BGC0000386: malleobactin A biosynthetic gene cluster from Burkholderia thailandensis E264
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Location: 2,748,130 - 2,778,630 nt. (total: 30,501 nt).
This entry is originally from NCBI GenBank CP000085.1.

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core biosynthetic genes
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Gene details
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General
Compounds
Genes
NRP
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0000386
Short description malleobactin A biosynthetic gene cluster from Burkholderia thailandensis E264
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP (NRP siderophore)
Loci NCBI GenBank: CP000085.1
Compounds
  • malleobactin A
  • malleobactin B
  • malleobactin C
  • malleobactin D
Species Burkholderia thailandensis E264 [taxonomy]
References
Chemical products information
malleobactin A
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C23H40N8O13
Chemical database entries
NPAtlas
malleobactin B
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C23H42N8O12
Chemical database entries
NPAtlas
malleobactin C
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C23H40N8O12
Chemical database entries
NPAtlas
malleobactin D
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C46H80N16O23
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BTH_II2238
  • ABC36087.1
2748379 - 2749479 (-) OpgC protein, putative
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  • BTH_II2239
  • ABC34383.1
  • rarD
2749947 - 2750840 (-) rarD protein
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  • BTH_II2240
  • ABC35014.1
2750837 - 2751304 (-) acylphosphatase
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  • BTH_II2241
  • ABC35136.1
2751285 - 2752301 (+) dihydroflavonol-4-reductase family protein
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  • BTH_II2242
  • ABC34098.1
2754016 - 2755209 (-) glycosyl transferase, group 2 family protein
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  • BTH_II2243
  • ABC35745.1
  • ispH-2
2755594 - 2756535 (+) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase
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  • BTH_II2244
  • ABC35620.1
2756593 - 2757708 (+) radical SAM domain protein
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  • BTH_II2245
  • ABC36259.1
2758257 - 2758610 (+) conserved hypothetical protein
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  • BTH_II2246
  • ABC34072.1
2758820 - 2759431 (+) ISBm1, transposase orfB, degenerate
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  • BTH_II2247
  • ABC34555.1
2759946 - 2760869 (+) transcriptional regulator, LysR family
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  • BTH_II2248
  • ABC35404.1
2761165 - 2761884 (+) conserved hypothetical protein
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  • BTH_II2249
  • ABC35928.1
2761844 - 2763517 (+) glutamate-1-semialdehyde aminotransferase
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  • BTH_II2250
  • ABC34969.1
2763827 - 2764273 (+) conserved hypothetical protein
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  • BTH_II2251
  • ABC34913.1
2764443 - 2764649 (-) Uncharacterized small protein
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  • BTH_II2252
  • ABC35419.1
  • cstA
2764662 - 2766740 (-) carbon starvation protein A
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  • BTH_II2253
  • ABC34458.1
2766999 - 2767511 (-) cytochrome p460
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  • BTH_II2254
  • ABC36182.1
2767529 - 2768572 (-) epoxide hydrolase
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  • BTH_II2255
  • ABC35703.1
2768751 - 2770328 (-) MlrC C-terminus family
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  • BTH_II2256
  • ABC34078.1
2770419 - 2771420 (+) transcriptional regulator, LysR family, putative
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  • BTH_II2257
  • ABC36150.1
2771396 - 2771590 (-) glyoxalase family protein superfamily
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  • BTH_II2258
  • ABC36107.1
2771722 - 2772108 (-) GtrA-like protein family
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  • BTH_II2259
  • ABC34479.1
2772105 - 2772851 (-) Generic methyltransferase
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  • BTH_II2260
  • ABC35888.1
2772879 - 2773940 (-) Bactoprenol glucosyl transferase
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  • BTH_II2261
  • ABC34186.1
2773925 - 2775349 (-) membrane protein, putative
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  • BTH_II2262
  • ABC34632.1
2775346 - 2776590 (-) membrane protein, putative
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  • BTH_II2263
  • ABC35056.1
2777694 - 2777864 (+) PilA-related protein
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  • BTH_II2264
  • ABC35863.1
2777972 - 2778190 (+) Flp/Fap pilin component superfamily
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NRP-specific information
Subclass NRP siderophore
Cyclic? no
NRP-synthases
Gene Modules
ABC36450
Module 1
Specificity: N5-Hydroxyornithine
Evidence for specificity:
Condensation domain type: LCL
Module 2
Specificity: Aspartate
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
Modification domains: beta-hydroxylation
Module 3
Specificity: Serine
Evidence for specificity:
Condensation domain type: LCL
ABC37099
Module 3
Condensation domain type: LCL
Module 4
Specificity: N5-hydroxy-N5-formylornitine
Evidence for specificity:
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: F65XGYSSLMUEJC2Q4T3BLCPS, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
Similar known gene clusters
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Detailed domain annotation
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