BGC0000388: mannopeptimycin biosynthetic gene cluster from Streptomyces hygroscopicus
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 48,200 nt. (total: 48,200 nt).
This entry is originally from NCBI GenBank AY735112.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000388
Short description mannopeptimycin biosynthetic gene cluster from Streptomyces hygroscopicus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: AY735112.1
Compounds
  • mannopeptimycin
Species Streptomyces hygroscopicus [taxonomy]
References
Chemical products information
mannopeptimycin
Copy SMILES
C58H86N12O26
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAU34194.1
  • mppC
 77 - 1048 (+) acetyltransferase MppC
copy AA seq
copy Nt seq
  • AAU34195.1
  • mppD
 1045 - 2460 (+) sugar binding protein MppD
copy AA seq
copy Nt seq
  • AAU34196.1
  • mppE
 2495 - 3406 (+) ABC transporter MppE
copy AA seq
copy Nt seq
  • AAU34197.1
  • mppF
 3403 - 4293 (+) ABC transporter MppF
copy AA seq
copy Nt seq
  • AAU34198.1
  • mppG
 4359 - 5636 (+) polyprenyl mannose synthase MppG
copy AA seq
copy Nt seq
  • AAU34199.1
  • mppH
 5822 - 7234 (+) polyprenyl phospho-mannosyltransferase MppH
copy AA seq
copy Nt seq
  • AAU34200.1
  • mppI
 7293 - 8822 (+) polyprenyl phospho-mannosyltransferase MppI
copy AA seq
copy Nt seq
  • AAU34201.1
  • mppJ
 9012 - 10025 (+) methyltransferase MppJ
copy AA seq
copy Nt seq
  • AAU34202.1
  • mppA
 10069 - 18312 (+) mannopeptimycin peptide synthetase MppA
copy AA seq
copy Nt seq
  • AAU34203.1
  • mppB
 18309 - 29315 (+) mannopeptimycin peptide synthetase MppB
copy AA seq
copy Nt seq
  • AAU34204.1
  • mppK
 29319 - 30638 (+) alpha/beta hydrolase MppK
copy AA seq
copy Nt seq
  • AAU34205.1
  • mppL
 30658 - 32010 (+) ABC transporter MppL
copy AA seq
copy Nt seq
  • AAU34206.1
  • mppM
 32181 - 33407 (+) isovaleryltransferase MppM
copy AA seq
copy Nt seq
  • AAU34207.1
  • mppN
 33422 - 34792 (+) isovaleryltransferase MppN
copy AA seq
copy Nt seq
  • AAU34208.1
  • mppO
 34905 - 35930 (+) predicted non-heme iron hydroxylase MppO
copy AA seq
copy Nt seq
  • AAU34209.1
  • mppP
 36383 - 37264 (+) PLP-dependent aminotransferase MppP
copy AA seq
copy Nt seq
  • AAU34210.1
  • mppQ
 37264 - 38511 (+) PLP-dependent aminotransferase MppQ
copy AA seq
copy Nt seq
  • AAU34211.1
  • mppR
 38466 - 39374 (+) conserved hypothetical protein MppR
copy AA seq
copy Nt seq
  • AAU34212.1
  • mppS
 39389 - 40378 (+) putative transcriptional regulator MppS
copy AA seq
copy Nt seq
  • AAU34213.1
  • mppT
 40440 - 40655 (+) conserved hypothetical protein MppT
copy AA seq
copy Nt seq
  • AAU34214.1
  • mppU
 40773 - 41441 (+) two component response regulator MppU
copy AA seq
copy Nt seq
  • AAU34215.1
  • mppV
 41586 - 42758 (+) two component sensor kinase MppV
copy AA seq
copy Nt seq
  • AAU34216.1
  • mppW
 42817 - 43245 (+) hypothetical lipoprotein MppW
copy AA seq
copy Nt seq
  • AAU34217.1
  • mppX
 43248 - 44168 (+) ABC transporter MppX
copy AA seq
copy Nt seq
  • AAU34218.1
  • mppY
 44182 - 45813 (+) conserved hypothetical protein MppY
copy AA seq
copy Nt seq
  • AAU34219.1
  • mppZ
 46384 - 47649 (+) conserved hypothetical protein MppZ
copy AA seq
copy Nt seq
  • AAU34220.1
  • mppZ1
 47770 - 48180 (+) lactone-dependent transcriptional regulator MppZ1
copy AA seq
copy Nt seq
NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
mppA
Module ?
Specificity: serine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: glycine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: phenylalanine
Evidence for specificity:
  • Structure-based inference
mppB
Module ?
Specificity: tyrosine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: S-beta-hydroxyenduracididine
Evidence for specificity:
  • ATP-PPi exchange assay
  • Structure-based inference
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.