                      serine (evidence: Structure-based inference, Sequence-based prediction)
                      Integrated Monomers
                      Domains
                      adenylation
                      Annotation changelog

                      Entry version: 4

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2022-10-07
                      Update chemical activity to schema version 2.11
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 3

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2022-09-15
                      Set start/end coordinates according to publication
                      • (ID: 3UOU7PODQJXIM6BEPUHHRRA5)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2022-09-15
                      Updated bioactivity data
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2022-09-15
                      Added NRP substrate specificities
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 2

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2019-10-16
                      Migrated from v1.4
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2019-10-16
                      Updated compound(s) information (NPAtlas curation)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 1

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2015-06-12
                      Submitted
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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