BGC0000386: malleobactin A biosynthetic gene cluster from Burkholderia thailandensis E264
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Location: 2,748,130 - 2,778,630 nt. (total: 30,501 nt).
This entry is originally from NCBI GenBank CP000086.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000386
Short description malleobactin A biosynthetic gene cluster from Burkholderia thailandensis E264
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP (NRP siderophore)
Loci NCBI GenBank: CP000086.1
Compounds
  • malleobactin A
  • malleobactin B
  • malleobactin C
  • malleobactin D
Species Burkholderia thailandensis E264 [taxonomy]
References
Chemical products information
malleobactin A
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C23H40N8O13
Chemical database entries
NPAtlas
malleobactin B
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C23H42N8O12
Chemical database entries
NPAtlas
malleobactin C
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C23H40N8O12
Chemical database entries
NPAtlas
malleobactin D
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C46H80N16O23
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BTH_I2414
  • ABC39200.1
 2748130 - 2748873 (-) conserved hypothetical protein
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  • BTH_I2415
  • ABC36518.1
 2749034 - 2751250 (-) TonB-dependent siderophore receptor
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  • BTH_I2416
  • ABC39452.1
 2751297 - 2752811 (-) l-ornithine 5-monooxygenase
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  • BTH_I2417
  • ABC37099.1
 2752877 - 2758195 (-) non-ribosomal peptide synthetase, putative
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  • BTH_I2418
  • ABC36450.1
 2758217 - 2768107 (-) peptide synthetase-like protein
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  • BTH_I2419
  • ABC39037.1
 2768600 - 2770288 (+) cyclic peptide ABC transporter, ATP-binding protein
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  • BTH_I2420
  • ABC37936.1
 2770766 - 2771341 (+) conserved hypothetical protein
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  • BTH_I2421
  • ABC36332.1
 2771511 - 2772770 (-) iron compound ABC transporter, periplasmic iron-compound-binding protein
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  • BTH_I2422
  • ABC37230.1
 2772701 - 2773495 (-) ferric iron reductase protein FhuF
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  • BTH_I2423
  • ABC38164.1
 2773492 - 2775471 (-) iron compound ABC transporter, permease protein
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  • BTH_I2424
  • ABC39054.1
  • fxuB
 2775609 - 2776517 (-) iron compound ABC transporter, ATP-binding protein
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  • BTH_I2425
  • ABC37410.1
 2776541 - 2777632 (-) syringomycin biosynthesis enzyme, putative
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  • BTH_I2426
  • ABC37505.1
 2777613 - 2777861 (-) mbtH-like protein
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  • BTH_I2427
  • ABC38442.1
 2777917 - 2778630 (-) RNA polymerase sigma-70 factor, ECF subfamily
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NRP-specific information
Subclass NRP siderophore
Cyclic? no
NRP-synthases
Gene Modules
BTH_I2418
Module 1
Specificity: N5-hydroxyornithine
Evidence for specificity:
Condensation domain type: LCL
Module 2
Specificity: aspartic acid
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
Modification domains: beta-hydroxylation
Module 3
Specificity: serine
Evidence for specificity:
Condensation domain type: LCL
BTH_I2417
Module 3
Condensation domain type: LCL
Module 4
Specificity: N5-formyl-N5-hydroxyornithine
Evidence for specificity:
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: F65XGYSSLMUEJC2Q4T3BLCPS, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Fix incorrect accession
  • Corrected NRP module activity
  • Corrected gene identifiers
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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