BGC0000386: malleobactin A biosynthetic gene cluster from Burkholderia thailandensis E264
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Location: 2,748,130 - 2,778,630 nt. (total: 30,501 nt).
This entry is originally from NCBI GenBank CP000086.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000386
Short description malleobactin A biosynthetic gene cluster from Burkholderia thailandensis E264
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
CP000086.1
2748130 - 2778630
via Knock-out studies
Compounds
  • malleobactin A
  • malleobactin B
  • malleobactin C
  • malleobactin D
Species Burkholderia thailandensis E264 [taxonomy]
References
Chemical products information
malleobactin A Evidence:
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C23H40N8O13
Chemical database entries
NPAtlas
malleobactin B Evidence:
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C23H42N8O12
Chemical database entries
NPAtlas
malleobactin C Evidence:
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C23H40N8O12
Chemical database entries
NPAtlas
malleobactin D Evidence:
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C46H80N16O23
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BTH_I2414
  • ABC39200.1
 2748130 - 2748873 (-) conserved hypothetical protein
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    • BTH_I2415
    • ABC36518.1
    		 2749034 - 2751250 (-) TonB-dependent siderophore receptor
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      • BTH_I2416
      • ABC39452.1
      		 2751297 - 2752811 (-) l-ornithine 5-monooxygenase
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        • BTH_I2417
        • ABC37099.1
        		 2752877 - 2758195 (-) non-ribosomal peptide synthetase, putative
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          • BTH_I2418
          • ABC36450.1
          		 2758217 - 2768107 (-) peptide synthetase-like protein
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            • BTH_I2419
            • ABC39037.1
            		 2768600 - 2770288 (+) cyclic peptide ABC transporter, ATP-binding protein
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              • BTH_I2420
              • ABC37936.1
              		 2770766 - 2771341 (+) conserved hypothetical protein
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                • BTH_I2421
                • ABC36332.1
                		 2771511 - 2772770 (-) iron compound ABC transporter, periplasmic iron-compound-binding protein
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                  • BTH_I2422
                  • ABC37230.1
                  		 2772701 - 2773495 (-) ferric iron reductase protein FhuF
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                    • BTH_I2423
                    • ABC38164.1
                    		 2773492 - 2775471 (-) iron compound ABC transporter, permease protein
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                      • BTH_I2424
                      • ABC39054.1
                      • fxuB
                      		 2775609 - 2776517 (-) iron compound ABC transporter, ATP-binding protein
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                        • BTH_I2425
                        • ABC37410.1
                        		 2776541 - 2777632 (-) syringomycin biosynthesis enzyme, putative
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                          • BTH_I2426
                          • ABC37505.1
                          		 2777613 - 2777861 (-) mbtH-like protein
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                            • BTH_I2427
                            • ABC38442.1
                            		 2777917 - 2778630 (-) RNA polymerase sigma-70 factor, ECF subfamily
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                              Biosynthesis information

                              Biosynthetic modules

                              Name
                              1
                              Type
                              nrps-type1
                              Genes
                              BTH_I2418
                              Substrates
                              N5-hydroxyornithine (evidence: )
                              Integrated Monomers
                              Domains
                              condensation (LCL), adenylation
                              Name
                              2
                              Type
                              nrps-type1
                              Genes
                              BTH_I2418
                              Substrates
                              aspartic acid (evidence: Sequence-based prediction)
                              Integrated Monomers
                              Domains
                              condensation (LCL), adenylation, epimerase, hydroxylase
                              Name
                              3
                              Type
                              nrps-type1
                              Genes
                              BTH_I2418 BTH_I2417
                              Substrates
                              serine (evidence: )
                              Integrated Monomers
                              Domains
                              condensation (LCL), adenylation
                              Name
                              4
                              Type
                              nrps-type1
                              Genes
                              BTH_I2417
                              Substrates
                              N5-formyl-N5-hydroxyornithine (evidence: )
                              Integrated Monomers
                              Domains
                              condensation (LCL), adenylation
                              Annotation changelog

                              Entry version: 4

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2022-10-07
                              Update chemical activity to schema version 2.11
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 3

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2022-09-15
                              Fix incorrect accession
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-09-15
                              Corrected NRP module activity
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-09-15
                              Corrected gene identifiers
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-09-15
                              Updated bioactivity data
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 2

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2019-10-16
                              Migrated from v1.4
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2019-10-16
                              Updated compound(s) information (NPAtlas curation)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 1

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2015-06-12
                              Submitted
                              • (ID: F65XGYSSLMUEJC2Q4T3BLCPS)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              Detailed domain annotation
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