Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000386.1:
Cluster 1NRP130501

BGC0000386, malleobactin biosynthetic gene cluster from Burkholderia thailandensis. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Malleobactin A
SMILES string: Copy to clipboard
Molecular formula: C23H40N8O13
Exact molecular mass: 635.265 Da ([M-H]-)
Molecular activity: Siderophore

Class-specific details

Biosynthetic class(es):
NRP
NRP siderophore (linear)
Thioesterase type:
None
Release / cyclization type:
Other

Nonribosomal peptide synthetases:
ABC36450
Module 1
A specificity: N5-Hydroxyornithine
Evidence for specificity: Unknown
Amino acid biosynthesis subcluster:
C domain subtype: LCL
Module 2
A specificity: Aspartate
Evidence for specificity: Sequence-based prediction
AA is epimerized
C domain subtype: LCL
Scaffold-modifying domain: beta-hydroxylation
Module 3
A specificity: Serine
Evidence for specificity: Unknown
C domain subtype: LCL
ABC37099
Module 3
A specificity: None
Evidence for specificity: Unknown
C domain subtype: LCL
Module 4
A specificity: N5-hydroxy-N5-formylornitine
Evidence for specificity: Unknown
Amino acid biosynthesis subcluster:
C domain subtype: LCL

Gene cluster description

malleobactin (BGC0000386). Gene Cluster 1. Biosynthetic class = NRP. GenBank CP000085, positions 2748130-2778630. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Keishi Ishida (Leipniz Institute for Natural Product Research and Infection Biology)

Literature references

1. Franke J et al. (2013) Nitro versus hydroxamate in siderophores of pathogenic bacteria: effect of missing hydroxylamine protection in malleobactin biosynthesis. Angew Chem Int Ed Engl 52(32):8271-5. doi: 10.1002/anie.201303196.
2. Franke J et al. (2014) Evolution of siderophore pathways in human pathogenic bacteria. J Am Chem Soc 136(15):5599-602. doi: 10.1021/ja501597w. Epub 2014
3. Alice AF et al. (2006) Genetic and transcriptional analysis of the siderophore malleobactin biosynthesis and transport genes in the human pathogen Burkholderia pseudomallei K96243. J Bacteriol 188(4):1551-66. doi: 10.1128/JB.188.4.1551-1566.2006.